Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Leukotriene A-4 hydrolase
(Homo sapiens (Human)) | BDBM24221
(1-(1-{2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl...)Show SMILES O=C1CCCCN1C1CCN(CCOc2ccc(Oc3nc4ccccc4s3)cc2)CC1 Show InChI InChI=1S/C25H29N3O3S/c29-24-7-3-4-14-28(24)19-12-15-27(16-13-19)17-18-30-20-8-10-21(11-9-20)31-25-26-22-5-1-2-6-23(22)32-25/h1-2,5-6,8-11,19H,3-4,7,12-18H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Johnson & Johnson Pharmaceutical
| Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,... |
J Med Chem 51: 4150-69 (2008)
Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM24221
(1-(1-{2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl...)Show SMILES O=C1CCCCN1C1CCN(CCOc2ccc(Oc3nc4ccccc4s3)cc2)CC1 Show InChI InChI=1S/C25H29N3O3S/c29-24-7-3-4-14-28(24)19-12-15-27(16-13-19)17-18-30-20-8-10-21(11-9-20)31-25-26-22-5-1-2-6-23(22)32-25/h1-2,5-6,8-11,19H,3-4,7,12-18H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | 25 |
Johnson & Johnson Pharmaceutical
| Assay Description Compounds were assessed for their ability to displace [3H]astemizole using membranes from HEK-293 cells expressing the hERG K+ channel. |
J Med Chem 51: 4150-69 (2008)
Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX |
More data for this Ligand-Target Pair | |