Found 4 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phenylethanolamine N-methyltransferase
(Homo sapiens (Human)) | BDBM50081952
(((R)-7-Bromo-1,2,3,4-tetrahydro-isoquinolin-3-yl)-...)Show InChI InChI=1S/C10H12BrNO/c11-9-2-1-7-4-10(6-13)12-5-8(7)3-9/h1-3,10,12-13H,4-6H2/t10-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| 4.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan
Curated by ChEMBL
| Assay Description Inhibitory binding affinity for phenylethanolamine N-methyltransferase (PNMT) |
Bioorg Med Chem Lett 14: 4217-20 (2004)
Article DOI: 10.1016/j.bmcl.2004.06.009 BindingDB Entry DOI: 10.7270/Q2R49Q6M |
More data for this Ligand-Target Pair | |
Phenylethanolamine N-methyltransferase
(Homo sapiens (Human)) | BDBM50081952
(((R)-7-Bromo-1,2,3,4-tetrahydro-isoquinolin-3-yl)-...)Show InChI InChI=1S/C10H12BrNO/c11-9-2-1-7-4-10(6-13)12-5-8(7)3-9/h1-3,10,12-13H,4-6H2/t10-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| PubMed
| 300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by ChEMBL
| Assay Description Inhibitory constant against human phenylethanolamine N-methyl-transferase over-expressed in Escherichia coli |
Bioorg Med Chem Lett 11: 1579-82 (2001)
BindingDB Entry DOI: 10.7270/Q2GF0V17 |
More data for this Ligand-Target Pair | |
Phenylethanolamine N-methyltransferase
(Bos taurus (bovine)) | BDBM50081952
(((R)-7-Bromo-1,2,3,4-tetrahydro-isoquinolin-3-yl)-...)Show InChI InChI=1S/C10H12BrNO/c11-9-2-1-7-4-10(6-13)12-5-8(7)3-9/h1-3,10,12-13H,4-6H2/t10-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| PubMed
| 380 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by ChEMBL
| Assay Description Inhibitory constant against bovine phenylethanolamine N-methyl-transferase |
Bioorg Med Chem Lett 11: 1579-82 (2001)
BindingDB Entry DOI: 10.7270/Q2GF0V17 |
More data for this Ligand-Target Pair | |
Phenylethanolamine N-methyltransferase
(Bos taurus (bovine)) | BDBM50081952
(((R)-7-Bromo-1,2,3,4-tetrahydro-isoquinolin-3-yl)-...)Show InChI InChI=1S/C10H12BrNO/c11-9-2-1-7-4-10(6-13)12-5-8(7)3-9/h1-3,10,12-13H,4-6H2/t10-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| PubMed
| 380 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by ChEMBL
| Assay Description In vitro inhibition of PNMT (Phenylethanolamine N-Methyltransferase). |
J Med Chem 42: 4351-61 (1999)
BindingDB Entry DOI: 10.7270/Q2X0667W |
More data for this Ligand-Target Pair | |