Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Muscarinic acetylcholine receptor M2
(Homo sapiens (Human)) | BDBM50521777
(CHEMBL4558206)Show SMILES Cc1nc2cc(C)c3c(N)c(sc3n2n1)C(=O)NC1CN(C1)c1cnc(nc1)C1CC1 Show InChI InChI=1S/C21H22N8OS/c1-10-5-15-25-11(2)27-29(15)21-16(10)17(22)18(31-21)20(30)26-13-8-28(9-13)14-6-23-19(24-7-14)12-3-4-12/h5-7,12-13H,3-4,8-9,22H2,1-2H3,(H,26,30) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 600 | n/a | n/a | n/a | n/a |
Vanderbilt University
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of human M2 AchR |
Bioorg Med Chem Lett 29: 2224-2228 (2019)
Article DOI: 10.1016/j.bmcl.2019.06.032
BindingDB Entry DOI: 10.7270/Q2X351VJ |
More data for this
Ligand-Target Pair | |
Muscarinic acetylcholine receptor M4
(Homo sapiens (Human)) | BDBM50521777
(CHEMBL4558206)Show SMILES Cc1nc2cc(C)c3c(N)c(sc3n2n1)C(=O)NC1CN(C1)c1cnc(nc1)C1CC1 Show InChI InChI=1S/C21H22N8OS/c1-10-5-15-25-11(2)27-29(15)21-16(10)17(22)18(31-21)20(30)26-13-8-28(9-13)14-6-23-19(24-7-14)12-3-4-12/h5-7,12-13H,3-4,8-9,22H2,1-2H3,(H,26,30) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 120 | n/a | n/a | n/a | n/a |
Vanderbilt University
Curated by ChEMBL
| Assay Description
Positive allosteric modulation of human M4 AchR expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induced calcium mobil... |
Bioorg Med Chem Lett 29: 2224-2228 (2019)
Article DOI: 10.1016/j.bmcl.2019.06.032
BindingDB Entry DOI: 10.7270/Q2X351VJ |
More data for this
Ligand-Target Pair | |