BindingDB PrimarySearch

Found 22 hits Enz. Inhib. hit(s) with Target = 'Potassium voltage-gated channel subfamily A member 4'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Potassium voltage-gated channel subfamily A member 4 (Homo sapiens (Human))	BDBM50279106 (4-(4-phenoxybutoxy)-7H-furo[3,2-g]chromen-7-one \| ...) Show SMILES O=c1ccc2c(OCCCCOc3ccccc3)c3ccoc3cc2o1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
University of Ljubljana Curated by ChEMBL					Assay Description Inhibition of human Kv1.4 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method				Eur J Med Chem 139: 232-241 (2017) Article DOI: 10.1016/j.ejmech.2017.08.015 BindingDB Entry DOI: 10.7270/Q2668GT4
University of Ljubljana Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 4 (Rattus norvegicus)	BDBM50456982 (CHEMBL4208517) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	230	n/a	n/a	n/a	n/a	n/a	n/a
University of Ljubljana Curated by ChEMBL					Assay Description Inhibition of rat Kv1.4 expressed in Xenopus laevis oocytes at -90 mV holding potential by two-electrode voltage clamp assay				Eur J Med Chem 139: 232-241 (2017) Article DOI: 10.1016/j.ejmech.2017.08.015 BindingDB Entry DOI: 10.7270/Q2668GT4
University of Ljubljana Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 4 (Rattus norvegicus)	BDBM50456975 (CHEMBL4213446) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	380	n/a	n/a	n/a	n/a	n/a	n/a
University of Ljubljana Curated by ChEMBL					Assay Description Inhibition of rat Kv1.4 expressed in Xenopus laevis oocytes at -90 mV holding potential by two-electrode voltage clamp assay				Eur J Med Chem 139: 232-241 (2017) Article DOI: 10.1016/j.ejmech.2017.08.015 BindingDB Entry DOI: 10.7270/Q2668GT4
University of Ljubljana Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 4 (Rattus norvegicus)	BDBM50456976 (CHEMBL4207745) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
University of Ljubljana Curated by ChEMBL					Assay Description Inhibition of rat Kv1.4 expressed in Xenopus laevis oocytes at -90 mV holding potential by two-electrode voltage clamp assay				Eur J Med Chem 139: 232-241 (2017) Article DOI: 10.1016/j.ejmech.2017.08.015 BindingDB Entry DOI: 10.7270/Q2668GT4
University of Ljubljana Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 4 (Rattus norvegicus)	BDBM50456969 (CHEMBL4202870) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	730	n/a	n/a	n/a	n/a	n/a	n/a
University of Ljubljana Curated by ChEMBL					Assay Description Inhibition of rat Kv1.4 expressed in Xenopus laevis oocytes at -90 mV holding potential by two-electrode voltage clamp assay				Eur J Med Chem 139: 232-241 (2017) Article DOI: 10.1016/j.ejmech.2017.08.015 BindingDB Entry DOI: 10.7270/Q2668GT4
University of Ljubljana Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 4 (Homo sapiens (Human))	BDBM50456976 (CHEMBL4207745) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Ljubljana Curated by ChEMBL					Assay Description Inhibition of human Kv1.4 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method				Eur J Med Chem 139: 232-241 (2017) Article DOI: 10.1016/j.ejmech.2017.08.015 BindingDB Entry DOI: 10.7270/Q2668GT4
University of Ljubljana Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 4 (Homo sapiens (Human))	BDBM50220547 (4,5-Dibromo-1H-pyrrole-2-carboxylic acid [3-(2-ami...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Ljubljana Curated by ChEMBL					Assay Description Inhibition of human Kv1.4 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method				Eur J Med Chem 139: 232-241 (2017) Article DOI: 10.1016/j.ejmech.2017.08.015 BindingDB Entry DOI: 10.7270/Q2668GT4
University of Ljubljana Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 4 (Homo sapiens (Human))	BDBM50456974 (CHEMBL3621636) Show SMILES Nc1nc(\C=C\CNC(=O)c2cc(Br)c[nH]2)c[nH]1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Ljubljana Curated by ChEMBL					Assay Description Inhibition of human Kv1.4 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method				Eur J Med Chem 139: 232-241 (2017) Article DOI: 10.1016/j.ejmech.2017.08.015 BindingDB Entry DOI: 10.7270/Q2668GT4
University of Ljubljana Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 4 (Rattus norvegicus)	BDBM50220547 (4,5-Dibromo-1H-pyrrole-2-carboxylic acid [3-(2-ami...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	5.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Ljubljana Curated by ChEMBL					Assay Description Inhibition of rat Kv1.4 expressed in Xenopus laevis oocytes at -90 mV holding potential by two-electrode voltage clamp assay				Eur J Med Chem 139: 232-241 (2017) Article DOI: 10.1016/j.ejmech.2017.08.015 BindingDB Entry DOI: 10.7270/Q2668GT4
University of Ljubljana Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 4 (Homo sapiens (Human))	BDBM50456970 (CHEMBL3261431) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Ljubljana Curated by ChEMBL					Assay Description Inhibition of human Kv1.4 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method				Eur J Med Chem 139: 232-241 (2017) Article DOI: 10.1016/j.ejmech.2017.08.015 BindingDB Entry DOI: 10.7270/Q2668GT4
University of Ljubljana Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 4 (Homo sapiens (Human))	BDBM50456975 (CHEMBL4213446) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Ljubljana Curated by ChEMBL					Assay Description Inhibition of human Kv1.4 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method				Eur J Med Chem 139: 232-241 (2017) Article DOI: 10.1016/j.ejmech.2017.08.015 BindingDB Entry DOI: 10.7270/Q2668GT4
University of Ljubljana Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 4 (Homo sapiens (Human))	BDBM50456982 (CHEMBL4208517) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Ljubljana Curated by ChEMBL					Assay Description Inhibition of human Kv1.4 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method				Eur J Med Chem 139: 232-241 (2017) Article DOI: 10.1016/j.ejmech.2017.08.015 BindingDB Entry DOI: 10.7270/Q2668GT4
University of Ljubljana Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 4 (Homo sapiens (Human))	BDBM50456977 (CHEMBL3261430) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Ljubljana Curated by ChEMBL					Assay Description Inhibition of human Kv1.4 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method				Eur J Med Chem 139: 232-241 (2017) Article DOI: 10.1016/j.ejmech.2017.08.015 BindingDB Entry DOI: 10.7270/Q2668GT4
University of Ljubljana Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 4 (Homo sapiens (Human))	BDBM50456969 (CHEMBL4202870) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Ljubljana Curated by ChEMBL					Assay Description Inhibition of human Kv1.4 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method				Eur J Med Chem 139: 232-241 (2017) Article DOI: 10.1016/j.ejmech.2017.08.015 BindingDB Entry DOI: 10.7270/Q2668GT4
University of Ljubljana Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 4 (Homo sapiens (Human))	BDBM50456971 (CHEMBL4210636) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Ljubljana Curated by ChEMBL					Assay Description Inhibition of human Kv1.4 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method				Eur J Med Chem 139: 232-241 (2017) Article DOI: 10.1016/j.ejmech.2017.08.015 BindingDB Entry DOI: 10.7270/Q2668GT4
University of Ljubljana Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 4 (Homo sapiens (Human))	BDBM50237157 (CHEMBL4079366) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Dublin Institute of Technology Curated by ChEMBL					Assay Description Inhibition of Kv1.4 (unknown origin) expressed in HEK293 cells by whole cell patch clamp Qpatch method				J Med Chem 60: 2245-2256 (2017) Article DOI: 10.1021/acs.jmedchem.6b01262 BindingDB Entry DOI: 10.7270/Q29K4DHG
Dublin Institute of Technology Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 4 (Homo sapiens (Human))	BDBM50456973 (Clathrodin) Show SMILES Nc1ncc(\C=C\CNC(=O)c2ccc[nH]2)[nH]1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Ljubljana Curated by ChEMBL					Assay Description Inhibition of human Kv1.4 expressed in CHO cells at -80 mV holding potential by whole cell automated patch clamp method				Eur J Med Chem 139: 232-241 (2017) Article DOI: 10.1016/j.ejmech.2017.08.015 BindingDB Entry DOI: 10.7270/Q2668GT4
University of Ljubljana Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 4 (Homo sapiens (Human))	BDBM50375409 (CHEMBL408488) Show SMILES CC1(C)OCC(Br)(CO1)[N+]([O-])=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of Kv1.4 channel inactivation expressed in xenopus oocytes by voltage clamp assay				Bioorg Med Chem 16: 3067-75 (2008) Article DOI: 10.1016/j.bmc.2007.12.031 BindingDB Entry DOI: 10.7270/Q2M04697
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 4 (Homo sapiens (Human))	BDBM50182585 (5-acetyl-7-(4'-bromo)benzyloxy-6-hydroxy-4-methoxy...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.30E+3	n/a	n/a	n/a	n/a
Institute of Medical Research Biotechnology Centre Curated by ChEMBL					Assay Description Effect on blockade of Kv1.4 channel				J Med Chem 49: 1433-41 (2006) Article DOI: 10.1021/jm050839v BindingDB Entry DOI: 10.7270/Q2KW5FM6
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 4 (Homo sapiens (Human))	BDBM50182597 (5-acetyl-4,7-benzyloxy-6-hydroxybenzofuran \| CHEMB...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a
Institute of Medical Research Biotechnology Centre Curated by ChEMBL					Assay Description Effect on blockade of Kv1.4 channel				J Med Chem 49: 1433-41 (2006) Article DOI: 10.1021/jm050839v BindingDB Entry DOI: 10.7270/Q2KW5FM6
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 4 (Homo sapiens (Human))	BDBM50182587 (5-acetyl-4-(4'-chloro)benzyloxy-6-hydroxy-7-methox...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.80E+3	n/a	n/a	n/a	n/a
Institute of Medical Research Biotechnology Centre Curated by ChEMBL					Assay Description Effect on blockade of Kv1.4 channel				J Med Chem 49: 1433-41 (2006) Article DOI: 10.1021/jm050839v BindingDB Entry DOI: 10.7270/Q2KW5FM6
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 4 (Homo sapiens (Human))	BDBM50375408 (CHEMBL259345) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of Kv1.4 channel inactivation expressed in xenopus oocytes by voltage clamp assay				Bioorg Med Chem 16: 3067-75 (2008) Article DOI: 10.1016/j.bmc.2007.12.031 BindingDB Entry DOI: 10.7270/Q2M04697
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair