Found 5 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Dual specificity protein kinase CLK1
(Mus musculus) | BDBM50242622
(CHEMBL4065204)Show SMILES COc1cc2ncnc(Nc3cc(-c4ccccc4)n(n3)-c3ccccc3)c2cc1OC Show InChI InChI=1S/C25H21N5O2/c1-31-22-13-19-20(14-23(22)32-2)26-16-27-25(19)28-24-15-21(17-9-5-3-6-10-17)30(29-24)18-11-7-4-8-12-18/h3-16H,1-2H3,(H,26,27,28,29) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Rajiv Gandhi Proudyogiki Vishwavidyalaya
Curated by ChEMBL
| Assay Description Inhibition of recombinant mouse GST-fused CLK1 expressed in Escherichia coli using RS peptide as substrate after 30 mins in presence of ATP by scinti... |
Bioorg Med Chem Lett 27: 2663-2667 (2017)
Article DOI: 10.1016/j.bmcl.2017.04.080 BindingDB Entry DOI: 10.7270/Q28P62X6 |
More data for this Ligand-Target Pair | |
Cyclin-T1/Cyclin-dependent kinase 9
(Homo sapiens (Human)) | BDBM50242622
(CHEMBL4065204)Show SMILES COc1cc2ncnc(Nc3cc(-c4ccccc4)n(n3)-c3ccccc3)c2cc1OC Show InChI InChI=1S/C25H21N5O2/c1-31-22-13-19-20(14-23(22)32-2)26-16-27-25(19)28-24-15-21(17-9-5-3-6-10-17)30(29-24)18-11-7-4-8-12-18/h3-16H,1-2H3,(H,26,27,28,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Rajiv Gandhi Proudyogiki Vishwavidyalaya
Curated by ChEMBL
| Assay Description Inhibition of recombinant human CDK9/cyclin T expressed in insect cells using YSPTSPSYSPTSPSYSPTSPSKKKK as substrate after 30 mins in presence of ATP... |
Bioorg Med Chem Lett 27: 2663-2667 (2017)
Article DOI: 10.1016/j.bmcl.2017.04.080 BindingDB Entry DOI: 10.7270/Q28P62X6 |
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM50242622
(CHEMBL4065204)Show SMILES COc1cc2ncnc(Nc3cc(-c4ccccc4)n(n3)-c3ccccc3)c2cc1OC Show InChI InChI=1S/C25H21N5O2/c1-31-22-13-19-20(14-23(22)32-2)26-16-27-25(19)28-24-15-21(17-9-5-3-6-10-17)30(29-24)18-11-7-4-8-12-18/h3-16H,1-2H3,(H,26,27,28,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Rajiv Gandhi Proudyogiki Vishwavidyalaya
Curated by ChEMBL
| Assay Description Inhibition of recombinant full length human GST-fused DYRK1A expressed in Escherichia coli using RS peptide as substrate after 30 mins in presence of... |
Bioorg Med Chem Lett 27: 2663-2667 (2017)
Article DOI: 10.1016/j.bmcl.2017.04.080 BindingDB Entry DOI: 10.7270/Q28P62X6 |
More data for this Ligand-Target Pair | |
Cyclin-A2/Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50242622
(CHEMBL4065204)Show SMILES COc1cc2ncnc(Nc3cc(-c4ccccc4)n(n3)-c3ccccc3)c2cc1OC Show InChI InChI=1S/C25H21N5O2/c1-31-22-13-19-20(14-23(22)32-2)26-16-27-25(19)28-24-15-21(17-9-5-3-6-10-17)30(29-24)18-11-7-4-8-12-18/h3-16H,1-2H3,(H,26,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Rajiv Gandhi Proudyogiki Vishwavidyalaya
Curated by ChEMBL
| Assay Description Inhibition of recombinant human CDK2/cyclin A using histone H1 as substrate after 30 mins in presence of ATP by scintillation counting method |
Bioorg Med Chem Lett 27: 2663-2667 (2017)
Article DOI: 10.1016/j.bmcl.2017.04.080 BindingDB Entry DOI: 10.7270/Q28P62X6 |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 5 activator 1
(Homo sapiens (Human)) | BDBM50242622
(CHEMBL4065204)Show SMILES COc1cc2ncnc(Nc3cc(-c4ccccc4)n(n3)-c3ccccc3)c2cc1OC Show InChI InChI=1S/C25H21N5O2/c1-31-22-13-19-20(14-23(22)32-2)26-16-27-25(19)28-24-15-21(17-9-5-3-6-10-17)30(29-24)18-11-7-4-8-12-18/h3-16H,1-2H3,(H,26,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Rajiv Gandhi Proudyogiki Vishwavidyalaya
Curated by ChEMBL
| Assay Description Inhibition of recombinant human CDK5/p25 expressed in Escherichia coli using histone H1 as substrate after 30 mins in presence of ATP by scintillatio... |
Bioorg Med Chem Lett 27: 2663-2667 (2017)
Article DOI: 10.1016/j.bmcl.2017.04.080 BindingDB Entry DOI: 10.7270/Q28P62X6 |
More data for this Ligand-Target Pair | |