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Target
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Marvin 2D Structure
The following exact ligands are found in BindingDB
Wt: 466.9
BDBM50573814
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
3
hits in this display
Target/Host
(Institution)
Ligand
Target/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
k
off
s
-1
k
on
M
-1
s
-1
pH
Temp
°C
Dipeptidyl peptidase 1
(Homo sapiens (Human))
BDBM50573814
(CHEMBL4850341)
Show SMILES
FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)N3CCSCC3)ncc2Cl)c1
Show InChI
PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
408
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of human recombinant Cathepsin C using H-Gly-Arg-AMC as substrate pretreated for 30 mins followed by substrate addition incubated for 60 m...
Citation and Details
Article DOI:
10.1021/acs.jmedchem.1c00104
BindingDB Entry DOI:
10.7270/Q2QZ2FS7
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 1
(Homo sapiens (Human))
BDBM50573814
(CHEMBL4850341)
Show SMILES
FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)N3CCSCC3)ncc2Cl)c1
Show InChI
PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
1.48E+3
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of human Cathepsin C in human U-937 cells using H-Gly-Phe-AFC as substrate pretreated for 60 mins followed by substrate addition incubated...
Citation and Details
Article DOI:
10.1021/acs.jmedchem.1c00104
BindingDB Entry DOI:
10.7270/Q2QZ2FS7
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 1
(Homo sapiens (Human))
BDBM50573814
(CHEMBL4850341)
Show SMILES
FC(F)(F)c1cccc(Nc2nc(Nc3ccc(cn3)N3CCSCC3)ncc2Cl)c1
Show InChI
PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
>3.00E+3
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of human Cathepsin C in human THP-1 cells using H-Gly-Phe-AFC as substrate pretreated for 60 mins followed by substrate addition incubated...
Citation and Details
Article DOI:
10.1021/acs.jmedchem.1c00104
BindingDB Entry DOI:
10.7270/Q2QZ2FS7
More data for this
Ligand-Target Pair