Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Cyclin-dependent kinase 6
(Homo sapiens (Human)) | BDBM132479
(US8841312, 228)Show SMILES Fc1nccc2c3cnc(Nc4ccc(cn4)S(=O)(=O)N4CCNCC4)nc3n(C3CCCC3)c12 Show InChI InChI=1S/C23H25FN8O2S/c24-21-20-17(7-8-26-21)18-14-28-23(30-22(18)32(20)15-3-1-2-4-15)29-19-6-5-16(13-27-19)35(33,34)31-11-9-25-10-12-31/h5-8,13-15,25H,1-4,9-12H2,(H,27,28,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Amgen Inc.
US Patent
| Assay Description The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr... |
US Patent US8841312 (2014)
BindingDB Entry DOI: 10.7270/Q2H41Q4H |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4
(Homo sapiens (Human)) | BDBM132479
(US8841312, 228)Show SMILES Fc1nccc2c3cnc(Nc4ccc(cn4)S(=O)(=O)N4CCNCC4)nc3n(C3CCCC3)c12 Show InChI InChI=1S/C23H25FN8O2S/c24-21-20-17(7-8-26-21)18-14-28-23(30-22(18)32(20)15-3-1-2-4-15)29-19-6-5-16(13-27-19)35(33,34)31-11-9-25-10-12-31/h5-8,13-15,25H,1-4,9-12H2,(H,27,28,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Amgen Inc.
US Patent
| Assay Description The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr... |
US Patent US8841312 (2014)
BindingDB Entry DOI: 10.7270/Q2H41Q4H |
More data for this Ligand-Target Pair | |