Found 8 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
cGMP-dependent protein kinase
() | BDBM340946
(3-tert-butyl-1-(6-methoxynaphthalen-2- yl)imidazo[...)Show SMILES COc1ccc2cc(ccc2c1)-c1nc(n2ccnc(N)c12)C(C)(C)C Show InChI InChI=1S/C21H22N4O/c1-21(2,3)20-24-17(18-19(22)23-9-10-25(18)20)15-6-5-14-12-16(26-4)8-7-13(14)11-15/h5-12H,1-4H3,(H2,22,23) | UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2K077GQ |
More data for this Ligand-Target Pair | |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM340946
(3-tert-butyl-1-(6-methoxynaphthalen-2- yl)imidazo[...)Show SMILES COc1ccc2cc(ccc2c1)-c1nc(n2ccnc(N)c12)C(C)(C)C Show InChI InChI=1S/C21H22N4O/c1-21(2,3)20-24-17(18-19(22)23-9-10-25(18)20)15-6-5-14-12-16(26-4)8-7-13(14)11-15/h5-12H,1-4H3,(H2,22,23) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center for Commercialization
US Patent
| Assay Description Most known kinase inhibitors bind in the ATP-binding pocket of the active site19,20. These inhibitors exploit many of the same hydrophobic contacts a... |
US Patent US9765037 (2017)
BindingDB Entry DOI: 10.7270/Q2B56MVC |
More data for this Ligand-Target Pair | |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM340946
(3-tert-butyl-1-(6-methoxynaphthalen-2- yl)imidazo[...)Show SMILES COc1ccc2cc(ccc2c1)-c1nc(n2ccnc(N)c12)C(C)(C)C Show InChI InChI=1S/C21H22N4O/c1-21(2,3)20-24-17(18-19(22)23-9-10-25(18)20)15-6-5-14-12-16(26-4)8-7-13(14)11-15/h5-12H,1-4H3,(H2,22,23) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR CO
US Patent
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US10544104 (2020)
BindingDB Entry DOI: 10.7270/Q2D79DSF |
More data for this Ligand-Target Pair | |
Calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands
(Cryptosporidium parvum (strain Iowa II)) | BDBM340946
(3-tert-butyl-1-(6-methoxynaphthalen-2- yl)imidazo[...)Show SMILES COc1ccc2cc(ccc2c1)-c1nc(n2ccnc(N)c12)C(C)(C)C Show InChI InChI=1S/C21H22N4O/c1-21(2,3)20-24-17(18-19(22)23-9-10-25(18)20)15-6-5-14-12-16(26-4)8-7-13(14)11-15/h5-12H,1-4H3,(H2,22,23) | UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 5.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2K077GQ |
More data for this Ligand-Target Pair | |
Calcium-dependent protein kinase 1
(Cryptosporidium parvum) | BDBM340946
(3-tert-butyl-1-(6-methoxynaphthalen-2- yl)imidazo[...)Show SMILES COc1ccc2cc(ccc2c1)-c1nc(n2ccnc(N)c12)C(C)(C)C Show InChI InChI=1S/C21H22N4O/c1-21(2,3)20-24-17(18-19(22)23-9-10-25(18)20)15-6-5-14-12-16(26-4)8-7-13(14)11-15/h5-12H,1-4H3,(H2,22,23) | UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 5.30 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center for Commercialization
US Patent
| Assay Description Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha... |
US Patent US9765037 (2017)
BindingDB Entry DOI: 10.7270/Q2B56MVC |
More data for this Ligand-Target Pair | |
Calmodulin-domain protein kinase 1, putative
(Cryptosporidium parvum (strain Iowa II)) | BDBM340946
(3-tert-butyl-1-(6-methoxynaphthalen-2- yl)imidazo[...)Show SMILES COc1ccc2cc(ccc2c1)-c1nc(n2ccnc(N)c12)C(C)(C)C Show InChI InChI=1S/C21H22N4O/c1-21(2,3)20-24-17(18-19(22)23-9-10-25(18)20)15-6-5-14-12-16(26-4)8-7-13(14)11-15/h5-12H,1-4H3,(H2,22,23) | PDB MMDB
UniProtKB/TrEMBL
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 5.30 | n/a | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR CO
US Patent
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US10544104 (2020)
BindingDB Entry DOI: 10.7270/Q2D79DSF |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM340946
(3-tert-butyl-1-(6-methoxynaphthalen-2- yl)imidazo[...)Show SMILES COc1ccc2cc(ccc2c1)-c1nc(n2ccnc(N)c12)C(C)(C)C Show InChI InChI=1S/C21H22N4O/c1-21(2,3)20-24-17(18-19(22)23-9-10-25(18)20)15-6-5-14-12-16(26-4)8-7-13(14)11-15/h5-12H,1-4H3,(H2,22,23) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 6.09E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR CO
US Patent
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US10544104 (2020)
BindingDB Entry DOI: 10.7270/Q2D79DSF |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase ABL1
(Homo sapiens (Human)) | BDBM340946
(3-tert-butyl-1-(6-methoxynaphthalen-2- yl)imidazo[...)Show SMILES COc1ccc2cc(ccc2c1)-c1nc(n2ccnc(N)c12)C(C)(C)C Show InChI InChI=1S/C21H22N4O/c1-21(2,3)20-24-17(18-19(22)23-9-10-25(18)20)15-6-5-14-12-16(26-4)8-7-13(14)11-15/h5-12H,1-4H3,(H2,22,23) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR CO
US Patent
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US10544104 (2020)
BindingDB Entry DOI: 10.7270/Q2D79DSF |
More data for this Ligand-Target Pair | |