BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 900 hits Enz. Inhib. hit(s) with Target = 'Acid ceramidase'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Acid ceramidase


(Homo sapiens (Human))		BDBM367184
PNG
(2-oxo-N-(4-phenylbutyl)-1,3- benzoxazole-3-carboxa...)
Show SMILES O=C(NCCCCc1ccccc1)n1c2ccccc2oc1=O
Show InChI InChI=1S/C18H18N2O3/c21-17(19-13-7-6-10-14-8-2-1-3-9-14)20-15-11-4-5-12-16(15)23-18(20)22/h1-5,8-9,11-12H,6-7,10,13H2,(H,19,21)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
 64n/an/an/an/an/an/an/an/a



Argonne National Laboratory

Curated by ChEMBL


Assay Description
Non-competitive inhibition of human acid ceramidase

J Med Chem 62: 987-992 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01723
BindingDB Entry DOI: 10.7270/Q2KS6VXJ
More data for this
Ligand-Target Pair
Acid ceramidase


(Homo sapiens (Human))		BDBM29080
PNG
(CHEMBL280065 | N-oleoylethanolamine | Oleamide MEA...)
Show SMILES CCCCCCCC\C=C/CCCCCCCC(=O)NCCO
Show InChI InChI=1S/C20H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)21-18-19-22/h9-10,22H,2-8,11-19H2,1H3,(H,21,23)/b10-9-
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
KEGG
PC cid
PC sid
PDB
UniChem

Patents

Similars
Article
PubMed
 5.00E+5n/an/an/an/an/an/an/an/a



Fondazione Istituto Italiano di Tecnologia

Curated by ChEMBL


Assay Description
Inhibition of acid ceramidase (unknown origin)

J Med Chem 56: 3518-30 (2013)


Article DOI: 10.1021/jm301879g
BindingDB Entry DOI: 10.7270/Q27D2WH5
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))		BDBM50538919
PNG
(CHEMBL4633233)
Show SMILES COc1ccc(cc1F)-c1ccc(COC2(CN(C2)C#N)C2CC2)c(F)c1
Show InChI InChI=1S/C21H20F2N2O2/c1-26-20-7-4-15(9-19(20)23)14-2-3-16(18(22)8-14)10-27-21(17-5-6-17)11-25(12-21)13-24/h2-4,7-9,17H,5-6,10-12H2,1H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.350n/an/an/an/an/an/a



Northeastern University

Curated by ChEMBL


Assay Description
Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2019.115195
BindingDB Entry DOI: 10.7270/Q2K35Z63
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))		BDBM393375
PNG
(3-((4'-Methyl-[1,1'-biphenyl]-4-yl)methoxy)azetidi...)
Show SMILES Cc1ccc(cc1)-c1ccc(COC2CN(C2)C#N)cc1
Show InChI InChI=1S/C18H18N2O/c1-14-2-6-16(7-3-14)17-8-4-15(5-9-17)12-21-18-10-20(11-18)13-19/h2-9,18H,10-12H2,1H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.460n/an/an/an/an/an/a



Northeastern University

Curated by ChEMBL


Assay Description
Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2019.115195
BindingDB Entry DOI: 10.7270/Q2K35Z63
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))		BDBM393377
PNG
(3-((3-Fluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)metho...)
Show SMILES COc1cccc(c1)-c1ccc(COC2CN(C2)C#N)c(F)c1
Show InChI InChI=1S/C18H17FN2O2/c1-22-16-4-2-3-13(7-16)14-5-6-15(18(19)8-14)11-23-17-9-21(10-17)12-20/h2-8,17H,9-11H2,1H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.470n/an/an/an/an/an/a



Northeastern University

Curated by ChEMBL


Assay Description
Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2019.115195
BindingDB Entry DOI: 10.7270/Q2K35Z63
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))		BDBM393376
PNG
(3-((4'-Fluoro-[1,1'-biphenyl]-4-yl)methoxy)azetidi...)
Show SMILES Fc1ccc(cc1)-c1ccc(COC2CN(C2)C#N)cc1
Show InChI InChI=1S/C17H15FN2O/c18-16-7-5-15(6-8-16)14-3-1-13(2-4-14)11-21-17-9-20(10-17)12-19/h1-8,17H,9-11H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.680n/an/an/an/an/an/a



Northeastern University

Curated by ChEMBL


Assay Description
Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2019.115195
BindingDB Entry DOI: 10.7270/Q2K35Z63
More data for this
Ligand-Target Pair
Acid ceramidase


(Homo sapiens (Human))		BDBM367209
PNG
(2-oxo-4-phenyl-N-(4- phenylbutyl)-1,3- benzoxazole...)
Show SMILES O=C(NCCCCc1ccccc1)n1c2c(cccc2oc1=O)-c1ccccc1
Show InChI InChI=1S/C24H22N2O3/c27-23(25-17-8-7-12-18-10-3-1-4-11-18)26-22-20(19-13-5-2-6-14-19)15-9-16-21(22)29-24(26)28/h1-6,9-11,13-16H,7-8,12,17H2,(H,25,27)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.800n/an/an/an/an/an/a



Fondazione Istituto Italiano di Tecnologia

Curated by ChEMBL


Assay Description
Inhibition of recombinant human acid ceramidase expressed in HEK293 cells using N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)-4-(2-oxochromen-7-yl)-oxybutyl...

J Med Chem 58: 9258-72 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01188
BindingDB Entry DOI: 10.7270/Q2CF9T36
More data for this
Ligand-Target Pair
Acid ceramidase


(Homo sapiens (Human))		BDBM367209
PNG
(2-oxo-4-phenyl-N-(4- phenylbutyl)-1,3- benzoxazole...)
Show SMILES O=C(NCCCCc1ccccc1)n1c2c(cccc2oc1=O)-c1ccccc1
Show InChI InChI=1S/C24H22N2O3/c27-23(25-17-8-7-12-18-10-3-1-4-11-18)26-22-20(19-13-5-2-6-14-19)15-9-16-21(22)29-24(26)28/h1-6,9-11,13-16H,7-8,12,17H2,(H,25,27)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.800n/an/an/an/an/an/a



Biogen Idec



Assay Description
The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...

J Med Chem 50: 2767-78 (2007)


BindingDB Entry DOI: 10.7270/Q23T9KH0
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))		BDBM393378
PNG
(3-((3'-Methoxy-3-(trifluoromethyl)-[1,1'-biphenyl]...)
Show SMILES COc1cccc(c1)-c1ccc(COC2CN(C2)C#N)c(c1)C(F)(F)F
Show InChI InChI=1S/C19H17F3N2O2/c1-25-16-4-2-3-13(7-16)14-5-6-15(18(8-14)19(20,21)22)11-26-17-9-24(10-17)12-23/h2-8,17H,9-11H2,1H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.850n/an/an/an/an/an/a



Northeastern University

Curated by ChEMBL


Assay Description
Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2019.115195
BindingDB Entry DOI: 10.7270/Q2K35Z63
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))		BDBM393368
PNG
(3-((2',3'-Dimethoxy-[1,1'-biphenyl]-4-yl)methoxy)a...)
Show SMILES COc1cccc(-c2ccc(COC3CN(C3)C#N)cc2)c1OC
Show InChI InChI=1S/C19H20N2O3/c1-22-18-5-3-4-17(19(18)23-2)15-8-6-14(7-9-15)12-24-16-10-21(11-16)13-20/h3-9,16H,10-12H2,1-2H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.880n/an/an/an/an/an/a



Northeastern University

Curated by ChEMBL


Assay Description
Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2019.115195
BindingDB Entry DOI: 10.7270/Q2K35Z63
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))		BDBM393366
PNG
(3-((3'-Methoxy-[1,1'-biphenyl]-4-yl)methoxy)azetid...)
Show SMILES COc1cccc(c1)-c1ccc(COC2CN(C2)C#N)cc1
Show InChI InChI=1S/C18H18N2O2/c1-21-17-4-2-3-16(9-17)15-7-5-14(6-8-15)12-22-18-10-20(11-18)13-19/h2-9,18H,10-12H2,1H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.890n/an/an/an/an/an/a



Northeastern University

Curated by ChEMBL


Assay Description
Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2019.115195
BindingDB Entry DOI: 10.7270/Q2K35Z63
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))		BDBM393366
PNG
(3-((3'-Methoxy-[1,1'-biphenyl]-4-yl)methoxy)azetid...)
Show SMILES COc1cccc(c1)-c1ccc(COC2CN(C2)C#N)cc1
Show InChI InChI=1S/C18H18N2O2/c1-21-17-4-2-3-16(9-17)15-7-5-14(6-8-15)12-22-18-10-20(11-18)13-19/h2-9,18H,10-12H2,1H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.900n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of NAAA (unknown origin)

Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00076
BindingDB Entry DOI: 10.7270/Q2C25175
More data for this
Ligand-Target Pair
Acid ceramidase


(Homo sapiens (Human))		BDBM50238556
PNG
(CHEMBL4093029)
Show SMILES Nc1nc2ccccc2n1C(=O)NCCCCc1ccccc1
Show InChI InChI=1S/C18H20N4O/c19-17-21-15-11-4-5-12-16(15)22(17)18(23)20-13-7-6-10-14-8-2-1-3-9-14/h1-5,8-9,11-12H,6-7,10,13H2,(H2,19,21)(H,20,23)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 0.900n/an/an/an/an/an/a



Istituto Italiano di Tecnologia

Curated by ChEMBL


Assay Description
Inhibition of 5-HT uptake in rat synaptosomal fraction

J Med Chem 60: 5800-5815 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00472
BindingDB Entry DOI: 10.7270/Q2SB481G
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))		BDBM393362
PNG
(US9963444, Example 63)
Show SMILES COc1ccc(cc1)-c1ccc(COC2CN(C2)C#N)cc1
Show InChI InChI=1S/C18H18N2O2/c1-21-17-8-6-16(7-9-17)15-4-2-14(3-5-15)12-22-18-10-20(11-18)13-19/h2-9,18H,10-12H2,1H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.940n/an/an/an/an/an/a



Northeastern University

Curated by ChEMBL


Assay Description
Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2019.115195
BindingDB Entry DOI: 10.7270/Q2K35Z63
More data for this
Ligand-Target Pair
Acid ceramidase


(Homo sapiens (Human))		BDBM50238557
PNG
(CHEMBL4103207)
Show SMILES Cc1nc2ccccc2n1C(=O)NCCCCc1ccccc1
Show InChI InChI=1S/C19H21N3O/c1-15-21-17-12-5-6-13-18(17)22(15)19(23)20-14-8-7-11-16-9-3-2-4-10-16/h2-6,9-10,12-13H,7-8,11,14H2,1H3,(H,20,23)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1n/an/an/an/an/an/a



Istituto Italiano di Tecnologia

Curated by ChEMBL


Assay Description
Inhibition of noradrenaline uptake in rat synaptosomal fraction

J Med Chem 60: 5800-5815 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00472
BindingDB Entry DOI: 10.7270/Q2SB481G
More data for this
Ligand-Target Pair
Acid ceramidase


(Homo sapiens (Human))		BDBM367226
PNG
(4-fluoro-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole...)
Show SMILES Fc1cccc2oc(=O)n(C(=O)NCCCCc3ccccc3)c12
Show InChI InChI=1S/C18H17FN2O3/c19-14-10-6-11-15-16(14)21(18(23)24-15)17(22)20-12-5-4-9-13-7-2-1-3-8-13/h1-3,6-8,10-11H,4-5,9,12H2,(H,20,22)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Biogen Idec



Assay Description
The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...

J Med Chem 50: 2767-78 (2007)


BindingDB Entry DOI: 10.7270/Q23T9KH0
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))		BDBM50538909
PNG
(CHEMBL4637701)
Show SMILES Brc1cc(Oc2ccccc2)ccc1COC1CN(C1)C#N
Show InChI InChI=1S/C17H15BrN2O2/c18-17-8-15(22-14-4-2-1-3-5-14)7-6-13(17)11-21-16-9-20(10-16)12-19/h1-8,16H,9-11H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1n/an/an/an/an/an/a



Northeastern University

Curated by ChEMBL


Assay Description
Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2019.115195
BindingDB Entry DOI: 10.7270/Q2K35Z63
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))		BDBM393380
PNG
(3-((4-Phenoxybenzyl)oxy)azetidine-1-carbonitrile |...)
Show SMILES N#CN1CC(C1)OCc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C17H16N2O2/c18-13-19-10-17(11-19)20-12-14-6-8-16(9-7-14)21-15-4-2-1-3-5-15/h1-9,17H,10-12H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.10n/an/an/an/an/an/a



Northeastern University

Curated by ChEMBL


Assay Description
Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2019.115195
BindingDB Entry DOI: 10.7270/Q2K35Z63
More data for this
Ligand-Target Pair
Acid ceramidase


(Homo sapiens (Human))		BDBM50238562
PNG
(CHEMBL4084295)
Show SMILES O=C(NCCCCc1ccccc1)n1nnc2ncccc12
Show InChI InChI=1S/C16H17N5O/c22-16(21-14-10-6-12-17-15(14)19-20-21)18-11-5-4-9-13-7-2-1-3-8-13/h1-3,6-8,10,12H,4-5,9,11H2,(H,18,22)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.30n/an/an/an/an/an/a



Istituto Italiano di Tecnologia

Curated by ChEMBL


Assay Description
Inhibition of 5-HT uptake in rat synaptosomal fraction

J Med Chem 60: 5800-5815 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00472
BindingDB Entry DOI: 10.7270/Q2SB481G
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))		BDBM393384
PNG
(US9963444, Example 85)
Show SMILES N#CN1CC(C1)OCc1ccc(cc1)-c1cccc(OCc2ccccc2)c1
Show InChI InChI=1S/C24H22N2O2/c25-18-26-14-24(15-26)28-17-20-9-11-21(12-10-20)22-7-4-8-23(13-22)27-16-19-5-2-1-3-6-19/h1-13,24H,14-17H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.40n/an/an/an/an/an/a



Northeastern University

Curated by ChEMBL


Assay Description
Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2019.115195
BindingDB Entry DOI: 10.7270/Q2K35Z63
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))		BDBM50538911
PNG
(CHEMBL4635238)
Show SMILES COc1cccc(c1)-c1ccc(cc1)C(=O)NC1(C)CN(C1)C#N
Show InChI InChI=1S/C19H19N3O2/c1-19(11-22(12-19)13-20)21-18(23)15-8-6-14(7-9-15)16-4-3-5-17(10-16)24-2/h3-10H,11-12H2,1-2H3,(H,21,23)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.60n/an/an/an/an/an/a



Northeastern University

Curated by ChEMBL


Assay Description
Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2019.115195
BindingDB Entry DOI: 10.7270/Q2K35Z63
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))		BDBM50538910
PNG
(CHEMBL4645560)
Show SMILES COc1ccc(cc1F)-c1ccc2CN(Cc2c1)C1CN(C1)C#N
Show InChI InChI=1S/C19H18FN3O/c1-24-19-5-4-14(7-18(19)20)13-2-3-15-8-23(9-16(15)6-13)17-10-22(11-17)12-21/h2-7,17H,8-11H2,1H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.60n/an/an/an/an/an/a



Northeastern University

Curated by ChEMBL


Assay Description
Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2019.115195
BindingDB Entry DOI: 10.7270/Q2K35Z63
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))		BDBM50538916
PNG
(CHEMBL4646586)
Show SMILES FC(F)(F)c1ccc(cc1)-c1ccc(COC2CN(C2)C#N)cc1
Show InChI InChI=1S/C18H15F3N2O/c19-18(20,21)16-7-5-15(6-8-16)14-3-1-13(2-4-14)11-24-17-9-23(10-17)12-22/h1-8,17H,9-11H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.60n/an/an/an/an/an/a



Northeastern University

Curated by ChEMBL


Assay Description
Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2019.115195
BindingDB Entry DOI: 10.7270/Q2K35Z63
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))		BDBM393394
PNG
(US9963444, Example 95)
Show SMILES COc1cccc(c1)-c1ccc(COC2(C)CN(C2)C#N)cc1
Show InChI InChI=1S/C19H20N2O2/c1-19(12-21(13-19)14-20)23-11-15-6-8-16(9-7-15)17-4-3-5-18(10-17)22-2/h3-10H,11-13H2,1-2H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.80n/an/an/an/an/an/a



Northeastern University

Curated by ChEMBL


Assay Description
Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2019.115195
BindingDB Entry DOI: 10.7270/Q2K35Z63
More data for this
Ligand-Target Pair
Acid ceramidase


(Homo sapiens (Human))		BDBM50238574
PNG
(CHEMBL4092051)
Show SMILES O=C(NCCCCc1ccccc1)n1nnc2ccccc12
Show InChI InChI=1S/C17H18N4O/c22-17(21-16-12-5-4-11-15(16)19-20-21)18-13-7-6-10-14-8-2-1-3-9-14/h1-5,8-9,11-12H,6-7,10,13H2,(H,18,22)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2.10n/an/an/an/an/an/a



Istituto Italiano di Tecnologia

Curated by ChEMBL


Assay Description
Inhibition of human C-terminal His-tagged acid ceramidase variant 1 expressed in HEK293 cells using fluorogenic substrate Rbm-14-12 preincubated for ...

J Med Chem 60: 5800-5815 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00472
BindingDB Entry DOI: 10.7270/Q2SB481G
More data for this
Ligand-Target Pair
Acid ceramidase


(Homo sapiens (Human))		BDBM50238573
PNG
(CHEMBL4062592)
Show SMILES CCCCCCNC(=O)n1nnc2ncccc12
Show InChI InChI=1S/C12H17N5O/c1-2-3-4-5-8-14-12(18)17-10-7-6-9-13-11(10)15-16-17/h6-7,9H,2-5,8H2,1H3,(H,14,18)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2.20n/an/an/an/an/an/a



Istituto Italiano di Tecnologia

Curated by ChEMBL


Assay Description
Inhibition of human C-terminal His-tagged acid ceramidase variant 1 expressed in HEK293 cells using fluorogenic substrate Rbm-14-12 preincubated for ...

J Med Chem 60: 5800-5815 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00472
BindingDB Entry DOI: 10.7270/Q2SB481G
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))		BDBM447488
PNG
(US10689357, Example 25)
Show SMILES COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@H]1C[C@H](C1)N=C=S |r,wU:18.19,20.24,(-9.61,-3.62,;-8.28,-4.39,;-6.94,-3.62,;-6.94,-2.08,;-5.61,-1.31,;-4.28,-2.08,;-4.28,-3.62,;-5.61,-4.39,;-2.94,-1.31,;-2.94,.23,;-1.61,1,;-.28,.23,;-.28,-1.31,;-1.61,-2.08,;1.06,1,;.29,2.33,;1.83,2.33,;2.39,.23,;3.72,1,;4.12,2.48,;5.61,2.08,;5.21,.6,;6.94,2.85,;8.28,3.62,;9.61,4.39,)|
Show InChI InChI=1S/C18H18N2O3S2/c1-23-17-6-2-13(3-7-17)14-4-8-18(9-5-14)25(21,22)20-16-10-15(11-16)19-12-24/h2-9,15-16,20H,10-11H2,1H3/t15-,16+
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.30n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human NAAA using N-(4-methyl coumarin)-palmitamide as fluorogenic substrate preincubated for 90 mins followed by substrate addition by ...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00076
BindingDB Entry DOI: 10.7270/Q2C25175
More data for this
Ligand-Target Pair
Acid ceramidase


(Homo sapiens (Human))		BDBM50238569
PNG
(CHEMBL4075447)
Show SMILES O=C(NCCCCc1ccccc1)N1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C19H18N2O3/c22-17-15-11-4-5-12-16(15)18(23)21(17)19(24)20-13-7-6-10-14-8-2-1-3-9-14/h1-5,8-9,11-12H,6-7,10,13H2,(H,20,24)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2.40n/an/an/an/an/an/a



Istituto Italiano di Tecnologia

Curated by ChEMBL


Assay Description
Inhibition of human C-terminal His-tagged acid ceramidase variant 1 expressed in HEK293 cells using fluorogenic substrate Rbm-14-12 preincubated for ...

J Med Chem 60: 5800-5815 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00472
BindingDB Entry DOI: 10.7270/Q2SB481G
More data for this
Ligand-Target Pair
Acid ceramidase


(Homo sapiens (Human))		BDBM50238572
PNG
(CHEMBL4065362)
Show SMILES CCCCCCNC(=O)n1c(N)nc2ccccc12
Show InChI InChI=1S/C14H20N4O/c1-2-3-4-7-10-16-14(19)18-12-9-6-5-8-11(12)17-13(18)15/h5-6,8-9H,2-4,7,10H2,1H3,(H2,15,17)(H,16,19)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2.40n/an/an/an/an/an/a



Istituto Italiano di Tecnologia

Curated by ChEMBL


Assay Description
Inhibition of noradrenaline uptake in rat synaptosomal fraction

J Med Chem 60: 5800-5815 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00472
BindingDB Entry DOI: 10.7270/Q2SB481G
More data for this
Ligand-Target Pair
Acid ceramidase


(Homo sapiens (Human))		BDBM50238568
PNG
(CHEMBL4100744)
Show SMILES O=C(NCCCCc1ccccc1)n1cnc2ccccc12
Show InChI InChI=1S/C18H19N3O/c22-18(21-14-20-16-11-4-5-12-17(16)21)19-13-7-6-10-15-8-2-1-3-9-15/h1-5,8-9,11-12,14H,6-7,10,13H2,(H,19,22)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2.5n/an/an/an/an/an/a



Istituto Italiano di Tecnologia

Curated by ChEMBL


Assay Description
Inhibition of human C-terminal His-tagged acid ceramidase variant 1 expressed in HEK293 cells using fluorogenic substrate Rbm-14-12 preincubated for ...

J Med Chem 60: 5800-5815 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00472
BindingDB Entry DOI: 10.7270/Q2SB481G
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))		BDBM393391
PNG
(3-((4'-Cyano-5-phenoxy-[1,1'-biphenyl]-2-yl)methox...)
Show SMILES N#CN1CC(C1)OCc1ccc(Oc2ccccc2)cc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C24H19N3O2/c25-13-18-6-8-19(9-7-18)24-12-22(29-21-4-2-1-3-5-21)11-10-20(24)16-28-23-14-27(15-23)17-26/h1-12,23H,14-16H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.5n/an/an/an/an/an/a



Northeastern University

Curated by ChEMBL


Assay Description
Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2019.115195
BindingDB Entry DOI: 10.7270/Q2K35Z63
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))		BDBM393363
PNG
(3-([1,1'-Biphenyl]-4-ylmethoxy)azetidine-1-carboni...)
Show SMILES N#CN1CC(C1)OCc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C17H16N2O/c18-13-19-10-17(11-19)20-12-14-6-8-16(9-7-14)15-4-2-1-3-5-15/h1-9,17H,10-12H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.80n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of NAAA (unknown origin)

Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00076
BindingDB Entry DOI: 10.7270/Q2C25175
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))		BDBM50538914
PNG
(CHEMBL4637755)
Show SMILES COc1cccc(c1)-c1ccc(cc1)S(=O)(=O)N1CCC11CN(C1)C#N
Show InChI InChI=1S/C19H19N3O3S/c1-25-17-4-2-3-16(11-17)15-5-7-18(8-6-15)26(23,24)22-10-9-19(22)12-21(13-19)14-20/h2-8,11H,9-10,12-13H2,1H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.80n/an/an/an/an/an/a



Northeastern University

Curated by ChEMBL


Assay Description
Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2019.115195
BindingDB Entry DOI: 10.7270/Q2K35Z63
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))		BDBM393379
PNG
(3-((3,3'-Dimethoxy-[1,1'-biphenyl]-4-yl)methoxy)az...)
Show SMILES COc1cccc(c1)-c1ccc(COC2CN(C2)C#N)c(OC)c1
Show InChI InChI=1S/C19H20N2O3/c1-22-17-5-3-4-14(8-17)15-6-7-16(19(9-15)23-2)12-24-18-10-21(11-18)13-20/h3-9,18H,10-12H2,1-2H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.80n/an/an/an/an/an/a



Northeastern University

Curated by ChEMBL


Assay Description
Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2019.115195
BindingDB Entry DOI: 10.7270/Q2K35Z63
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))		BDBM393363
PNG
(3-([1,1'-Biphenyl]-4-ylmethoxy)azetidine-1-carboni...)
Show SMILES N#CN1CC(C1)OCc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C17H16N2O/c18-13-19-10-17(11-19)20-12-14-6-8-16(9-7-14)15-4-2-1-3-5-15/h1-9,17H,10-12H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.80n/an/an/an/an/an/a



Northeastern University

Curated by ChEMBL


Assay Description
Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2019.115195
BindingDB Entry DOI: 10.7270/Q2K35Z63
More data for this
Ligand-Target Pair
Acid ceramidase


(Homo sapiens (Human))		BDBM367195
PNG
(6-nitro-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole-...)
Show SMILES [O-][N+](=O)c1ccc2n(C(=O)NCCCCc3ccccc3)c(=O)oc2c1
Show InChI InChI=1S/C18H17N3O5/c22-17(19-11-5-4-8-13-6-2-1-3-7-13)20-15-10-9-14(21(24)25)12-16(15)26-18(20)23/h1-3,6-7,9-10,12H,4-5,8,11H2,(H,19,22)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3n/an/an/an/an/an/a



Fondazione Istituto Italiano di Tecnologia

Curated by ChEMBL


Assay Description
Inhibition of recombinant human acid ceramidase expressed in HEK293 cells using N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)-4-(2-oxochromen-7-yl)-oxybutyl...

J Med Chem 58: 9258-72 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01188
BindingDB Entry DOI: 10.7270/Q2CF9T36
More data for this
Ligand-Target Pair
Acid ceramidase


(Homo sapiens (Human))		BDBM367194
PNG
(5-nitro-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole-...)
Show SMILES [O-][N+](=O)c1ccc2oc(=O)n(C(=O)NCCCCc3ccccc3)c2c1
Show InChI InChI=1S/C18H17N3O5/c22-17(19-11-5-4-8-13-6-2-1-3-7-13)20-15-12-14(21(24)25)9-10-16(15)26-18(20)23/h1-3,6-7,9-10,12H,4-5,8,11H2,(H,19,22)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



Biogen Idec



Assay Description
The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...

J Med Chem 50: 2767-78 (2007)


BindingDB Entry DOI: 10.7270/Q23T9KH0
More data for this
Ligand-Target Pair
Acid ceramidase


(Homo sapiens (Human))		BDBM367194
PNG
(5-nitro-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole-...)
Show SMILES [O-][N+](=O)c1ccc2oc(=O)n(C(=O)NCCCCc3ccccc3)c2c1
Show InChI InChI=1S/C18H17N3O5/c22-17(19-11-5-4-8-13-6-2-1-3-7-13)20-15-12-14(21(24)25)9-10-16(15)26-18(20)23/h1-3,6-7,9-10,12H,4-5,8,11H2,(H,19,22)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3n/an/an/an/an/an/a



Fondazione Istituto Italiano di Tecnologia

Curated by ChEMBL


Assay Description
Inhibition of recombinant human acid ceramidase expressed in HEK293 cells using N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)-4-(2-oxochromen-7-yl)-oxybutyl...

J Med Chem 58: 9258-72 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01188
BindingDB Entry DOI: 10.7270/Q2CF9T36
More data for this
Ligand-Target Pair
Acid ceramidase


(Homo sapiens (Human))		BDBM367195
PNG
(6-nitro-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole-...)
Show SMILES [O-][N+](=O)c1ccc2n(C(=O)NCCCCc3ccccc3)c(=O)oc2c1
Show InChI InChI=1S/C18H17N3O5/c22-17(19-11-5-4-8-13-6-2-1-3-7-13)20-15-10-9-14(21(24)25)12-16(15)26-18(20)23/h1-3,6-7,9-10,12H,4-5,8,11H2,(H,19,22)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



Biogen Idec



Assay Description
The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...

J Med Chem 50: 2767-78 (2007)


BindingDB Entry DOI: 10.7270/Q23T9KH0
More data for this
Ligand-Target Pair
Acid ceramidase


(Homo sapiens (Human))		BDBM50511300
PNG
(CHEMBL4580541)
Show SMILES O=C(NCCCCc1ccccc1)n1c2ccncc2oc1=O
Show InChI InChI=1S/C17H17N3O3/c21-16(19-10-5-4-8-13-6-2-1-3-7-13)20-14-9-11-18-12-15(14)23-17(20)22/h1-3,6-7,9,11-12H,4-5,8,10H2,(H,19,21)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3n/an/an/an/an/an/a



University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Inhibition of human acid ceramidase expressed in HEK293 cells using Rbm14-12 as substrate preincubated for 10 mins followed by substrate addition and...

J Med Chem 63: 3634-3664 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02004
BindingDB Entry DOI: 10.7270/Q20C503N
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))		BDBM447493
PNG
(US10689357, Example 30)
Show SMILES COc1ccc(cc1F)-c1ccc(cc1)S(=O)(=O)N[C@H]1C[C@H](C1)N=C=S |r,wU:19.20,21.25,(-11.93,2.49,;-11.4,1.04,;-9.86,1.04,;-9.09,2.37,;-7.55,2.37,;-6.78,1.04,;-7.55,-.3,;-9.09,-.3,;-9.86,-1.63,;-5.24,1.04,;-4.47,-.3,;-2.93,-.3,;-2.16,1.04,;-2.93,2.37,;-4.47,2.37,;-.62,1.04,;-.62,-.5,;-.62,2.58,;.92,1.04,;2.46,1.04,;3.54,2.13,;5.14,1.04,;3.54,-.05,;7.03,1.04,;7.98,2.68,;8.93,4.32,)|
Show InChI InChI=1S/C18H17FN2O3S2/c1-24-18-7-4-13(8-17(18)19)12-2-5-16(6-3-12)26(22,23)21-15-9-14(10-15)20-11-25/h2-8,14-15,21H,9-10H2,1H3/t14-,15+
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.20n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human NAAA using N-(4-methyl coumarin)-palmitamide as fluorogenic substrate preincubated for 90 mins followed by substrate addition by ...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00076
BindingDB Entry DOI: 10.7270/Q2C25175
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))		BDBM50538912
PNG
(CHEMBL4643588)
Show SMILES COc1cccc(c1)-c1ccc(cc1)S(=O)(=O)NC1(C)CN(C1)C#N
Show InChI InChI=1S/C18H19N3O3S/c1-18(11-21(12-18)13-19)20-25(22,23)17-8-6-14(7-9-17)15-4-3-5-16(10-15)24-2/h3-10,20H,11-12H2,1-2H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.20n/an/an/an/an/an/a



Northeastern University

Curated by ChEMBL


Assay Description
Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2019.115195
BindingDB Entry DOI: 10.7270/Q2K35Z63
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))		BDBM393385
PNG
(US9963444, Example 86)
Show SMILES N#CN1CC(COCc2ccc(cc2)-c2ccccc2)C1
Show InChI InChI=1S/C18H18N2O/c19-14-20-10-16(11-20)13-21-12-15-6-8-18(9-7-15)17-4-2-1-3-5-17/h1-9,16H,10-13H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.40n/an/an/an/an/an/a



Northeastern University

Curated by ChEMBL


Assay Description
Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2019.115195
BindingDB Entry DOI: 10.7270/Q2K35Z63
More data for this
Ligand-Target Pair
Acid ceramidase


(Rattus norvegicus (Rat))		BDBM50431244
PNG
(CHEMBL2333064)
Show SMILES CCCCCCCCNC(=O)n1cc(F)c(=O)n(C(=O)OC)c1=O
Show InChI InChI=1S/C15H22FN3O5/c1-3-4-5-6-7-8-9-17-13(21)18-10-11(16)12(20)19(14(18)22)15(23)24-2/h10H,3-9H2,1-2H3,(H,17,21)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 4n/an/an/an/an/an/a



Fondazione Istituto Italiano di Tecnologia

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant acid ceramidase expressed in human HEK293 cells using N-lauroylceramide as substrate incubated for 30 mins prior to sub...

J Med Chem 56: 3518-30 (2013)


Article DOI: 10.1021/jm301879g
BindingDB Entry DOI: 10.7270/Q27D2WH5
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))		BDBM233790
PNG
(US9353075, 47)
Show SMILES CC[C@H]1OC(=O)[C@@H]1NC(=O)OCCCCCc1ccccc1 |r|
Show InChI InChI=1S/C17H23NO4/c1-2-14-15(16(19)22-14)18-17(20)21-12-8-4-7-11-13-9-5-3-6-10-13/h3,5-6,9-10,14-15H,2,4,7-8,11-12H2,1H3,(H,18,20)/t14-,15-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4n/an/an/an/a4.5n/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
The assay was run in Optiplate 96-wells black plates, in a total reaction volume of 200 μL. NAAA protein preparation (4.0 μg) was pre-incub...

US Patent US9353075 (2016)


BindingDB Entry DOI: 10.7270/Q23N229Q
More data for this
Ligand-Target Pair
Acid ceramidase


(Homo sapiens (Human))		BDBM50238578
PNG
(CHEMBL4071239)
Show SMILES CCCCCCNC(=O)n1nnc2ccccc12
Show InChI InChI=1S/C13H18N4O/c1-2-3-4-7-10-14-13(18)17-12-9-6-5-8-11(12)15-16-17/h5-6,8-9H,2-4,7,10H2,1H3,(H,14,18)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 4.10n/an/an/an/an/an/a



Istituto Italiano di Tecnologia

Curated by ChEMBL


Assay Description
Inhibition of 5-HT uptake in rat synaptosomal fraction

J Med Chem 60: 5800-5815 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00472
BindingDB Entry DOI: 10.7270/Q2SB481G
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))		BDBM50576137
PNG
(CHEMBL4863412)
Show SMILES Fc1cc(ccc1CO[C@H]1C[C@H](C1)N=C=S)-c1ccc2OCCc2c1 |r,wU:9.9,11.14,(13.46,-17.55,;12.7,-18.88,;11.16,-18.9,;10.4,-20.24,;11.19,-21.57,;12.73,-21.55,;13.49,-20.22,;15.02,-20.2,;15.81,-21.53,;17.35,-21.52,;18.42,-20.42,;19.52,-21.5,;18.44,-22.59,;21.06,-21.48,;21.84,-22.81,;22.6,-24.13,;8.86,-20.26,;8.09,-18.93,;6.55,-18.94,;5.78,-20.28,;4.27,-20.63,;4.13,-22.17,;5.56,-22.78,;6.58,-21.61,;8.12,-21.59,)|
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 4.5n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human NAAA using N-(4-methyl coumarin)-palmitamide as fluorogenic substrate preincubated for 90 mins followed by substrate addition by ...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00076
BindingDB Entry DOI: 10.7270/Q2C25175
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))		BDBM50538918
PNG
(CHEMBL4638402)
Show SMILES COc1ccc(cc1F)-c1ccc(COC2(CN(C2)C#N)c2cccnc2)c(F)c1
Show InChI InChI=1S/C23H19F2N3O2/c1-29-22-7-6-17(10-21(22)25)16-4-5-18(20(24)9-16)12-30-23(13-28(14-23)15-26)19-3-2-8-27-11-19/h2-11H,12-14H2,1H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 4.60n/an/an/an/an/an/a



Northeastern University

Curated by ChEMBL


Assay Description
Inhibition of activated human NAAA using fluorogenic PAMCA and N-4-methylcoumarin as substrate incubated for 90 mins by fluorescence based assay

Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2019.115195
BindingDB Entry DOI: 10.7270/Q2K35Z63
More data for this
Ligand-Target Pair
Acid ceramidase


(Homo sapiens (Human))		BDBM50238558
PNG
(CHEMBL4075028)
Show SMILES O=C(NCCCCc1ccccc1)n1ncc2ccccc12
Show InChI InChI=1S/C18H19N3O/c22-18(21-17-12-5-4-11-16(17)14-20-21)19-13-7-6-10-15-8-2-1-3-9-15/h1-5,8-9,11-12,14H,6-7,10,13H2,(H,19,22)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 4.70n/an/an/an/an/an/a



Istituto Italiano di Tecnologia

Curated by ChEMBL


Assay Description
Inhibition of human C-terminal His-tagged acid ceramidase variant 1 expressed in HEK293 cells using fluorogenic substrate Rbm-14-12 preincubated for ...

J Med Chem 60: 5800-5815 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00472
BindingDB Entry DOI: 10.7270/Q2SB481G
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))		BDBM50439649
PNG
(CHEMBL2419811 | US9353075, 7)
Show SMILES CCCCCCC[C@H](C)OC(=O)N[C@@H]1[C@H](C)OC1=O |r|
Show InChI InChI=1S/C14H25NO4/c1-4-5-6-7-8-9-10(2)18-14(17)15-12-11(3)19-13(12)16/h10-12H,4-9H2,1-3H3,(H,15,17)/t10-,11-,12+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 5n/an/an/an/a4.537



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
NAAA protein preparation (10 ug) was pre-incubated with various concentrations of test compound or vehicle control in 100 mM NaH2PO4, 100 mM Tri Sodi...

US Patent US9353075 (2016)


BindingDB Entry DOI: 10.7270/Q23N229Q
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 900 total )  |  Next  |  Last  >>
Jump to: