Compile Data Set for Download or QSAR

Found 6 hits Enz. Inhib. hit(s) with Target = 'Friend leukemia integration 1 transcription factor'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Friend leukemia integration 1 transcription factor (Homo sapiens (Human))	BDBM50497660 (CHEMBL3360409) Show SMILES CN(C)c1ccc(cc1)C(=O)CC1(O)C(=O)Nc2c1c(Cl)ccc2Cl Show InChI InChI=1S/C18H16Cl2N2O3/c1-22(2)11-5-3-10(4-6-11)14(23)9-18(25)15-12(19)7-8-13(20)16(15)21-17(18)24/h3-8,25H,9H2,1-2H3,(H,21,24)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University Medical Center Curated by ChEMBL					Assay Description Inhibition of transcriptional activity of full-length EWS-FLI1 (unknown origin) expressed in COS7 cells by NR0B1-luciferase reporter gene assay				J Med Chem 57: 10290-303 (2014) Article DOI: 10.1021/jm501372p BindingDB Entry DOI: 10.7270/Q29G5QTK
					More data for this Ligand-Target Pair
Friend leukemia integration 1 transcription factor (Homo sapiens (Human))	BDBM50497662 (CHEMBL3360408) Show SMILES CNc1ccc(cc1)C(=O)CC1(O)C(=O)Nc2c1c(Cl)ccc2Cl Show InChI InChI=1S/C17H14Cl2N2O3/c1-20-10-4-2-9(3-5-10)13(22)8-17(24)14-11(18)6-7-12(19)15(14)21-16(17)23/h2-7,20,24H,8H2,1H3,(H,21,23)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University Medical Center Curated by ChEMBL					Assay Description Inhibition of transcriptional activity of full-length EWS-FLI1 (unknown origin) expressed in COS7 cells by NR0B1-luciferase reporter gene assay				J Med Chem 57: 10290-303 (2014) Article DOI: 10.1021/jm501372p BindingDB Entry DOI: 10.7270/Q29G5QTK
					More data for this Ligand-Target Pair
Friend leukemia integration 1 transcription factor (Homo sapiens (Human))	BDBM50497659 (CHEMBL3360406) Show SMILES CSc1ccc(cc1)C(=O)CC1(O)C(=O)Nc2c1c(Cl)ccc2Cl Show InChI InChI=1S/C17H13Cl2NO3S/c1-24-10-4-2-9(3-5-10)13(21)8-17(23)14-11(18)6-7-12(19)15(14)20-16(17)22/h2-7,23H,8H2,1H3,(H,20,22)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	330	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University Medical Center Curated by ChEMBL					Assay Description Inhibition of transcriptional activity of full-length EWS-FLI1 (unknown origin) expressed in COS7 cells by NR0B1-luciferase reporter gene assay				J Med Chem 57: 10290-303 (2014) Article DOI: 10.1021/jm501372p BindingDB Entry DOI: 10.7270/Q29G5QTK
					More data for this Ligand-Target Pair
Friend leukemia integration 1 transcription factor (Homo sapiens (Human))	BDBM50379275 (CHEMBL2011500) Show SMILES COc1ccc(cc1)C(=O)CC1(O)C(=O)Nc2c1c(Cl)ccc2Cl Show InChI InChI=1S/C17H13Cl2NO4/c1-24-10-4-2-9(3-5-10)13(21)8-17(23)14-11(18)6-7-12(19)15(14)20-16(17)22/h2-7,23H,8H2,1H3,(H,20,22)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University Medical Center Curated by ChEMBL					Assay Description Inhibition of transcriptional activity of full-length EWS-FLI1 (unknown origin) expressed in COS7 cells by NR0B1-luciferase reporter gene assay				J Med Chem 57: 10290-303 (2014) Article DOI: 10.1021/jm501372p BindingDB Entry DOI: 10.7270/Q29G5QTK
					More data for this Ligand-Target Pair
Friend leukemia integration 1 transcription factor/RNA-binding protein EWS (Homo sapiens-Homo sapiens (Human))	BDBM50497658 (CHEMBL3360384) Show SMILES COc1ccc(cc1)C(=O)CC1(O)C(=O)Nc2c1c(OC)ccc2OC Show InChI InChI=1S/C19H19NO6/c1-24-12-6-4-11(5-7-12)13(21)10-19(23)16-14(25-2)8-9-15(26-3)17(16)20-18(19)22/h4-9,23H,10H2,1-3H3,(H,20,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	770	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University Medical Center Curated by ChEMBL					Assay Description Inhibition of transcriptional activity of full-length EWS-FLI1 (unknown origin) expressed in COS7 cells by NR0B1-luciferase reporter gene assay				J Med Chem 57: 10290-303 (2014) Article DOI: 10.1021/jm501372p BindingDB Entry DOI: 10.7270/Q29G5QTK
					More data for this Ligand-Target Pair
Friend leukemia integration 1 transcription factor (Homo sapiens (Human))	BDBM50497661 (CHEMBL3360410) Show SMILES CN(C(=O)CCCCCNC(=O)CCCC[C@H]1SCC2NC(=O)NC12)c1ccc(cc1)C(=O)CC1(O)C(=O)Nc2c1c(Cl)ccc2Cl |r| Show InChI InChI=1S/C33H39Cl2N5O6S/c1-40(20-12-10-19(11-13-20)24(41)17-33(46)28-21(34)14-15-22(35)29(28)38-31(33)44)27(43)9-3-2-6-16-36-26(42)8-5-4-7-25-30-23(18-47-25)37-32(45)39-30/h10-15,23,25,30,46H,2-9,16-18H2,1H3,(H,36,42)(H,38,44)(H2,37,39,45)/t23?,25-,30?,33?/m1/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	4.80E+3	n/a	n/a	n/a	n/a	n/a
Georgetown University Medical Center Curated by ChEMBL					Assay Description Binding affinity to purified recombinant EWS-FLI1 (unknown origin) after 1 hr by colorimetric phosphatase assay				J Med Chem 57: 10290-303 (2014) Article DOI: 10.1021/jm501372p BindingDB Entry DOI: 10.7270/Q29G5QTK
					More data for this Ligand-Target Pair