Found 4 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Polymerase acidic protein
() | BDBM474353
((S)-6-(bis(3-fluorophenyl)methyl)-11- hydroxy-5,6-...)Show SMILES Oc1c2-c3nccn3C[C@H](C(c3cccc(F)c3)c3cccc(F)c3)n2ncc1=O |r| Show InChI InChI=1S/C22H16F2N4O2/c23-15-5-1-3-13(9-15)19(14-4-2-6-16(24)10-14)17-12-27-8-7-25-22(27)20-21(30)18(29)11-26-28(17)20/h1-11,17,19,30H,12H2/t17-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description Compounds were dissolved and serially diluted in 100% DMSO then 0.5 μl was transferred to 384-well plates. 50 nM truncated Influenza A/victoria/... |
US Patent US10858366 (2020)
BindingDB Entry DOI: 10.7270/Q2KH0RDJ |
More data for this Ligand-Target Pair | |
Polymerase acidic protein
() | BDBM474353
((S)-6-(bis(3-fluorophenyl)methyl)-11- hydroxy-5,6-...)Show SMILES Oc1c2-c3nccn3C[C@H](C(c3cccc(F)c3)c3cccc(F)c3)n2ncc1=O |r| Show InChI InChI=1S/C22H16F2N4O2/c23-15-5-1-3-13(9-15)19(14-4-2-6-16(24)10-14)17-12-27-8-7-25-22(27)20-21(30)18(29)11-26-28(17)20/h1-11,17,19,30H,12H2/t17-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compounds were dissolved and serially diluted in 100% DMSO then 0.5 μl was transferred to 384-well plates. 50 nM truncated Influenza A/victoria/... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2Z60S8G |
More data for this Ligand-Target Pair | |
Polymerase acidic protein
() | BDBM474341
(6-(bis(3-fluorophenyl)methyl)-11-hydroxy- 5,6-dihy...)Show SMILES Oc1c2-c3nccn3CC(C(c3cccc(F)c3)c3cccc(F)c3)n2ncc1=O Show InChI InChI=1S/C22H16F2N4O2/c23-15-5-1-3-13(9-15)19(14-4-2-6-16(24)10-14)17-12-27-8-7-25-22(27)20-21(30)18(29)11-26-28(17)20/h1-11,17,19,30H,12H2 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Compounds were dissolved and serially diluted in 100% DMSO then 0.5 μl was transferred to 384-well plates. 50 nM truncated Influenza A/victoria/... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2Z60S8G |
More data for this Ligand-Target Pair | |
Polymerase acidic protein
() | BDBM474341
(6-(bis(3-fluorophenyl)methyl)-11-hydroxy- 5,6-dihy...)Show SMILES Oc1c2-c3nccn3CC(C(c3cccc(F)c3)c3cccc(F)c3)n2ncc1=O Show InChI InChI=1S/C22H16F2N4O2/c23-15-5-1-3-13(9-15)19(14-4-2-6-16(24)10-14)17-12-27-8-7-25-22(27)20-21(30)18(29)11-26-28(17)20/h1-11,17,19,30H,12H2 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description Compounds were dissolved and serially diluted in 100% DMSO then 0.5 μl was transferred to 384-well plates. 50 nM truncated Influenza A/victoria/... |
US Patent US10858366 (2020)
BindingDB Entry DOI: 10.7270/Q2KH0RDJ |
More data for this Ligand-Target Pair | |