Found 9 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Alpha-1B adrenergic receptor
(Homo sapiens (Human)) | BDBM50057463
(1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piper...)Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)COc1c(OC)cccc1C(C)C Show InChI InChI=1S/C26H33N5O5/c1-16(2)17-7-6-8-20(33-3)24(17)36-15-23(32)30-9-11-31(12-10-30)26-28-19-14-22(35-5)21(34-4)13-18(19)25(27)29-26/h6-8,13-14,16H,9-12,15H2,1-5H3,(H2,27,28,29) | UniProtKB/SwissProt
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| Article PubMed
| 0.450 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Recordati S.p.A.
Curated by ChEMBL
| Assay Description The binding affinity of the compound was determined towards Alpha-1B adrenergic receptor in the COS cell line. |
J Med Chem 42: 427-37 (1999)
Article DOI: 10.1021/jm9805337 BindingDB Entry DOI: 10.7270/Q2FN15CK |
More data for this Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50057463
(1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piper...)Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)COc1c(OC)cccc1C(C)C Show InChI InChI=1S/C26H33N5O5/c1-16(2)17-7-6-8-20(33-3)24(17)36-15-23(32)30-9-11-31(12-10-30)26-28-19-14-22(35-5)21(34-4)13-18(19)25(27)29-26/h6-8,13-14,16H,9-12,15H2,1-5H3,(H2,27,28,29) | PDB
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| Article PubMed
| 7.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Recordati S.p.A.
Curated by ChEMBL
| Assay Description The binding affinity of the compound was determined towards Alpha-1A adrenergic receptor in the COS cell line. |
J Med Chem 42: 427-37 (1999)
Article DOI: 10.1021/jm9805337 BindingDB Entry DOI: 10.7270/Q2FN15CK |
More data for this Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Homo sapiens (Human)) | BDBM50057463
(1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piper...)Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)COc1c(OC)cccc1C(C)C Show InChI InChI=1S/C26H33N5O5/c1-16(2)17-7-6-8-20(33-3)24(17)36-15-23(32)30-9-11-31(12-10-30)26-28-19-14-22(35-5)21(34-4)13-18(19)25(27)29-26/h6-8,13-14,16H,9-12,15H2,1-5H3,(H2,27,28,29) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 10.3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Recordati S.p.A.
Curated by ChEMBL
| Assay Description The binding affinity of the compound was determined towards Alpha-1C adrenergic receptor in the COS cell line. |
J Med Chem 42: 427-37 (1999)
Article DOI: 10.1021/jm9805337 BindingDB Entry DOI: 10.7270/Q2FN15CK |
More data for this Ligand-Target Pair | |
Alpha-1B adrenergic receptor
(Homo sapiens (Human)) | BDBM50057463
(1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piper...)Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)COc1c(OC)cccc1C(C)C Show InChI InChI=1S/C26H33N5O5/c1-16(2)17-7-6-8-20(33-3)24(17)36-15-23(32)30-9-11-31(12-10-30)26-28-19-14-22(35-5)21(34-4)13-18(19)25(27)29-26/h6-8,13-14,16H,9-12,15H2,1-5H3,(H2,27,28,29) | UniProtKB/SwissProt
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| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Central Research
Curated by ChEMBL
| Assay Description Binding affinity was tested on cloned hamster Alpha-1B adrenergic receptor |
J Med Chem 40: 1293-315 (1997)
Article DOI: 10.1021/jm960697s BindingDB Entry DOI: 10.7270/Q2W096MN |
More data for this Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(CALF) | BDBM50057463
(1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piper...)Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)COc1c(OC)cccc1C(C)C Show InChI InChI=1S/C26H33N5O5/c1-16(2)17-7-6-8-20(33-3)24(17)36-15-23(32)30-9-11-31(12-10-30)26-28-19-14-22(35-5)21(34-4)13-18(19)25(27)29-26/h6-8,13-14,16H,9-12,15H2,1-5H3,(H2,27,28,29) | PDB
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| Article PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Central Research
Curated by ChEMBL
| Assay Description Binding affinity was tested on cloned bovine Alpha-1A adrenergic receptor |
J Med Chem 40: 1293-315 (1997)
Article DOI: 10.1021/jm960697s BindingDB Entry DOI: 10.7270/Q2W096MN |
More data for this Ligand-Target Pair | |
Alpha-1D adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50057463
(1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piper...)Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)COc1c(OC)cccc1C(C)C Show InChI InChI=1S/C26H33N5O5/c1-16(2)17-7-6-8-20(33-3)24(17)36-15-23(32)30-9-11-31(12-10-30)26-28-19-14-22(35-5)21(34-4)13-18(19)25(27)29-26/h6-8,13-14,16H,9-12,15H2,1-5H3,(H2,27,28,29) | KEGG
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CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Central Research
Curated by ChEMBL
| Assay Description Binding affinity was tested on cloned rat Alpha-1D adrenergic receptor |
J Med Chem 40: 1293-315 (1997)
Article DOI: 10.1021/jm960697s BindingDB Entry DOI: 10.7270/Q2W096MN |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat)) | BDBM50057463
(1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piper...)Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)COc1c(OC)cccc1C(C)C Show InChI InChI=1S/C26H33N5O5/c1-16(2)17-7-6-8-20(33-3)24(17)36-15-23(32)30-9-11-31(12-10-30)26-28-19-14-22(35-5)21(34-4)13-18(19)25(27)29-26/h6-8,13-14,16H,9-12,15H2,1-5H3,(H2,27,28,29) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL MCE PC cid PC sid UniChem
Patents
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| Article PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Recordati S.p.A.
Curated by ChEMBL
| Assay Description Inhibitory concentration against 5-hydroxytryptamine 2A receptor (Inactive at >1000 nM concentration) |
J Med Chem 42: 427-37 (1999)
Article DOI: 10.1021/jm9805337 BindingDB Entry DOI: 10.7270/Q2FN15CK |
More data for this Ligand-Target Pair | |
D(2) dopamine receptor
(Rattus norvegicus (rat)) | BDBM50057463
(1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piper...)Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)COc1c(OC)cccc1C(C)C Show InChI InChI=1S/C26H33N5O5/c1-16(2)17-7-6-8-20(33-3)24(17)36-15-23(32)30-9-11-31(12-10-30)26-28-19-14-22(35-5)21(34-4)13-18(19)25(27)29-26/h6-8,13-14,16H,9-12,15H2,1-5H3,(H2,27,28,29) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL MCE PC cid PC sid UniChem
Patents
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| Article PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Recordati S.p.A.
Curated by ChEMBL
| Assay Description Inhibitory concentration against Dopamine receptor D2 (Inactive at >1000 nM concentration) |
J Med Chem 42: 427-37 (1999)
Article DOI: 10.1021/jm9805337 BindingDB Entry DOI: 10.7270/Q2FN15CK |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat)) | BDBM50057463
(1-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piper...)Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)COc1c(OC)cccc1C(C)C Show InChI InChI=1S/C26H33N5O5/c1-16(2)17-7-6-8-20(33-3)24(17)36-15-23(32)30-9-11-31(12-10-30)26-28-19-14-22(35-5)21(34-4)13-18(19)25(27)29-26/h6-8,13-14,16H,9-12,15H2,1-5H3,(H2,27,28,29) | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Recordati S.p.A.
Curated by ChEMBL
| Assay Description Inhibitory concentration against 5-hydroxytryptamine 1A receptor (Inactive at >1000 nM concentration) |
J Med Chem 42: 427-37 (1999)
Article DOI: 10.1021/jm9805337 BindingDB Entry DOI: 10.7270/Q2FN15CK |
More data for this Ligand-Target Pair | |