Found 8 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
cGMP-dependent protein kinase
() | BDBM340932
(3-(1-methyl-1H-indol-5-yl)-1-(piperidin-4- ylmethy...)Show SMILES Cn1ccc2cc(ccc12)-c1nn(CC2CCNCC2)c2ncnc(N)c12 Show InChI InChI=1S/C20H23N7/c1-26-9-6-14-10-15(2-3-16(14)26)18-17-19(21)23-12-24-20(17)27(25-18)11-13-4-7-22-8-5-13/h2-3,6,9-10,12-13,22H,4-5,7-8,11H2,1H3,(H2,21,23,24) | UniProtKB/SwissProt
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2K077GQ |
More data for this
Ligand-Target Pair | |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM340932
(3-(1-methyl-1H-indol-5-yl)-1-(piperidin-4- ylmethy...)Show SMILES Cn1ccc2cc(ccc12)-c1nn(CC2CCNCC2)c2ncnc(N)c12 Show InChI InChI=1S/C20H23N7/c1-26-9-6-14-10-15(2-3-16(14)26)18-17-19(21)23-12-24-20(17)27(25-18)11-13-4-7-22-8-5-13/h2-3,6,9-10,12-13,22H,4-5,7-8,11H2,1H3,(H2,21,23,24) | PDB
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center for Commercialization
US Patent
| Assay Description
Most known kinase inhibitors bind in the ATP-binding pocket of the active site19,20. These inhibitors exploit many of the same hydrophobic contacts a... |
US Patent US9765037 (2017)
BindingDB Entry DOI: 10.7270/Q2B56MVC |
More data for this
Ligand-Target Pair | |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM340932
(3-(1-methyl-1H-indol-5-yl)-1-(piperidin-4- ylmethy...)Show SMILES Cn1ccc2cc(ccc12)-c1nn(CC2CCNCC2)c2ncnc(N)c12 Show InChI InChI=1S/C20H23N7/c1-26-9-6-14-10-15(2-3-16(14)26)18-17-19(21)23-12-24-20(17)27(25-18)11-13-4-7-22-8-5-13/h2-3,6,9-10,12-13,22H,4-5,7-8,11H2,1H3,(H2,21,23,24) | PDB
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR CO
US Patent
| Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US10544104 (2020)
BindingDB Entry DOI: 10.7270/Q2D79DSF |
More data for this
Ligand-Target Pair | |
Calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands
(Cryptosporidium parvum (strain Iowa II)) | BDBM340932
(3-(1-methyl-1H-indol-5-yl)-1-(piperidin-4- ylmethy...)Show SMILES Cn1ccc2cc(ccc12)-c1nn(CC2CCNCC2)c2ncnc(N)c12 Show InChI InChI=1S/C20H23N7/c1-26-9-6-14-10-15(2-3-16(14)26)18-17-19(21)23-12-24-20(17)27(25-18)11-13-4-7-22-8-5-13/h2-3,6,9-10,12-13,22H,4-5,7-8,11H2,1H3,(H2,21,23,24) | UniProtKB/TrEMBL
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 13.4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2K077GQ |
More data for this
Ligand-Target Pair | |
Calcium-dependent protein kinase 1
(Cryptosporidium parvum) | BDBM340932
(3-(1-methyl-1H-indol-5-yl)-1-(piperidin-4- ylmethy...)Show SMILES Cn1ccc2cc(ccc12)-c1nn(CC2CCNCC2)c2ncnc(N)c12 Show InChI InChI=1S/C20H23N7/c1-26-9-6-14-10-15(2-3-16(14)26)18-17-19(21)23-12-24-20(17)27(25-18)11-13-4-7-22-8-5-13/h2-3,6,9-10,12-13,22H,4-5,7-8,11H2,1H3,(H2,21,23,24) | UniProtKB/TrEMBL
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 13.4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center for Commercialization
US Patent
| Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha... |
US Patent US9765037 (2017)
BindingDB Entry DOI: 10.7270/Q2B56MVC |
More data for this
Ligand-Target Pair | |
Calmodulin-domain protein kinase 1, putative
(Cryptosporidium parvum (strain Iowa II)) | BDBM340932
(3-(1-methyl-1H-indol-5-yl)-1-(piperidin-4- ylmethy...)Show SMILES Cn1ccc2cc(ccc12)-c1nn(CC2CCNCC2)c2ncnc(N)c12 Show InChI InChI=1S/C20H23N7/c1-26-9-6-14-10-15(2-3-16(14)26)18-17-19(21)23-12-24-20(17)27(25-18)11-13-4-7-22-8-5-13/h2-3,6,9-10,12-13,22H,4-5,7-8,11H2,1H3,(H2,21,23,24) | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 13.4 | n/a | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR CO
US Patent
| Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US10544104 (2020)
BindingDB Entry DOI: 10.7270/Q2D79DSF |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM340932
(3-(1-methyl-1H-indol-5-yl)-1-(piperidin-4- ylmethy...)Show SMILES Cn1ccc2cc(ccc12)-c1nn(CC2CCNCC2)c2ncnc(N)c12 Show InChI InChI=1S/C20H23N7/c1-26-9-6-14-10-15(2-3-16(14)26)18-17-19(21)23-12-24-20(17)27(25-18)11-13-4-7-22-8-5-13/h2-3,6,9-10,12-13,22H,4-5,7-8,11H2,1H3,(H2,21,23,24) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR CO
US Patent
| Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US10544104 (2020)
BindingDB Entry DOI: 10.7270/Q2D79DSF |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase ABL1
(Homo sapiens (Human)) | BDBM340932
(3-(1-methyl-1H-indol-5-yl)-1-(piperidin-4- ylmethy...)Show SMILES Cn1ccc2cc(ccc12)-c1nn(CC2CCNCC2)c2ncnc(N)c12 Show InChI InChI=1S/C20H23N7/c1-26-9-6-14-10-15(2-3-16(14)26)18-17-19(21)23-12-24-20(17)27(25-18)11-13-4-7-22-8-5-13/h2-3,6,9-10,12-13,22H,4-5,7-8,11H2,1H3,(H2,21,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR CO
US Patent
| Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US10544104 (2020)
BindingDB Entry DOI: 10.7270/Q2D79DSF |
More data for this
Ligand-Target Pair | |