Found 3 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
(Homo sapiens (Human)) | BDBM27437
(12-phenyl-8-thia-3,5,10-triazatricyclo[7.4.0.0^{2,...)Show InChI InChI=1S/C15H10N4S/c16-14-13-12(18-8-19-14)11-6-10(7-17-15(11)20-13)9-4-2-1-3-5-9/h1-8H,(H2,16,18,19) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 900 | -35.9 | 9.00E+3 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Roche
| Assay Description The assay was carried out in the reaction buffer containing Cdc7/Dbf4, His6-MCM2, and ATP/[gamma-33P]ATP in the presence of test compounds. After inc... |
Bioorg Med Chem Lett 19: 319-23 (2009)
Article DOI: 10.1016/j.bmcl.2008.11.093 BindingDB Entry DOI: 10.7270/Q20G3HG2 |
More data for this Ligand-Target Pair | |
Dual specificity protein kinase CLK1
(Homo sapiens (Human)) | BDBM27437
(12-phenyl-8-thia-3,5,10-triazatricyclo[7.4.0.0^{2,...)Show InChI InChI=1S/C15H10N4S/c16-14-13-12(18-8-19-14)11-6-10(7-17-15(11)20-13)9-4-2-1-3-5-9/h1-8H,(H2,16,18,19) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
UMR 6014& FR 3038; Univ Rouen; INSA Rouen; CNRS
Curated by ChEMBL
| Assay Description Inhibition of human recombinant GST-tagged CLK1 expressed in Escherichia coli using GRSRSRSRSRSR as substrate after 30 mins |
Eur J Med Chem 92: 124-34 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.038 BindingDB Entry DOI: 10.7270/Q2BR8TVG |
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(RAT) | BDBM27437
(12-phenyl-8-thia-3,5,10-triazatricyclo[7.4.0.0^{2,...)Show InChI InChI=1S/C15H10N4S/c16-14-13-12(18-8-19-14)11-6-10(7-17-15(11)20-13)9-4-2-1-3-5-9/h1-8H,(H2,16,18,19) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
UMR 6014& FR 3038; Univ Rouen; INSA Rouen; CNRS
Curated by ChEMBL
| Assay Description Inhibition of rat recombinant GST-tagged DYRK1A expressed in Escherichia coli using KKISGRLSPIMTEQ as substrate after 30 mins by scintillation counti... |
Eur J Med Chem 92: 124-34 (2015)
Article DOI: 10.1016/j.ejmech.2014.12.038 BindingDB Entry DOI: 10.7270/Q2BR8TVG |
More data for this Ligand-Target Pair | |