| Reaction Details |
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 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M2 |
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| Ligand | BDBM50521777 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1885235 (CHEMBL4386817) |
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| EC50 | 600±n/a nM |
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| Citation |  Chopko, TC; Han, C; Gregro, AR; Engers, DW; Felts, AS; Poslusney, MS; Bollinger, KA; Morrison, RD; Bubser, M; Lamsal, A; Luscombe, VB; Cho, HP; Schnetz-Boutaud, NC; Rodriguez, AL; Chang, S; Daniels, JS; Stec, DF; Niswender, CM; Jones, CK; Wood, MR; Wood, MW; Duggan, ME; Brandon, NJ; Conn, PJ; Bridges, TM; Lindsley, CW; Melancon, BJ SAR inspired by aldehyde oxidase (AO) metabolism: Discovery of novel, CNS penetrant tricyclic M Bioorg Med Chem Lett29:2224-2228 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Muscarinic acetylcholine receptor M2 |
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| Name: | Muscarinic acetylcholine receptor M2 |
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| Synonyms: | ACM2_HUMAN | CHRM2 | Cholinergic, muscarinic M2 | Muscarinic acetylcholine receptor M2 and M4 | Muscarinic acetylcholine receptor M2 and M5 | RecName: Full=Muscarinic acetylcholine receptor M2 |
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| Type: | GPCR |
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| Mol. Mass.: | 51730.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08172 |
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| Residue: | 466 |
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| Sequence: | MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI
VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE
ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI
VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT
VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
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| BDBM50521777 |
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| n/a |
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| Name | BDBM50521777 |
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| Synonyms: | CHEMBL4558206 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H22N8OS |
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| Mol. Mass. | 434.517 |
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| SMILES | Cc1nc2cc(C)c3c(N)c(sc3n2n1)C(=O)NC1CN(C1)c1cnc(nc1)C1CC1 |
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| Structure | 
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