Found 5 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM150611
(US10238633, Example 285 | US8987249, 285 | US97136...)Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-n1cc(cn1)C(F)(F)F |r| Show InChI InChI=1S/C20H19F4N5O/c21-17-7-16(29-10-13(9-26-29)20(22,23)24)4-2-11(17)5-15(8-25)28-19(30)18-12-1-3-14(6-12)27-18/h2,4,7,9-10,12,14-15,18,27H,1,3,5-6H2,(H,28,30)/t12-,14+,15-,18-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 9.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer HealthCare Pharmaceuticals Corporation
| Assay Description The recombinant human DPPI was diluted in TAGZyme buffer to 1 U/ml (38.1 μg/ml, respectively), and then activated by mixing in a 1:2 ratio with ... |
J Med Chem 50: 984-1000 (2007)
BindingDB Entry DOI: 10.7270/Q22R3TZF |
More data for this Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM150611
(US10238633, Example 285 | US8987249, 285 | US97136...)Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-n1cc(cn1)C(F)(F)F |r| Show InChI InChI=1S/C20H19F4N5O/c21-17-7-16(29-10-13(9-26-29)20(22,23)24)4-2-11(17)5-15(8-25)28-19(30)18-12-1-3-14(6-12)27-18/h2,4,7,9-10,12,14-15,18,27H,1,3,5-6H2,(H,28,30)/t12-,14+,15-,18-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 9.30 | n/a | n/a | n/a | n/a | 6.0 | 25 |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod.... |
US Patent US9713606 (2017)
BindingDB Entry DOI: 10.7270/Q21G0P8M |
More data for this Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM150611
(US10238633, Example 285 | US8987249, 285 | US97136...)Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-n1cc(cn1)C(F)(F)F |r| Show InChI InChI=1S/C20H19F4N5O/c21-17-7-16(29-10-13(9-26-29)20(22,23)24)4-2-11(17)5-15(8-25)28-19(30)18-12-1-3-14(6-12)27-18/h2,4,7,9-10,12,14-15,18,27H,1,3,5-6H2,(H,28,30)/t12-,14+,15-,18-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 9.30 | n/a | n/a | n/a | n/a | n/a | 25 |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description The recombinant human DPPI was diluted in TAGZyme buffer to 1 U/ml (38.1 ug/ml, respectively), and then activated by mixing in a 1:2 ratio with a Cys... |
US Patent US8987249 (2015)
BindingDB Entry DOI: 10.7270/Q2KP80WG |
More data for this Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM150611
(US10238633, Example 285 | US8987249, 285 | US97136...)Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-n1cc(cn1)C(F)(F)F |r| Show InChI InChI=1S/C20H19F4N5O/c21-17-7-16(29-10-13(9-26-29)20(22,23)24)4-2-11(17)5-15(8-25)28-19(30)18-12-1-3-14(6-12)27-18/h2,4,7,9-10,12,14-15,18,27H,1,3,5-6H2,(H,28,30)/t12-,14+,15-,18-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 8.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer HealthCare Pharmaceuticals Corporation
| Assay Description To activate the proenzyme, 5 μl procathepsin K were mixed with 1 ul activation buffer, and incubated at room temperature for 30 min.5 μL te... |
J Med Chem 50: 984-1000 (2007)
BindingDB Entry DOI: 10.7270/Q22R3TZF |
More data for this Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM150611
(US10238633, Example 285 | US8987249, 285 | US97136...)Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-n1cc(cn1)C(F)(F)F |r| Show InChI InChI=1S/C20H19F4N5O/c21-17-7-16(29-10-13(9-26-29)20(22,23)24)4-2-11(17)5-15(8-25)28-19(30)18-12-1-3-14(6-12)27-18/h2,4,7,9-10,12,14-15,18,27H,1,3,5-6H2,(H,28,30)/t12-,14+,15-,18-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 8.70E+3 | n/a | n/a | n/a | n/a | 3.5 | 25 |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr... |
US Patent US9713606 (2017)
BindingDB Entry DOI: 10.7270/Q21G0P8M |
More data for this Ligand-Target Pair | |