Compile Data Set for Download or QSAR

Found 5 hits Enz. Inhib. hit(s) with Target = 'Dihydropteridine reductase'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dihydropteridine reductase (Rattus norvegicus)	BDBM50025881 (4-(3,4-Dihydroxy-phenyl)-1-methyl-pyridinium; brom...) Show SMILES C[n+]1ccc(cc1)-c1ccc(O)c(O)c1 Show InChI InChI=1S/C12H11NO2/c1-13-6-4-9(5-7-13)10-2-3-11(14)12(15)8-10/h2-8,15H,1H3/p+1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Noncompetitive Inhibitory activity against rat striatal synaptosomal DHPR enzyme				J Med Chem 28: 311-7 (1985) BindingDB Entry DOI: 10.7270/Q2XK8DKG
					More data for this Ligand-Target Pair
Dihydropteridine reductase (Homo sapiens (Human))	BDBM50025879 (4-(1-Methyl-1,2,3,6-tetrahydro-pyridin-4-yl)-pheno...) Show SMILES CN1CCC(=CC1)c1ccc(O)cc1 |c:4| Show InChI InChI=1S/C12H15NO/c1-13-8-6-11(7-9-13)10-2-4-12(14)5-3-10/h2-6,14H,7-9H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PubMed	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity against Dihydrofolate reductase of rat liver				J Med Chem 28: 311-7 (1985) BindingDB Entry DOI: 10.7270/Q2XK8DKG
					More data for this Ligand-Target Pair
Dihydropteridine reductase (Rattus norvegicus)	BDBM50025878 (4-(1-Methyl-1,2,3,6-tetrahydro-pyridin-4-yl)-benze...) Show SMILES CN1CCC(=CC1)c1ccc(O)c(O)c1 |c:4| Show InChI InChI=1S/C12H15NO2/c1-13-6-4-9(5-7-13)10-2-3-11(14)12(15)8-10/h2-4,8,14-15H,5-7H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	3.30E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity against Dihydrofolate reductase of rat liver				J Med Chem 28: 311-7 (1985) BindingDB Entry DOI: 10.7270/Q2XK8DKG
					More data for this Ligand-Target Pair
Dihydropteridine reductase (Rattus norvegicus)	BDBM50025880 (4-(1-Methyl-piperidin-4-yl)-benzene-1,2-diol | CHE...) Show SMILES CN1CCC(CC1)c1ccc(O)c(O)c1 Show InChI InChI=1S/C12H17NO2/c1-13-6-4-9(5-7-13)10-2-3-11(14)12(15)8-10/h2-3,8-9,14-15H,4-7H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	7.40E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity against Dihydrofolate reductase of rat liver				J Med Chem 28: 311-7 (1985) BindingDB Entry DOI: 10.7270/Q2XK8DKG
					More data for this Ligand-Target Pair
Oxygen-insensitive NAD(P)H nitroreductase (Escherichia coli K-12)	BDBM50505033 (CHEMBL4518887) Show SMILES [O-][N+](=O)c1ccc2CNP(=O)(Oc2c1)N(CCCl)CCCl Show InChI InChI=1S/C11H14Cl2N3O4P/c12-3-5-15(6-4-13)21(19)14-8-9-1-2-10(16(17)18)7-11(9)20-21/h1-2,7H,3-6,8H2,(H,14,19)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Taipei Medical University Curated by ChEMBL					Assay Description Inhibition of Escherichia coli nitroreductase expressed in human HCT116 cells				J Med Chem 62: 2851-2893 (2019) Article DOI: 10.1021/acs.jmedchem.8b00147 BindingDB Entry DOI: 10.7270/Q2ZP49CC
					More data for this Ligand-Target Pair