Compile Data Set for Download or QSAR

Found 37 hits Enz. Inhib. hit(s) with Target = 'Mast/stem cell growth factor receptor Kit [544-976]'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mast/stem cell growth factor receptor Kit [544-976] (Homo sapiens (Human))	BDBM239022 (US10028934, Compound 33 | US10478423, Cpd. 33 | US...) Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccc(cc3)C(F)(F)F)ccc12 Show InChI InChI=1S/C29H30F3N5O3/c1-36-12-14-37(15-13-36)23-8-4-21(5-9-23)28(38)33-27-25-11-10-24(18-26(25)34-35-27)40-17-16-39-19-20-2-6-22(7-3-20)29(30,31)32/h2-11,18H,12-17,19H2,1H3,(H2,33,34,35,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.9	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...				US Patent US9408850 (2016) BindingDB Entry DOI: 10.7270/Q2F47N2F
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [544-976] (Homo sapiens (Human))	BDBM239023 (US10028934, Compound 32 | US10478423, Cpd. 32 | US...) Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccc(F)cc3)ccc12 Show InChI InChI=1S/C28H30FN5O3/c1-33-12-14-34(15-13-33)23-8-4-21(5-9-23)28(35)30-27-25-11-10-24(18-26(25)31-32-27)37-17-16-36-19-20-2-6-22(29)7-3-20/h2-11,18H,12-17,19H2,1H3,(H2,30,31,32,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	7.9	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...				US Patent US9408850 (2016) BindingDB Entry DOI: 10.7270/Q2F47N2F
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [544-976] (Homo sapiens (Human))	BDBM239043 (US10028934, Compound 20 | US10478423, Cpd. 20 | US...) Show SMILES O=C(Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12)c1ccc(cc1)N1CCNCC1 Show InChI InChI=1S/C27H29N5O3/c33-27(21-6-8-22(9-7-21)32-14-12-28-13-15-32)29-26-24-11-10-23(18-25(24)30-31-26)35-17-16-34-19-20-4-2-1-3-5-20/h1-11,18,28H,12-17,19H2,(H2,29,30,31,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	52	n/a	n/a	n/a	n/a	7.9	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...				US Patent US9408850 (2016) BindingDB Entry DOI: 10.7270/Q2F47N2F
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [544-976] (Homo sapiens (Human))	BDBM239019 (US10028934, Compound 22 | US10478423, Cpd. 22 | US...) Show SMILES CN1CCC(CC1)Oc1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12 Show InChI InChI=1S/C29H32N4O4/c1-33-15-13-24(14-16-33)37-23-9-7-22(8-10-23)29(34)30-28-26-12-11-25(19-27(26)31-32-28)36-18-17-35-20-21-5-3-2-4-6-21/h2-12,19,24H,13-18,20H2,1H3,(H2,30,31,32,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	7.9	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...				US Patent US9408850 (2016) BindingDB Entry DOI: 10.7270/Q2F47N2F
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [544-976] (Homo sapiens (Human))	BDBM239042 (US10028934, Compound 42 | US10478423, Cpd. 42 | US...) Show SMILES C[N+]1([O-])CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccc(cc3)C(F)(F)F)ccc12 Show InChI InChI=1S/C29H30F3N5O4/c1-37(39)14-12-36(13-15-37)23-8-4-21(5-9-23)28(38)33-27-25-11-10-24(18-26(25)34-35-27)41-17-16-40-19-20-2-6-22(7-3-20)29(30,31)32/h2-11,18H,12-17,19H2,1H3,(H2,33,34,35,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	7.9	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...				US Patent US9408850 (2016) BindingDB Entry DOI: 10.7270/Q2F47N2F
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [544-976] (Homo sapiens (Human))	BDBM239024 (US10028934, Compound 34 | US10478423, Cpd. 34 | US...) Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3cccc(c3)C(F)(F)F)ccc12 Show InChI InChI=1S/C29H30F3N5O3/c1-36-11-13-37(14-12-36)23-7-5-21(6-8-23)28(38)33-27-25-10-9-24(18-26(25)34-35-27)40-16-15-39-19-20-3-2-4-22(17-20)29(30,31)32/h2-10,17-18H,11-16,19H2,1H3,(H2,33,34,35,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	58	n/a	n/a	n/a	n/a	7.9	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...				US Patent US9408850 (2016) BindingDB Entry DOI: 10.7270/Q2F47N2F
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [544-976] (Homo sapiens (Human))	BDBM239033 (US10028934, Compound 19 | US10478423, Cpd. 19 | US...) Show SMILES CN1CCC(CC1)Nc1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12 Show InChI InChI=1S/C29H33N5O3/c1-34-15-13-24(14-16-34)30-23-9-7-22(8-10-23)29(35)31-28-26-12-11-25(19-27(26)32-33-28)37-18-17-36-20-21-5-3-2-4-6-21/h2-12,19,24,30H,13-18,20H2,1H3,(H2,31,32,33,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	61	n/a	n/a	n/a	n/a	7.9	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...				US Patent US9408850 (2016) BindingDB Entry DOI: 10.7270/Q2F47N2F
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [544-976] (Homo sapiens (Human))	BDBM239029 (US10028934, Compound 15 | US10478423, Cpd. 15 | US...) Show SMILES CN(C)C1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12 Show InChI InChI=1S/C30H35N5O3/c1-34(2)24-14-16-35(17-15-24)25-10-8-23(9-11-25)30(36)31-29-27-13-12-26(20-28(27)32-33-29)38-19-18-37-21-22-6-4-3-5-7-22/h3-13,20,24H,14-19,21H2,1-2H3,(H2,31,32,33,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	76	n/a	n/a	n/a	n/a	7.9	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...				US Patent US9408850 (2016) BindingDB Entry DOI: 10.7270/Q2F47N2F
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [544-976] (Homo sapiens (Human))	BDBM239026 (US10028934, Compound 40 | US10478423, Cpd. 40 | US...) Show SMILES COc1ccc(COCCOc2ccc3c(NC(=O)c4ccc(cc4)N4CCN(C)CC4)n[nH]c3c2)cc1 Show InChI InChI=1S/C29H33N5O4/c1-33-13-15-34(16-14-33)23-7-5-22(6-8-23)29(35)30-28-26-12-11-25(19-27(26)31-32-28)38-18-17-37-20-21-3-9-24(36-2)10-4-21/h3-12,19H,13-18,20H2,1-2H3,(H2,30,31,32,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	88	n/a	n/a	n/a	n/a	7.9	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...				US Patent US9408850 (2016) BindingDB Entry DOI: 10.7270/Q2F47N2F
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [544-976] (Homo sapiens (Human))	BDBM239038 (US10028934, Compound 27 | US10478423, Cpd. 27 | US...) Show SMILES CN1CCC(CNc2ccc(cc2)C(=O)Nc2n[nH]c3cc(OCCOCc4ccccc4)ccc23)CC1 Show InChI InChI=1S/C30H35N5O3/c1-35-15-13-22(14-16-35)20-31-25-9-7-24(8-10-25)30(36)32-29-27-12-11-26(19-28(27)33-34-29)38-18-17-37-21-23-5-3-2-4-6-23/h2-12,19,22,31H,13-18,20-21H2,1H3,(H2,32,33,34,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	91	n/a	n/a	n/a	n/a	7.9	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...				US Patent US9408850 (2016) BindingDB Entry DOI: 10.7270/Q2F47N2F
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [544-976] (Homo sapiens (Human))	BDBM239030 (US10028934, Compound 16 | US10478423, Cpd. 16 | US...) Show SMILES CN(C)CCN(C)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12 Show InChI InChI=1S/C28H33N5O3/c1-32(2)15-16-33(3)23-11-9-22(10-12-23)28(34)29-27-25-14-13-24(19-26(25)30-31-27)36-18-17-35-20-21-7-5-4-6-8-21/h4-14,19H,15-18,20H2,1-3H3,(H2,29,30,31,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	106	n/a	n/a	n/a	n/a	7.9	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...				US Patent US9408850 (2016) BindingDB Entry DOI: 10.7270/Q2F47N2F
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [544-976] (Homo sapiens (Human))	BDBM239034 (US10028934, Compound 23 | US10478423, Cpd. 23 | US...) Show SMILES CN(C1CCN(C)CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12 Show InChI InChI=1S/C30H35N5O3/c1-34-16-14-25(15-17-34)35(2)24-10-8-23(9-11-24)30(36)31-29-27-13-12-26(20-28(27)32-33-29)38-19-18-37-21-22-6-4-3-5-7-22/h3-13,20,25H,14-19,21H2,1-2H3,(H2,31,32,33,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	109	n/a	n/a	n/a	n/a	7.9	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...				US Patent US9408850 (2016) BindingDB Entry DOI: 10.7270/Q2F47N2F
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [544-976] (Homo sapiens (Human))	BDBM239017 (US10028934, Compound 11 | US10478423, Cpd. 11 | US...) Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12 Show InChI InChI=1S/C28H31N5O3/c1-32-13-15-33(16-14-32)23-9-7-22(8-10-23)28(34)29-27-25-12-11-24(19-26(25)30-31-27)36-18-17-35-20-21-5-3-2-4-6-21/h2-12,19H,13-18,20H2,1H3,(H2,29,30,31,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	113	n/a	n/a	n/a	n/a	7.9	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...				US Patent US9408850 (2016) BindingDB Entry DOI: 10.7270/Q2F47N2F
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [544-976] (Homo sapiens (Human))	BDBM239040 (US10028934, Compound 14 | US10478423, Cpd. 14 | US...) Show SMILES C[N+]1([O-])CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12 Show InChI InChI=1S/C28H31N5O4/c1-33(35)15-13-32(14-16-33)23-9-7-22(8-10-23)28(34)29-27-25-12-11-24(19-26(25)30-31-27)37-18-17-36-20-21-5-3-2-4-6-21/h2-12,19H,13-18,20H2,1H3,(H2,29,30,31,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	118	n/a	n/a	n/a	n/a	7.9	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...				US Patent US9408850 (2016) BindingDB Entry DOI: 10.7270/Q2F47N2F
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [544-976] (Homo sapiens (Human))	BDBM239037 (US10028934, Compound 26 | US10478423, Cpd. 26 | US...) Show SMILES O=C(Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12)c1ccc(NC2CCOCC2)cc1 Show InChI InChI=1S/C28H30N4O4/c33-28(21-6-8-22(9-7-21)29-23-12-14-34-15-13-23)30-27-25-11-10-24(18-26(25)31-32-27)36-17-16-35-19-20-4-2-1-3-5-20/h1-11,18,23,29H,12-17,19H2,(H2,30,31,32,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	124	n/a	n/a	n/a	n/a	7.9	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...				US Patent US9408850 (2016) BindingDB Entry DOI: 10.7270/Q2F47N2F
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [544-976] (Homo sapiens (Human))	BDBM239018 (US10028934, Compound 21 | US10478423, Cpd. 21 | US...) Show SMILES CN(C)Cc1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12 Show InChI InChI=1S/C26H28N4O3/c1-30(2)17-19-8-10-21(11-9-19)26(31)27-25-23-13-12-22(16-24(23)28-29-25)33-15-14-32-18-20-6-4-3-5-7-20/h3-13,16H,14-15,17-18H2,1-2H3,(H2,27,28,29,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	134	n/a	n/a	n/a	n/a	7.9	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...				US Patent US9408850 (2016) BindingDB Entry DOI: 10.7270/Q2F47N2F
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [544-976] (Homo sapiens (Human))	BDBM239031 (US10028934, Compound 17 | US10478423, Cpd. 17 | US...) Show SMILES CN(C)CCCN(C)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12 Show InChI InChI=1S/C29H35N5O3/c1-33(2)16-7-17-34(3)24-12-10-23(11-13-24)29(35)30-28-26-15-14-25(20-27(26)31-32-28)37-19-18-36-21-22-8-5-4-6-9-22/h4-6,8-15,20H,7,16-19,21H2,1-3H3,(H2,30,31,32,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	146	n/a	n/a	n/a	n/a	7.9	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...				US Patent US9408850 (2016) BindingDB Entry DOI: 10.7270/Q2F47N2F
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [544-976] (Homo sapiens (Human))	BDBM239013 (US10028934, Compound 2 | US10478423, Cpd. 2 | US94...) Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(Oc3ccccc3)ccc12 Show InChI InChI=1S/C25H25N5O2/c1-29-13-15-30(16-14-29)19-9-7-18(8-10-19)25(31)26-24-22-12-11-21(17-23(22)27-28-24)32-20-5-3-2-4-6-20/h2-12,17H,13-16H2,1H3,(H2,26,27,28,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	172	n/a	n/a	n/a	n/a	7.9	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...				US Patent US9408850 (2016) BindingDB Entry DOI: 10.7270/Q2F47N2F
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [544-976] (Homo sapiens (Human))	BDBM239041 (US10028934, Compound 41 | US10478423, Cpd. 41 | US...) Show SMILES CN(C1CC[N+](C)([O-])CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12 |(3.97,5.33,;5.06,4.24,;6.55,4.64,;7.64,3.55,;9.13,3.95,;9.53,5.43,;11.01,5.03,;9.92,6.92,;8.44,6.52,;6.95,6.12,;4.66,2.75,;5.75,1.66,;5.36,.17,;3.87,-.22,;2.78,.86,;3.18,2.35,;3.47,-1.71,;1.98,-2.11,;4.56,-2.8,;3.79,-4.13,;4.69,-5.38,;3.79,-6.63,;2.32,-6.15,;.99,-6.92,;-.34,-6.15,;-1.68,-6.92,;-3.01,-6.15,;-4.34,-6.92,;-5.68,-6.15,;-7.01,-6.92,;-8.35,-6.15,;-8.35,-4.61,;-9.68,-3.84,;-11.01,-4.61,;-11.01,-6.15,;-9.68,-6.92,;-.34,-4.61,;.99,-3.84,;2.32,-4.61,)| Show InChI InChI=1S/C30H35N5O4/c1-34(25-14-16-35(2,37)17-15-25)24-10-8-23(9-11-24)30(36)31-29-27-13-12-26(20-28(27)32-33-29)39-19-18-38-21-22-6-4-3-5-7-22/h3-13,20,25H,14-19,21H2,1-2H3,(H2,31,32,33,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	180	n/a	n/a	n/a	n/a	7.9	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...				US Patent US9408850 (2016) BindingDB Entry DOI: 10.7270/Q2F47N2F
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [544-976] (Homo sapiens (Human))	BDBM239036 (US10028934, Compound 25 | US10478423, Cpd. 25 | US...) Show SMILES O=C(Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12)c1ccc(NCCN2CCOCC2)cc1 Show InChI InChI=1S/C29H33N5O4/c35-29(23-6-8-24(9-7-23)30-12-13-34-14-16-36-17-15-34)31-28-26-11-10-25(20-27(26)32-33-28)38-19-18-37-21-22-4-2-1-3-5-22/h1-11,20,30H,12-19,21H2,(H2,31,32,33,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	197	n/a	n/a	n/a	n/a	7.9	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...				US Patent US9408850 (2016) BindingDB Entry DOI: 10.7270/Q2F47N2F
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [544-976] (Homo sapiens (Human))	BDBM239035 (US10028934, Compound 24 | US10478423, Cpd. 24 | US...) Show SMILES O=C(Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12)c1ccc(cc1)N1CCOCC1 Show InChI InChI=1S/C27H28N4O4/c32-27(21-6-8-22(9-7-21)31-12-14-33-15-13-31)28-26-24-11-10-23(18-25(24)29-30-26)35-17-16-34-19-20-4-2-1-3-5-20/h1-11,18H,12-17,19H2,(H2,28,29,30,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	260	n/a	n/a	n/a	n/a	7.9	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...				US Patent US9408850 (2016) BindingDB Entry DOI: 10.7270/Q2F47N2F
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [544-976] (Homo sapiens (Human))	BDBM239039 (US10028934, Compound 28 | US10478423, Cpd. 28 | US...) Show SMILES O=C(Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12)c1ccc(cc1)N1CC(C1)N1CCCC1 Show InChI InChI=1S/C30H33N5O3/c36-30(23-8-10-24(11-9-23)35-19-25(20-35)34-14-4-5-15-34)31-29-27-13-12-26(18-28(27)32-33-29)38-17-16-37-21-22-6-2-1-3-7-22/h1-3,6-13,18,25H,4-5,14-17,19-21H2,(H2,31,32,33,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	306	n/a	n/a	n/a	n/a	7.9	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...				US Patent US9408850 (2016) BindingDB Entry DOI: 10.7270/Q2F47N2F
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [544-976] (Homo sapiens (Human))	BDBM239028 (US10028934, Compound 39 | US10478423, Cpd. 39 | US...) Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OC\C=C\c3ccccc3)ccc12 Show InChI InChI=1S/C28H29N5O2/c1-32-15-17-33(18-16-32)23-11-9-22(10-12-23)28(34)29-27-25-14-13-24(20-26(25)30-31-27)35-19-5-8-21-6-3-2-4-7-21/h2-14,20H,15-19H2,1H3,(H2,29,30,31,34)/b8-5+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	528	n/a	n/a	n/a	n/a	7.9	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...				US Patent US9408850 (2016) BindingDB Entry DOI: 10.7270/Q2F47N2F
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [544-976] (Homo sapiens (Human))	BDBM239014 (US10028934, Compound 3 | US10478423, Cpd. 3 | US94...) Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(Oc3cccc(F)c3)ccc12 Show InChI InChI=1S/C25H24FN5O2/c1-30-11-13-31(14-12-30)19-7-5-17(6-8-19)25(32)27-24-22-10-9-21(16-23(22)28-29-24)33-20-4-2-3-18(26)15-20/h2-10,15-16H,11-14H2,1H3,(H2,27,28,29,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	564	n/a	n/a	n/a	n/a	7.9	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...				US Patent US9408850 (2016) BindingDB Entry DOI: 10.7270/Q2F47N2F
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [544-976] (Homo sapiens (Human))	BDBM239021 (US10028934, Compound 38 | US10478423, Cpd. 38 | US...) Show SMILES CN1CCN(CC1)c1ccc(C(=O)Nc2n[nH]c3cc(OCCOCc4ccccc4)ccc23)c(F)c1 Show InChI InChI=1S/C28H30FN5O3/c1-33-11-13-34(14-12-33)21-7-9-23(25(29)17-21)28(35)30-27-24-10-8-22(18-26(24)31-32-27)37-16-15-36-19-20-5-3-2-4-6-20/h2-10,17-18H,11-16,19H2,1H3,(H2,30,31,32,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	613	n/a	n/a	n/a	n/a	7.9	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...				US Patent US9408850 (2016) BindingDB Entry DOI: 10.7270/Q2F47N2F
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [544-976] (Homo sapiens (Human))	BDBM239016 (US10028934, Compound 9 | US10478423, Cpd. 9 | US94...) Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(Oc3cccc(OCc4ccccc4)c3)ccc12 Show InChI InChI=1S/C32H31N5O3/c1-36-16-18-37(19-17-36)25-12-10-24(11-13-25)32(38)33-31-29-15-14-28(21-30(29)34-35-31)40-27-9-5-8-26(20-27)39-22-23-6-3-2-4-7-23/h2-15,20-21H,16-19,22H2,1H3,(H2,33,34,35,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	713	n/a	n/a	n/a	n/a	7.9	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...				US Patent US9408850 (2016) BindingDB Entry DOI: 10.7270/Q2F47N2F
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [544-976] (Homo sapiens (Human))	BDBM239012 (US10028934, Compound 10 | US10478423, Cpd. 10 | US...) Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOc3ccccc3)ccc12 Show InChI InChI=1S/C27H29N5O3/c1-31-13-15-32(16-14-31)21-9-7-20(8-10-21)27(33)28-26-24-12-11-23(19-25(24)29-30-26)35-18-17-34-22-5-3-2-4-6-22/h2-12,19H,13-18H2,1H3,(H2,28,29,30,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	956	n/a	n/a	n/a	n/a	7.9	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...				US Patent US9408850 (2016) BindingDB Entry DOI: 10.7270/Q2F47N2F
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [544-976] (Homo sapiens (Human))	BDBM239020 (US10028934, Compound 29 | US10478423, Cpd. 29 | US...) Show SMILES CN1CCN(CC1)c1cccc(c1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12 Show InChI InChI=1S/C28H31N5O3/c1-32-12-14-33(15-13-32)23-9-5-8-22(18-23)28(34)29-27-25-11-10-24(19-26(25)30-31-27)36-17-16-35-20-21-6-3-2-4-7-21/h2-11,18-19H,12-17,20H2,1H3,(H2,29,30,31,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.08E+3	n/a	n/a	n/a	n/a	7.9	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...				US Patent US9408850 (2016) BindingDB Entry DOI: 10.7270/Q2F47N2F
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [544-976] (Homo sapiens (Human))	BDBM239032 (US10028934, Compound 18 | US10478423, Cpd. 18 | US...) Show SMILES CC(C)(C)OC(=O)N1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12 Show InChI InChI=1S/C32H37N5O5/c1-32(2,3)42-31(39)37-17-15-36(16-18-37)25-11-9-24(10-12-25)30(38)33-29-27-14-13-26(21-28(27)34-35-29)41-20-19-40-22-23-7-5-4-6-8-23/h4-14,21H,15-20,22H2,1-3H3,(H2,33,34,35,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.39E+3	n/a	n/a	n/a	n/a	7.9	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...				US Patent US9408850 (2016) BindingDB Entry DOI: 10.7270/Q2F47N2F
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [544-976] (Homo sapiens (Human))	BDBM239025 (US10028934, Compound 30 | US10478423, Cpd. 30 | US...) Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3F)ccc12 Show InChI InChI=1S/C28H30FN5O3/c1-33-12-14-34(15-13-33)22-8-6-20(7-9-22)28(35)30-27-24-11-10-23(18-26(24)31-32-27)37-17-16-36-19-21-4-2-3-5-25(21)29/h2-11,18H,12-17,19H2,1H3,(H2,30,31,32,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.41E+3	n/a	n/a	n/a	n/a	7.9	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...				US Patent US9408850 (2016) BindingDB Entry DOI: 10.7270/Q2F47N2F
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [544-976] (Homo sapiens (Human))	BDBM239010 (US10028934, Compound 7 | US10478423, Cpd. 7 | US94...) Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCC#Cc3ccccc3)ccc12 Show InChI InChI=1S/C28H27N5O2/c1-32-15-17-33(18-16-32)23-11-9-22(10-12-23)28(34)29-27-25-14-13-24(20-26(25)30-31-27)35-19-5-8-21-6-3-2-4-7-21/h2-4,6-7,9-14,20H,15-19H2,1H3,(H2,29,30,31,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.51E+3	n/a	n/a	n/a	n/a	7.9	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...				US Patent US9408850 (2016) BindingDB Entry DOI: 10.7270/Q2F47N2F
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [544-976] (Homo sapiens (Human))	BDBM239027 (US10028934, Compound 35 | US10478423, Cpd. 35 | US...) Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccncc3)ccc12 Show InChI InChI=1S/C27H30N6O3/c1-32-12-14-33(15-13-32)22-4-2-21(3-5-22)27(34)29-26-24-7-6-23(18-25(24)30-31-26)36-17-16-35-19-20-8-10-28-11-9-20/h2-11,18H,12-17,19H2,1H3,(H2,29,30,31,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.37E+3	n/a	n/a	n/a	n/a	7.9	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...				US Patent US9408850 (2016) BindingDB Entry DOI: 10.7270/Q2F47N2F
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [544-976] (Homo sapiens (Human))	BDBM239008 (US10028934, Compound 5 | US10478423, Cpd. 5 | US94...) Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCc3cccc(Oc4ccccc4)c3)ccc12 Show InChI InChI=1S/C32H31N5O3/c1-36-16-18-37(19-17-36)25-12-10-24(11-13-25)32(38)33-31-29-15-14-27(21-30(29)34-35-31)39-22-23-6-5-9-28(20-23)40-26-7-3-2-4-8-26/h2-15,20-21H,16-19,22H2,1H3,(H2,33,34,35,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.62E+3	n/a	n/a	n/a	n/a	7.9	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...				US Patent US9408850 (2016) BindingDB Entry DOI: 10.7270/Q2F47N2F
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [544-976] (Homo sapiens (Human))	BDBM239009 (US10028934, Compound 1 | US10478423, Cpd. 1 | US94...) Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCc3ccccc3)ccc12 Show InChI InChI=1S/C26H27N5O2/c1-30-13-15-31(16-14-30)21-9-7-20(8-10-21)26(32)27-25-23-12-11-22(17-24(23)28-29-25)33-18-19-5-3-2-4-6-19/h2-12,17H,13-16,18H2,1H3,(H2,27,28,29,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.81E+3	n/a	n/a	n/a	n/a	7.9	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...				US Patent US9408850 (2016) BindingDB Entry DOI: 10.7270/Q2F47N2F
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [544-976] (Homo sapiens (Human))	BDBM239011 (US10028934, Compound 6 | US10478423, Cpd. 6 | US94...) Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OC3CCN(Cc4ccccc4)CC3)ccc12 Show InChI InChI=1S/C31H36N6O2/c1-35-17-19-37(20-18-35)25-9-7-24(8-10-25)31(38)32-30-28-12-11-27(21-29(28)33-34-30)39-26-13-15-36(16-14-26)22-23-5-3-2-4-6-23/h2-12,21,26H,13-20,22H2,1H3,(H2,32,33,34,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.89E+3	n/a	n/a	n/a	n/a	7.9	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...				US Patent US9408850 (2016) BindingDB Entry DOI: 10.7270/Q2F47N2F
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [544-976] (Homo sapiens (Human))	BDBM239044 (US10478423, Ref. Compound | US9408850, Ref. Compou...) Show SMILES CN(C)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCc3ccccc3)ccc12 Show InChI InChI=1S/C23H22N4O2/c1-27(2)18-10-8-17(9-11-18)23(28)24-22-20-13-12-19(14-21(20)25-26-22)29-15-16-6-4-3-5-7-16/h3-14H,15H2,1-2H3,(H2,24,25,26,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	7.9	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...				US Patent US9408850 (2016) BindingDB Entry DOI: 10.7270/Q2F47N2F
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit [544-976] (Homo sapiens (Human))	BDBM239015 (US10028934, Compound 4 | US10478423, Cpd. 4 | US94...) Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(Oc3ccc(OCc4ccccc4)cc3)ccc12 Show InChI InChI=1S/C32H31N5O3/c1-36-17-19-37(20-18-36)25-9-7-24(8-10-25)32(38)33-31-29-16-15-28(21-30(29)34-35-31)40-27-13-11-26(12-14-27)39-22-23-5-3-2-4-6-23/h2-16,21H,17-20,22H2,1H3,(H2,33,34,35,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	7.9	n/a
NERVIANO MEDICAL SCIENCES S.R.L. US Patent					Assay Description The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) was pre ac...				US Patent US9408850 (2016) BindingDB Entry DOI: 10.7270/Q2F47N2F
					More data for this Ligand-Target Pair