Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dickkopf-related protein 1 (Mus musculus) | BDBM50135174 (CHEMBL3747431) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Aristotle University of Thessaloniki Curated by ChEMBL | Assay Description Inhibition of mouse DKK1 assessed as inhibition of DKK1-alkaline phophatase binding to LRP5 transfected in HEK293 cells | Eur J Med Chem 108: 28-38 (2016) Article DOI: 10.1016/j.ejmech.2015.11.024 BindingDB Entry DOI: 10.7270/Q2TF0067 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dickkopf-related protein 1 (Homo sapiens (Human)) | BDBM50303036 (CHEMBL569986 | N-((1-(4-(naphthalen-2-yl)pyrimidin...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a |
Wyeth Research Curated by ChEMBL | Assay Description Inhibition of Dkk1-mediated Wnt/beta-catenin signaling in osteosasrcoma cells assessed as potentiation of TCF-luciferase response | J Med Chem 52: 6962-5 (2009) Article DOI: 10.1021/jm9014197 BindingDB Entry DOI: 10.7270/Q2HM58JV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dickkopf-related protein 1 (Homo sapiens (Human)) | BDBM50303040 (4-(methyl(4-(5-methylthiophen-2-yl)pyrimidin-2-yl)...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 9.80E+3 | n/a | n/a | n/a | n/a |
Wyeth Research Curated by ChEMBL | Assay Description Inhibition of Dkk1-mediated Wnt/beta-catenin signaling in osteosasrcoma cells assessed as potentiation of TCF-luciferase response | J Med Chem 52: 6962-5 (2009) Article DOI: 10.1021/jm9014197 BindingDB Entry DOI: 10.7270/Q2HM58JV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dickkopf-related protein 1 (Homo sapiens (Human)) | BDBM50303038 (1-(4-(naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-a...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a |
Wyeth Research Curated by ChEMBL | Assay Description Inhibition of Dkk1-mediated Wnt/beta-catenin signaling in osteosasrcoma cells assessed as potentiation of TCF-luciferase response | J Med Chem 52: 6962-5 (2009) Article DOI: 10.1021/jm9014197 BindingDB Entry DOI: 10.7270/Q2HM58JV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dickkopf-related protein 1 (Homo sapiens (Human)) | BDBM50303039 (4-(4-(naphthalen-2-yl)pyrimidin-2-ylamino)benzenes...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a |
Wyeth Research Curated by ChEMBL | Assay Description Inhibition of Dkk1-mediated Wnt/beta-catenin signaling in osteosasrcoma cells assessed as potentiation of TCF-luciferase response | J Med Chem 52: 6962-5 (2009) Article DOI: 10.1021/jm9014197 BindingDB Entry DOI: 10.7270/Q2HM58JV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dickkopf-related protein 1 (Homo sapiens (Human)) | BDBM50303035 (4-(4-(5-methylthiophen-2-yl)pyrimidin-2-ylamino)be...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 7.80E+3 | n/a | n/a | n/a | n/a |
Wyeth Research Curated by ChEMBL | Assay Description Inhibition of Dkk1-mediated Wnt/beta-catenin signaling in osteosasrcoma cells assessed as potentiation of TCF-luciferase response | J Med Chem 52: 6962-5 (2009) Article DOI: 10.1021/jm9014197 BindingDB Entry DOI: 10.7270/Q2HM58JV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dickkopf-related protein 1 (Homo sapiens (Human)) | BDBM50303037 ((1-(4-(naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 630 | n/a | n/a | n/a | n/a |
Wyeth Research Curated by ChEMBL | Assay Description Inhibition of Dkk1-mediated Wnt/beta-catenin signaling in osteosasrcoma cells assessed as potentiation of TCF-luciferase response | J Med Chem 52: 6962-5 (2009) Article DOI: 10.1021/jm9014197 BindingDB Entry DOI: 10.7270/Q2HM58JV | |||||||||||
More data for this Ligand-Target Pair |