Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 289.5 BDBM50034961Purchase

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 4 hits in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA primase (Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)	BDBM50034961 (6-Chloro-N*4*-(3,4-dichloro-phenyl)-pyrimidine-2,4...) Show SMILES Nc1nc(Cl)cc(Nc2ccc(Cl)c(Cl)c2)n1 Show InChI InChI=1S/C10H7Cl3N4/c11-6-2-1-5(3-7(6)12)15-9-4-8(13)16-10(14)17-9/h1-4H,(H3,14,15,16,17)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	8.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Stanford University Medical School Curated by ChEMBL					Assay Description Inhibition against Primase by coupled primase-DNA polymerase-I assay with the two subunit recombinant HSV-1 helicase primase				J Med Chem 38: 1820-5 (1995) BindingDB Entry DOI: 10.7270/Q29K4983
					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Homo sapiens (Human))	BDBM50034961 (6-Chloro-N*4*-(3,4-dichloro-phenyl)-pyrimidine-2,4...) Show SMILES Nc1nc(Cl)cc(Nc2ccc(Cl)c(Cl)c2)n1 Show InChI InChI=1S/C10H7Cl3N4/c11-6-2-1-5(3-7(6)12)15-9-4-8(13)16-10(14)17-9/h1-4H,(H3,14,15,16,17)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Stanford University Medical School Curated by ChEMBL					Assay Description Inhibition against DNA topoisomerase I by direct assay with activated DNA and 25 uM dNTPs including [3H]-dTTP				J Med Chem 38: 1820-5 (1995) BindingDB Entry DOI: 10.7270/Q29K4983
					More data for this Ligand-Target Pair
DNA polymerase alpha catalytic subunit (Homo sapiens (Human))	BDBM50034961 (6-Chloro-N*4*-(3,4-dichloro-phenyl)-pyrimidine-2,4...) Show SMILES Nc1nc(Cl)cc(Nc2ccc(Cl)c(Cl)c2)n1 Show InChI InChI=1S/C10H7Cl3N4/c11-6-2-1-5(3-7(6)12)15-9-4-8(13)16-10(14)17-9/h1-4H,(H3,14,15,16,17)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Stanford University Medical School Curated by ChEMBL					Assay Description Inhibition against DNA polymerase by direct assay with activated DNA and 25 uM dNTPs lacking the expected competitor substrate				J Med Chem 38: 1820-5 (1995) BindingDB Entry DOI: 10.7270/Q29K4983
					More data for this Ligand-Target Pair
DNA polymerase alpha catalytic subunit (Homo sapiens (Human))	BDBM50034961 (6-Chloro-N*4*-(3,4-dichloro-phenyl)-pyrimidine-2,4...) Show SMILES Nc1nc(Cl)cc(Nc2ccc(Cl)c(Cl)c2)n1 Show InChI InChI=1S/C10H7Cl3N4/c11-6-2-1-5(3-7(6)12)15-9-4-8(13)16-10(14)17-9/h1-4H,(H3,14,15,16,17)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Stanford University Medical School Curated by ChEMBL					Assay Description Inhibition against DNA polymerase by direct assay with activated DNA and 25 uM dNTPs lacking the expected competitor substrate				J Med Chem 38: 1820-5 (1995) BindingDB Entry DOI: 10.7270/Q29K4983
					More data for this Ligand-Target Pair