Compile Data Set for Download or QSAR

Found 73 hits Enz. Inhib. hit(s) with Target = 'ADP-ribosylhydrolase ARH3'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM495169 (3-[(2,4-Dimethylthiazol-5-yl)methyl]-N-(1-methylcy...) Show SMILES Cc1nnc(s1)-n1c2cc(ccc2c(Cc2sc(C)nc2C)c1=O)S(=O)(=O)NC1(C)CC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.67E+4	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				US Patent US10995073 (2021) BindingDB Entry DOI: 10.7270/Q28K7D68
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM421539 (3-[(2,4-Dimethylthiazol-5-yl)methyl]-N-(1-methylcy...) Show SMILES Cc1nnc(s1)-n1cc(Cc2sc(C)nc2C)c2ccc(cc12)S(=O)(=O)NC1(C)CC1 Show InChI InChI=1S/C21H23N5O2S3/c1-12-19(29-13(2)22-12)9-15-11-26(20-24-23-14(3)30-20)18-10-16(5-6-17(15)18)31(27,28)25-21(4)7-8-21/h5-6,10-11,25H,7-9H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.67E+4	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				US Patent US10508086 (2019) BindingDB Entry DOI: 10.7270/Q26112QF
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM421556 (3-[(4-Fluorophenyl)methyl]-N-(1-methylcyclopropyl)...) Show SMILES Cc1nnc(s1)-n1nc(Cc2ccc(F)cc2)c2ccc(cc12)S(=O)(=O)NC1(C)CC1 Show InChI InChI=1S/C21H20FN5O2S2/c1-13-23-24-20(30-13)27-19-12-16(31(28,29)26-21(2)9-10-21)7-8-17(19)18(25-27)11-14-3-5-15(22)6-4-14/h3-8,12,26H,9-11H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.67E+4	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				US Patent US10508086 (2019) BindingDB Entry DOI: 10.7270/Q26112QF
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM421556 (3-[(4-Fluorophenyl)methyl]-N-(1-methylcyclopropyl)...) Show SMILES Cc1nnc(s1)-n1nc(Cc2ccc(F)cc2)c2ccc(cc12)S(=O)(=O)NC1(C)CC1 Show InChI InChI=1S/C21H20FN5O2S2/c1-13-23-24-20(30-13)27-19-12-16(31(28,29)26-21(2)9-10-21)7-8-17(19)18(25-27)11-14-3-5-15(22)6-4-14/h3-8,12,26H,9-11H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.67E+4	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				US Patent US10995073 (2021) BindingDB Entry DOI: 10.7270/Q28K7D68
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM421584 (3-[5-(difluoromethyl)-1,3,4-thiadiazol-2-yl]-6-flu...) Show SMILES Cn1c2cc(F)c(cc2n(-c2nnc(s2)C(F)F)c1=O)S(=O)(=O)NC1(CF)CC1 Show InChI InChI=1S/C15H13F4N5O3S2/c1-23-8-4-7(17)10(29(26,27)22-15(6-16)2-3-15)5-9(8)24(14(23)25)13-21-20-12(28-13)11(18)19/h4-5,11,22H,2-3,6H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				US Patent US10995073 (2021) BindingDB Entry DOI: 10.7270/Q28K7D68
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM421584 (3-[5-(difluoromethyl)-1,3,4-thiadiazol-2-yl]-6-flu...) Show SMILES Cn1c2cc(F)c(cc2n(-c2nnc(s2)C(F)F)c1=O)S(=O)(=O)NC1(CF)CC1 Show InChI InChI=1S/C15H13F4N5O3S2/c1-23-8-4-7(17)10(29(26,27)22-15(6-16)2-3-15)5-9(8)24(14(23)25)13-21-20-12(28-13)11(18)19/h4-5,11,22H,2-3,6H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				US Patent US10508086 (2019) BindingDB Entry DOI: 10.7270/Q26112QF
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM421497 (US10508086, Example 87 | US10995073, Example 87) Show SMILES Cc1nnc(s1)-n1c2cc(ccc2n(Cc2sc(C)nc2C)c1=O)S(=O)(=O)NC1(C)CC1 Show InChI InChI=1S/C20H22N6O3S3/c1-11-17(30-12(2)21-11)10-25-15-6-5-14(32(28,29)24-20(4)7-8-20)9-16(15)26(19(25)27)18-23-22-13(3)31-18/h5-6,9,24H,7-8,10H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.67E+4	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				US Patent US10508086 (2019) BindingDB Entry DOI: 10.7270/Q26112QF
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM421497 (US10508086, Example 87 | US10995073, Example 87) Show SMILES Cc1nnc(s1)-n1c2cc(ccc2n(Cc2sc(C)nc2C)c1=O)S(=O)(=O)NC1(C)CC1 Show InChI InChI=1S/C20H22N6O3S3/c1-11-17(30-12(2)21-11)10-25-15-6-5-14(32(28,29)24-20(4)7-8-20)9-16(15)26(19(25)27)18-23-22-13(3)31-18/h5-6,9,24H,7-8,10H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.67E+4	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				US Patent US10995073 (2021) BindingDB Entry DOI: 10.7270/Q28K7D68
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM371026 (US10239843, Example 133) Show SMILES Cc1nc(C)c(Cn2c3ccc(cc3c(=O)n(C)c2=O)S(=O)(=O)NC2(C)CC2)s1 Show InChI InChI=1S/C19H22N4O4S2/c1-11-16(28-12(2)20-11)10-23-15-6-5-13(29(26,27)21-19(3)7-8-19)9-14(15)17(24)22(4)18(23)25/h5-6,9,21H,7-8,10H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Superiore di Sanita					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				J Med Chem 51: 1058-62 (2008) BindingDB Entry DOI: 10.7270/Q21R6SSM
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM371049 (US10239843, Example 156) Show SMILES Cc1ncc(Cn2c(=O)n(CC3CC3)c3ccc(cc3c2=O)S(=O)(=O)NC2(C)CC2)s1 Show InChI InChI=1S/C21H24N4O4S2/c1-13-22-10-15(30-13)12-25-19(26)17-9-16(31(28,29)23-21(2)7-8-21)5-6-18(17)24(20(25)27)11-14-3-4-14/h5-6,9-10,14,23H,3-4,7-8,11-12H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Superiore di Sanita					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				J Med Chem 51: 1058-62 (2008) BindingDB Entry DOI: 10.7270/Q21R6SSM
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM371051 (US10239843, Example 158) Show SMILES Cc1noc(C)c1Cn1c(=O)n(CC2CC2)c2ccc(cc2c1=O)S(=O)(=O)NC1(C)CC1 Show InChI InChI=1S/C22H26N4O5S/c1-13-18(14(2)31-23-13)12-26-20(27)17-10-16(32(29,30)24-22(3)8-9-22)6-7-19(17)25(21(26)28)11-15-4-5-15/h6-7,10,15,24H,4-5,8-9,11-12H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Superiore di Sanita					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				J Med Chem 51: 1058-62 (2008) BindingDB Entry DOI: 10.7270/Q21R6SSM
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM371054 (US10239843, Example 161) Show SMILES Cc1ncc(Cn2c(=O)n(CC#C)c3ccc(cc3c2=O)S(=O)(=O)NC2(C)CC2)s1 Show InChI InChI=1S/C20H20N4O4S2/c1-4-9-23-17-6-5-15(30(27,28)22-20(3)7-8-20)10-16(17)18(25)24(19(23)26)12-14-11-21-13(2)29-14/h1,5-6,10-11,22H,7-9,12H2,2-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Superiore di Sanita					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				J Med Chem 51: 1058-62 (2008) BindingDB Entry DOI: 10.7270/Q21R6SSM
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM371055 (US10239843, Example 162) Show SMILES Cc1ncc(Cn2c(=O)n(Cc3sc(C)nc3C)c3ccc(cc3c2=O)S(=O)(=O)NC2(C)CC2)s1 Show InChI InChI=1S/C23H25N5O4S3/c1-13-20(34-15(3)25-13)12-27-19-6-5-17(35(31,32)26-23(4)7-8-23)9-18(19)21(29)28(22(27)30)11-16-10-24-14(2)33-16/h5-6,9-10,26H,7-8,11-12H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Superiore di Sanita					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				J Med Chem 51: 1058-62 (2008) BindingDB Entry DOI: 10.7270/Q21R6SSM
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM371056 (US10239843, Example 163) Show SMILES Cc1cc(Cn2c3ccc(cc3c(=O)n(Cc3cnc(C)n3)c2=O)S(=O)(=O)NC2(C)CC2)n(C)n1 Show InChI InChI=1S/C23H26N7O4S/c1-14-9-17(28(4)26-14)13-29-20-6-5-18(35(33,34)27-23(3)7-8-23)10-19(20)21(31)30(22(29)32)12-16-11-24-15(2)25-16/h5-6,9-11,27H,7-8,12-13H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Superiore di Sanita					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				J Med Chem 51: 1058-62 (2008) BindingDB Entry DOI: 10.7270/Q21R6SSM
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM371058 (US10239843, Example 165) Show SMILES Cc1nc(C)c(Cn2c3ccc(cc3c(=O)n(Cc3c(C)noc3C)c2=O)S(=O)(=O)NC2(C)CC2)s1 Show InChI InChI=1S/C24H27N5O5S2/c1-13-19(15(3)34-26-13)11-29-22(30)18-10-17(36(32,33)27-24(5)8-9-24)6-7-20(18)28(23(29)31)12-21-14(2)25-16(4)35-21/h6-7,10,27H,8-9,11-12H2,1-5H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Superiore di Sanita					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				J Med Chem 51: 1058-62 (2008) BindingDB Entry DOI: 10.7270/Q21R6SSM
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM421482 (US10508086, Example 73 | US10995073, Example 73) Show SMILES Cc1nnc(s1)-n1c2cc(ccc2n(Cc2ccc(F)cc2)c1=O)S(=O)(=O)NC1(C)CC1 Show InChI InChI=1S/C21H20FN5O3S2/c1-13-23-24-19(31-13)27-18-11-16(32(29,30)25-21(2)9-10-21)7-8-17(18)26(20(27)28)12-14-3-5-15(22)6-4-14/h3-8,11,25H,9-10,12H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				US Patent US10508086 (2019) BindingDB Entry DOI: 10.7270/Q26112QF
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM421488 (US10508086, Example 79 | US10995073, Example 79) Show SMILES Cn1c2ccc(cc2n(-c2nnc(s2)C(F)F)c1=O)S(=O)(=O)NC1(C)CC1 Show InChI InChI=1S/C15H15F2N5O3S2/c1-15(5-6-15)20-27(24,25)8-3-4-9-10(7-8)22(14(23)21(9)2)13-19-18-12(26-13)11(16)17/h3-4,7,11,20H,5-6H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				US Patent US10508086 (2019) BindingDB Entry DOI: 10.7270/Q26112QF
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM421492 (US10508086, Example 82 | US10995073, Example 82) Show SMILES Cc1nnc(s1)-n1c2cc(ccc2n(CC2CC2)c1=O)S(=O)(=O)NC1(C)CC1 Show InChI InChI=1S/C18H21N5O3S2/c1-11-19-20-16(27-11)23-15-9-13(28(25,26)21-18(2)7-8-18)5-6-14(15)22(17(23)24)10-12-3-4-12/h5-6,9,12,21H,3-4,7-8,10H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				US Patent US10508086 (2019) BindingDB Entry DOI: 10.7270/Q26112QF
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM421493 (US10508086, Example 83 | US10995073, Example 83) Show SMILES Cc1ncc(Cn2c3ccc(cc3n(-c3nnc(C)s3)c2=O)S(=O)(=O)NC2(C)CC2)s1 Show InChI InChI=1S/C19H20N6O3S3/c1-11-20-9-13(29-11)10-24-15-5-4-14(31(27,28)23-19(3)6-7-19)8-16(15)25(18(24)26)17-22-21-12(2)30-17/h4-5,8-9,23H,6-7,10H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				US Patent US10508086 (2019) BindingDB Entry DOI: 10.7270/Q26112QF
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM421498 (US10508086, Example 88 | US10995073, Example 88) Show SMILES Cc1nc(C)c(Cn2c3ccc(cc3n(-c3nnc(s3)C(F)F)c2=O)S(=O)(=O)NC2(C)CC2)s1 Show InChI InChI=1S/C20H20F2N6O3S3/c1-10-15(32-11(2)23-10)9-27-13-5-4-12(34(30,31)26-20(3)6-7-20)8-14(13)28(19(27)29)18-25-24-17(33-18)16(21)22/h4-5,8,16,26H,6-7,9H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				US Patent US10508086 (2019) BindingDB Entry DOI: 10.7270/Q26112QF
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM205480 (PDD00017238 (5) | US10508086, Example 90 | US10995...) Show SMILES Cc1nc(C)c(Cn2c3ccc(cc3n(-c3ncns3)c2=O)S(=O)(=O)NC2(C)CC2)s1 Show InChI InChI=1S/C19H20N6O3S3/c1-11-16(29-12(2)22-11)9-24-14-5-4-13(31(27,28)23-19(3)6-7-19)8-15(14)25(18(24)26)17-20-10-21-30-17/h4-5,8,10,23H,6-7,9H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				US Patent US10508086 (2019) BindingDB Entry DOI: 10.7270/Q26112QF
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM421482 (US10508086, Example 73 | US10995073, Example 73) Show SMILES Cc1nnc(s1)-n1c2cc(ccc2n(Cc2ccc(F)cc2)c1=O)S(=O)(=O)NC1(C)CC1 Show InChI InChI=1S/C21H20FN5O3S2/c1-13-23-24-19(31-13)27-18-11-16(32(29,30)25-21(2)9-10-21)7-8-17(18)26(20(27)28)12-14-3-5-15(22)6-4-14/h3-8,11,25H,9-10,12H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				US Patent US10995073 (2021) BindingDB Entry DOI: 10.7270/Q28K7D68
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM421488 (US10508086, Example 79 | US10995073, Example 79) Show SMILES Cn1c2ccc(cc2n(-c2nnc(s2)C(F)F)c1=O)S(=O)(=O)NC1(C)CC1 Show InChI InChI=1S/C15H15F2N5O3S2/c1-15(5-6-15)20-27(24,25)8-3-4-9-10(7-8)22(14(23)21(9)2)13-19-18-12(26-13)11(16)17/h3-4,7,11,20H,5-6H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				US Patent US10995073 (2021) BindingDB Entry DOI: 10.7270/Q28K7D68
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM421492 (US10508086, Example 82 | US10995073, Example 82) Show SMILES Cc1nnc(s1)-n1c2cc(ccc2n(CC2CC2)c1=O)S(=O)(=O)NC1(C)CC1 Show InChI InChI=1S/C18H21N5O3S2/c1-11-19-20-16(27-11)23-15-9-13(28(25,26)21-18(2)7-8-18)5-6-14(15)22(17(23)24)10-12-3-4-12/h5-6,9,12,21H,3-4,7-8,10H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				US Patent US10995073 (2021) BindingDB Entry DOI: 10.7270/Q28K7D68
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM421493 (US10508086, Example 83 | US10995073, Example 83) Show SMILES Cc1ncc(Cn2c3ccc(cc3n(-c3nnc(C)s3)c2=O)S(=O)(=O)NC2(C)CC2)s1 Show InChI InChI=1S/C19H20N6O3S3/c1-11-20-9-13(29-11)10-24-15-5-4-14(31(27,28)23-19(3)6-7-19)8-16(15)25(18(24)26)17-22-21-12(2)30-17/h4-5,8-9,23H,6-7,10H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				US Patent US10995073 (2021) BindingDB Entry DOI: 10.7270/Q28K7D68
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM421498 (US10508086, Example 88 | US10995073, Example 88) Show SMILES Cc1nc(C)c(Cn2c3ccc(cc3n(-c3nnc(s3)C(F)F)c2=O)S(=O)(=O)NC2(C)CC2)s1 Show InChI InChI=1S/C20H20F2N6O3S3/c1-10-15(32-11(2)23-10)9-27-13-5-4-12(34(30,31)26-20(3)6-7-20)8-14(13)28(19(27)29)18-25-24-17(33-18)16(21)22/h4-5,8,16,26H,6-7,9H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				US Patent US10995073 (2021) BindingDB Entry DOI: 10.7270/Q28K7D68
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM205480 (PDD00017238 (5) | US10508086, Example 90 | US10995...) Show SMILES Cc1nc(C)c(Cn2c3ccc(cc3n(-c3ncns3)c2=O)S(=O)(=O)NC2(C)CC2)s1 Show InChI InChI=1S/C19H20N6O3S3/c1-11-16(29-12(2)22-11)9-24-14-5-4-13(31(27,28)23-19(3)6-7-19)8-15(14)25(18(24)26)17-20-10-21-30-17/h4-5,8,10,23H,6-7,9H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				US Patent US10995073 (2021) BindingDB Entry DOI: 10.7270/Q28K7D68
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM370915 (1-(Cyclopropylmethyl)-4-methyl-N-(1-methylcyclopro...) Show SMILES Cn1c2cc(ccc2n(CC2CC2)c(=O)c1=O)S(=O)(=O)NC1(C)CC1 Show InChI InChI=1S/C17H21N3O4S/c1-17(7-8-17)18-25(23,24)12-5-6-13-14(9-12)19(2)15(21)16(22)20(13)10-11-3-4-11/h5-6,9,11,18H,3-4,7-8,10H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Superiore di Sanita					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				J Med Chem 51: 1058-62 (2008) BindingDB Entry DOI: 10.7270/Q21R6SSM
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM421626 (3-[5-(Difluoromethyl)-1,3,4-thiadiazol-2-yl]-6-flu...) Show SMILES FCCn1c2cc(F)c(cc2n(-c2nnc(s2)C(F)F)c1=O)S(=O)(=O)NC1(CF)CC1 Show InChI InChI=1S/C16H14F5N5O3S2/c17-3-4-25-9-5-8(19)11(31(28,29)24-16(7-18)1-2-16)6-10(9)26(15(25)27)14-23-22-13(30-14)12(20)21/h5-6,12,24H,1-4,7H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research Technology Limited US Patent					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				US Patent US10995073 (2021) BindingDB Entry DOI: 10.7270/Q28K7D68
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM370973 (US10239843, Example 80) Show SMILES Cn1c(nc2ccc(cc2c1=O)S(=O)(=O)NC1(C)CC1)C1CC1 Show InChI InChI=1S/C16H19N3O3S/c1-16(7-8-16)18-23(21,22)11-5-6-13-12(9-11)15(20)19(2)14(17-13)10-3-4-10/h5-6,9-10,18H,3-4,7-8H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Superiore di Sanita					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				J Med Chem 51: 1058-62 (2008) BindingDB Entry DOI: 10.7270/Q21R6SSM
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM370991 (US10239843, Example 98) Show SMILES CC1(CC1)NS(=O)(=O)c1ccc2nc([nH]c(=O)c2c1)N1CCCC1 Show InChI InChI=1S/C16H20N4O3S/c1-16(6-7-16)19-24(22,23)11-4-5-13-12(10-11)14(21)18-15(17-13)20-8-2-3-9-20/h4-5,10,19H,2-3,6-9H2,1H3,(H,17,18,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Superiore di Sanita					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				J Med Chem 51: 1058-62 (2008) BindingDB Entry DOI: 10.7270/Q21R6SSM
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM371186 (US10239843, Example 293) Show SMILES CC(C)OC[N]1=CN(Cc2cnn(C)c2)C(=O)c2cc(ccc12)S(=O)(=O)NC1(C)CC1 |t:5| Show InChI InChI=1S/C21H28N5O4S/c1-15(2)30-14-26-13-25(12-16-10-22-24(4)11-16)20(27)18-9-17(5-6-19(18)26)31(28,29)23-21(3)7-8-21/h5-6,9-11,13,15,23H,7-8,12,14H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Superiore di Sanita					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				J Med Chem 51: 1058-62 (2008) BindingDB Entry DOI: 10.7270/Q21R6SSM
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM371191 (US10239843, Example 298) Show SMILES Cc1cc(Cn2nc(Cc3ccccc3)c3ccc(cc3c2=O)S(=O)(=O)NC2(C)CC2)on1 Show InChI InChI=1S/C24H24N4O4S/c1-16-12-18(32-26-16)15-28-23(29)21-14-19(33(30,31)27-24(2)10-11-24)8-9-20(21)22(25-28)13-17-6-4-3-5-7-17/h3-9,12,14,27H,10-11,13,15H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Superiore di Sanita					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				J Med Chem 51: 1058-62 (2008) BindingDB Entry DOI: 10.7270/Q21R6SSM
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM371201 (US10239843, Example 308) Show SMILES Cc1cc(Cn2nc(CC3CCOCC3)c3ccc(cc3c2=O)S(=O)(=O)NC2(C)CC2)on1 Show InChI InChI=1S/C23H28N4O5S/c1-15-11-17(32-25-15)14-27-22(28)20-13-18(33(29,30)26-23(2)7-8-23)3-4-19(20)21(24-27)12-16-5-9-31-10-6-16/h3-4,11,13,16,26H,5-10,12,14H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Superiore di Sanita					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				J Med Chem 51: 1058-62 (2008) BindingDB Entry DOI: 10.7270/Q21R6SSM
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM371204 (4-(Cyclopropanecarbonyl)-N-(1-methylcyclopropyl)-2...) Show SMILES Cc1cc(Cn2cc(C(=O)C3CC3)c3ccc(cc3c2=O)S(=O)(=O)NC2(C)CC2)on1 Show InChI InChI=1S/C22H23N3O5S/c1-13-9-15(30-23-13)11-25-12-19(20(26)14-3-4-14)17-6-5-16(10-18(17)21(25)27)31(28,29)24-22(2)7-8-22/h5-6,9-10,12,14,24H,3-4,7-8,11H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Superiore di Sanita					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				J Med Chem 51: 1058-62 (2008) BindingDB Entry DOI: 10.7270/Q21R6SSM
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM371066 (US10239843, Example 173) Show SMILES Cc1cc(Cn2c3ccc(cc3c(=O)n(Cc3cnn(C)c3)c2=O)S(=O)(=O)NC2(C)CC2)n(C)n1 Show InChI InChI=1S/C23H27N7O4S/c1-15-9-17(28(4)25-15)14-29-20-6-5-18(35(33,34)26-23(2)7-8-23)10-19(20)21(31)30(22(29)32)13-16-11-24-27(3)12-16/h5-6,9-12,26H,7-8,13-14H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Superiore di Sanita					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				J Med Chem 51: 1058-62 (2008) BindingDB Entry DOI: 10.7270/Q21R6SSM
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM371355 (1-[(2,4-Dimethylthiazol-5-yl)methyl]-N-[1-(fluorom...) Show SMILES Cc1nc(C)c(Cn2c3ccc(cc3c(=O)n(Cc3cnn(C)c3)c2=O)S(=O)(=O)NC2(CF)CC2)s1 Show InChI InChI=1S/C23H25FN6O4S2/c1-14-20(35-15(2)26-14)12-29-19-5-4-17(36(33,34)27-23(13-24)6-7-23)8-18(19)21(31)30(22(29)32)11-16-9-25-28(3)10-16/h4-5,8-10,27H,6-7,11-13H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Superiore di Sanita					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				J Med Chem 51: 1058-62 (2008) BindingDB Entry DOI: 10.7270/Q21R6SSM
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM371376 (1-Chloro-N-(1-methylcyclopropyl)isoquinoline-7-sul...) Show SMILES CC1(CC1)NS(=O)(=O)c1ccc2ccnc(Cl)c2c1 Show InChI InChI=1S/C13H13ClN2O2S/c1-13(5-6-13)16-19(17,18)10-3-2-9-4-7-15-12(14)11(9)8-10/h2-4,7-8,16H,5-6H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Superiore di Sanita					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				J Med Chem 51: 1058-62 (2008) BindingDB Entry DOI: 10.7270/Q21R6SSM
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM371463 (N-[1-(Fluoromethyl)cyclopropyl]-3-[(1-methylpyrazo...) Show SMILES Cc1ncsc1Cn1c2ccc(cc2c(=O)n(Cc2cnn(C)c2)c1=O)S(=O)(=O)NC1(CF)CC1 Show InChI InChI=1S/C22H23FN6O4S2/c1-14-19(34-13-24-14)11-28-18-4-3-16(35(32,33)26-22(12-23)5-6-22)7-17(18)20(30)29(21(28)31)10-15-8-25-27(2)9-15/h3-4,7-9,13,26H,5-6,10-12H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Superiore di Sanita					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				J Med Chem 51: 1058-62 (2008) BindingDB Entry DOI: 10.7270/Q21R6SSM
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM371469 (N-[1-(Fluoromethyl)cyclopropyl]-1-(isothiazol-5-yl...) Show SMILES Cn1cc(Cn2c(=O)n(Cc3ccns3)c3ccc(cc3c2=O)S(=O)(=O)NC2(CF)CC2)cn1 Show InChI InChI=1S/C21H21FN6O4S2/c1-26-10-14(9-23-26)11-28-19(29)17-8-16(34(31,32)25-21(13-22)5-6-21)2-3-18(17)27(20(28)30)12-15-4-7-24-33-15/h2-4,7-10,25H,5-6,11-13H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Superiore di Sanita					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				J Med Chem 51: 1058-62 (2008) BindingDB Entry DOI: 10.7270/Q21R6SSM
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM371470 (N-[1-(Fluoromethyl)cyclopropyl]-1-[(5-methylisoxaz...) Show SMILES Cc1oncc1Cn1c2ccc(cc2c(=O)n(Cc2cnn(C)c2)c1=O)S(=O)(=O)NC1(CF)CC1 Show InChI InChI=1S/C22H23FN6O5S/c1-14-16(9-25-34-14)12-28-19-4-3-17(35(32,33)26-22(13-23)5-6-22)7-18(19)20(30)29(21(28)31)11-15-8-24-27(2)10-15/h3-4,7-10,26H,5-6,11-13H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Superiore di Sanita					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				J Med Chem 51: 1058-62 (2008) BindingDB Entry DOI: 10.7270/Q21R6SSM
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM371493 (1-Ethyl-N-[1-(fluoromethyl)cyclopropyl]-3-[(5-meth...) Show SMILES CCn1c2ccc(cc2c(=O)n(Cc2nnc(C)s2)c1=O)S(=O)(=O)NC1(CF)CC1 Show InChI InChI=1S/C18H20FN5O4S2/c1-3-23-14-5-4-12(30(27,28)22-18(10-19)6-7-18)8-13(14)16(25)24(17(23)26)9-15-21-20-11(2)29-15/h4-5,8,22H,3,6-7,9-10H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Superiore di Sanita					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				J Med Chem 51: 1058-62 (2008) BindingDB Entry DOI: 10.7270/Q21R6SSM
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM371504 (1-Ethyl-N-(1-methylcyclopropyl)-3-[(5-methyl-1,3,4...) Show SMILES CCn1c2ccc(cc2c(=O)n(Cc2nnc(C)s2)c1=O)S(=O)(=O)NC1(C)CC1 Show InChI InChI=1S/C18H21N5O4S2/c1-4-22-14-6-5-12(29(26,27)21-18(3)7-8-18)9-13(14)16(24)23(17(22)25)10-15-20-19-11(2)28-15/h5-6,9,21H,4,7-8,10H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Superiore di Sanita					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				J Med Chem 51: 1058-62 (2008) BindingDB Entry DOI: 10.7270/Q21R6SSM
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM371506 (1-[(2,4-Dimethylthiazol-5-yl)methyl]-N-[1-(fluorom...) Show SMILES Cc1cc(Cn2c(=O)n(Cc3sc(C)nc3C)c3ccc(cc3c2=O)S(=O)(=O)NC2(CF)CC2)on1 Show InChI InChI=1S/C23H24FN5O5S2/c1-13-8-16(34-26-13)10-29-21(30)18-9-17(36(32,33)27-23(12-24)6-7-23)4-5-19(18)28(22(29)31)11-20-14(2)25-15(3)35-20/h4-5,8-9,27H,6-7,10-12H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Superiore di Sanita					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				J Med Chem 51: 1058-62 (2008) BindingDB Entry DOI: 10.7270/Q21R6SSM
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM371507 (1-Butyl-N-[1-(fluoromethyl)cyclopropyl]-3-[(1-meth...) Show SMILES CCCCn1c2ccc(cc2c(=O)n(Cc2cnn(C)c2)c1=O)S(=O)(=O)NC1(CF)CC1 Show InChI InChI=1S/C21H26FN5O4S/c1-3-4-9-26-18-6-5-16(32(30,31)24-21(14-22)7-8-21)10-17(18)19(28)27(20(26)29)13-15-11-23-25(2)12-15/h5-6,10-12,24H,3-4,7-9,13-14H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Superiore di Sanita					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				J Med Chem 51: 1058-62 (2008) BindingDB Entry DOI: 10.7270/Q21R6SSM
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM371073 (US10239843, Example 180) Show SMILES Cc1cc(Cn2c(=O)n(C)c3ccc(cc3c2=O)S(=O)(=O)NC2(C)CC2)on1 Show InChI InChI=1S/C18H20N4O5S/c1-11-8-12(27-19-11)10-22-16(23)14-9-13(4-5-15(14)21(3)17(22)24)28(25,26)20-18(2)6-7-18/h4-5,8-9,20H,6-7,10H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Superiore di Sanita					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				J Med Chem 51: 1058-62 (2008) BindingDB Entry DOI: 10.7270/Q21R6SSM
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM371514 (N-[1-(Fluoromethyl)cyclopropyl]-1-methyl-3-[(3-met...) Show SMILES Cc1cc(Cn2c(=O)n(C)c3ccc(cc3c2=O)S(=O)(=O)NC2(CF)CC2)sn1 Show InChI InChI=1S/C18H19FN4O4S2/c1-11-7-12(28-20-11)9-23-16(24)14-8-13(3-4-15(14)22(2)17(23)25)29(26,27)21-18(10-19)5-6-18/h3-4,7-8,21H,5-6,9-10H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Superiore di Sanita					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				J Med Chem 51: 1058-62 (2008) BindingDB Entry DOI: 10.7270/Q21R6SSM
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM371518 (1-(2-Fluoroethyl)-N-[1-(fluoromethyl)cyclopropyl]-...) Show SMILES Cc1nnc(Cn2c(=O)n(CCF)c3ccc(cc3c2=O)S(=O)(=O)NC2(CF)CC2)s1 Show InChI InChI=1S/C18H19F2N5O4S2/c1-11-21-22-15(30-11)9-25-16(26)13-8-12(31(28,29)23-18(10-20)4-5-18)2-3-14(13)24(7-6-19)17(25)27/h2-3,8,23H,4-7,9-10H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Superiore di Sanita					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				J Med Chem 51: 1058-62 (2008) BindingDB Entry DOI: 10.7270/Q21R6SSM
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM371519 (N-[1-(Fluoromethyl)cyclopropyl]-1-[(1-methylpyrazo...) Show SMILES Cc1nnc(Cn2c(=O)n(Cc3cnn(C)c3)c3ccc(cc3c2=O)S(=O)(=O)NC2(CF)CC2)s1 Show InChI InChI=1S/C21H22FN7O4S2/c1-13-24-25-18(34-13)11-29-19(30)16-7-15(35(32,33)26-21(12-22)5-6-21)3-4-17(16)28(20(29)31)10-14-8-23-27(2)9-14/h3-4,7-9,26H,5-6,10-12H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Superiore di Sanita					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				J Med Chem 51: 1058-62 (2008) BindingDB Entry DOI: 10.7270/Q21R6SSM
					More data for this Ligand-Target Pair
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human))	BDBM371520 (N-[1-(Fluoromethyl)cyclopropyl]-1-[(5-methyl-1,2,4...) Show SMILES Cc1nc(Cn2c3ccc(cc3c(=O)n(Cc3nnc(C)s3)c2=O)S(=O)(=O)NC2(CF)CC2)no1 Show InChI InChI=1S/C20H20FN7O5S2/c1-11-22-16(25-33-11)8-27-15-4-3-13(35(31,32)26-20(10-21)5-6-20)7-14(15)18(29)28(19(27)30)9-17-24-23-12(2)34-17/h3-4,7,26H,5-6,8-10H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Superiore di Sanita					Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...				J Med Chem 51: 1058-62 (2008) BindingDB Entry DOI: 10.7270/Q21R6SSM
					More data for this Ligand-Target Pair

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