Compile Data Set for Download or QSAR

Found 1108 hits Enz. Inhib. hit(s) with Target = 'Cyclic GMP-AMP synthase'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM639724 (3-[[6,7-Dichloro-3-(1H-pyrazol-4-yl)-1H-indol-4-yl...) Show SMILES OCCCOc1cc(Cl)c(Cl)c2[nH]cc(-c3cn[nH]c3)c12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	3.22	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM639875 ((S)—N-(5,6-Dichloro-8-(cyanomethoxy)-9-(1H-py...) Show SMILES OCC(=O)N[C@H]1CCn2c1c(-c1cn[nH]c1)c1c(OCC#N)cc(Cl)c(Cl)c21 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	3.38	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM639703 (N-[6, 7-Dichloro-3-(1H-pyrazol-4-yl)-1H-indol-4-yl...) Show SMILES FC(F)C(=O)Nc1cc(Cl)c(Cl)c2[nH]cc(-c3cn[nH]c3)c12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	3.56	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM639763 ((S)—N-(5,6-Dichloro-8-(cyanomethoxy)-9-(1H-py...) Show SMILES CC(=O)N[C@H]1CCn2c1c(-c1cn[nH]c1)c1c(OCC#N)cc(Cl)c(Cl)c21 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	3.76	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM639676 (3-[[6,7-Dichloro-3-(1H-pyrazol-4-yl)-1H-indol-4-yl...) Show SMILES OCCCNc1cc(Cl)c(Cl)c2[nH]cc(-c3cn[nH]c3)c12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	4.33	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM639869 (3-((6,7-Dichloro-2-(hydroxymethyl)-3-(1H-pyrazol-4...) Show SMILES OCCCOc1cc(Cl)c(Cl)c2[nH]c(CO)c(-c3cn[nH]c3)c12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	4.74	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM639655 (6,7-Dichloro-N-(2-fluoroethyl)-3-(1H-pyrazol-4-yl)...) Show SMILES FCCNc1cc(Cl)c(Cl)c2[nH]cc(-c3cn[nH]c3)c12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	4.91	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM639685 (N-((6,7-Dichloro-4-(cyanomethoxy)-3-(1H-pyrazol-4-...) Show SMILES CC(=O)NCc1[nH]c2c(Cl)c(Cl)cc(OCC#N)c2c1-c1cn[nH]c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	5.11	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM639781 (3-[[6,7-Dichloro-3-(1H-pyrazol-4-yl)-1H-indazol-4-...) Show SMILES OCCCNc1cc(Cl)c(Cl)c2[nH]nc(-c3cn[nH]c3)c12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	5.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM639702 (N-(6,7-Dichloro-3-(1H-pyrazol-4-yl)-1H-indol-4-yl)...) Show SMILES FCC(=O)Nc1cc(Cl)c(Cl)c2[nH]cc(-c3cn[nH]c3)c12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	5.67	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM639874 ((S)—N-(5,6-Dichloro-8-ethoxy-9-(1H-pyrazol-4-...) Show SMILES CCOc1cc(Cl)c(Cl)c2n3CC[C@H](NC(=O)CO)c3c(-c3cn[nH]c3)c12 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	6.14	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM639734 (2-((6,7-Dichloro-2-(5-methyl-1,3,4-thiadiazol-2-yl...) Show SMILES Cc1nnc(s1)N1CCn2c(C1)c(-c1cn[nH]c1)c1c(OCC#N)cc(Cl)c(Cl)c21 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	6.77	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM639879 (3,4-Dichloro-1-(3-hydroxypropoxy)-10-(1H-pyrazol-4...) Show SMILES OCCCOc1cc(Cl)c(Cl)c2n3CC(O)CCc3c(-c3cn[nH]c3)c12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	6.95	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM639810 (2-((6,7-Dichloro-2-(2-methoxyacetyl)-10-(1H-pyrazo...) Show SMILES COCC(=O)N1CCn2c(c(-c3cn[nH]c3)c3c(OCC#N)cc(Cl)c(Cl)c23)C1=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	7.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM639768 (N-(5,6-Dichloro-9-(1H-pyrazol-4-yl)-2,3-dihydro-1H...) Show SMILES OCC(=O)NC1CCn2c1c(-c1cn[nH]c1)c1ccc(Cl)c(Cl)c21 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	7.69	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM639870 (6,7-Dichloro-9-(3-hydroxypropoxy)-2-methyl-10-(1H-...) Show SMILES CN1CCn2c(c(-c3cn[nH]c3)c3c(OCCCO)cc(Cl)c(Cl)c23)C1=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	7.89	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM639811 (US20230391786, Example 280) Show SMILES CC(=O)N1CCn2c(C1)c(-c1cn[nH]c1)c1c(OCC#N)cc(Cl)c(Cl)c21 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	8.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM639812 (US20230391786, Example 281) Show SMILES CN1CCO[C@H](C1)C(=O)N1CCn2c(C1)c(-c1cn[nH]c1)c1c(OCC#N)cc(Cl)c(Cl)c21 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	8.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM639728 (22-[6, 7-Dichloro-1-[1-(2-hydroxy ethyl)triazol-4-...) Show SMILES OCCn1cc(nn1)-n1cc(-c2cn[nH]c2)c2c(OCC#N)cc(Cl)c(Cl)c12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	8.93	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM639813 (US20230391786, Example 282) Show SMILES Cc1nc(no1)C(=O)N1CCn2c(C1)c(-c1cn[nH]c1)c1c(OCC#N)cc(Cl)c(Cl)c21 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	8.96	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM639775 ((S)—N-(2-Acetamido-5,6-dichloro-9-(1H-pyrazol...) Show SMILES CC(=O)N[C@H]1Cc2c(-c3cn[nH]c3)c3c(NC(=O)C(F)F)cc(Cl)c(Cl)c3n2C1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	9.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM50582698 (CHEMBL4448176) Show SMILES Nc1ccc(cn1)-c1cc(Cl)c(Cl)c2[nH]c3CCN(Cc3c12)C(=O)CO Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2022.114480 BindingDB Entry DOI: 10.7270/Q2K35ZMG
					More data for this Ligand-Target Pair				3D Structure (crystal)
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM50582698 (CHEMBL4448176) Show SMILES Nc1ccc(cn1)-c1cc(Cl)c(Cl)c2[nH]c3CCN(Cc3c12)C(=O)CO Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human cGAS				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00398 BindingDB Entry DOI: 10.7270/Q2RF5ZXH
					More data for this Ligand-Target Pair				3D Structure (crystal)
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM50582698 (CHEMBL4448176) Show SMILES Nc1ccc(cn1)-c1cc(Cl)c(Cl)c2[nH]c3CCN(Cc3c12)C(=O)CO Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.bmcl.2021.128101 BindingDB Entry DOI: 10.7270/Q2W95F4V
					More data for this Ligand-Target Pair				3D Structure (crystal)
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM639871 (2-((6,7-Dichloro-2-(hydroxymethyl)-3-(1H-pyrazol-4...) Show SMILES OCc1[nH]c2c(Cl)c(Cl)cc(OCC#N)c2c1-c1cn[nH]c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	10.2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM639657 (3-((6,7-Dichloro-3-(1H-pyrazol-4-yl)-1H-indol-4-yl...) Show SMILES CC(CO)COc1cc(Cl)c(Cl)c2[nH]cc(-c3cn[nH]c3)c12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	10.3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM639718 (3-[[6,7-Dichloro-3-(1H-pyrazol-4-yl)-1H-indol-4-yl...) Show SMILES OCC(F)CNc1cc(Cl)c(Cl)c2[nH]cc(-c3cn[nH]c3)c12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	10.4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM639814 (US20230391786, Example 283) Show SMILES Cn1cnc(n1)C(=O)N1CCn2c(C1)c(-c1cn[nH]c1)c1c(OCC#N)cc(Cl)c(Cl)c21 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	10.6	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM639729 (3-[[6,7-Dichloro-1-[1-(2-hydroxyethyl)triazol-4-yl...) Show SMILES OCCCNc1cc(Cl)c(Cl)c2n(cc(-c3cn[nH]c3)c12)-c1cn(CCO)nn1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM639623 (2-((6,7-Dichloro-2-(2-hydroxyacetyl)-10-(1H-pyrazo...) Show SMILES OCC(=O)N1CCn2c(C1)c(-c1cn[nH]c1)c1c(OCC#N)cc(Cl)c(Cl)c21 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	11.2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM639665 (N-[[6,7-Dichloro-1-methyl-3-(1H-pyrazol-4-yl)indol...) Show SMILES Cn1c(CNC(=O)CO)c(-c2cn[nH]c2)c2ccc(Cl)c(Cl)c12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	11.2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM639711 (5-[6,7-Dichloro-10-(1H-pyrazol-4-yl)-3,4-dihydro-1...) Show SMILES Clc1ccc2c(-c3cn[nH]c3)c3CN(CCn3c2c1Cl)C(=O)C1CNC(=O)O1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	11.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM639547 (3,4-Dichloro-10-(1H-pyrazol-4-yl)-6,7,8,9-tetrahyd...) Show SMILES OC(=O)[C@H]1CCn2c(C1)c(-c1cn[nH]c1)c1ccc(Cl)c(Cl)c21 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	11.7	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM639714 (6,7-Dichloro-4-(2-fluoroethoxy)-3-(1H-pyrazol-4-yl...) Show SMILES FCCOc1cc(Cl)c(Cl)c2[nH]cc(-c3cn[nH]c3)c12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	11.8	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM639756 (N-[6,7-Dichloro-2-(2-hydroxyethyl)-3-(1H-pyrazol-4...) Show SMILES OCCc1[nH]c2c(Cl)c(Cl)cc(NC(=O)C(F)F)c2c1-c1cn[nH]c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	12.1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM639776 ((S)—N-(5,6-Dichloro-8-(cyanomethoxy)-9-(1H-py...) Show SMILES CC(=O)N[C@H]1Cc2c(-c3cn[nH]c3)c3c(OCC#N)cc(Cl)c(Cl)c3n2C1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	12.2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM639878 (2-((5,6-Dichloro-1-(hydroxymethyl)-9-(1H-pyrazol-4...) Show SMILES OCC1CCn2c1c(-c1cn[nH]c1)c1c(OCC#N)cc(Cl)c(Cl)c21 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	12.2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM639815 (US20230391786, Example 284) Show SMILES Clc1cc(OCC#N)c2c(-c3cn[nH]c3)c3CN(CCn3c2c1Cl)C(=O)CN1CCOC1=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	12.4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM639868 (N-(6,7-Dichloro-3-(1H-pyrazol-4-yl)-1H-indazol-4-y...) Show SMILES FC(F)C(=O)Nc1cc(Cl)c(Cl)c2[nH]nc(-c3cn[nH]c3)c12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	12.4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM639743 (2-[4-[6,7-Dichloro-3-(1H-pyrazol-4-yl)indol-1-yl]t...) Show SMILES OC(=O)Cn1cc(nn1)-n1cc(-c2cn[nH]c2)c2ccc(Cl)c(Cl)c12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM639816 (US20230391786, Example 285) Show SMILES Clc1cc(OCC#N)c2c(-c3cn[nH]c3)c3CN(CCn3c2c1Cl)C(=O)[C@@H]1COCCO1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	12.6	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM639674 (2-[[6,7-Dichloro-2-(2-hydroxyethyl)-1-oxo-10-(1H-p...) Show SMILES OCCN1CCn2c(c(-c3cn[nH]c3)c3c(OCC#N)cc(Cl)c(Cl)c23)C1=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	12.7	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM639717 (3-[[6,7-Dichloro-3-(1H-pyrazol-4-yl)-1H-indol-4-yl...) Show SMILES OCC(F)(F)CNc1cc(Cl)c(Cl)c2[nH]cc(-c3cn[nH]c3)c12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	12.7	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM639817 (US20230391786, Example 286) Show SMILES Clc1cc(OCC#N)c2c(-c3cn[nH]c3)c3CN(CCn3c2c1Cl)C(=O)c1cnccn1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	13.1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM639663 (N-(6,7-Dichloro-2-(hydroxymethyl)-3-(1H-pyrazol-4-...) Show SMILES OCc1[nH]c2c(Cl)c(Cl)cc(NC(=O)C(F)F)c2c1-c1cn[nH]c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	13.1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM639654 (6, 7-Dichloro-N-(2,2-difluoroethyl)-3-(1H-pyrazol-...) Show SMILES FC(F)CNc1cc(Cl)c(Cl)c2[nH]cc(-c3cn[nH]c3)c12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	13.7	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM639701 (N-(6,7-Dichloro-3-(1H-pyrazol-4-yl)-1H-indol-4-yl)...) Show SMILES OCC(F)(F)C(=O)Nc1cc(Cl)c(Cl)c2[nH]cc(-c3cn[nH]c3)c12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	13.8	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM50582657 (CHEMBL5082056) Show SMILES Cn1ccc(n1)-c1cc(Cl)c(Cl)c2[nH]c3CCN(Cc3c12)C(=O)CO Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human cGAS				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00398 BindingDB Entry DOI: 10.7270/Q2RF5ZXH
					More data for this Ligand-Target Pair
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM639784 (1-[6,7-Dichloro-9-(3-hydroxypropylamino)-10-(1H-py...) Show SMILES CC(=O)N1CCn2c(C1)c(-c1cn[nH]c1)c1c(NCCCO)cc(Cl)c(Cl)c21 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclic GMP-AMP synthase (Homo sapiens)	BDBM50590390 (CHEMBL5174318) Show SMILES Cn1cc(cn1)-c1cc(Cl)c(Cl)c2[nH]c3CCN(Cc3c12)C(=O)CO Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2022.114480 BindingDB Entry DOI: 10.7270/Q2K35ZMG
					More data for this Ligand-Target Pair

Displayed 1 to 50 (of 1108 total )  |  Next  |  Last  >>

Jump to: