Found 99 hits Enz. Inhib. hit(s) with Target = 'S-adenosylmethionine synthase isoform type-1' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
S-adenosylmethionine synthase isoform type-1
(Rattus norvegicus) | BDBM50368140
(CHEMBL3706401 | CHEMBL611854)Show SMILES [H][C@@]1(O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(SCCCC)ncnc12)[C@H](CSCC[C@H](N)C(O)=O)OP(O)(=O)OP(O)(=O)NP(O)(O)=O |r| Show InChI InChI=1S/C19H33N6O14P3S2/c1-2-3-5-44-17-12-16(21-8-22-17)25(9-23-12)18-14(27)13(26)15(37-18)11(7-43-6-4-10(20)19(28)29)38-42(35,36)39-41(33,34)24-40(30,31)32/h8-11,13-15,18,26-27H,2-7,20H2,1H3,(H,28,29)(H,35,36)(H4,24,30,31,32,33,34)/t10?,11-,13-,14+,15+,18?/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Cancer Research
Curated by ChEMBL
| Assay Description Inhibition constants with Met (L-methionine) substrate site of M-2 (kidney form) variant of rat Methionine adenosyltransferase |
J Med Chem 33: 2545-51 (1990)
BindingDB Entry DOI: 10.7270/Q2SJ1M6S |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1/type-2
(Rattus norvegicus) | BDBM50228186
(CHEMBL3706404)Show SMILES [H][C@@]1(O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)[C@@H](CCSCCC(N)C(O)=O)OP(O)(=O)OP(O)(=O)NP(O)(O)=O |r| Show InChI InChI=1S/C16H28N7O14P3S/c17-7(16(26)27)1-3-41-4-2-8(36-40(33,34)37-39(31,32)22-38(28,29)30)12-10(24)11(25)15(35-12)23-6-21-9-13(18)19-5-20-14(9)23/h5-8,10-12,15,24-25H,1-4,17H2,(H,26,27)(H,33,34)(H2,18,19,20)(H4,22,28,29,30,31,32)/t7?,8-,10+,11-,12-,15-/m1/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Fox Chase Cancer Center
Curated by ChEMBL
| Assay Description Compound was tested for inhibition constant with kidney form of M-2 variants of Rat methionine adenosyltransferase when ATP was the variable substrat... |
J Med Chem 32: 885-90 (1989)
BindingDB Entry DOI: 10.7270/Q2K939Q8 |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1
(Rattus norvegicus) | BDBM50368140
(CHEMBL3706401 | CHEMBL611854)Show SMILES [H][C@@]1(O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(SCCCC)ncnc12)[C@H](CSCC[C@H](N)C(O)=O)OP(O)(=O)OP(O)(=O)NP(O)(O)=O |r| Show InChI InChI=1S/C19H33N6O14P3S2/c1-2-3-5-44-17-12-16(21-8-22-17)25(9-23-12)18-14(27)13(26)15(37-18)11(7-43-6-4-10(20)19(28)29)38-42(35,36)39-41(33,34)24-40(30,31)32/h8-11,13-15,18,26-27H,2-7,20H2,1H3,(H,28,29)(H,35,36)(H4,24,30,31,32,33,34)/t10?,11-,13-,14+,15+,18?/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Cancer Research
Curated by ChEMBL
| Assay Description Inhibition constants against ATP substrate site of M-T (Novikoff Ascitic Hepatoma form) variant of rat Methionine adenosyltransferase |
J Med Chem 33: 2545-51 (1990)
BindingDB Entry DOI: 10.7270/Q2SJ1M6S |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1/type-2
(Rattus norvegicus) | BDBM50226974
(CHEMBL603986)Show SMILES [H][C@@]1(OC([C@H](O)[C@@H]1O)n1cnc2C(N)N=CNc12)[C@@H](CSCCC(N)C(O)=O)OP(O)(=O)OP(O)(=O)ONP(O)(O)=O |r,c:15| Show InChI InChI=1S/C15H28N7O15P3S/c16-6(15(25)26)1-2-41-3-7(35-39(30,31)37-40(32,33)36-21-38(27,28)29)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-12,14,23-24H,1-3,16-17H2,(H,18,19)(H,25,26)(H,30,31)(H,32,33)(H3,21,27,28,29)/t6?,7-,9+,10-,11-,12?,14?/m1/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Patents
Similars
| PubMed
| 130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition constants of M-2 Forms of rat methionine adenosyltransferase using ATP as the variable substrate; Inhibition is competitive type |
J Med Chem 30: 1599-603 (1987)
BindingDB Entry DOI: 10.7270/Q2CV4KZR |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1
(Rattus norvegicus) | BDBM50227269
(CHEMBL3706402)Show SMILES [H][C@@]1(O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)[C@H](CSCCC(N)C(O)=O)OP(O)(=O)OP(O)(=O)NP(O)(O)=O |r| Show InChI InChI=1S/C15H26N7O14P3S/c16-6(15(25)26)1-2-40-3-7(35-39(32,33)36-38(30,31)21-37(27,28)29)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-11,14,23-24H,1-3,16H2,(H,25,26)(H,32,33)(H2,17,18,19)(H4,21,27,28,29,30,31)/t6?,7-,9-,10+,11+,14+/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Cancer Research
Curated by ChEMBL
| Assay Description Inhibition constants against ATP substrate site of M-2 (kidney form) variant of rat Methionine adenosyltransferase |
J Med Chem 33: 2545-51 (1990)
BindingDB Entry DOI: 10.7270/Q2SJ1M6S |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1/type-2
(Rattus norvegicus) | BDBM50227269
(CHEMBL3706402)Show SMILES [H][C@@]1(O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)[C@H](CSCCC(N)C(O)=O)OP(O)(=O)OP(O)(=O)NP(O)(O)=O |r| Show InChI InChI=1S/C15H26N7O14P3S/c16-6(15(25)26)1-2-40-3-7(35-39(32,33)36-38(30,31)21-37(27,28)29)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-11,14,23-24H,1-3,16H2,(H,25,26)(H,32,33)(H2,17,18,19)(H4,21,27,28,29,30,31)/t6?,7-,9-,10+,11+,14+/m0/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Fox Chase Cancer Center
Curated by ChEMBL
| Assay Description Compound was tested for inhibition constant with kidney form of M-2 variants of Rat methionine adenosyltransferase when ATP was the variable substrat... |
J Med Chem 32: 885-90 (1989)
BindingDB Entry DOI: 10.7270/Q2K939Q8 |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1/type-2
(Rattus norvegicus) | BDBM50227269
(CHEMBL3706402)Show SMILES [H][C@@]1(O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)[C@H](CSCCC(N)C(O)=O)OP(O)(=O)OP(O)(=O)NP(O)(O)=O |r| Show InChI InChI=1S/C15H26N7O14P3S/c16-6(15(25)26)1-2-40-3-7(35-39(32,33)36-38(30,31)21-37(27,28)29)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-11,14,23-24H,1-3,16H2,(H,25,26)(H,32,33)(H2,17,18,19)(H4,21,27,28,29,30,31)/t6?,7-,9-,10+,11+,14+/m0/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Fox Chase Cancer Center
Curated by ChEMBL
| Assay Description Inhibition constant of ATP varied compound was measured on M-2 variate Methionine adenosyltransferase in rat kidney |
J Med Chem 31: 384-9 (1988)
BindingDB Entry DOI: 10.7270/Q2736T3C |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1/type-2
(Rattus norvegicus) | BDBM50228186
(CHEMBL3706404)Show SMILES [H][C@@]1(O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)[C@@H](CCSCCC(N)C(O)=O)OP(O)(=O)OP(O)(=O)NP(O)(O)=O |r| Show InChI InChI=1S/C16H28N7O14P3S/c17-7(16(26)27)1-3-41-4-2-8(36-40(33,34)37-39(31,32)22-38(28,29)30)12-10(24)11(25)15(35-12)23-6-21-9-13(18)19-5-20-14(9)23/h5-8,10-12,15,24-25H,1-4,17H2,(H,26,27)(H,33,34)(H2,18,19,20)(H4,22,28,29,30,31,32)/t7?,8-,10+,11-,12-,15-/m1/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Fox Chase Cancer Center
Curated by ChEMBL
| Assay Description Compound was tested for inhibition constant with kidney form of M-T variants of Rat methionine adenosyltransferase when ATP was the variable substrat... |
J Med Chem 32: 885-90 (1989)
BindingDB Entry DOI: 10.7270/Q2K939Q8 |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1
(Rattus norvegicus) | BDBM50227269
(CHEMBL3706402)Show SMILES [H][C@@]1(O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)[C@H](CSCCC(N)C(O)=O)OP(O)(=O)OP(O)(=O)NP(O)(O)=O |r| Show InChI InChI=1S/C15H26N7O14P3S/c16-6(15(25)26)1-2-40-3-7(35-39(32,33)36-38(30,31)21-37(27,28)29)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-11,14,23-24H,1-3,16H2,(H,25,26)(H,32,33)(H2,17,18,19)(H4,21,27,28,29,30,31)/t6?,7-,9-,10+,11+,14+/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 210 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Cancer Research
Curated by ChEMBL
| Assay Description Inhibition constants against Met (L-methionine)P substrate site of M-T (Novikoff Ascitic Hepatoma form) variant of rat Methionine adenosyltransferase |
J Med Chem 33: 2545-51 (1990)
BindingDB Entry DOI: 10.7270/Q2SJ1M6S |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1/type-2
(Rattus norvegicus) | BDBM50226974
(CHEMBL603986)Show SMILES [H][C@@]1(OC([C@H](O)[C@@H]1O)n1cnc2C(N)N=CNc12)[C@@H](CSCCC(N)C(O)=O)OP(O)(=O)OP(O)(=O)ONP(O)(O)=O |r,c:15| Show InChI InChI=1S/C15H28N7O15P3S/c16-6(15(25)26)1-2-41-3-7(35-39(30,31)37-40(32,33)36-21-38(27,28)29)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-12,14,23-24H,1-3,16-17H2,(H,18,19)(H,25,26)(H,30,31)(H,32,33)(H3,21,27,28,29)/t6?,7-,9+,10-,11-,12?,14?/m1/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Patents
Similars
| PubMed
| 210 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition constants of MT Forms of rat Novikoff Ascitic Hepatomae using ATP as the variable substrate; Inhibition is competitive type |
J Med Chem 30: 1599-603 (1987)
BindingDB Entry DOI: 10.7270/Q2CV4KZR |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1/type-2
(Rattus norvegicus) | BDBM50227269
(CHEMBL3706402)Show SMILES [H][C@@]1(O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)[C@H](CSCCC(N)C(O)=O)OP(O)(=O)OP(O)(=O)NP(O)(O)=O |r| Show InChI InChI=1S/C15H26N7O14P3S/c16-6(15(25)26)1-2-40-3-7(35-39(32,33)36-38(30,31)21-37(27,28)29)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-11,14,23-24H,1-3,16H2,(H,25,26)(H,32,33)(H2,17,18,19)(H4,21,27,28,29,30,31)/t6?,7-,9-,10+,11+,14+/m0/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 210 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Fox Chase Cancer Center
Curated by ChEMBL
| Assay Description Compound was tested for inhibition constant with kidney form of M-T variants of Rat methionine adenosyltransferase when ATP was the variable substrat... |
J Med Chem 32: 885-90 (1989)
BindingDB Entry DOI: 10.7270/Q2K939Q8 |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1/type-2
(Rattus norvegicus) | BDBM50227269
(CHEMBL3706402)Show SMILES [H][C@@]1(O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)[C@H](CSCCC(N)C(O)=O)OP(O)(=O)OP(O)(=O)NP(O)(O)=O |r| Show InChI InChI=1S/C15H26N7O14P3S/c16-6(15(25)26)1-2-40-3-7(35-39(32,33)36-38(30,31)21-37(27,28)29)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-11,14,23-24H,1-3,16H2,(H,25,26)(H,32,33)(H2,17,18,19)(H4,21,27,28,29,30,31)/t6?,7-,9-,10+,11+,14+/m0/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 210 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Fox Chase Cancer Center
Curated by ChEMBL
| Assay Description Inhibition constant of ATP varied compound was measured on MT variant methionine adenosyltransferase in rat ascitic hepatoma cells |
J Med Chem 31: 384-9 (1988)
BindingDB Entry DOI: 10.7270/Q2736T3C |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1/type-2
(Rattus norvegicus) | BDBM50226972
(CHEMBL606493)Show SMILES [H][C@@]1(OC([C@H](O)[C@@H]1O)n1cnc2C(N)N=CNc12)[C@H](CNP(O)(=O)OP(O)(=O)OP(O)(O)=O)SCCC(N)C(O)=O |r,c:15| Show InChI InChI=1S/C15H28N7O14P3S/c16-6(15(25)26)1-2-40-7(3-21-37(27,28)35-39(32,33)36-38(29,30)31)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-12,14,23-24H,1-3,16-17H2,(H,18,19)(H,25,26)(H,32,33)(H2,21,27,28)(H2,29,30,31)/t6?,7-,9-,10+,11+,12?,14?/m0/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Patents
Similars
| PubMed
| 270 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition constants of MT Forms of rat Novikoff Ascitic Hepatomae using ATP as the variable substrate; Inhibition is competitive type |
J Med Chem 30: 1599-603 (1987)
BindingDB Entry DOI: 10.7270/Q2CV4KZR |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1/type-2
(Rattus norvegicus) | BDBM50226768
(CHEMBL1791426)Show SMILES [H][C@](CNP(O)(=O)OP(O)(=O)OP(O)(O)=O)(SCCC(N)C(O)=O)[C@@]1([H])O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |r| Show InChI InChI=1S/C15H26N7O14P3S/c16-6(15(25)26)1-2-40-7(3-21-37(27,28)35-39(32,33)36-38(29,30)31)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-11,14,23-24H,1-3,16H2,(H,25,26)(H,32,33)(H2,17,18,19)(H2,21,27,28)(H2,29,30,31)/t6?,7-,9+,10-,11-,14-/m1/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Patents
Similars
| PubMed
| 270 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Fox Chase Cancer Center
Curated by ChEMBL
| Assay Description Inhibition constant of ATP varied compound was measured on MT variant methionine adenosyltransferase in rat ascitic hepatoma cells |
J Med Chem 31: 384-9 (1988)
BindingDB Entry DOI: 10.7270/Q2736T3C |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1/type-2
(Rattus norvegicus) | BDBM50226770
(CHEMBL609078)Show SMILES [H][C@@]1(OC([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)[C@H](CNP(O)(=O)OP(O)(=O)OP(O)(O)=O)SCCC(N)C(O)=O |r| Show InChI InChI=1S/C15H26N7O14P3S/c16-6(15(25)26)1-2-40-7(3-21-37(27,28)35-39(32,33)36-38(29,30)31)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-11,14,23-24H,1-3,16H2,(H,25,26)(H,32,33)(H2,17,18,19)(H2,21,27,28)(H2,29,30,31)/t6?,7-,9-,10+,11+,14?/m0/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 270 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition constant of compound with Novikoff ascitic hepatoma (M-T) form of rat methionine adenosyltransferase when ATP was used as variable substra... |
J Med Chem 30: 888-94 (1987)
BindingDB Entry DOI: 10.7270/Q22J6F29 |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1/type-2
(Rattus norvegicus) | BDBM50228185
(CHEMBL3706405)Show SMILES [H][C@@]1(O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)[C@H](CCSCCC(N)C(O)=O)OP(O)(=O)OP(O)(=O)NP(O)(O)=O |r| Show InChI InChI=1S/C16H28N7O14P3S/c17-7(16(26)27)1-3-41-4-2-8(36-40(33,34)37-39(31,32)22-38(28,29)30)12-10(24)11(25)15(35-12)23-6-21-9-13(18)19-5-20-14(9)23/h5-8,10-12,15,24-25H,1-4,17H2,(H,26,27)(H,33,34)(H2,18,19,20)(H4,22,28,29,30,31,32)/t7?,8-,10-,11+,12+,15+/m0/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 270 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Fox Chase Cancer Center
Curated by ChEMBL
| Assay Description Compound was tested for inhibition constant with kidney form of M-2 variants of Rat methionine adenosyltransferase when ATP was the variable substrat... |
J Med Chem 32: 885-90 (1989)
BindingDB Entry DOI: 10.7270/Q2K939Q8 |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1/type-2
(Rattus norvegicus) | BDBM50226972
(CHEMBL606493)Show SMILES [H][C@@]1(OC([C@H](O)[C@@H]1O)n1cnc2C(N)N=CNc12)[C@H](CNP(O)(=O)OP(O)(=O)OP(O)(O)=O)SCCC(N)C(O)=O |r,c:15| Show InChI InChI=1S/C15H28N7O14P3S/c16-6(15(25)26)1-2-40-7(3-21-37(27,28)35-39(32,33)36-38(29,30)31)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-12,14,23-24H,1-3,16-17H2,(H,18,19)(H,25,26)(H,32,33)(H2,21,27,28)(H2,29,30,31)/t6?,7-,9-,10+,11+,12?,14?/m0/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Patents
Similars
| PubMed
| 360 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition constants of M-2 Forms of rat methionine adenosyltransferase using ATP as the variable substrate; Inhibition is competitive type |
J Med Chem 30: 1599-603 (1987)
BindingDB Entry DOI: 10.7270/Q2CV4KZR |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1/type-2
(Rattus norvegicus) | BDBM50226770
(CHEMBL609078)Show SMILES [H][C@@]1(OC([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)[C@H](CNP(O)(=O)OP(O)(=O)OP(O)(O)=O)SCCC(N)C(O)=O |r| Show InChI InChI=1S/C15H26N7O14P3S/c16-6(15(25)26)1-2-40-7(3-21-37(27,28)35-39(32,33)36-38(29,30)31)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-11,14,23-24H,1-3,16H2,(H,25,26)(H,32,33)(H2,17,18,19)(H2,21,27,28)(H2,29,30,31)/t6?,7-,9-,10+,11+,14?/m0/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 360 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition constant of compound with kidney (M-2) form of rat methionine adenosyltransferase when ATP was used as variable substrate;Competitive type... |
J Med Chem 30: 888-94 (1987)
BindingDB Entry DOI: 10.7270/Q22J6F29 |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1/type-2
(Rattus norvegicus) | BDBM50226768
(CHEMBL1791426)Show SMILES [H][C@](CNP(O)(=O)OP(O)(=O)OP(O)(O)=O)(SCCC(N)C(O)=O)[C@@]1([H])O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |r| Show InChI InChI=1S/C15H26N7O14P3S/c16-6(15(25)26)1-2-40-7(3-21-37(27,28)35-39(32,33)36-38(29,30)31)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-11,14,23-24H,1-3,16H2,(H,25,26)(H,32,33)(H2,17,18,19)(H2,21,27,28)(H2,29,30,31)/t6?,7-,9+,10-,11-,14-/m1/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Patents
Similars
| PubMed
| 360 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Fox Chase Cancer Center
Curated by ChEMBL
| Assay Description Inhibition constant of ATP varied compound was measured on M-2 variate methionine adenosyltransferase in rat kidney |
J Med Chem 31: 384-9 (1988)
BindingDB Entry DOI: 10.7270/Q2736T3C |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1/type-2
(Rattus norvegicus) | BDBM50227270
(CHEMBL3706403)Show SMILES N[C@@H](CCSCC(C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)OP(O)(=O)OP(O)(=O)NP(O)(O)=O)C(O)=O |r| Show InChI InChI=1S/C16H28N7O14P3S/c17-8(16(26)27)1-2-41-4-7(36-40(33,34)37-39(31,32)22-38(28,29)30)3-9-11(24)12(25)15(35-9)23-6-21-10-13(18)19-5-20-14(10)23/h5-9,11-12,15,24-25H,1-4,17H2,(H,26,27)(H,33,34)(H2,18,19,20)(H4,22,28,29,30,31,32)/t7?,8-,9+,11+,12+,15+/m0/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 390 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Fox Chase Cancer Center
Curated by ChEMBL
| Assay Description Inhibition constant of ATP varied compound was measured on M-2 variate methionine adenosyltransferase in rat kidney |
J Med Chem 31: 384-9 (1988)
BindingDB Entry DOI: 10.7270/Q2736T3C |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1/type-2
(Rattus norvegicus) | BDBM50228185
(CHEMBL3706405)Show SMILES [H][C@@]1(O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)[C@H](CCSCCC(N)C(O)=O)OP(O)(=O)OP(O)(=O)NP(O)(O)=O |r| Show InChI InChI=1S/C16H28N7O14P3S/c17-7(16(26)27)1-3-41-4-2-8(36-40(33,34)37-39(31,32)22-38(28,29)30)12-10(24)11(25)15(35-12)23-6-21-9-13(18)19-5-20-14(9)23/h5-8,10-12,15,24-25H,1-4,17H2,(H,26,27)(H,33,34)(H2,18,19,20)(H4,22,28,29,30,31,32)/t7?,8-,10-,11+,12+,15+/m0/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 410 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Fox Chase Cancer Center
Curated by ChEMBL
| Assay Description Compound was tested for inhibition constant with kidney form of M-T variants of Rat methionine adenosyltransferase when ATP was the variable substrat... |
J Med Chem 32: 885-90 (1989)
BindingDB Entry DOI: 10.7270/Q2K939Q8 |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1/type-2
(Rattus norvegicus) | BDBM50227271
(CHEMBL1791425)Show SMILES NC(CCSC(CCOP(O)(=O)OP(O)(=O)NP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O |r| Show InChI InChI=1S/C16H28N7O14P3S/c17-7(16(26)27)2-4-41-8(1-3-35-40(33,34)37-39(31,32)22-38(28,29)30)12-10(24)11(25)15(36-12)23-6-21-9-13(18)19-5-20-14(9)23/h5-8,10-12,15,24-25H,1-4,17H2,(H,26,27)(H,33,34)(H2,18,19,20)(H4,22,28,29,30,31,32)/t7?,8?,10-,11+,12+,15+/m0/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 440 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Fox Chase Cancer Center
Curated by ChEMBL
| Assay Description Inhibition constant of ATP varied compound was measured on M-2 variate methionine adenosyltransferase in rat kidney |
J Med Chem 31: 384-9 (1988)
BindingDB Entry DOI: 10.7270/Q2736T3C |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1/type-2
(Rattus norvegicus) | BDBM50227270
(CHEMBL3706403)Show SMILES N[C@@H](CCSCC(C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)OP(O)(=O)OP(O)(=O)NP(O)(O)=O)C(O)=O |r| Show InChI InChI=1S/C16H28N7O14P3S/c17-8(16(26)27)1-2-41-4-7(36-40(33,34)37-39(31,32)22-38(28,29)30)3-9-11(24)12(25)15(35-9)23-6-21-10-13(18)19-5-20-14(10)23/h5-9,11-12,15,24-25H,1-4,17H2,(H,26,27)(H,33,34)(H2,18,19,20)(H4,22,28,29,30,31,32)/t7?,8-,9+,11+,12+,15+/m0/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 630 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Fox Chase Cancer Center
Curated by ChEMBL
| Assay Description Inhibition constant of ATP varied compound was measured on MT variant methionine adenosyltransferase in rat ascitic hepatoma cells |
J Med Chem 31: 384-9 (1988)
BindingDB Entry DOI: 10.7270/Q2736T3C |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1/type-2
(Rattus norvegicus) | BDBM50226974
(CHEMBL603986)Show SMILES [H][C@@]1(OC([C@H](O)[C@@H]1O)n1cnc2C(N)N=CNc12)[C@@H](CSCCC(N)C(O)=O)OP(O)(=O)OP(O)(=O)ONP(O)(O)=O |r,c:15| Show InChI InChI=1S/C15H28N7O15P3S/c16-6(15(25)26)1-2-41-3-7(35-39(30,31)37-40(32,33)36-21-38(27,28)29)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-12,14,23-24H,1-3,16-17H2,(H,18,19)(H,25,26)(H,30,31)(H,32,33)(H3,21,27,28,29)/t6?,7-,9+,10-,11-,12?,14?/m1/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Patents
Similars
| PubMed
| 650 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition constants of M-2 Forms of rat methionine adenosyltransferase using Methionine as the variable substrate; Inhibition is non competitive typ... |
J Med Chem 30: 1599-603 (1987)
BindingDB Entry DOI: 10.7270/Q2CV4KZR |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1
(Rattus norvegicus) | BDBM50227269
(CHEMBL3706402)Show SMILES [H][C@@]1(O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)[C@H](CSCCC(N)C(O)=O)OP(O)(=O)OP(O)(=O)NP(O)(O)=O |r| Show InChI InChI=1S/C15H26N7O14P3S/c16-6(15(25)26)1-2-40-3-7(35-39(32,33)36-38(30,31)21-37(27,28)29)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-11,14,23-24H,1-3,16H2,(H,25,26)(H,32,33)(H2,17,18,19)(H4,21,27,28,29,30,31)/t6?,7-,9-,10+,11+,14+/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 650 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Cancer Research
Curated by ChEMBL
| Assay Description Inhibition constants with Met (L-methionine) substrate site of M-2 (kidney form) variant of rat Methionine adenosyltransferase |
J Med Chem 33: 2545-51 (1990)
BindingDB Entry DOI: 10.7270/Q2SJ1M6S |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1/type-2
(Rattus norvegicus) | BDBM50227269
(CHEMBL3706402)Show SMILES [H][C@@]1(O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)[C@H](CSCCC(N)C(O)=O)OP(O)(=O)OP(O)(=O)NP(O)(O)=O |r| Show InChI InChI=1S/C15H26N7O14P3S/c16-6(15(25)26)1-2-40-3-7(35-39(32,33)36-38(30,31)21-37(27,28)29)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-11,14,23-24H,1-3,16H2,(H,25,26)(H,32,33)(H2,17,18,19)(H4,21,27,28,29,30,31)/t6?,7-,9-,10+,11+,14+/m0/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 650 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Fox Chase Cancer Center
Curated by ChEMBL
| Assay Description Compound was tested for inhibition constant with kidney form of M-2 variants of Rat methionine adenosyltransferase when Methionine was the variable s... |
J Med Chem 32: 885-90 (1989)
BindingDB Entry DOI: 10.7270/Q2K939Q8 |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1/type-2
(Rattus norvegicus) | BDBM50227269
(CHEMBL3706402)Show SMILES [H][C@@]1(O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)[C@H](CSCCC(N)C(O)=O)OP(O)(=O)OP(O)(=O)NP(O)(O)=O |r| Show InChI InChI=1S/C15H26N7O14P3S/c16-6(15(25)26)1-2-40-3-7(35-39(32,33)36-38(30,31)21-37(27,28)29)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-11,14,23-24H,1-3,16H2,(H,25,26)(H,32,33)(H2,17,18,19)(H4,21,27,28,29,30,31)/t6?,7-,9-,10+,11+,14+/m0/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 650 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Fox Chase Cancer Center
Curated by ChEMBL
| Assay Description Inhibition constant of Met varied compound was measured on M-2 variant Methionine adenosyltransferase in rat kidney |
J Med Chem 31: 384-9 (1988)
BindingDB Entry DOI: 10.7270/Q2736T3C |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1/type-2
(Rattus norvegicus) | BDBM50226974
(CHEMBL603986)Show SMILES [H][C@@]1(OC([C@H](O)[C@@H]1O)n1cnc2C(N)N=CNc12)[C@@H](CSCCC(N)C(O)=O)OP(O)(=O)OP(O)(=O)ONP(O)(O)=O |r,c:15| Show InChI InChI=1S/C15H28N7O15P3S/c16-6(15(25)26)1-2-41-3-7(35-39(30,31)37-40(32,33)36-21-38(27,28)29)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-12,14,23-24H,1-3,16-17H2,(H,18,19)(H,25,26)(H,30,31)(H,32,33)(H3,21,27,28,29)/t6?,7-,9+,10-,11-,12?,14?/m1/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Patents
Similars
| PubMed
| 670 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition constants of MT Forms of rat Novikoff Ascitic Hepatomae using Methionine as the variable substrate; Inhibition is non competitive type |
J Med Chem 30: 1599-603 (1987)
BindingDB Entry DOI: 10.7270/Q2CV4KZR |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1
(Rattus norvegicus) | BDBM50227269
(CHEMBL3706402)Show SMILES [H][C@@]1(O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)[C@H](CSCCC(N)C(O)=O)OP(O)(=O)OP(O)(=O)NP(O)(O)=O |r| Show InChI InChI=1S/C15H26N7O14P3S/c16-6(15(25)26)1-2-40-3-7(35-39(32,33)36-38(30,31)21-37(27,28)29)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-11,14,23-24H,1-3,16H2,(H,25,26)(H,32,33)(H2,17,18,19)(H4,21,27,28,29,30,31)/t6?,7-,9-,10+,11+,14+/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 670 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Cancer Research
Curated by ChEMBL
| Assay Description Inhibition constants against Met (L-methionine)P substrate site of M-T (Novikoff Ascitic Hepatoma form) variant of rat Methionine adenosyltransferase |
J Med Chem 33: 2545-51 (1990)
BindingDB Entry DOI: 10.7270/Q2SJ1M6S |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1/type-2
(Rattus norvegicus) | BDBM50227269
(CHEMBL3706402)Show SMILES [H][C@@]1(O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)[C@H](CSCCC(N)C(O)=O)OP(O)(=O)OP(O)(=O)NP(O)(O)=O |r| Show InChI InChI=1S/C15H26N7O14P3S/c16-6(15(25)26)1-2-40-3-7(35-39(32,33)36-38(30,31)21-37(27,28)29)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-11,14,23-24H,1-3,16H2,(H,25,26)(H,32,33)(H2,17,18,19)(H4,21,27,28,29,30,31)/t6?,7-,9-,10+,11+,14+/m0/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 670 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Fox Chase Cancer Center
Curated by ChEMBL
| Assay Description Inhibition constant of Met varied compound was measured on MT variant methionine adenosyltransferase in rat ascitic hepatoma cells |
J Med Chem 31: 384-9 (1988)
BindingDB Entry DOI: 10.7270/Q2736T3C |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1/type-2
(Rattus norvegicus) | BDBM50227269
(CHEMBL3706402)Show SMILES [H][C@@]1(O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)[C@H](CSCCC(N)C(O)=O)OP(O)(=O)OP(O)(=O)NP(O)(O)=O |r| Show InChI InChI=1S/C15H26N7O14P3S/c16-6(15(25)26)1-2-40-3-7(35-39(32,33)36-38(30,31)21-37(27,28)29)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-11,14,23-24H,1-3,16H2,(H,25,26)(H,32,33)(H2,17,18,19)(H4,21,27,28,29,30,31)/t6?,7-,9-,10+,11+,14+/m0/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 670 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Fox Chase Cancer Center
Curated by ChEMBL
| Assay Description Compound was tested for inhibition constant with kidney form of M-T variants of Rat methionine adenosyltransferase when Methionine was the variable s... |
J Med Chem 32: 885-90 (1989)
BindingDB Entry DOI: 10.7270/Q2K939Q8 |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1
(Rattus norvegicus) | BDBM50368140
(CHEMBL3706401 | CHEMBL611854)Show SMILES [H][C@@]1(O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(SCCCC)ncnc12)[C@H](CSCC[C@H](N)C(O)=O)OP(O)(=O)OP(O)(=O)NP(O)(O)=O |r| Show InChI InChI=1S/C19H33N6O14P3S2/c1-2-3-5-44-17-12-16(21-8-22-17)25(9-23-12)18-14(27)13(26)15(37-18)11(7-43-6-4-10(20)19(28)29)38-42(35,36)39-41(33,34)24-40(30,31)32/h8-11,13-15,18,26-27H,2-7,20H2,1H3,(H,28,29)(H,35,36)(H4,24,30,31,32,33,34)/t10?,11-,13-,14+,15+,18?/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 740 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Cancer Research
Curated by ChEMBL
| Assay Description Inhibition constants against Met (L-methionine)P substrate site of M-T (Novikoff Ascitic Hepatoma form) variant of rat Methionine adenosyltransferase |
J Med Chem 33: 2545-51 (1990)
BindingDB Entry DOI: 10.7270/Q2SJ1M6S |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1/type-2
(Rattus norvegicus) | BDBM50227271
(CHEMBL1791425)Show SMILES NC(CCSC(CCOP(O)(=O)OP(O)(=O)NP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O |r| Show InChI InChI=1S/C16H28N7O14P3S/c17-7(16(26)27)2-4-41-8(1-3-35-40(33,34)37-39(31,32)22-38(28,29)30)12-10(24)11(25)15(36-12)23-6-21-9-13(18)19-5-20-14(9)23/h5-8,10-12,15,24-25H,1-4,17H2,(H,26,27)(H,33,34)(H2,18,19,20)(H4,22,28,29,30,31,32)/t7?,8?,10-,11+,12+,15+/m0/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 810 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Fox Chase Cancer Center
Curated by ChEMBL
| Assay Description Inhibition constant of ATP varied compound was measured on MT variant methionine adenosyltransferase in rat ascitic hepatoma cells |
J Med Chem 31: 384-9 (1988)
BindingDB Entry DOI: 10.7270/Q2736T3C |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1/type-2
(Rattus norvegicus) | BDBM50228186
(CHEMBL3706404)Show SMILES [H][C@@]1(O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)[C@@H](CCSCCC(N)C(O)=O)OP(O)(=O)OP(O)(=O)NP(O)(O)=O |r| Show InChI InChI=1S/C16H28N7O14P3S/c17-7(16(26)27)1-3-41-4-2-8(36-40(33,34)37-39(31,32)22-38(28,29)30)12-10(24)11(25)15(35-12)23-6-21-9-13(18)19-5-20-14(9)23/h5-8,10-12,15,24-25H,1-4,17H2,(H,26,27)(H,33,34)(H2,18,19,20)(H4,22,28,29,30,31,32)/t7?,8-,10+,11-,12-,15-/m1/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Fox Chase Cancer Center
Curated by ChEMBL
| Assay Description Compound was tested for inhibition constant with kidney form of M-T variants of Rat methionine adenosyltransferase when Methionine was the variable s... |
J Med Chem 32: 885-90 (1989)
BindingDB Entry DOI: 10.7270/Q2K939Q8 |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1/type-2
(Rattus norvegicus) | BDBM50227271
(CHEMBL1791425)Show SMILES NC(CCSC(CCOP(O)(=O)OP(O)(=O)NP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O |r| Show InChI InChI=1S/C16H28N7O14P3S/c17-7(16(26)27)2-4-41-8(1-3-35-40(33,34)37-39(31,32)22-38(28,29)30)12-10(24)11(25)15(36-12)23-6-21-9-13(18)19-5-20-14(9)23/h5-8,10-12,15,24-25H,1-4,17H2,(H,26,27)(H,33,34)(H2,18,19,20)(H4,22,28,29,30,31,32)/t7?,8?,10-,11+,12+,15+/m0/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Fox Chase Cancer Center
Curated by ChEMBL
| Assay Description Inhibition constant of Met varied compound was measured on MT variant methionine adenosyltransferase in rat ascitic hepatoma cells |
J Med Chem 31: 384-9 (1988)
BindingDB Entry DOI: 10.7270/Q2736T3C |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1/type-2
(Rattus norvegicus) | BDBM50228186
(CHEMBL3706404)Show SMILES [H][C@@]1(O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)[C@@H](CCSCCC(N)C(O)=O)OP(O)(=O)OP(O)(=O)NP(O)(O)=O |r| Show InChI InChI=1S/C16H28N7O14P3S/c17-7(16(26)27)1-3-41-4-2-8(36-40(33,34)37-39(31,32)22-38(28,29)30)12-10(24)11(25)15(35-12)23-6-21-9-13(18)19-5-20-14(9)23/h5-8,10-12,15,24-25H,1-4,17H2,(H,26,27)(H,33,34)(H2,18,19,20)(H4,22,28,29,30,31,32)/t7?,8-,10+,11-,12-,15-/m1/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Fox Chase Cancer Center
Curated by ChEMBL
| Assay Description Compound was tested for inhibition constant with kidney form of M-2 variants of Rat methionine adenosyltransferase when Methionine was the variable s... |
J Med Chem 32: 885-90 (1989)
BindingDB Entry DOI: 10.7270/Q2K939Q8 |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1/type-2
(Rattus norvegicus) | BDBM50227271
(CHEMBL1791425)Show SMILES NC(CCSC(CCOP(O)(=O)OP(O)(=O)NP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O |r| Show InChI InChI=1S/C16H28N7O14P3S/c17-7(16(26)27)2-4-41-8(1-3-35-40(33,34)37-39(31,32)22-38(28,29)30)12-10(24)11(25)15(36-12)23-6-21-9-13(18)19-5-20-14(9)23/h5-8,10-12,15,24-25H,1-4,17H2,(H,26,27)(H,33,34)(H2,18,19,20)(H4,22,28,29,30,31,32)/t7?,8?,10-,11+,12+,15+/m0/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Fox Chase Cancer Center
Curated by ChEMBL
| Assay Description Inhibition constant of Met varied compound was measured on M-2 variant methionine adenosyltransferase in rat kidney |
J Med Chem 31: 384-9 (1988)
BindingDB Entry DOI: 10.7270/Q2736T3C |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1/type-2
(Rattus norvegicus) | BDBM50227270
(CHEMBL3706403)Show SMILES N[C@@H](CCSCC(C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)OP(O)(=O)OP(O)(=O)NP(O)(O)=O)C(O)=O |r| Show InChI InChI=1S/C16H28N7O14P3S/c17-8(16(26)27)1-2-41-4-7(36-40(33,34)37-39(31,32)22-38(28,29)30)3-9-11(24)12(25)15(35-9)23-6-21-10-13(18)19-5-20-14(10)23/h5-9,11-12,15,24-25H,1-4,17H2,(H,26,27)(H,33,34)(H2,18,19,20)(H4,22,28,29,30,31,32)/t7?,8-,9+,11+,12+,15+/m0/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Fox Chase Cancer Center
Curated by ChEMBL
| Assay Description Inhibition constant of Met varied compound was measured on M-2 variant methionine adenosyltransferase in rat kidney |
J Med Chem 31: 384-9 (1988)
BindingDB Entry DOI: 10.7270/Q2736T3C |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1/type-2
(Rattus norvegicus) | BDBM50226768
(CHEMBL1791426)Show SMILES [H][C@](CNP(O)(=O)OP(O)(=O)OP(O)(O)=O)(SCCC(N)C(O)=O)[C@@]1([H])O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |r| Show InChI InChI=1S/C15H26N7O14P3S/c16-6(15(25)26)1-2-40-7(3-21-37(27,28)35-39(32,33)36-38(29,30)31)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-11,14,23-24H,1-3,16H2,(H,25,26)(H,32,33)(H2,17,18,19)(H2,21,27,28)(H2,29,30,31)/t6?,7-,9+,10-,11-,14-/m1/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Patents
Similars
| PubMed
| 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Fox Chase Cancer Center
Curated by ChEMBL
| Assay Description Inhibition constant of Met varied compound was measured on MT variant methionine adenosyltransferase in rat ascitic hepatoma cells |
J Med Chem 31: 384-9 (1988)
BindingDB Entry DOI: 10.7270/Q2736T3C |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1/type-2
(Rattus norvegicus) | BDBM50226770
(CHEMBL609078)Show SMILES [H][C@@]1(OC([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)[C@H](CNP(O)(=O)OP(O)(=O)OP(O)(O)=O)SCCC(N)C(O)=O |r| Show InChI InChI=1S/C15H26N7O14P3S/c16-6(15(25)26)1-2-40-7(3-21-37(27,28)35-39(32,33)36-38(29,30)31)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-11,14,23-24H,1-3,16H2,(H,25,26)(H,32,33)(H2,17,18,19)(H2,21,27,28)(H2,29,30,31)/t6?,7-,9-,10+,11+,14?/m0/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition constant of compound with Novikoff ascitic hepatoma (M-T) form of rat methionine adenosyltransferase when methionine was used as variable ... |
J Med Chem 30: 888-94 (1987)
BindingDB Entry DOI: 10.7270/Q22J6F29 |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1/type-2
(Rattus norvegicus) | BDBM50226972
(CHEMBL606493)Show SMILES [H][C@@]1(OC([C@H](O)[C@@H]1O)n1cnc2C(N)N=CNc12)[C@H](CNP(O)(=O)OP(O)(=O)OP(O)(O)=O)SCCC(N)C(O)=O |r,c:15| Show InChI InChI=1S/C15H28N7O14P3S/c16-6(15(25)26)1-2-40-7(3-21-37(27,28)35-39(32,33)36-38(29,30)31)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-12,14,23-24H,1-3,16-17H2,(H,18,19)(H,25,26)(H,32,33)(H2,21,27,28)(H2,29,30,31)/t6?,7-,9-,10+,11+,12?,14?/m0/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Patents
Similars
| PubMed
| 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition constants of MT Forms of rat Novikoff Ascitic Hepatomae using Methionine as the variable substrate; Inhibition is non competitive type |
J Med Chem 30: 1599-603 (1987)
BindingDB Entry DOI: 10.7270/Q2CV4KZR |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1/type-2
(Rattus norvegicus) | BDBM50228185
(CHEMBL3706405)Show SMILES [H][C@@]1(O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)[C@H](CCSCCC(N)C(O)=O)OP(O)(=O)OP(O)(=O)NP(O)(O)=O |r| Show InChI InChI=1S/C16H28N7O14P3S/c17-7(16(26)27)1-3-41-4-2-8(36-40(33,34)37-39(31,32)22-38(28,29)30)12-10(24)11(25)15(35-12)23-6-21-9-13(18)19-5-20-14(9)23/h5-8,10-12,15,24-25H,1-4,17H2,(H,26,27)(H,33,34)(H2,18,19,20)(H4,22,28,29,30,31,32)/t7?,8-,10-,11+,12+,15+/m0/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Fox Chase Cancer Center
Curated by ChEMBL
| Assay Description Compound was tested for inhibition constant with kidney form of M-T variants of Rat methionine adenosyltransferase when Methionine was the variable s... |
J Med Chem 32: 885-90 (1989)
BindingDB Entry DOI: 10.7270/Q2K939Q8 |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1/type-2
(Rattus norvegicus) | BDBM50227270
(CHEMBL3706403)Show SMILES N[C@@H](CCSCC(C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)OP(O)(=O)OP(O)(=O)NP(O)(O)=O)C(O)=O |r| Show InChI InChI=1S/C16H28N7O14P3S/c17-8(16(26)27)1-2-41-4-7(36-40(33,34)37-39(31,32)22-38(28,29)30)3-9-11(24)12(25)15(35-9)23-6-21-10-13(18)19-5-20-14(10)23/h5-9,11-12,15,24-25H,1-4,17H2,(H,26,27)(H,33,34)(H2,18,19,20)(H4,22,28,29,30,31,32)/t7?,8-,9+,11+,12+,15+/m0/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Fox Chase Cancer Center
Curated by ChEMBL
| Assay Description Inhibition constant of Met varied compound was measured on MT variant methionine adenosyltransferase in rat ascitic hepatoma cells |
J Med Chem 31: 384-9 (1988)
BindingDB Entry DOI: 10.7270/Q2736T3C |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1
(Rattus norvegicus) | BDBM50368140
(CHEMBL3706401 | CHEMBL611854)Show SMILES [H][C@@]1(O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(SCCCC)ncnc12)[C@H](CSCC[C@H](N)C(O)=O)OP(O)(=O)OP(O)(=O)NP(O)(O)=O |r| Show InChI InChI=1S/C19H33N6O14P3S2/c1-2-3-5-44-17-12-16(21-8-22-17)25(9-23-12)18-14(27)13(26)15(37-18)11(7-43-6-4-10(20)19(28)29)38-42(35,36)39-41(33,34)24-40(30,31)32/h8-11,13-15,18,26-27H,2-7,20H2,1H3,(H,28,29)(H,35,36)(H4,24,30,31,32,33,34)/t10?,11-,13-,14+,15+,18?/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 2.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Cancer Research
Curated by ChEMBL
| Assay Description Inhibition constants against ATP substrate site of M-T (Novikoff Ascitic Hepatoma form) variant of rat Methionine adenosyltransferase |
J Med Chem 33: 2545-51 (1990)
BindingDB Entry DOI: 10.7270/Q2SJ1M6S |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1/type-2
(Rattus norvegicus) | BDBM50226768
(CHEMBL1791426)Show SMILES [H][C@](CNP(O)(=O)OP(O)(=O)OP(O)(O)=O)(SCCC(N)C(O)=O)[C@@]1([H])O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |r| Show InChI InChI=1S/C15H26N7O14P3S/c16-6(15(25)26)1-2-40-7(3-21-37(27,28)35-39(32,33)36-38(29,30)31)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-11,14,23-24H,1-3,16H2,(H,25,26)(H,32,33)(H2,17,18,19)(H2,21,27,28)(H2,29,30,31)/t6?,7-,9+,10-,11-,14-/m1/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Patents
Similars
| PubMed
| 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Fox Chase Cancer Center
Curated by ChEMBL
| Assay Description Inhibition constant of Met varied compound was measured on M-2 variant methionine adenosyltransferase in rat kidney |
J Med Chem 31: 384-9 (1988)
BindingDB Entry DOI: 10.7270/Q2736T3C |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1/type-2
(Rattus norvegicus) | BDBM50226770
(CHEMBL609078)Show SMILES [H][C@@]1(OC([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)[C@H](CNP(O)(=O)OP(O)(=O)OP(O)(O)=O)SCCC(N)C(O)=O |r| Show InChI InChI=1S/C15H26N7O14P3S/c16-6(15(25)26)1-2-40-7(3-21-37(27,28)35-39(32,33)36-38(29,30)31)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-11,14,23-24H,1-3,16H2,(H,25,26)(H,32,33)(H2,17,18,19)(H2,21,27,28)(H2,29,30,31)/t6?,7-,9-,10+,11+,14?/m0/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition constant of compound with kidney (M-2) form of rat methionine adenosyltransferase when methionine was used as variable substrate;Simple no... |
J Med Chem 30: 888-94 (1987)
BindingDB Entry DOI: 10.7270/Q22J6F29 |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1/type-2
(Rattus norvegicus) | BDBM50226972
(CHEMBL606493)Show SMILES [H][C@@]1(OC([C@H](O)[C@@H]1O)n1cnc2C(N)N=CNc12)[C@H](CNP(O)(=O)OP(O)(=O)OP(O)(O)=O)SCCC(N)C(O)=O |r,c:15| Show InChI InChI=1S/C15H28N7O14P3S/c16-6(15(25)26)1-2-40-7(3-21-37(27,28)35-39(32,33)36-38(29,30)31)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-12,14,23-24H,1-3,16-17H2,(H,18,19)(H,25,26)(H,32,33)(H2,21,27,28)(H2,29,30,31)/t6?,7-,9-,10+,11+,12?,14?/m0/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Patents
Similars
| PubMed
| 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition constants of M-2 Forms of rat methionine adenosyltransferase using Methionine as the variable substrate; Inhibition is non competitive typ... |
J Med Chem 30: 1599-603 (1987)
BindingDB Entry DOI: 10.7270/Q2CV4KZR |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1/type-2
(Rattus norvegicus) | BDBM18134
(({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-...)Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)NP(O)(O)=O)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C10H17N6O12P3/c11-8-5-9(13-2-12-8)16(3-14-5)10-7(18)6(17)4(27-10)1-26-31(24,25)28-30(22,23)15-29(19,20)21/h2-4,6-7,10,17-18H,1H2,(H,24,25)(H2,11,12,13)(H4,15,19,20,21,22,23)/t4-,6-,7-,10-/m1/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory constant against rat Methionine adenosyltransferase was reported |
J Med Chem 29: 318-22 (1986)
BindingDB Entry DOI: 10.7270/Q2DF6RSH |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1/type-2
(Rattus norvegicus) | BDBM50228185
(CHEMBL3706405)Show SMILES [H][C@@]1(O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)[C@H](CCSCCC(N)C(O)=O)OP(O)(=O)OP(O)(=O)NP(O)(O)=O |r| Show InChI InChI=1S/C16H28N7O14P3S/c17-7(16(26)27)1-3-41-4-2-8(36-40(33,34)37-39(31,32)22-38(28,29)30)12-10(24)11(25)15(35-12)23-6-21-9-13(18)19-5-20-14(9)23/h5-8,10-12,15,24-25H,1-4,17H2,(H,26,27)(H,33,34)(H2,18,19,20)(H4,22,28,29,30,31,32)/t7?,8-,10-,11+,12+,15+/m0/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 5.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Fox Chase Cancer Center
Curated by ChEMBL
| Assay Description Compound was tested for inhibition constant with kidney form of M-2 variants of Rat methionine adenosyltransferase when Methionine was the variable s... |
J Med Chem 32: 885-90 (1989)
BindingDB Entry DOI: 10.7270/Q2K939Q8 |
More data for this Ligand-Target Pair | |
S-adenosylmethionine synthase isoform type-1
(Rattus norvegicus) | BDBM50367305
(CHEMBL1791430)Show SMILES CC(OP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |r| Show InChI InChI=1S/C11H18N5O13P3/c1-4(27-31(22,23)29-32(24,25)28-30(19,20)21)8-6(17)7(18)11(26-8)16-3-15-5-9(12)13-2-14-10(5)16/h2-4,6-8,11,17-18H,1H3,(H,22,23)(H,24,25)(H2,12,13,14)(H2,19,20,21)/t4?,6-,7+,8+,11+/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory constant against rat liver Methionine adenosyltransferase I, activity expressed as Ki |
J Med Chem 29: 318-22 (1986)
BindingDB Entry DOI: 10.7270/Q2DF6RSH |
More data for this Ligand-Target Pair | |