Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Beta-secretase 1/2 (Homo sapiens (Human)) | BDBM186049 (US9163011, 3) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Dart Neuroscience LLC Curated by ChEMBL | Assay Description Inhibition of BACE1/BACE2 (unknown origin) transfected in CHO cells assessed as release of amyloid beta (1 to 40) after 24 hrs by immunoassay | ACS Med Chem Lett 4: 433-4 (2013) Article DOI: 10.1021/ml400104f BindingDB Entry DOI: 10.7270/Q24M97F6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1/2 (Homo sapiens (Human)) | BDBM186080 (US9163011, 35) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Dart Neuroscience LLC Curated by ChEMBL | Assay Description Inhibition of BACE1/BACE2 (unknown origin) transfected in CHO cells assessed as release of amyloid beta (1 to 40) after 24 hrs by immunoassay | ACS Med Chem Lett 4: 433-4 (2013) Article DOI: 10.1021/ml400104f BindingDB Entry DOI: 10.7270/Q24M97F6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1/2 (Homo sapiens (Human)) | BDBM186048 (US9163011, 2) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Dart Neuroscience LLC Curated by ChEMBL | Assay Description Inhibition of BACE1/BACE2 (unknown origin) transfected in CHO cells assessed as release of amyloid beta (1 to 40) after 24 hrs by immunoassay | ACS Med Chem Lett 4: 433-4 (2013) Article DOI: 10.1021/ml400104f BindingDB Entry DOI: 10.7270/Q24M97F6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1/2 (Homo sapiens (Human)) | BDBM186055 (US9163011, 9) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Dart Neuroscience LLC Curated by ChEMBL | Assay Description Inhibition of BACE1/BACE2 (unknown origin) transfected in CHO cells assessed as release of amyloid beta (1 to 40) after 24 hrs by immunoassay | ACS Med Chem Lett 4: 433-4 (2013) Article DOI: 10.1021/ml400104f BindingDB Entry DOI: 10.7270/Q24M97F6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1/2 (Homo sapiens (Human)) | BDBM186075 (US9163011, 30) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Dart Neuroscience LLC Curated by ChEMBL | Assay Description Inhibition of BACE1/BACE2 (unknown origin) transfected in CHO cells assessed as release of amyloid beta (1 to 40) after 24 hrs by immunoassay | ACS Med Chem Lett 4: 433-4 (2013) Article DOI: 10.1021/ml400104f BindingDB Entry DOI: 10.7270/Q24M97F6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1/2 (Homo sapiens (Human)) | BDBM186053 (US9163011, 7) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Dart Neuroscience LLC Curated by ChEMBL | Assay Description Inhibition of BACE1/BACE2 (unknown origin) transfected in CHO cells assessed as release of amyloid beta (1 to 40) after 24 hrs by immunoassay | ACS Med Chem Lett 4: 433-4 (2013) Article DOI: 10.1021/ml400104f BindingDB Entry DOI: 10.7270/Q24M97F6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1/2 (Homo sapiens (Human)) | BDBM50100436 (CHEMBL412768 | NH2-Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description In vitro inhibition of beta-secretase was evaluated | J Med Chem 44: 2039-60 (2001) BindingDB Entry DOI: 10.7270/Q27S7PGX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1/2 (Homo sapiens (Human)) | BDBM186050 (US9163011, 4) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 49 | n/a | n/a | n/a | n/a | n/a | n/a |
Dart Neuroscience LLC Curated by ChEMBL | Assay Description Inhibition of BACE1/BACE2 (unknown origin) transfected in CHO cells assessed as release of amyloid beta (1 to 40) after 24 hrs by immunoassay | ACS Med Chem Lett 4: 433-4 (2013) Article DOI: 10.1021/ml400104f BindingDB Entry DOI: 10.7270/Q24M97F6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1/2 (Homo sapiens (Human)) | BDBM50100434 (CHEMBL302004 | L-68458 | L-685458 | tert-butyl (2S...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description Inhibition of beta-secretase activity | J Med Chem 44: 2039-60 (2001) BindingDB Entry DOI: 10.7270/Q27S7PGX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1/2 (Homo sapiens (Human)) | BDBM186057 (US9163011, 11) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
Dart Neuroscience LLC Curated by ChEMBL | Assay Description Inhibition of BACE1/BACE2 (unknown origin) transfected in CHO cells assessed as release of amyloid beta (1 to 40) after 24 hrs by immunoassay | ACS Med Chem Lett 4: 433-4 (2013) Article DOI: 10.1021/ml400104f BindingDB Entry DOI: 10.7270/Q24M97F6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1/2 (Homo sapiens (Human)) | BDBM50470133 (CHEMBL277046) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Affymax Research Institute Curated by ChEMBL | Assay Description Inhibitory activity against aspartyl protease | J Med Chem 37: 1233-51 (1994) Article DOI: 10.1021/jm00035a001 BindingDB Entry DOI: 10.7270/Q2GT5QWG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1/2 (Homo sapiens (Human)) | BDBM50171338 (5-[3-(3,5-Bis-trifluoromethyl-phenyl)-ureido]-2-di...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.70E+4 | n/a | n/a | n/a | n/a |
University of Zürich Curated by ChEMBL | Assay Description Beta-secretase inhibitory activity as inhibition of secreted alkaline phosphatase in HEK293 cells expressing SEAP-APP fusion protein | J Med Chem 48: 5108-11 (2005) Article DOI: 10.1021/jm050499d BindingDB Entry DOI: 10.7270/Q228074P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1/2 (Homo sapiens (Human)) | BDBM50171337 (5-[3-(3-Chloro-phenyl)-ureido]-2-dimethylamino-N-(...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 23 | n/a | n/a | n/a | n/a |
University of Zürich Curated by ChEMBL | Assay Description Beta-secretase inhibitory activity as inhibition of secreted alkaline phosphatase in HEK293 cells expressing SEAP-APP fusion protein | J Med Chem 48: 5108-11 (2005) Article DOI: 10.1021/jm050499d BindingDB Entry DOI: 10.7270/Q228074P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1/2 (Homo sapiens (Human)) | BDBM50171340 (5-[3-(3,5-Bis-trifluoromethyl-phenyl)-ureido]-2-di...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 3.5 | n/a | n/a | n/a | n/a |
University of Zürich Curated by ChEMBL | Assay Description Beta-secretase inhibitory activity as inhibition of secreted alkaline phosphatase in HEK293 cells expressing SEAP-APP fusion protein | J Med Chem 48: 5108-11 (2005) Article DOI: 10.1021/jm050499d BindingDB Entry DOI: 10.7270/Q228074P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1/2 (Homo sapiens (Human)) | BDBM50171339 (1-(3-Acetyl-phenyl)-3-(3-ethylsulfanyl-[1,2,4]thia...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 11 | n/a | n/a | n/a | n/a |
University of Zürich Curated by ChEMBL | Assay Description Beta-secretase inhibitory activity as inhibition of secreted alkaline phosphatase in HEK293 cells expressing SEAP-APP fusion protein | J Med Chem 48: 5108-11 (2005) Article DOI: 10.1021/jm050499d BindingDB Entry DOI: 10.7270/Q228074P | |||||||||||
More data for this Ligand-Target Pair |