Found 6 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM50342919
(6-(benzo[d][1,3]dioxol-5-yl)-N-methyl-N-((4-methyl...)Show SMILES CN(Cc1nc(C)cs1)c1ncnc2ccc(cc12)-c1ccc2OCOc2c1 Show InChI InChI=1S/C21H18N4O2S/c1-13-10-28-20(24-13)9-25(2)21-16-7-14(3-5-17(16)22-11-23-21)15-4-6-18-19(8-15)27-12-26-18/h3-8,10-11H,9,12H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
National Human Genome Research Institute
Curated by ChEMBL
| Assay Description Inhibition of Dyrk1A kinase using ATP as substrate by 33P radiolabelled kinase assay |
Bioorg Med Chem Lett 21: 3152-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.114 BindingDB Entry DOI: 10.7270/Q2J67H83 |
More data for this Ligand-Target Pair | |
Dual specificity protein kinase CLK4
(Homo sapiens (Human)) | BDBM50342919
(6-(benzo[d][1,3]dioxol-5-yl)-N-methyl-N-((4-methyl...)Show SMILES CN(Cc1nc(C)cs1)c1ncnc2ccc(cc12)-c1ccc2OCOc2c1 Show InChI InChI=1S/C21H18N4O2S/c1-13-10-28-20(24-13)9-25(2)21-16-7-14(3-5-17(16)22-11-23-21)15-4-6-18-19(8-15)27-12-26-18/h3-8,10-11H,9,12H2,1-2H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
National Human Genome Research Institute
Curated by ChEMBL
| Assay Description Inhibition of Clk4 kinase using ATP as substrate by 33P radiolabelled kinase assay |
Bioorg Med Chem Lett 21: 3152-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.114 BindingDB Entry DOI: 10.7270/Q2J67H83 |
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1B
(Homo sapiens (Human)) | BDBM50342919
(6-(benzo[d][1,3]dioxol-5-yl)-N-methyl-N-((4-methyl...)Show SMILES CN(Cc1nc(C)cs1)c1ncnc2ccc(cc12)-c1ccc2OCOc2c1 Show InChI InChI=1S/C21H18N4O2S/c1-13-10-28-20(24-13)9-25(2)21-16-7-14(3-5-17(16)22-11-23-21)15-4-6-18-19(8-15)27-12-26-18/h3-8,10-11H,9,12H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
National Human Genome Research Institute
Curated by ChEMBL
| Assay Description Inhibition of Dyrk1B kinase using ATP as substrate by 33P radiolabelled kinase assay |
Bioorg Med Chem Lett 21: 3152-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.114 BindingDB Entry DOI: 10.7270/Q2J67H83 |
More data for this Ligand-Target Pair | |
Dual specificity protein kinase CLK1
(Homo sapiens (Human)) | BDBM50342919
(6-(benzo[d][1,3]dioxol-5-yl)-N-methyl-N-((4-methyl...)Show SMILES CN(Cc1nc(C)cs1)c1ncnc2ccc(cc12)-c1ccc2OCOc2c1 Show InChI InChI=1S/C21H18N4O2S/c1-13-10-28-20(24-13)9-25(2)21-16-7-14(3-5-17(16)22-11-23-21)15-4-6-18-19(8-15)27-12-26-18/h3-8,10-11H,9,12H2,1-2H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 128 | n/a | n/a | n/a | n/a | n/a | n/a |
National Human Genome Research Institute
Curated by ChEMBL
| Assay Description Inhibition of Clk1 kinase using ATP as substrate by 33P radiolabelled kinase assay |
Bioorg Med Chem Lett 21: 3152-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.114 BindingDB Entry DOI: 10.7270/Q2J67H83 |
More data for this Ligand-Target Pair | |
Dual specificity protein kinase CLK2
(Homo sapiens (Human)) | BDBM50342919
(6-(benzo[d][1,3]dioxol-5-yl)-N-methyl-N-((4-methyl...)Show SMILES CN(Cc1nc(C)cs1)c1ncnc2ccc(cc12)-c1ccc2OCOc2c1 Show InChI InChI=1S/C21H18N4O2S/c1-13-10-28-20(24-13)9-25(2)21-16-7-14(3-5-17(16)22-11-23-21)15-4-6-18-19(8-15)27-12-26-18/h3-8,10-11H,9,12H2,1-2H3 | PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 195 | n/a | n/a | n/a | n/a | n/a | n/a |
National Human Genome Research Institute
Curated by ChEMBL
| Assay Description Inhibition of Clk2 kinase using ATP as substrate by 33P radiolabelled kinase assay |
Bioorg Med Chem Lett 21: 3152-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.114 BindingDB Entry DOI: 10.7270/Q2J67H83 |
More data for this Ligand-Target Pair | |
Dual specificity protein kinase CLK3
(Homo sapiens (Human)) | BDBM50342919
(6-(benzo[d][1,3]dioxol-5-yl)-N-methyl-N-((4-methyl...)Show SMILES CN(Cc1nc(C)cs1)c1ncnc2ccc(cc12)-c1ccc2OCOc2c1 Show InChI InChI=1S/C21H18N4O2S/c1-13-10-28-20(24-13)9-25(2)21-16-7-14(3-5-17(16)22-11-23-21)15-4-6-18-19(8-15)27-12-26-18/h3-8,10-11H,9,12H2,1-2H3 | PDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.02E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Human Genome Research Institute
Curated by ChEMBL
| Assay Description Inhibition of Clk3 kinase using ATP as substrate by 33P radiolabelled kinase assay |
Bioorg Med Chem Lett 21: 3152-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.114 BindingDB Entry DOI: 10.7270/Q2J67H83 |
More data for this Ligand-Target Pair | |