Home
Info
Download
About us
Email us
Contribute data
Web Services
Beta Site
myBDB
logout
Search and Browse
Target
Sequence
Name
&
Ki
IC50
Kd
EC50
Rate constants
ΔG°
ΔH°
-TΔS°
pH (Enzymatic Assay)
pH (ITC)
Substrate or Competitor
Compound Mol. Wt.
Chemical Structure
Pathways
Source Organism
Number of Compounds
Monomer List in csv
Het List in SDF
Compound
FDA Drugs
Important Compounds
Chemical Structure
Name
SMILES
Number of Data
/
Targets
Special tools
3D Structure Series
Find My Compound's Targets
Find Compounds for My Targets
Do Virtual Screening
SCOP
Citation
Author
Journal/Citation
Institution
PubMed
PubChem BioAssay
US Patent
Special Data Sets
D3R
Host Guest Systems
Prot-Lig Validation Sets
Other Databases
PDB
85%
100%
Seq ID
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
PubMed
Download
All Compounds & Data
Target Names &
Ki
IC50
Kd
EC50
ΔG°
ΔH°
-TΔS°
Enter Data
Deposition
Contribute data
Sent Comments
Compile Data Set for Download or QSAR
Marvin 2D Structure
The following exact ligands are found in BindingDB
Wt: 146.1
BDBM12342
Purchase
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
73
hits in this display
Target/Host
(Institution)
Ligand
Target/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
k
off
s
-1
k
on
M
-1
s
-1
pH
Temp
°C
Carbonic anhydrase 14
(Homo sapiens (Human))
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
48
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Universita degli Studi di Firenze
Curated by
ChEMBL
Assay Description
Inhibition of human carbonic anhydrase 14 by stopped flow CO2 hydration assay
J Med Chem
53:
335
-
44
(2010)
Article DOI:
10.1021/jm901287j
BindingDB Entry DOI:
10.7270/Q2MS3TP5
More data for this
Ligand-Target Pair
Zn finger protein
(Nicotiana tabacum)
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
UniProtKB/TrEMBL
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
>100
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Università degli Studi di Firenze
Curated by
ChEMBL
Assay Description
Inhibition of human recombinant CA12 catalytic domain by stopped-flow CO2 hydration method
Bioorg Med Chem Lett
20:
7255
-
8
(2010)
Article DOI:
10.1016/j.bmcl.2010.10.094
BindingDB Entry DOI:
10.7270/Q2416X9P
More data for this
Ligand-Target Pair
Carbonic anhydrase 9
(Homo sapiens (Human))
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
>100
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Università degli Studi di Firenze
Curated by
ChEMBL
Assay Description
Inhibition of human recombinant CA9 catalytic domain by stopped-flow CO2 hydration method
Bioorg Med Chem Lett
20:
7255
-
8
(2010)
Article DOI:
10.1016/j.bmcl.2010.10.094
BindingDB Entry DOI:
10.7270/Q2416X9P
More data for this
Ligand-Target Pair
Carbonic anhydrase 6
(Homo sapiens (Human))
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
2.00E+3
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Universita degli Studi di Firenze
Curated by
ChEMBL
Assay Description
Inhibition of human carbonic anhydrase 6 by stopped flow CO2 hydration assay
J Med Chem
53:
335
-
44
(2010)
Article DOI:
10.1021/jm901287j
BindingDB Entry DOI:
10.7270/Q2MS3TP5
More data for this
Ligand-Target Pair
Carbonic anhydrase 1
(Homo sapiens (Human))
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
3.10E+3
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Universita degli Studi di Firenze
Curated by
ChEMBL
Assay Description
Inhibition of human carbonic anhydrase 1 by stopped flow CO2 hydration assay
J Med Chem
53:
335
-
44
(2010)
Article DOI:
10.1021/jm901287j
BindingDB Entry DOI:
10.7270/Q2MS3TP5
More data for this
Ligand-Target Pair
Carbonic anhydrase 1
(Homo sapiens (Human))
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
3.10E+3
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Università degli Studi di Firenze
Curated by
ChEMBL
Assay Description
Inhibition of full length human CA1 cytosolic isoform by stopped-flow CO2 hydration method
Bioorg Med Chem Lett
20:
7255
-
8
(2010)
Article DOI:
10.1016/j.bmcl.2010.10.094
BindingDB Entry DOI:
10.7270/Q2416X9P
More data for this
Ligand-Target Pair
Carbonic anhydrase 1
(Homo sapiens (Human))
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
3.10E+3
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Latvian Association of Human Genetics
Curated by
ChEMBL
Assay Description
Inhibition of full length human recombinant CA1 cytosolic isoform after 6 hrs by stopped-flow CO2 hydration method
J Med Chem
56:
293
-
300
(2013)
Article DOI:
10.1021/jm301625s
BindingDB Entry DOI:
10.7270/Q2XK8GVW
More data for this
Ligand-Target Pair
Carbonic anhydrase 1
(Homo sapiens (Human))
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
3.10E+3
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Universit£ degli Studi di Firenze
Curated by
ChEMBL
Assay Description
Inhibition of human CA1 pre-incubated for 15 mins to 24 hrs measured after 6 hrs by phenol red-based stopped-flow CO2 hydrase assay
Bioorg Med Chem Lett
22:
267
-
70
(2011)
Article DOI:
10.1016/j.bmcl.2011.11.018
BindingDB Entry DOI:
10.7270/Q22Z15ZW
More data for this
Ligand-Target Pair
Carbonic anhydrase 1
(Homo sapiens (Human))
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
3.10E+3
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Griffith University
Curated by
ChEMBL
Assay Description
Inhibition of human carbonic anhydrase 1 preincubated for 6 hrs by CO2 hydration stopped-flow assay
Bioorg Med Chem
21:
1539
-
43
(2013)
Article DOI:
10.1016/j.bmc.2012.07.021
BindingDB Entry DOI:
10.7270/Q2S75HNS
More data for this
Ligand-Target Pair
Carbonic anhydrase 1
(Homo sapiens (Human))
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
3.10E+3
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Universit£ degli Studi di Firenze
Curated by
ChEMBL
Assay Description
Inhibition of human carbonic anhydrase 1 after 6 hrs by stop-flow CO2 hydration assay
Bioorg Med Chem
20:
2266
-
73
(2012)
Article DOI:
10.1016/j.bmc.2012.02.014
BindingDB Entry DOI:
10.7270/Q2P26ZK0
More data for this
Ligand-Target Pair
Carbonic anhydrase 1
(Homo sapiens (Human))
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
3.10E+3
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Universit£ degli Studi di Firenze
Curated by
ChEMBL
Assay Description
Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins to 72 hrs measured after 6 hrs by stopped flow CO2 hydration method
Bioorg Med Chem Lett
22:
2182
-
5
(2012)
Article DOI:
10.1016/j.bmcl.2012.01.129
BindingDB Entry DOI:
10.7270/Q2FJ2H78
More data for this
Ligand-Target Pair
Carbonic anhydrase 1
(Homo sapiens (Human))
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
3.10E+3
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Universit£ degli Studi di Firenze
Curated by
ChEMBL
Assay Description
Inhibition of human carbonic anhydrase 1 by Stopped-Flow CO2 Hydrase assay
J Med Chem
59:
462
-
73
(2016)
Article DOI:
10.1021/acs.jmedchem.5b01720
BindingDB Entry DOI:
10.7270/Q2P2710K
More data for this
Ligand-Target Pair
Carbonic anhydrase 1
(Homo sapiens (Human))
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
3.10E+3
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Ecole Nationale Sup£rieure de Chimie de Montpellier
Curated by
ChEMBL
Assay Description
Inhibition of human full-length cytosolic CA1 after 6 hrs by stopped flow CO2 hydration assay
J Med Chem
54:
8271
-
7
(2011)
Article DOI:
10.1021/jm200983e
BindingDB Entry DOI:
10.7270/Q2KP82MQ
More data for this
Ligand-Target Pair
Carbonic anhydrase 7
(Homo sapiens (Human))
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
3.30E+3
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Universita degli Studi di Firenze
Curated by
ChEMBL
Assay Description
Inhibition of human carbonic anhydrase 7 by stopped flow CO2 hydration assay
J Med Chem
53:
335
-
44
(2010)
Article DOI:
10.1021/jm901287j
BindingDB Entry DOI:
10.7270/Q2MS3TP5
More data for this
Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1
(Homo sapiens (Human))
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
PDB
MMDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
4.06E+3
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Displacement of FAM-Bid peptide from recombinant N-terminal His6x-tagged human Mcl-1 expressed in Escherichia coli BL21 (DE3) incubated for 30 mins b...
Citation and Details
Article DOI:
10.1016/j.bmc.2020.115851
BindingDB Entry DOI:
10.7270/Q2959N7J
More data for this
Ligand-Target Pair
Carbonic anhydrase 5B, mitochondrial
(Homo sapiens (Human))
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
5.20E+3
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Universita degli Studi di Firenze
Curated by
ChEMBL
Assay Description
Inhibition of human carbonic anhydrase 5B by stopped flow CO2 hydration assay
J Med Chem
53:
335
-
44
(2010)
Article DOI:
10.1021/jm901287j
BindingDB Entry DOI:
10.7270/Q2MS3TP5
More data for this
Ligand-Target Pair
Carbonic anhydrase 3
(Homo sapiens (Human))
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
5.60E+3
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Universita degli Studi di Firenze
Curated by
ChEMBL
Assay Description
Inhibition of human carbonic anhydrase 3 by stopped flow CO2 hydration assay
J Med Chem
53:
335
-
44
(2010)
Article DOI:
10.1021/jm901287j
BindingDB Entry DOI:
10.7270/Q2MS3TP5
More data for this
Ligand-Target Pair
Carbonic anhydrase 4
(Homo sapiens (Human))
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
6.80E+3
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Universita degli Studi di Firenze
Curated by
ChEMBL
Assay Description
Inhibition of human carbonic anhydrase 4 by stopped flow CO2 hydration assay
J Med Chem
53:
335
-
44
(2010)
Article DOI:
10.1021/jm901287j
BindingDB Entry DOI:
10.7270/Q2MS3TP5
More data for this
Ligand-Target Pair
Carbonic anhydrase 12
(Homo sapiens (Human))
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
8.90E+3
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Universita degli Studi di Firenze
Curated by
ChEMBL
Assay Description
Inhibition of human carbonic anhydrase 12 by stopped flow CO2 hydration assay
J Med Chem
53:
335
-
44
(2010)
Article DOI:
10.1021/jm901287j
BindingDB Entry DOI:
10.7270/Q2MS3TP5
More data for this
Ligand-Target Pair
Carbonic anhydrase 9
(Homo sapiens (Human))
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
9.10E+3
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Universita degli Studi di Firenze
Curated by
ChEMBL
Assay Description
Inhibition of human carbonic anhydrase 9 by stopped flow CO2 hydration assay
J Med Chem
53:
335
-
44
(2010)
Article DOI:
10.1021/jm901287j
BindingDB Entry DOI:
10.7270/Q2MS3TP5
More data for this
Ligand-Target Pair
Carbonic anhydrase 13
(Mus musculus (mouse))
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
9.20E+3
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Universita degli Studi di Firenze
Curated by
ChEMBL
Assay Description
Inhibition of mouse carbonic anhydrase 13 by stopped flow CO2 hydration assay
J Med Chem
53:
335
-
44
(2010)
Article DOI:
10.1021/jm901287j
BindingDB Entry DOI:
10.7270/Q2MS3TP5
More data for this
Ligand-Target Pair
Carbonic anhydrase 2
(Homo sapiens (Human))
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
9.20E+3
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Latvian Association of Human Genetics
Curated by
ChEMBL
Assay Description
Inhibition of full length human recombinant CA2 cytosolic isoform after 6 hrs by stopped-flow CO2 hydration method
J Med Chem
56:
293
-
300
(2013)
Article DOI:
10.1021/jm301625s
BindingDB Entry DOI:
10.7270/Q2XK8GVW
More data for this
Ligand-Target Pair
Carbonic anhydrase 2
(Homo sapiens (Human))
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
9.20E+3
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Griffith University
Curated by
ChEMBL
Assay Description
Inhibition of human carbonic anhydrase 2 preincubated for 6 hrs by CO2 hydration stopped-flow assay
Bioorg Med Chem
21:
1539
-
43
(2013)
Article DOI:
10.1016/j.bmc.2012.07.021
BindingDB Entry DOI:
10.7270/Q2S75HNS
More data for this
Ligand-Target Pair
Carbonic anhydrase 2
(Homo sapiens (Human))
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
9.20E+3
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Universit£ degli Studi di Firenze
Curated by
ChEMBL
Assay Description
Inhibition of human carbonic anhydrase 2 after 6 hrs by stop-flow CO2 hydration assay
Bioorg Med Chem
20:
2266
-
73
(2012)
Article DOI:
10.1016/j.bmc.2012.02.014
BindingDB Entry DOI:
10.7270/Q2P26ZK0
More data for this
Ligand-Target Pair
Carbonic anhydrase 2
(Homo sapiens (Human))
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
9.20E+3
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Universit£ degli Studi di Firenze
Curated by
ChEMBL
Assay Description
Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins to 72 hrs measured after 6 hrs by stopped flow CO2 hydration method
Bioorg Med Chem Lett
22:
2182
-
5
(2012)
Article DOI:
10.1016/j.bmcl.2012.01.129
BindingDB Entry DOI:
10.7270/Q2FJ2H78
More data for this
Ligand-Target Pair
Carbonic anhydrase 2
(Homo sapiens (Human))
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
9.20E+3
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Ecole Nationale Sup£rieure de Chimie de Montpellier
Curated by
ChEMBL
Assay Description
Inhibition of human full-length cytosolic CA2 after 6 hrs by stopped flow CO2 hydration assay
J Med Chem
54:
8271
-
7
(2011)
Article DOI:
10.1021/jm200983e
BindingDB Entry DOI:
10.7270/Q2KP82MQ
More data for this
Ligand-Target Pair
Carbonic anhydrase 2
(Homo sapiens (Human))
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
9.20E+3
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Universit£ degli Studi di Firenze
Curated by
ChEMBL
Assay Description
Inhibition of human CA2 pre-incubated for 15 mins to 24 hrs measured after 6 hrs by phenol red-based stopped-flow CO2 hydrase assay
Bioorg Med Chem Lett
22:
267
-
70
(2011)
Article DOI:
10.1016/j.bmcl.2011.11.018
BindingDB Entry DOI:
10.7270/Q22Z15ZW
More data for this
Ligand-Target Pair
Carbonic anhydrase 2
(Homo sapiens (Human))
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
9.20E+3
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Università degli Studi di Firenze
Curated by
ChEMBL
Assay Description
Inhibition of full length human CA2 cytosolic isoform by stopped-flow CO2 hydration method
Bioorg Med Chem Lett
20:
7255
-
8
(2010)
Article DOI:
10.1016/j.bmcl.2010.10.094
BindingDB Entry DOI:
10.7270/Q2416X9P
More data for this
Ligand-Target Pair
Carbonic anhydrase 2
(Homo sapiens (Human))
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
9.20E+3
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Universit£ degli Studi di Firenze
Curated by
ChEMBL
Assay Description
Inhibition of human carbonic anhydrase 2 by Stopped-Flow CO2 Hydrase assay
J Med Chem
59:
462
-
73
(2016)
Article DOI:
10.1021/acs.jmedchem.5b01720
BindingDB Entry DOI:
10.7270/Q2P2710K
More data for this
Ligand-Target Pair
Acetylcholinesterase
(Mus musculus (mouse))
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
9.30E+3
-28.7
n/a
n/a
n/a
n/a
n/a
7.0
25
Mayo Clinic College of Medicine
Assay Description
Assays were conducted at 25 C in 20 mM sodium phosphate buffer (pH 7.0) and 0.01% bovine serum albumin unless otherwise noted. AChE concentrations we...
Biochemistry
52:
7486
-
99
(2013)
Article DOI:
10.1021/bi401043w
BindingDB Entry DOI:
10.7270/Q24X56GT
More data for this
Ligand-Target Pair
Carbonic anhydrase 5A, mitochondrial
(Homo sapiens (Human))
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
9.40E+3
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Universita degli Studi di Firenze
Curated by
ChEMBL
Assay Description
Inhibition of human carbonic anhydrase 5A by stopped flow CO2 hydration assay
J Med Chem
53:
335
-
44
(2010)
Article DOI:
10.1021/jm901287j
BindingDB Entry DOI:
10.7270/Q2MS3TP5
More data for this
Ligand-Target Pair
Carbonic anhydrase 15
(Mus musculus)
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
3.96E+4
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Universita degli Studi di Firenze
Curated by
ChEMBL
Assay Description
Inhibition of mouse carbonic anhydrase 15 by stopped flow CO2 hydration assay
J Med Chem
53:
335
-
44
(2010)
Article DOI:
10.1021/jm901287j
BindingDB Entry DOI:
10.7270/Q2MS3TP5
More data for this
Ligand-Target Pair
Carbonic anhydrase 4
(Homo sapiens (Human))
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
6.23E+4
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Universit£ degli Studi di Firenze
Curated by
ChEMBL
Assay Description
Inhibition of human recombinant carbonic anhydrase 4 preincubated for 15 mins to 72 hrs measured after 6 hrs by stopped flow CO2 hydration method
Bioorg Med Chem Lett
22:
2182
-
5
(2012)
Article DOI:
10.1016/j.bmcl.2012.01.129
BindingDB Entry DOI:
10.7270/Q2FJ2H78
More data for this
Ligand-Target Pair
Carbonic anhydrase 9
(Homo sapiens (Human))
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
>1.00E+5
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Latvian Association of Human Genetics
Curated by
ChEMBL
Assay Description
Inhibition of human recombinant transmembrane CA9 catalytic domain after 6 hrs by stopped-flow CO2 hydration method
J Med Chem
56:
293
-
300
(2013)
Article DOI:
10.1021/jm301625s
BindingDB Entry DOI:
10.7270/Q2XK8GVW
More data for this
Ligand-Target Pair
Carbonic anhydrase 12
(Homo sapiens (Human))
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
>1.00E+5
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Latvian Association of Human Genetics
Curated by
ChEMBL
Assay Description
Inhibition of human recombinant transmembrane CA12 catalytic domain after 6 hrs by stopped-flow CO2 hydration method
J Med Chem
56:
293
-
300
(2013)
Article DOI:
10.1021/jm301625s
BindingDB Entry DOI:
10.7270/Q2XK8GVW
More data for this
Ligand-Target Pair
Carbonic anhydrase 9
(Homo sapiens (Human))
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
>1.00E+5
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Universit£ degli Studi di Firenze
Curated by
ChEMBL
Assay Description
Inhibition of human carbonic anhydrase 9 catalytic domain by Stopped-Flow CO2 Hydrase assay
J Med Chem
59:
462
-
73
(2016)
Article DOI:
10.1021/acs.jmedchem.5b01720
BindingDB Entry DOI:
10.7270/Q2P2710K
More data for this
Ligand-Target Pair
Carbonic anhydrase 12
(Homo sapiens (Human))
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
>1.00E+5
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Universit£ degli Studi di Firenze
Curated by
ChEMBL
Assay Description
Inhibition of human carbonic anhydrase 12 catalytic domain by Stopped-Flow CO2 Hydrase assay
J Med Chem
59:
462
-
73
(2016)
Article DOI:
10.1021/acs.jmedchem.5b01720
BindingDB Entry DOI:
10.7270/Q2P2710K
More data for this
Ligand-Target Pair
Carbonic anhydrase 9
(Homo sapiens (Human))
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
>1.00E+5
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Universit£ degli Studi di Firenze
Curated by
ChEMBL
Assay Description
Inhibition of human CA9 pre-incubated for 15 mins to 24 hrs measured after 6 hrs by phenol red-based stopped-flow CO2 hydrase assay
Bioorg Med Chem Lett
22:
267
-
70
(2011)
Article DOI:
10.1016/j.bmcl.2011.11.018
BindingDB Entry DOI:
10.7270/Q22Z15ZW
More data for this
Ligand-Target Pair
Carbonic anhydrase 12
(Homo sapiens (Human))
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
>2.00E+5
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Universit£ degli Studi di Firenze
Curated by
ChEMBL
Assay Description
Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins to 72 hrs measured after 6 hrs by stopped flow CO2 hydration method
Bioorg Med Chem Lett
22:
2182
-
5
(2012)
Article DOI:
10.1016/j.bmcl.2012.01.129
BindingDB Entry DOI:
10.7270/Q2FJ2H78
More data for this
Ligand-Target Pair
Carbonic anhydrase 9
(Homo sapiens (Human))
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
>2.00E+5
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Universit£ degli Studi di Firenze
Curated by
ChEMBL
Assay Description
Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins to 72 hrs measured after 6 hrs by stopped flow CO2 hydration method
Bioorg Med Chem Lett
22:
2182
-
5
(2012)
Article DOI:
10.1016/j.bmcl.2012.01.129
BindingDB Entry DOI:
10.7270/Q2FJ2H78
More data for this
Ligand-Target Pair
Carbonic anhydrase 13
(Homo sapiens (Human))
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
>2.00E+5
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Universit£ degli Studi di Firenze
Curated by
ChEMBL
Assay Description
Inhibition of human recombinant carbonic anhydrase 13 preincubated for 15 mins to 72 hrs measured after 6 hrs by stopped flow CO2 hydration method
Bioorg Med Chem Lett
22:
2182
-
5
(2012)
Article DOI:
10.1016/j.bmcl.2012.01.129
BindingDB Entry DOI:
10.7270/Q2FJ2H78
More data for this
Ligand-Target Pair
Carbonic anhydrase 14
(Homo sapiens (Human))
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
>2.00E+5
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Universit£ degli Studi di Firenze
Curated by
ChEMBL
Assay Description
Inhibition of human recombinant carbonic anhydrase 14 preincubated for 15 mins to 72 hrs measured after 6 hrs by stopped flow CO2 hydration method
Bioorg Med Chem Lett
22:
2182
-
5
(2012)
Article DOI:
10.1016/j.bmcl.2012.01.129
BindingDB Entry DOI:
10.7270/Q2FJ2H78
More data for this
Ligand-Target Pair
Carbonic anhydrase 12
(Homo sapiens (Human))
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
>2.00E+5
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Universit£ degli Studi di Firenze
Curated by
ChEMBL
Assay Description
Inhibition of human carbonic anhydrase 12 after 6 hrs by stop-flow CO2 hydration assay
Bioorg Med Chem
20:
2266
-
73
(2012)
Article DOI:
10.1016/j.bmc.2012.02.014
BindingDB Entry DOI:
10.7270/Q2P26ZK0
More data for this
Ligand-Target Pair
Carbonic anhydrase 5A, mitochondrial
(Homo sapiens (Human))
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
>2.00E+5
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Universit£ degli Studi di Firenze
Curated by
ChEMBL
Assay Description
Inhibition of human recombinant carbonic anhydrase 5A preincubated for 15 mins to 72 hrs measured after 6 hrs by stopped flow CO2 hydration method
Bioorg Med Chem Lett
22:
2182
-
5
(2012)
Article DOI:
10.1016/j.bmcl.2012.01.129
BindingDB Entry DOI:
10.7270/Q2FJ2H78
More data for this
Ligand-Target Pair
Carbonic anhydrase 3
(Homo sapiens (Human))
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
>2.00E+5
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Universit£ degli Studi di Firenze
Curated by
ChEMBL
Assay Description
Inhibition of human recombinant carbonic anhydrase 3 preincubated for 15 mins to 72 hrs measured after 6 hrs by stopped flow CO2 hydration method
Bioorg Med Chem Lett
22:
2182
-
5
(2012)
Article DOI:
10.1016/j.bmcl.2012.01.129
BindingDB Entry DOI:
10.7270/Q2FJ2H78
More data for this
Ligand-Target Pair
Carbonic anhydrase 9
(Homo sapiens (Human))
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
>2.00E+5
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Universit£ degli Studi di Firenze
Curated by
ChEMBL
Assay Description
Inhibition of human carbonic anhydrase 9 after 6 hrs by stop-flow CO2 hydration assay
Bioorg Med Chem
20:
2266
-
73
(2012)
Article DOI:
10.1016/j.bmc.2012.02.014
BindingDB Entry DOI:
10.7270/Q2P26ZK0
More data for this
Ligand-Target Pair
Carbonic anhydrase 7
(Homo sapiens (Human))
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
>2.00E+5
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Universit£ degli Studi di Firenze
Curated by
ChEMBL
Assay Description
Inhibition of human recombinant carbonic anhydrase 7 preincubated for 15 mins to 72 hrs measured after 6 hrs by stopped flow CO2 hydration method
Bioorg Med Chem Lett
22:
2182
-
5
(2012)
Article DOI:
10.1016/j.bmcl.2012.01.129
BindingDB Entry DOI:
10.7270/Q2FJ2H78
More data for this
Ligand-Target Pair
Carbonic anhydrase 5B, mitochondrial
(Homo sapiens (Human))
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
>2.00E+5
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Universit£ degli Studi di Firenze
Curated by
ChEMBL
Assay Description
Inhibition of human recombinant carbonic anhydrase 5B preincubated for 15 mins to 72 hrs measured after 6 hrs by stopped flow CO2 hydration method
Bioorg Med Chem Lett
22:
2182
-
5
(2012)
Article DOI:
10.1016/j.bmcl.2012.01.129
BindingDB Entry DOI:
10.7270/Q2FJ2H78
More data for this
Ligand-Target Pair
Carbonic anhydrase 6
(Homo sapiens (Human))
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
>2.00E+5
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Universit£ degli Studi di Firenze
Curated by
ChEMBL
Assay Description
Inhibition of human recombinant carbonic anhydrase 6 preincubated for 15 mins to 72 hrs measured after 6 hrs by stopped flow CO2 hydration method
Bioorg Med Chem Lett
22:
2182
-
5
(2012)
Article DOI:
10.1016/j.bmcl.2012.01.129
BindingDB Entry DOI:
10.7270/Q2FJ2H78
More data for this
Ligand-Target Pair
Carbonic anhydrase 12
(Homo sapiens (Human))
BDBM12342
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES
O=c1ccc2ccccc2o1
Show InChI
InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Similars
Article
PubMed
>5.00E+5
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Ecole Nationale Sup£rieure de Chimie de Montpellier
Curated by
ChEMBL
Assay Description
Inhibition of human recombinant CA12 after 6 hrs by stopped flow CO2 hydration assay
J Med Chem
54:
8271
-
7
(2011)
Article DOI:
10.1021/jm200983e
BindingDB Entry DOI:
10.7270/Q2KP82MQ
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 73 total ) |
Next
|
Last
>>