Found 296 hits Enz. Inhib. hit(s) with Target = 'Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50249989
(CHEMBL1387422)Show SMILES CC(CNC(=O)CCCn1nc(C)c2c(C)n(nc2c1=O)-c1ccc(C)cc1)c1ccccc1 Show InChI InChI=1S/C27H31N5O2/c1-18-12-14-23(15-13-18)32-21(4)25-20(3)29-31(27(34)26(25)30-32)16-8-11-24(33)28-17-19(2)22-9-6-5-7-10-22/h5-7,9-10,12-15,19H,8,11,16-17H2,1-4H3,(H,28,33) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| Purchase
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to PDE delta (unknown origin) assessed as dissociation constant measured after 2 hrs by fluorescence polarization assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00670
BindingDB Entry DOI: 10.7270/Q2PC368T |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50583530
(CHEMBL5092661)Show SMILES Cc1n(nc2c1c(C)nn(CCCC(=O)NCCc1ccc(NC(=O)CCCC(=O)NCC34CC5CC(CC(C5)C3)C4)cc1)c2=O)-c1ccc(C)cc1 |TLB:35:36:33.34.39:40,THB:35:34:40:41.36.37,37:36:33:39.38.40,37:38:33:41.35.36| | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 8.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to PDE delta (unknown origin) assessed as dissociation constant measured after 2 hrs by fluorescence polarization assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00670
BindingDB Entry DOI: 10.7270/Q2PC368T |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50583533
(CHEMBL5084153)Show SMILES Cc1n(nc2c1c(C)nn(CCCC(=O)NCC13CC4CC(CC(C4)C1)C3)c2=O)-c1ccc(C)cc1 |TLB:20:21:18.19.24:25,THB:20:19:25:26.21.22,22:21:18:24.23.25,22:23:18:26.20.21| | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 9.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to PDE delta (unknown origin) assessed as dissociation constant measured after 2 hrs by fluorescence polarization assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00670
BindingDB Entry DOI: 10.7270/Q2PC368T |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50583534
(CHEMBL5089219)Show SMILES Cc1n(nc2c1c(C)nn(CCCC(=O)NC13CC4CC(CC(C4)C1)C3)c2=O)-c1ccc(C)cc1 |TLB:19:20:17.18.23:24,THB:19:18:24:25.20.21,21:20:17:23.22.24,21:22:17:25.19.20| | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to PDE delta (unknown origin) assessed as dissociation constant measured after 2 hrs by fluorescence polarization assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00670
BindingDB Entry DOI: 10.7270/Q2PC368T |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50583525
(CHEMBL5094121)Show SMILES Cc1n(nc2c1c(C)nn(CCCC(=O)NCCCCCCNC(=O)CC13CC4CC(CC(C4)C1)C3)c2=O)-c1ccc(C)cc1 |TLB:29:30:27.28.33:34,THB:29:28:35.30.31:34,31:30:27:33.32.34,31:32:27:35.30.29| | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to PDE delta (unknown origin) assessed as dissociation constant measured after 2 hrs by fluorescence polarization assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00670
BindingDB Entry DOI: 10.7270/Q2PC368T |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50583524
(CHEMBL5077941)Show SMILES Cc1n(nc2c1c(C)nn(CCCC(=O)NCCCCCCCCNC(=O)CC13CC4CC(CC(C4)C1)C3)c2=O)-c1ccc(C)cc1 |TLB:31:32:30.29.35:36,35:30:37:34.33.36,35:34:37:31.30.29,THB:31:30:37.32.33:36| | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 29 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to PDE delta (unknown origin) assessed as dissociation constant measured after 2 hrs by fluorescence polarization assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00670
BindingDB Entry DOI: 10.7270/Q2PC368T |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50583527
(CHEMBL5086138)Show SMILES Cc1n(nc2c1c(C)nn(CCCC(=O)NCCNC(=O)CC13CC4CC(CC(C4)C1)C3)c2=O)-c1ccc(C)cc1 |TLB:25:26:23.24.29:30,THB:25:24:31.26.27:30,27:26:23:29.28.30,27:28:23:31.26.25| | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 39 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to PDE delta (unknown origin) assessed as dissociation constant measured after 2 hrs by fluorescence polarization assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00670
BindingDB Entry DOI: 10.7270/Q2PC368T |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50583532
(CHEMBL5079726)Show SMILES Cc1n(nc2c1c(C)nn(CCCC(=O)NCCCC(=O)NCC13CC4CC(CC(C4)C1)C3)c2=O)-c1ccc(C)cc1 |TLB:26:27:24.25.30:31,THB:26:25:31:32.27.28,28:27:24:30.29.31,28:29:24:32.26.27| | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 41 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to PDE delta (unknown origin) assessed as dissociation constant measured after 2 hrs by fluorescence polarization assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00670
BindingDB Entry DOI: 10.7270/Q2PC368T |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50583531
(CHEMBL5083136)Show SMILES Cc1n(nc2c1c(C)nn(CCCC(=O)NCCCCCC(=O)NCC13CC4CC(CC(C4)C1)C3)c2=O)-c1ccc(C)cc1 |TLB:28:29:26.27.32:33,THB:28:27:33:34.29.30,30:29:26:32.31.33,30:31:26:34.28.29| | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 44 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to PDE delta (unknown origin) assessed as dissociation constant measured after 2 hrs by fluorescence polarization assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00670
BindingDB Entry DOI: 10.7270/Q2PC368T |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50583529
(CHEMBL5087129)Show SMILES Cc1n(nc2c1c(C)nn(CCCC(=O)NCCc1ccc(NC(=O)CCCCCC(=O)NCC34CC5CC(CC(C5)C3)C4)cc1)c2=O)-c1ccc(C)cc1 |TLB:37:38:35.36.41:42,THB:37:36:42:43.38.39,39:38:35:41.40.42,39:40:35:43.37.38| | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 45 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to PDE delta (unknown origin) assessed as dissociation constant measured after 2 hrs by fluorescence polarization assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00670
BindingDB Entry DOI: 10.7270/Q2PC368T |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50583526
(CHEMBL5072868)Show SMILES Cc1n(nc2c1c(C)nn(CCCC(=O)NCCCCNC(=O)CC13CC4CC(CC(C4)C1)C3)c2=O)-c1ccc(C)cc1 |TLB:27:28:25.26.31:32,THB:27:26:33.28.29:32,29:28:25:31.30.32,29:30:25:33.28.27| | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 49 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to PDE delta (unknown origin) assessed as dissociation constant measured after 2 hrs by fluorescence polarization assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00670
BindingDB Entry DOI: 10.7270/Q2PC368T |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50583523
(CHEMBL5084808)Show SMILES Cc1n(nc2c1c(C)nn(CCCC(=O)NCCOCCOCCNC(=O)CC13CC4CC(CC(C4)C1)C3)c2=O)-c1ccc(C)cc1 |TLB:31:32:29.30.35:36,THB:31:30:36:37.32.33,33:32:29:35.34.36,33:34:29:37.31.32| | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 132 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to PDE delta (unknown origin) assessed as dissociation constant measured after 2 hrs by fluorescence polarization assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00670
BindingDB Entry DOI: 10.7270/Q2PC368T |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50583522
(CHEMBL5082602)Show SMILES Cc1n(nc2c1c(C)nn(CCCC(=O)NCCc1ccc(NC(=O)CCCCCCNC(=O)CC34CC5CC(CC(C5)C3)C4)cc1)c2=O)-c1ccc(C)cc1 |TLB:38:39:36.37.42:43,THB:38:37:43:44.39.40,40:39:36:42.41.43,40:41:36:44.38.39| | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 147 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to PDE delta (unknown origin) assessed as dissociation constant measured after 2 hrs by fluorescence polarization assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00670
BindingDB Entry DOI: 10.7270/Q2PC368T |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50583528
(CHEMBL5092958)Show SMILES Cc1n(nc2c1c(C)nn(CCCC(=O)NCCc1ccc(NC(=O)CCCCCCCCCC(=O)NCC34CC5CC(CC(C5)C3)C4)cc1)c2=O)-c1ccc(C)cc1 |TLB:41:42:39.40.45:46,THB:41:40:46:47.42.43,43:42:39:45.44.46,43:44:39:47.41.42| | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to PDE delta (unknown origin) assessed as dissociation constant measured after 2 hrs by fluorescence polarization assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00670
BindingDB Entry DOI: 10.7270/Q2PC368T |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50581180
(CHEMBL5081214)Show SMILES [O-][n+]1cc(Cl)c(C[C@H](OC(=O)c2cccc(c2)S(=O)(=O)NC(C(=O)O[C@H]2CN3CCC2CC3)c2ccccc2)c2ccc(OC(F)F)c(OCC3CC3)c2)c(Cl)c1 |r,wU:7.7,wD:25.25,(36.66,-8.55,;35.33,-9.33,;33.99,-8.57,;32.66,-9.34,;31.32,-8.58,;32.68,-10.87,;31.35,-11.65,;30.01,-10.88,;30,-9.34,;28.67,-8.58,;27.34,-9.35,;28.66,-7.04,;27.33,-6.28,;27.32,-4.75,;28.65,-3.96,;29.99,-4.73,;29.99,-6.27,;31.31,-3.95,;32.85,-3.95,;32.08,-5.28,;31.32,-2.42,;32.65,-1.64,;33.98,-2.41,;33.99,-3.95,;35.31,-1.63,;36.65,-2.4,;36.65,-3.95,;37.98,-4.71,;39.31,-3.94,;39.31,-2.4,;37.98,-1.63,;38.68,-3.13,;37.19,-3.37,;32.64,-.1,;33.98,.68,;33.98,2.22,;32.64,2.99,;31.31,2.2,;31.32,.68,;28.68,-11.66,;28.68,-13.21,;27.35,-13.98,;26.01,-13.21,;24.68,-13.98,;23.34,-13.21,;22.01,-13.98,;23.35,-11.67,;26.01,-11.67,;24.68,-10.9,;24.68,-9.36,;23.35,-8.59,;22.58,-7.26,;21.81,-8.59,;27.34,-10.9,;34.01,-11.65,;34.01,-13.19,;35.34,-10.87,)| | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of PDE4 in human U-937 cells assessed as reduction in cAMP level by LANCE cAMP Assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00204
BindingDB Entry DOI: 10.7270/Q2DN48WC |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50581182
(CHEMBL5080391)Show SMILES [O-][n+]1cc(Cl)c(C[C@H](OC(=O)c2cccc(CN(C(=O)O[C@H]3CN4CCC3CC4)c3ccccc3)c2)c2ccc(OC(F)F)c(OCC3CC3)c2)c(Cl)c1 |r,wU:7.7,wD:21.20,(80.86,-8.1,;79.53,-8.88,;78.19,-8.11,;76.86,-8.89,;75.52,-8.13,;76.88,-10.42,;75.54,-11.2,;74.21,-10.43,;74.2,-8.89,;72.87,-8.13,;71.53,-8.9,;72.86,-6.59,;71.53,-5.83,;71.52,-4.3,;72.85,-3.51,;74.19,-4.28,;75.52,-3.5,;75.51,-1.96,;76.85,-1.19,;76.84,.35,;78.18,-1.96,;79.51,-1.18,;80.85,-1.95,;82.18,-1.19,;82.18,.36,;80.84,1.13,;79.5,.36,;80.36,-1.06,;81.39,.16,;74.18,-1.2,;74.18,.34,;72.85,1.12,;71.52,.34,;71.53,-1.21,;72.86,-1.97,;74.19,-5.82,;72.88,-11.21,;72.88,-12.76,;71.55,-13.53,;70.21,-12.76,;68.88,-13.53,;67.54,-12.76,;66.21,-13.53,;67.54,-11.22,;70.21,-11.22,;68.88,-10.45,;68.88,-8.91,;67.55,-8.14,;66.78,-6.81,;66.01,-8.14,;71.54,-10.44,;78.21,-11.19,;78.21,-12.73,;79.54,-10.42,)| | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.126 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of PDE4 in human U-937 cells assessed as reduction in cAMP level by LANCE cAMP Assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00204
BindingDB Entry DOI: 10.7270/Q2DN48WC |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50581183
(CHEMBL5087564)Show SMILES COc1ccc(cc1OC)[C@H](Cc1c(Cl)c[n+]([O-])cc1Cl)OC(=O)c1cccc(NC(C(=O)O[C@H]2CN3CCC2CC3)c2ccccc2)c1 |r,wU:10.22,wD:34.35,(2.97,-32.16,;4.31,-32.93,;5.64,-32.16,;6.98,-32.94,;8.31,-32.16,;8.31,-30.61,;6.97,-29.85,;5.64,-30.62,;4.31,-29.85,;4.31,-28.31,;9.64,-29.84,;10.98,-30.6,;12.31,-29.83,;12.29,-28.3,;10.95,-27.54,;13.62,-27.52,;14.96,-28.28,;16.29,-27.51,;14.97,-29.83,;13.64,-30.6,;13.64,-32.14,;9.63,-28.3,;8.3,-27.53,;6.97,-28.31,;8.29,-25.99,;6.96,-25.24,;6.95,-23.7,;8.28,-22.92,;9.62,-23.68,;10.95,-22.91,;10.95,-21.37,;12.28,-20.59,;12.27,-19.06,;13.61,-21.36,;14.94,-20.59,;16.28,-21.36,;17.61,-20.59,;17.61,-19.05,;16.27,-18.28,;14.93,-19.05,;15.79,-20.46,;16.82,-19.25,;9.61,-20.6,;9.61,-19.06,;8.28,-18.3,;6.95,-19.07,;6.96,-20.62,;8.29,-21.38,;9.62,-25.22,)| | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.158 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of PDE4 in human U-937 cells assessed as reduction in cAMP level by LANCE cAMP Assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00204
BindingDB Entry DOI: 10.7270/Q2DN48WC |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50581184
(CHEMBL5094110)Show SMILES COc1ccc(cc1OC)[C@H](Cc1c(Cl)c[n+]([O-])cc1Cl)OC(=O)c1cccc(c1)S(=O)(=O)NC(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1 |r,wU:10.22,wD:38.40,(23.58,-31.52,;24.91,-32.29,;26.24,-31.52,;27.58,-32.29,;28.92,-31.52,;28.91,-29.97,;27.58,-29.2,;26.25,-29.97,;24.91,-29.21,;24.91,-27.67,;30.24,-29.19,;31.58,-29.96,;32.91,-29.18,;32.9,-27.65,;31.56,-26.89,;34.22,-26.87,;35.57,-27.64,;36.9,-26.86,;35.57,-29.18,;34.24,-29.95,;34.24,-31.49,;30.24,-27.65,;28.9,-26.89,;27.57,-27.66,;28.89,-25.35,;27.56,-24.59,;27.55,-23.06,;28.88,-22.27,;30.22,-23.04,;30.23,-24.58,;31.55,-22.26,;33.09,-22.26,;32.32,-23.59,;31.55,-20.72,;32.88,-19.95,;34.22,-20.72,;34.22,-22.26,;35.55,-19.94,;36.88,-20.71,;36.88,-22.25,;38.21,-23.02,;39.55,-22.25,;39.55,-20.71,;38.21,-19.94,;38.91,-21.44,;37.43,-21.68,;32.87,-18.41,;34.22,-17.63,;34.21,-16.1,;32.87,-15.33,;31.54,-16.11,;31.55,-17.65,)| | PDB
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| n/a | n/a | 0.251 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of PDE4 in human U-937 cells assessed as reduction in cAMP level by LANCE cAMP Assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00204
BindingDB Entry DOI: 10.7270/Q2DN48WC |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50581185
(CHEMBL5076558)Show SMILES COc1ccc(cc1OC)[C@H](Cc1c(Cl)c[n+]([O-])cc1Cl)OC(=O)c1cccc(CNC(C(=O)O[C@H]2CN3CCC2CC3)c2ccccc2)c1 |r,wU:10.22,wD:35.36,(49.9,-16.29,;51.24,-17.06,;52.57,-16.29,;53.91,-17.06,;55.24,-16.29,;55.24,-14.74,;53.9,-13.98,;52.57,-14.75,;51.24,-13.98,;51.24,-12.44,;56.57,-13.96,;57.91,-14.73,;59.24,-13.95,;59.22,-12.42,;57.89,-11.66,;60.55,-11.65,;61.89,-12.41,;63.22,-11.63,;61.9,-13.95,;60.57,-14.73,;60.57,-16.27,;56.56,-12.42,;55.23,-11.66,;53.9,-12.43,;55.22,-10.12,;53.89,-9.36,;53.88,-7.83,;55.21,-7.04,;56.55,-7.81,;57.88,-7.04,;57.88,-5.5,;59.21,-4.72,;60.54,-5.49,;60.55,-7.03,;61.87,-4.71,;63.21,-5.48,;63.21,-7.03,;64.54,-7.79,;65.87,-7.02,;65.87,-5.48,;64.54,-4.71,;65.29,-6.04,;63.75,-6.45,;59.2,-3.18,;60.54,-2.41,;60.53,-.87,;59.19,-.1,;57.86,-.89,;57.87,-2.42,;56.55,-9.35,)| | PDB
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TBA
| Assay Description
Inhibition of PDE4 in human U-937 cells assessed as reduction in cAMP level by LANCE cAMP Assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00204
BindingDB Entry DOI: 10.7270/Q2DN48WC |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50581181
(CHEMBL5086895)Show SMILES [O-][n+]1cc(Cl)c(C[C@H](OC(=O)c2cccc(CNC(C(=O)O[C@H]3CN4CCC3CC4)c3ccccc3)c2)c2ccc(OC(F)F)c(OCC3CC3)c2)c(Cl)c1 |r,wU:7.7,wD:22.21,(59.38,-8.9,;58.05,-9.67,;56.71,-8.91,;55.38,-9.69,;54.04,-8.93,;55.39,-11.22,;54.06,-11.99,;52.73,-11.23,;52.72,-9.69,;51.38,-8.92,;50.05,-9.7,;51.38,-7.38,;50.05,-6.62,;50.04,-5.09,;51.37,-4.31,;52.71,-5.07,;54.03,-4.29,;54.03,-2.76,;55.36,-1.98,;56.7,-2.75,;56.71,-4.29,;58.03,-1.97,;59.37,-2.74,;59.37,-4.29,;60.7,-5.05,;62.03,-4.29,;62.03,-2.74,;60.69,-1.97,;61.4,-3.48,;59.91,-3.71,;55.36,-.44,;56.7,.34,;56.7,1.88,;55.36,2.65,;54.02,1.86,;54.04,.33,;52.71,-6.61,;51.4,-12,;51.4,-13.55,;50.06,-14.32,;48.73,-13.55,;47.4,-14.32,;46.06,-13.55,;44.73,-14.32,;46.06,-12.01,;48.73,-12.01,;47.4,-11.24,;47.4,-9.7,;46.06,-8.93,;45.3,-7.6,;44.53,-8.93,;50.06,-11.24,;56.73,-11.99,;56.73,-13.53,;58.06,-11.21,)| | PDB
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TBA
| Assay Description
Inhibition of PDE4 in human U-937 cells assessed as reduction in cAMP level by LANCE cAMP Assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00204
BindingDB Entry DOI: 10.7270/Q2DN48WC |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50581179
(CHEMBL5078680)Show SMILES [O-][n+]1cc(Cl)c(C[C@H](OC(=O)c2cccc(NC(C(=O)O[C@H]3CN4CCC3CC4)c3ccccc3)c2)c2ccc(OC(F)F)c(OCC3CC3)c2)c(Cl)c1 |r,wU:7.7,wD:21.20,(17.64,-7.86,;16.31,-8.64,;14.96,-7.87,;13.64,-8.65,;12.3,-7.89,;13.65,-10.18,;12.32,-10.96,;10.98,-10.19,;10.98,-8.65,;9.64,-7.89,;8.31,-8.66,;9.64,-6.35,;8.3,-5.59,;8.29,-4.05,;9.63,-3.27,;10.96,-4.04,;12.3,-3.26,;12.29,-1.72,;13.62,-.95,;13.62,.59,;14.96,-1.71,;16.29,-.94,;17.62,-1.71,;18.95,-.95,;18.95,.6,;17.62,1.37,;16.28,.6,;17.13,-.82,;18.17,.4,;10.95,-.96,;10.96,.58,;9.62,1.36,;8.29,.58,;8.3,-.97,;9.64,-1.73,;10.97,-5.58,;9.65,-10.97,;9.66,-12.52,;8.32,-13.29,;6.99,-12.52,;5.65,-13.29,;4.32,-12.52,;2.99,-13.29,;4.32,-10.98,;6.99,-10.97,;5.66,-10.2,;5.66,-8.66,;4.32,-7.89,;3.55,-6.57,;2.78,-7.9,;8.32,-10.2,;14.98,-10.95,;14.99,-12.49,;16.31,-10.18,)| | PDB
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TBA
| Assay Description
Inhibition of PDE4 in human U-937 cells assessed as reduction in cAMP level by LANCE cAMP Assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00204
BindingDB Entry DOI: 10.7270/Q2DN48WC |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50581186
(CHEMBL5088742)Show SMILES COc1ccc(cc1OC)[C@H](Cc1c(Cl)c[n+]([O-])cc1Cl)OC(=O)c1cccc(CN(C(=O)O[C@H]2CN3CCC2CC3)c2ccccc2)c1 |r,wU:10.22,wD:34.35,(67,-31.8,;68.33,-32.57,;69.66,-31.81,;71,-32.58,;72.34,-31.8,;72.33,-30.25,;70.99,-29.49,;69.67,-30.26,;68.33,-29.49,;68.33,-27.95,;73.66,-29.48,;75,-30.24,;76.33,-29.47,;76.32,-27.94,;74.98,-27.18,;77.64,-27.16,;78.99,-27.93,;80.32,-27.15,;78.99,-29.47,;77.66,-30.24,;77.66,-31.78,;73.66,-27.94,;72.32,-27.17,;70.99,-27.95,;72.31,-25.63,;70.98,-24.88,;70.97,-23.34,;72.3,-22.56,;73.64,-23.33,;74.97,-22.55,;74.97,-21.01,;76.3,-20.24,;76.29,-18.7,;77.63,-21,;78.97,-20.23,;80.3,-21,;81.63,-20.23,;81.63,-18.69,;80.3,-17.92,;78.96,-18.69,;79.81,-20.1,;80.84,-18.89,;73.63,-20.25,;73.64,-18.7,;72.3,-17.94,;70.97,-18.71,;70.98,-20.26,;72.31,-21.02,;73.65,-24.86,)| | PDB
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TBA
| Assay Description
Inhibition of PDE4 in human U-937 cells assessed as reduction in cAMP level by LANCE cAMP Assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00204
BindingDB Entry DOI: 10.7270/Q2DN48WC |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50019865
(CHEMBL3286929)Show SMILES C(Oc1ccc(cc1)-c1nc2ccccc2n1Cc1ccccc1)[C@H](C1CCNCC1)n1c(nc2ccccc12)-c1ccccc1 |r| Show InChI InChI=1S/C40H37N5O/c1-3-11-29(12-4-1)27-44-36-17-9-7-15-34(36)42-39(44)32-19-21-33(22-20-32)46-28-38(30-23-25-41-26-24-30)45-37-18-10-8-16-35(37)43-40(45)31-13-5-2-6-14-31/h1-22,30,38,41H,23-28H2/t38-/m1/s1 | PDB
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Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal His6-tagged PDEdelta (unknown origin) expressed in Escherichia coli BL21(DE3)-condon plus-RIL cells after 4 hrs by fluoresce... |
Eur J Med Chem 163: 597-609 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.018
BindingDB Entry DOI: 10.7270/Q2FF3WTS |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50529743
(CHEMBL4440294)Show SMILES CC(C)Cc1nnc(SCc2ccc(cc2)C(=O)Nc2ccc(cc2)N(C)C)n1Cc1ccccc1 Show InChI InChI=1S/C29H33N5OS/c1-21(2)18-27-31-32-29(34(27)19-22-8-6-5-7-9-22)36-20-23-10-12-24(13-11-23)28(35)30-25-14-16-26(17-15-25)33(3)4/h5-17,21H,18-20H2,1-4H3,(H,30,35) | PDB
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Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal His6-tagged PDEdelta (unknown origin) expressed in Escherichia coli BL21(DE3)-condon plus-RIL cells after 4 hrs by fluoresce... |
Eur J Med Chem 163: 597-609 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.018
BindingDB Entry DOI: 10.7270/Q2FF3WTS |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50529743
(CHEMBL4440294)Show SMILES CC(C)Cc1nnc(SCc2ccc(cc2)C(=O)Nc2ccc(cc2)N(C)C)n1Cc1ccccc1 Show InChI InChI=1S/C29H33N5OS/c1-21(2)18-27-31-32-29(34(27)19-22-8-6-5-7-9-22)36-20-23-10-12-24(13-11-23)28(35)30-25-14-16-26(17-15-25)33(3)4/h5-17,21H,18-20H2,1-4H3,(H,30,35) | PDB
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Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal His6-tagged PDEdelta (unknown origin) expressed in Escherichia coli BL21(DE3)-condon plus-RIL cells after 4 hrs by fluoresce... |
Eur J Med Chem 163: 597-609 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.018
BindingDB Entry DOI: 10.7270/Q2FF3WTS |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50019865
(CHEMBL3286929)Show SMILES C(Oc1ccc(cc1)-c1nc2ccccc2n1Cc1ccccc1)[C@H](C1CCNCC1)n1c(nc2ccccc12)-c1ccccc1 |r| Show InChI InChI=1S/C40H37N5O/c1-3-11-29(12-4-1)27-44-36-17-9-7-15-34(36)42-39(44)32-19-21-33(22-20-32)46-28-38(30-23-25-41-26-24-30)45-37-18-10-8-16-35(37)43-40(45)31-13-5-2-6-14-31/h1-22,30,38,41H,23-28H2/t38-/m1/s1 | PDB
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Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal His6-tagged PDEdelta (unknown origin) expressed in Escherichia coli BL21(DE3)-condon plus-RIL cells after 4 hrs by fluoresce... |
Eur J Med Chem 163: 597-609 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.018
BindingDB Entry DOI: 10.7270/Q2FF3WTS |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50529737
(CHEMBL4459864)Show SMILES COc1ccc(CSc2nnc(-c3ccc(OCC(=O)NC4CCCCC4)cc3)n2Cc2ccccc2)cc1 Show InChI InChI=1S/C31H34N4O3S/c1-37-27-16-12-24(13-17-27)22-39-31-34-33-30(35(31)20-23-8-4-2-5-9-23)25-14-18-28(19-15-25)38-21-29(36)32-26-10-6-3-7-11-26/h2,4-5,8-9,12-19,26H,3,6-7,10-11,20-22H2,1H3,(H,32,36) | PDB
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Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal His6-tagged PDEdelta (unknown origin) expressed in Escherichia coli BL21(DE3)-condon plus-RIL cells after 4 hrs by fluoresce... |
Eur J Med Chem 163: 597-609 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.018
BindingDB Entry DOI: 10.7270/Q2FF3WTS |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50529737
(CHEMBL4459864)Show SMILES COc1ccc(CSc2nnc(-c3ccc(OCC(=O)NC4CCCCC4)cc3)n2Cc2ccccc2)cc1 Show InChI InChI=1S/C31H34N4O3S/c1-37-27-16-12-24(13-17-27)22-39-31-34-33-30(35(31)20-23-8-4-2-5-9-23)25-14-18-28(19-15-25)38-21-29(36)32-26-10-6-3-7-11-26/h2,4-5,8-9,12-19,26H,3,6-7,10-11,20-22H2,1H3,(H,32,36) | PDB
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Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal His6-tagged PDEdelta (unknown origin) expressed in Escherichia coli BL21(DE3)-condon plus-RIL cells after 4 hrs by fluoresce... |
Eur J Med Chem 163: 597-609 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.018
BindingDB Entry DOI: 10.7270/Q2FF3WTS |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50529732
(CHEMBL4527667)Show SMILES COc1ccc(CSc2nnc(-c3ccc(OCC(=O)Nc4cccnc4)cc3)n2Cc2ccccc2)cc1 Show InChI InChI=1S/C30H27N5O3S/c1-37-26-13-9-23(10-14-26)21-39-30-34-33-29(35(30)19-22-6-3-2-4-7-22)24-11-15-27(16-12-24)38-20-28(36)32-25-8-5-17-31-18-25/h2-18H,19-21H2,1H3,(H,32,36) | PDB
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Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal His6-tagged PDEdelta (unknown origin) expressed in Escherichia coli BL21(DE3)-condon plus-RIL cells after 4 hrs by fluoresce... |
Eur J Med Chem 163: 597-609 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.018
BindingDB Entry DOI: 10.7270/Q2FF3WTS |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50529736
(CHEMBL4555739)Show SMILES COc1ccc(CCc2nnc(-c3ccc(OC(C)C(=O)Nc4cnn(C)c4)cc3)n2Cc2ccccc2)cc1 Show InChI InChI=1S/C31H32N6O3/c1-22(31(38)33-26-19-32-36(2)21-26)40-28-16-12-25(13-17-28)30-35-34-29(37(30)20-24-7-5-4-6-8-24)18-11-23-9-14-27(39-3)15-10-23/h4-10,12-17,19,21-22H,11,18,20H2,1-3H3,(H,33,38) | PDB
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Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal His6-tagged PDEdelta (unknown origin) expressed in Escherichia coli BL21(DE3)-condon plus-RIL cells after 4 hrs by fluoresce... |
Eur J Med Chem 163: 597-609 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.018
BindingDB Entry DOI: 10.7270/Q2FF3WTS |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50529736
(CHEMBL4555739)Show SMILES COc1ccc(CCc2nnc(-c3ccc(OC(C)C(=O)Nc4cnn(C)c4)cc3)n2Cc2ccccc2)cc1 Show InChI InChI=1S/C31H32N6O3/c1-22(31(38)33-26-19-32-36(2)21-26)40-28-16-12-25(13-17-28)30-35-34-29(37(30)20-24-7-5-4-6-8-24)18-11-23-9-14-27(39-3)15-10-23/h4-10,12-17,19,21-22H,11,18,20H2,1-3H3,(H,33,38) | PDB
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| PC cid
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UniChem
| Article
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| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal His6-tagged PDEdelta (unknown origin) expressed in Escherichia coli BL21(DE3)-condon plus-RIL cells after 4 hrs by fluoresce... |
Eur J Med Chem 163: 597-609 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.018
BindingDB Entry DOI: 10.7270/Q2FF3WTS |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50529732
(CHEMBL4527667)Show SMILES COc1ccc(CSc2nnc(-c3ccc(OCC(=O)Nc4cccnc4)cc3)n2Cc2ccccc2)cc1 Show InChI InChI=1S/C30H27N5O3S/c1-37-26-13-9-23(10-14-26)21-39-30-34-33-29(35(30)19-22-6-3-2-4-7-22)24-11-15-27(16-12-24)38-20-28(36)32-25-8-5-17-31-18-25/h2-18H,19-21H2,1H3,(H,32,36) | PDB
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UniChem
| Article
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| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal His6-tagged PDEdelta (unknown origin) expressed in Escherichia coli BL21(DE3)-condon plus-RIL cells after 4 hrs by fluoresce... |
Eur J Med Chem 163: 597-609 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.018
BindingDB Entry DOI: 10.7270/Q2FF3WTS |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50529734
(CHEMBL4532027)Show SMILES CCC(Oc1ccc(cc1)-c1nnc(CCc2ccc(OC)cc2)n1Cc1ccccc1)C(=O)Nc1cnn(C)c1 Show InChI InChI=1S/C32H34N6O3/c1-4-29(32(39)34-26-20-33-37(2)22-26)41-28-17-13-25(14-18-28)31-36-35-30(38(31)21-24-8-6-5-7-9-24)19-12-23-10-15-27(40-3)16-11-23/h5-11,13-18,20,22,29H,4,12,19,21H2,1-3H3,(H,34,39) | PDB
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| PC cid
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UniChem
| Article
PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal His6-tagged PDEdelta (unknown origin) expressed in Escherichia coli BL21(DE3)-condon plus-RIL cells after 4 hrs by fluoresce... |
Eur J Med Chem 163: 597-609 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.018
BindingDB Entry DOI: 10.7270/Q2FF3WTS |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50529734
(CHEMBL4532027)Show SMILES CCC(Oc1ccc(cc1)-c1nnc(CCc2ccc(OC)cc2)n1Cc1ccccc1)C(=O)Nc1cnn(C)c1 Show InChI InChI=1S/C32H34N6O3/c1-4-29(32(39)34-26-20-33-37(2)22-26)41-28-17-13-25(14-18-28)31-36-35-30(38(31)21-24-8-6-5-7-9-24)19-12-23-10-15-27(40-3)16-11-23/h5-11,13-18,20,22,29H,4,12,19,21H2,1-3H3,(H,34,39) | PDB
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal His6-tagged PDEdelta (unknown origin) expressed in Escherichia coli BL21(DE3)-condon plus-RIL cells after 4 hrs by fluoresce... |
Eur J Med Chem 163: 597-609 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.018
BindingDB Entry DOI: 10.7270/Q2FF3WTS |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50529738
(CHEMBL4514611)Show SMILES COc1ccc(CSc2nnc(-c3ccc(OCC(=O)Nc4cnn(C)c4)cc3)n2Cc2ccccc2)cc1 Show InChI InChI=1S/C29H28N6O3S/c1-34-18-24(16-30-34)31-27(36)19-38-26-14-10-23(11-15-26)28-32-33-29(35(28)17-21-6-4-3-5-7-21)39-20-22-8-12-25(37-2)13-9-22/h3-16,18H,17,19-20H2,1-2H3,(H,31,36) | PDB
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| PC cid
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UniChem
| Article
PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal His6-tagged PDEdelta (unknown origin) expressed in Escherichia coli BL21(DE3)-condon plus-RIL cells after 4 hrs by fluoresce... |
Eur J Med Chem 163: 597-609 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.018
BindingDB Entry DOI: 10.7270/Q2FF3WTS |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50529745
(CHEMBL4548659)Show SMILES CC(C)Cc1nnc(SCc2ccc(cc2)C(=O)Nc2ccc(F)cc2)n1Cc1ccccc1 Show InChI InChI=1S/C27H27FN4OS/c1-19(2)16-25-30-31-27(32(25)17-20-6-4-3-5-7-20)34-18-21-8-10-22(11-9-21)26(33)29-24-14-12-23(28)13-15-24/h3-15,19H,16-18H2,1-2H3,(H,29,33) | PDB
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| PC cid
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UniChem
| Article
PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal His6-tagged PDEdelta (unknown origin) expressed in Escherichia coli BL21(DE3)-condon plus-RIL cells after 4 hrs by fluoresce... |
Eur J Med Chem 163: 597-609 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.018
BindingDB Entry DOI: 10.7270/Q2FF3WTS |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50529745
(CHEMBL4548659)Show SMILES CC(C)Cc1nnc(SCc2ccc(cc2)C(=O)Nc2ccc(F)cc2)n1Cc1ccccc1 Show InChI InChI=1S/C27H27FN4OS/c1-19(2)16-25-30-31-27(32(25)17-20-6-4-3-5-7-20)34-18-21-8-10-22(11-9-21)26(33)29-24-14-12-23(28)13-15-24/h3-15,19H,16-18H2,1-2H3,(H,29,33) | PDB
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| PC cid
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UniChem
| Article
PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal His6-tagged PDEdelta (unknown origin) expressed in Escherichia coli BL21(DE3)-condon plus-RIL cells after 4 hrs by fluoresce... |
Eur J Med Chem 163: 597-609 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.018
BindingDB Entry DOI: 10.7270/Q2FF3WTS |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50529738
(CHEMBL4514611)Show SMILES COc1ccc(CSc2nnc(-c3ccc(OCC(=O)Nc4cnn(C)c4)cc3)n2Cc2ccccc2)cc1 Show InChI InChI=1S/C29H28N6O3S/c1-34-18-24(16-30-34)31-27(36)19-38-26-14-10-23(11-15-26)28-32-33-29(35(28)17-21-6-4-3-5-7-21)39-20-22-8-12-25(37-2)13-9-22/h3-16,18H,17,19-20H2,1-2H3,(H,31,36) | PDB
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal His6-tagged PDEdelta (unknown origin) expressed in Escherichia coli BL21(DE3)-condon plus-RIL cells after 4 hrs by fluoresce... |
Eur J Med Chem 163: 597-609 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.018
BindingDB Entry DOI: 10.7270/Q2FF3WTS |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50529740
(CHEMBL4536719)Show SMILES CC(C)Cc1nnc(SCc2ccc(cc2)C(=O)NC2CCCCC2)n1Cc1ccccc1 Show InChI InChI=1S/C27H34N4OS/c1-20(2)17-25-29-30-27(31(25)18-21-9-5-3-6-10-21)33-19-22-13-15-23(16-14-22)26(32)28-24-11-7-4-8-12-24/h3,5-6,9-10,13-16,20,24H,4,7-8,11-12,17-19H2,1-2H3,(H,28,32) | PDB
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| PC cid
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| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal His6-tagged PDEdelta (unknown origin) expressed in Escherichia coli BL21(DE3)-condon plus-RIL cells after 4 hrs by fluoresce... |
Eur J Med Chem 163: 597-609 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.018
BindingDB Entry DOI: 10.7270/Q2FF3WTS |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50529740
(CHEMBL4536719)Show SMILES CC(C)Cc1nnc(SCc2ccc(cc2)C(=O)NC2CCCCC2)n1Cc1ccccc1 Show InChI InChI=1S/C27H34N4OS/c1-20(2)17-25-29-30-27(31(25)18-21-9-5-3-6-10-21)33-19-22-13-15-23(16-14-22)26(32)28-24-11-7-4-8-12-24/h3,5-6,9-10,13-16,20,24H,4,7-8,11-12,17-19H2,1-2H3,(H,28,32) | PDB
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| PC cid
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UniChem
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal His6-tagged PDEdelta (unknown origin) expressed in Escherichia coli BL21(DE3)-condon plus-RIL cells after 4 hrs by fluoresce... |
Eur J Med Chem 163: 597-609 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.018
BindingDB Entry DOI: 10.7270/Q2FF3WTS |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50529749
(CHEMBL4440110)Show SMILES CC(C)Cc1nnc(SCc2ccc(cc2)C(=O)Nc2ccccc2F)n1Cc1ccccc1 Show InChI InChI=1S/C27H27FN4OS/c1-19(2)16-25-30-31-27(32(25)17-20-8-4-3-5-9-20)34-18-21-12-14-22(15-13-21)26(33)29-24-11-7-6-10-23(24)28/h3-15,19H,16-18H2,1-2H3,(H,29,33) | PDB
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal His6-tagged PDEdelta (unknown origin) expressed in Escherichia coli BL21(DE3)-condon plus-RIL cells after 4 hrs by fluoresce... |
Eur J Med Chem 163: 597-609 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.018
BindingDB Entry DOI: 10.7270/Q2FF3WTS |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50529749
(CHEMBL4440110)Show SMILES CC(C)Cc1nnc(SCc2ccc(cc2)C(=O)Nc2ccccc2F)n1Cc1ccccc1 Show InChI InChI=1S/C27H27FN4OS/c1-19(2)16-25-30-31-27(32(25)17-20-8-4-3-5-9-20)34-18-21-12-14-22(15-13-21)26(33)29-24-11-7-6-10-23(24)28/h3-15,19H,16-18H2,1-2H3,(H,29,33) | PDB
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal His6-tagged PDEdelta (unknown origin) expressed in Escherichia coli BL21(DE3)-condon plus-RIL cells after 4 hrs by fluoresce... |
Eur J Med Chem 163: 597-609 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.018
BindingDB Entry DOI: 10.7270/Q2FF3WTS |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50529746
(CHEMBL4589625)Show SMILES COc1ccc(CCc2nnc(-c3ccc(OC(C)(C)C(=O)Nc4cnn(C)c4)cc3)n2Cc2ccccc2)cc1 Show InChI InChI=1S/C32H34N6O3/c1-32(2,31(39)34-26-20-33-37(3)22-26)41-28-17-13-25(14-18-28)30-36-35-29(38(30)21-24-8-6-5-7-9-24)19-12-23-10-15-27(40-4)16-11-23/h5-11,13-18,20,22H,12,19,21H2,1-4H3,(H,34,39) | PDB
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal His6-tagged PDEdelta (unknown origin) expressed in Escherichia coli BL21(DE3)-condon plus-RIL cells after 4 hrs by fluoresce... |
Eur J Med Chem 163: 597-609 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.018
BindingDB Entry DOI: 10.7270/Q2FF3WTS |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50529746
(CHEMBL4589625)Show SMILES COc1ccc(CCc2nnc(-c3ccc(OC(C)(C)C(=O)Nc4cnn(C)c4)cc3)n2Cc2ccccc2)cc1 Show InChI InChI=1S/C32H34N6O3/c1-32(2,31(39)34-26-20-33-37(3)22-26)41-28-17-13-25(14-18-28)30-36-35-29(38(30)21-24-8-6-5-7-9-24)19-12-23-10-15-27(40-4)16-11-23/h5-11,13-18,20,22H,12,19,21H2,1-4H3,(H,34,39) | PDB
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal His6-tagged PDEdelta (unknown origin) expressed in Escherichia coli BL21(DE3)-condon plus-RIL cells after 4 hrs by fluoresce... |
Eur J Med Chem 163: 597-609 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.018
BindingDB Entry DOI: 10.7270/Q2FF3WTS |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50529744
(CHEMBL4588289)Show SMILES CC(C)Cc1nnc(SCc2ccc(cc2)C(=O)Nc2ccccc2)n1Cc1ccccc1 Show InChI InChI=1S/C27H28N4OS/c1-20(2)17-25-29-30-27(31(25)18-21-9-5-3-6-10-21)33-19-22-13-15-23(16-14-22)26(32)28-24-11-7-4-8-12-24/h3-16,20H,17-19H2,1-2H3,(H,28,32) | PDB
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal His6-tagged PDEdelta (unknown origin) expressed in Escherichia coli BL21(DE3)-condon plus-RIL cells after 4 hrs by fluoresce... |
Eur J Med Chem 163: 597-609 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.018
BindingDB Entry DOI: 10.7270/Q2FF3WTS |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50529744
(CHEMBL4588289)Show SMILES CC(C)Cc1nnc(SCc2ccc(cc2)C(=O)Nc2ccccc2)n1Cc1ccccc1 Show InChI InChI=1S/C27H28N4OS/c1-20(2)17-25-29-30-27(31(25)18-21-9-5-3-6-10-21)33-19-22-13-15-23(16-14-22)26(32)28-24-11-7-4-8-12-24/h3-16,20H,17-19H2,1-2H3,(H,28,32) | PDB
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal His6-tagged PDEdelta (unknown origin) expressed in Escherichia coli BL21(DE3)-condon plus-RIL cells after 4 hrs by fluoresce... |
Eur J Med Chem 163: 597-609 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.018
BindingDB Entry DOI: 10.7270/Q2FF3WTS |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50529731
(CHEMBL4566147)Show SMILES CC(C)Cc1nnc(SCc2ccc(cc2)C(=O)Nc2cccc(F)c2)n1Cc1ccccc1 Show InChI InChI=1S/C27H27FN4OS/c1-19(2)15-25-30-31-27(32(25)17-20-7-4-3-5-8-20)34-18-21-11-13-22(14-12-21)26(33)29-24-10-6-9-23(28)16-24/h3-14,16,19H,15,17-18H2,1-2H3,(H,29,33) | PDB
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| PC cid
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UniChem
| Article
PubMed
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal His6-tagged PDEdelta (unknown origin) expressed in Escherichia coli BL21(DE3)-condon plus-RIL cells after 4 hrs by fluoresce... |
Eur J Med Chem 163: 597-609 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.018
BindingDB Entry DOI: 10.7270/Q2FF3WTS |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50529731
(CHEMBL4566147)Show SMILES CC(C)Cc1nnc(SCc2ccc(cc2)C(=O)Nc2cccc(F)c2)n1Cc1ccccc1 Show InChI InChI=1S/C27H27FN4OS/c1-19(2)15-25-30-31-27(32(25)17-20-7-4-3-5-8-20)34-18-21-11-13-22(14-12-21)26(33)29-24-10-6-9-23(28)16-24/h3-14,16,19H,15,17-18H2,1-2H3,(H,29,33) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal His6-tagged PDEdelta (unknown origin) expressed in Escherichia coli BL21(DE3)-condon plus-RIL cells after 4 hrs by fluoresce... |
Eur J Med Chem 163: 597-609 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.018
BindingDB Entry DOI: 10.7270/Q2FF3WTS |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50529733
(CHEMBL4585643)Show SMILES CC(C)Cc1nnc(SCc2ccc(cc2)C(=O)Nc2ccc(cc2)-c2ccccc2)n1Cc1ccccc1 Show InChI InChI=1S/C33H32N4OS/c1-24(2)21-31-35-36-33(37(31)22-25-9-5-3-6-10-25)39-23-26-13-15-29(16-14-26)32(38)34-30-19-17-28(18-20-30)27-11-7-4-8-12-27/h3-20,24H,21-23H2,1-2H3,(H,34,38) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal His6-tagged PDEdelta (unknown origin) expressed in Escherichia coli BL21(DE3)-condon plus-RIL cells after 4 hrs by fluoresce... |
Eur J Med Chem 163: 597-609 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.018
BindingDB Entry DOI: 10.7270/Q2FF3WTS |
More data for this
Ligand-Target Pair | |
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
(Homo sapiens (Human)) | BDBM50529733
(CHEMBL4585643)Show SMILES CC(C)Cc1nnc(SCc2ccc(cc2)C(=O)Nc2ccc(cc2)-c2ccccc2)n1Cc1ccccc1 Show InChI InChI=1S/C33H32N4OS/c1-24(2)21-31-35-36-33(37(31)22-25-9-5-3-6-10-25)39-23-26-13-15-29(16-14-26)32(38)34-30-19-17-28(18-20-30)27-11-7-4-8-12-27/h3-20,24H,21-23H2,1-2H3,(H,34,38) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal His6-tagged PDEdelta (unknown origin) expressed in Escherichia coli BL21(DE3)-condon plus-RIL cells after 4 hrs by fluoresce... |
Eur J Med Chem 163: 597-609 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.018
BindingDB Entry DOI: 10.7270/Q2FF3WTS |
More data for this
Ligand-Target Pair | |
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