Compile Data Set for Download or QSAR

Found 135 hits Enz. Inhib. hit(s) with Target = 'Sentrin-specific protease 2'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sentrin-specific protease 2 (Homo sapiens (Human))	BDBM81515 (VEA-499) Show SMILES C[C@H](O)C(NC(=O)[C@H](CCC(N)=O)NC(=O)Cc1ccc(O)c(c1)N(=O)=O)C(=O)NCC(=O)NCC(=O)COC(=O)c1c2ccccc2cc2ccccc12 |r| Show InChI InChI=1S/C37H38N6O12/c1-20(44)34(42-35(50)27(11-13-30(38)47)41-31(48)15-21-10-12-29(46)28(14-21)43(53)54)36(51)40-18-32(49)39-17-24(45)19-55-37(52)33-25-8-4-2-6-22(25)16-23-7-3-5-9-26(23)33/h2-10,12,14,16,20,27,34,44,46H,11,13,15,17-19H2,1H3,(H2,38,47)(H,39,49)(H,40,51)(H,41,48)(H,42,50)/t20-,27-,34?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	8.0	37
Stanford University					Assay Description The fluorogenic substrate library screen was performed with hSENP1 in low salt tris buffer at final concentration of 2uM. Fluorophore release (AFC) ...				Chem Biol 18: 722-32 (2011) Article DOI: 10.1016/j.chembiol.2011.05.008 BindingDB Entry DOI: 10.7270/Q2542M2N
					More data for this Ligand-Target Pair
Sentrin-specific protease 2 (Homo sapiens (Human))	BDBM50565392 (CHEMBL4791433) Show SMILES CN(C)c1ccc2sc(C(=O)NCc3cccc(NC(=O)c4cccs4)c3)c(OCc3ccccc3)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	560	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human SNEP2 (365 to 589 residues) expressed in Escherichia coli (DE3) cells using RanGAP-SUMO2 substrate preincubated for 1...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112553 BindingDB Entry DOI: 10.7270/Q2H135RP
					More data for this Ligand-Target Pair
Sentrin-specific protease 2 (Homo sapiens (Human))	BDBM50565398 (CHEMBL4776158) Show SMILES CCOC(=O)CNc1ccc2sc(C(=O)NCc3cccc(NC(=O)c4cccs4)c3)c(OCc3ccccc3)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	690	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human SNEP2 (365 to 589 residues) expressed in Escherichia coli (DE3) cells using RanGAP-SUMO2 substrate preincubated for 1...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112553 BindingDB Entry DOI: 10.7270/Q2H135RP
					More data for this Ligand-Target Pair
Sentrin-specific protease 2 (Homo sapiens (Human))	BDBM81516 (VEA-500) Show SMILES C[C@H](O)C(NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)Cc1ccc(O)c(c1)N(=O)=O)C(=O)NCC(=O)NCC(=O)COC(=O)c1c2ccccc2cc2ccccc12 |r| Show InChI InChI=1S/C42H46N8O14/c1-22(51)38(41(60)46-20-36(57)45-19-26(52)21-64-42(61)37-27-8-4-2-6-24(27)18-25-7-3-5-9-28(25)37)49-40(59)30(12-15-34(44)55)48-39(58)29(11-14-33(43)54)47-35(56)17-23-10-13-32(53)31(16-23)50(62)63/h2-10,13,16,18,22,29-30,38,51,53H,11-12,14-15,17,19-21H2,1H3,(H2,43,54)(H2,44,55)(H,45,57)(H,46,60)(H,47,56)(H,48,58)(H,49,59)/t22-,29-,30-,38?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	860	n/a	n/a	n/a	n/a	8.0	37
Stanford University					Assay Description The fluorogenic substrate library screen was performed with hSENP1 in low salt tris buffer at final concentration of 2uM. Fluorophore release (AFC) ...				Chem Biol 18: 722-32 (2011) Article DOI: 10.1016/j.chembiol.2011.05.008 BindingDB Entry DOI: 10.7270/Q2542M2N
					More data for this Ligand-Target Pair
Sentrin-specific protease 2 (Homo sapiens (Human))	BDBM103826 (SPI-01 | US11041859, Code SPI-01 | US9791447, Comp...) Show SMILES Nc1ccc2ccccc2c1\N=N\c1ccc(\C=C\c2ccc(cc2S(O)(=O)=O)\N=N\c2c(N)ccc3ccccc23)c(c1)S(O)(=O)=O Show InChI InChI=1S/C34H26N6O6S2/c35-29-17-13-21-5-1-3-7-27(21)33(29)39-37-25-15-11-23(31(19-25)47(41,42)43)9-10-24-12-16-26(20-32(24)48(44,45)46)38-40-34-28-8-4-2-6-22(28)14-18-30(34)36/h1-20H,35-36H2,(H,41,42,43)(H,44,45,46)/b10-9+,39-37+,40-38+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	7.4	n/a
Beckman Research Institute of the City of Hope					Assay Description Assays were performedby incubating SENPs with various concentrations of the inhibitor (0−60 μM) at RT for 10 min in assay buffer (50 mM Tr...				ACS Chem Biol 8: 1435-41 (2013) Article DOI: 10.1021/cb400177q BindingDB Entry DOI: 10.7270/Q2KH0KZN
					More data for this Ligand-Target Pair
Sentrin-specific protease 2 (Homo sapiens (Human))	BDBM50565346 (CHEMBL4781794) Show SMILES Nc1ccc2ccccc2c1\N=N\c1ccc(\C=C\c2ccc(cc2S(O)(=O)=O)\N=N\c2cccc3ccccc23)c(c1)S(O)(=O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human His-tagged SENP2 (364 to 589 residues) expressed in Escherichia coli (DE3) cells using DUB-Glo as substrate preincubated for 10 m...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112553 BindingDB Entry DOI: 10.7270/Q2H135RP
					More data for this Ligand-Target Pair
Sentrin-specific protease 2 (Homo sapiens (Human))	BDBM50565391 (CHEMBL4792569) Show SMILES CNc1ccc2sc(C(=O)NCc3cccc(NC(=O)c4cccs4)c3)c(OCc3ccccc3)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human SNEP2 (365 to 589 residues) expressed in Escherichia coli (DE3) cells using RanGAP-SUMO2 substrate preincubated for 1...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112553 BindingDB Entry DOI: 10.7270/Q2H135RP
					More data for this Ligand-Target Pair
Sentrin-specific protease 2 (Homo sapiens (Human))	BDBM50565393 (CHEMBL4780770) Show SMILES CCNc1ccc2sc(C(=O)NCc3cccc(NC(=O)c4cccs4)c3)c(OCc3ccccc3)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human SNEP2 (365 to 589 residues) expressed in Escherichia coli (DE3) cells using RanGAP-SUMO2 substrate preincubated for 1...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112553 BindingDB Entry DOI: 10.7270/Q2H135RP
					More data for this Ligand-Target Pair
Sentrin-specific protease 2/Small ubiquitin-related modifier 1 (Homo sapiens (Human))	BDBM103826 (SPI-01 | US11041859, Code SPI-01 | US9791447, Comp...) Show SMILES Nc1ccc2ccccc2c1\N=N\c1ccc(\C=C\c2ccc(cc2S(O)(=O)=O)\N=N\c2c(N)ccc3ccccc23)c(c1)S(O)(=O)=O Show InChI InChI=1S/C34H26N6O6S2/c35-29-17-13-21-5-1-3-7-27(21)33(29)39-37-25-15-11-23(31(19-25)47(41,42)43)9-10-24-12-16-26(20-32(24)48(44,45)46)38-40-34-28-8-4-2-6-22(28)14-18-30(34)36/h1-20H,35-36H2,(H,41,42,43)(H,44,45,46)/b10-9+,39-37+,40-38+	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.42E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...				Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JKM
					More data for this Ligand-Target Pair
Sentrin-specific protease 2 (Homo sapiens (Human))	BDBM103826 (SPI-01 | US11041859, Code SPI-01 | US9791447, Comp...) Show SMILES Nc1ccc2ccccc2c1\N=N\c1ccc(\C=C\c2ccc(cc2S(O)(=O)=O)\N=N\c2c(N)ccc3ccccc23)c(c1)S(O)(=O)=O Show InChI InChI=1S/C34H26N6O6S2/c35-29-17-13-21-5-1-3-7-27(21)33(29)39-37-25-15-11-23(31(19-25)47(41,42)43)9-10-24-12-16-26(20-32(24)48(44,45)46)38-40-34-28-8-4-2-6-22(28)14-18-30(34)36/h1-20H,35-36H2,(H,41,42,43)(H,44,45,46)/b10-9+,39-37+,40-38+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.42E+3	n/a	n/a	n/a	n/a	7.4	n/a
Beckman Research Institute of the City of Hope					Assay Description Assays were performedby incubating SENPs with various concentrations of the inhibitor (0−60 μM) at RT for 10 min in assay buffer (50 mM Tr...				ACS Chem Biol 8: 1435-41 (2013) Article DOI: 10.1021/cb400177q BindingDB Entry DOI: 10.7270/Q2KH0KZN
					More data for this Ligand-Target Pair
Sentrin-specific protease 2 (Homo sapiens (Human))	BDBM103829 (SPI-04 | US11041859, Code SPI-04 | US9791447, Comp...) Show SMILES Nc1ccc(\N=N\c2ccc(\C=C\c3ccc(cc3S(O)(=O)=O)\N=N\c3ccc(N)c4ccc(cc34)S([O-])(=O)=O)c(c2)S(O)(=O)=O)c2cc(ccc12)S(O)(=O)=O Show InChI InChI=1S/C34H26N6O12S4/c35-29-11-13-31(27-17-23(53(41,42)43)7-9-25(27)29)39-37-21-5-3-19(33(15-21)55(47,48)49)1-2-20-4-6-22(16-34(20)56(50,51)52)38-40-32-14-12-30(36)26-10-8-24(18-28(26)32)54(44,45)46/h1-18H,35-36H2,(H,41,42,43)(H,44,45,46)(H,47,48,49)(H,50,51,52)/p-1/b2-1+,39-37+,40-38+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	7.4	n/a
Beckman Research Institute of the City of Hope					Assay Description Assays were performedby incubating SENPs with various concentrations of the inhibitor (0−60 μM) at RT for 10 min in assay buffer (50 mM Tr...				ACS Chem Biol 8: 1435-41 (2013) Article DOI: 10.1021/cb400177q BindingDB Entry DOI: 10.7270/Q2KH0KZN
					More data for this Ligand-Target Pair
Sentrin-specific protease 2/Small ubiquitin-related modifier 1 (Homo sapiens (Human))	BDBM103829 (SPI-04 | US11041859, Code SPI-04 | US9791447, Comp...) Show SMILES Nc1ccc(\N=N\c2ccc(\C=C\c3ccc(cc3S(O)(=O)=O)\N=N\c3ccc(N)c4ccc(cc34)S([O-])(=O)=O)c(c2)S(O)(=O)=O)c2cc(ccc12)S(O)(=O)=O Show InChI InChI=1S/C34H26N6O12S4/c35-29-11-13-31(27-17-23(53(41,42)43)7-9-25(27)29)39-37-21-5-3-19(33(15-21)55(47,48)49)1-2-20-4-6-22(16-34(20)56(50,51)52)38-40-32-14-12-30(36)26-10-8-24(18-28(26)32)54(44,45)46/h1-18H,35-36H2,(H,41,42,43)(H,44,45,46)(H,47,48,49)(H,50,51,52)/p-1/b2-1+,39-37+,40-38+	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...				Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JKM
					More data for this Ligand-Target Pair
Sentrin-specific protease 2 (Homo sapiens (Human))	BDBM50565390 (CHEMBL4780586) Show SMILES Nc1ccc2sc(C(=O)NCc3cccc(NC(=O)c4cccs4)c3)c(OCc3ccccc3)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human SNEP2 (365 to 589 residues) expressed in Escherichia coli (DE3) cells using RanGAP-SUMO2 substrate preincubated for 1...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112553 BindingDB Entry DOI: 10.7270/Q2H135RP
					More data for this Ligand-Target Pair
Sentrin-specific protease 2 (Homo sapiens (Human))	BDBM103827 (SPI-02 | US11041859, Code SPI-02 | US9791447, Comp...) Show SMILES Cc1cc(ccc1\N=N\c1c(N)ccc2cc(ccc12)S(O)(=O)=O)-c1ccc(\N=N\c2c(N)c(cc3cc(ccc23)S(O)(=O)=O)S(O)(=O)=O)c(C)c1 Show InChI InChI=1S/C34H28N6O9S3/c1-18-13-20(4-11-29(18)37-39-33-26-8-6-24(50(41,42)43)15-22(26)3-10-28(33)35)21-5-12-30(19(2)14-21)38-40-34-27-9-7-25(51(44,45)46)16-23(27)17-31(32(34)36)52(47,48)49/h3-17H,35-36H2,1-2H3,(H,41,42,43)(H,44,45,46)(H,47,48,49)/b39-37+,40-38+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
City of Hope US Patent					Assay Description The binding of SPI-01 to the enzyme-substrate complex was investigated. CSP analysis was carried out on the 40 kDa complex of 15N-labeled full length...				US Patent US9791447 (2017) BindingDB Entry DOI: 10.7270/Q2J67K27
					More data for this Ligand-Target Pair
Sentrin-specific protease 2 (Homo sapiens (Human))	BDBM103827 (SPI-02 | US11041859, Code SPI-02 | US9791447, Comp...) Show SMILES Cc1cc(ccc1\N=N\c1c(N)ccc2cc(ccc12)S(O)(=O)=O)-c1ccc(\N=N\c2c(N)c(cc3cc(ccc23)S(O)(=O)=O)S(O)(=O)=O)c(C)c1 Show InChI InChI=1S/C34H28N6O9S3/c1-18-13-20(4-11-29(18)37-39-33-26-8-6-24(50(41,42)43)15-22(26)3-10-28(33)35)21-5-12-30(19(2)14-21)38-40-34-27-9-7-25(51(44,45)46)16-23(27)17-31(32(34)36)52(47,48)49/h3-17H,35-36H2,1-2H3,(H,41,42,43)(H,44,45,46)(H,47,48,49)/b39-37+,40-38+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...				Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JKM
					More data for this Ligand-Target Pair
Sentrin-specific protease 2 (Homo sapiens (Human))	BDBM103827 (SPI-02 | US11041859, Code SPI-02 | US9791447, Comp...) Show SMILES Cc1cc(ccc1\N=N\c1c(N)ccc2cc(ccc12)S(O)(=O)=O)-c1ccc(\N=N\c2c(N)c(cc3cc(ccc23)S(O)(=O)=O)S(O)(=O)=O)c(C)c1 Show InChI InChI=1S/C34H28N6O9S3/c1-18-13-20(4-11-29(18)37-39-33-26-8-6-24(50(41,42)43)15-22(26)3-10-28(33)35)21-5-12-30(19(2)14-21)38-40-34-27-9-7-25(51(44,45)46)16-23(27)17-31(32(34)36)52(47,48)49/h3-17H,35-36H2,1-2H3,(H,41,42,43)(H,44,45,46)(H,47,48,49)/b39-37+,40-38+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2022.114227 BindingDB Entry DOI: 10.7270/Q2T43Z3H
					More data for this Ligand-Target Pair
Sentrin-specific protease 2 (Homo sapiens (Human))	BDBM103827 (SPI-02 | US11041859, Code SPI-02 | US9791447, Comp...) Show SMILES Cc1cc(ccc1\N=N\c1c(N)ccc2cc(ccc12)S(O)(=O)=O)-c1ccc(\N=N\c2c(N)c(cc3cc(ccc23)S(O)(=O)=O)S(O)(=O)=O)c(C)c1 Show InChI InChI=1S/C34H28N6O9S3/c1-18-13-20(4-11-29(18)37-39-33-26-8-6-24(50(41,42)43)15-22(26)3-10-28(33)35)21-5-12-30(19(2)14-21)38-40-34-27-9-7-25(51(44,45)46)16-23(27)17-31(32(34)36)52(47,48)49/h3-17H,35-36H2,1-2H3,(H,41,42,43)(H,44,45,46)(H,47,48,49)/b39-37+,40-38+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars		n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sentrin-specific protease 2 (Homo sapiens (Human))	BDBM103829 (SPI-04 | US11041859, Code SPI-04 | US9791447, Comp...) Show SMILES Nc1ccc(\N=N\c2ccc(\C=C\c3ccc(cc3S(O)(=O)=O)\N=N\c3ccc(N)c4ccc(cc34)S([O-])(=O)=O)c(c2)S(O)(=O)=O)c2cc(ccc12)S(O)(=O)=O Show InChI InChI=1S/C34H26N6O12S4/c35-29-11-13-31(27-17-23(53(41,42)43)7-9-25(27)29)39-37-21-5-3-19(33(15-21)55(47,48)49)1-2-20-4-6-22(16-34(20)56(50,51)52)38-40-32-14-12-30(36)26-10-8-24(18-28(26)32)54(44,45)46/h1-18H,35-36H2,(H,41,42,43)(H,44,45,46)(H,47,48,49)(H,50,51,52)/p-1/b2-1+,39-37+,40-38+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.15E+3	n/a	n/a	n/a	n/a	7.4	n/a
Beckman Research Institute of the City of Hope					Assay Description Assays were performedby incubating SENPs with various concentrations of the inhibitor (0−60 μM) at RT for 10 min in assay buffer (50 mM Tr...				ACS Chem Biol 8: 1435-41 (2013) Article DOI: 10.1021/cb400177q BindingDB Entry DOI: 10.7270/Q2KH0KZN
					More data for this Ligand-Target Pair
Sentrin-specific protease 2 (Homo sapiens (Human))	BDBM50565350 (CHEMBL4796113) Show SMILES O=C(NCc1cccc(NC(=O)c2ccccc2)c1)c1sc2ccccc2c1OCc1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human SNEP2 (365 to 589 residues) expressed in Escherichia coli (DE3) cells using RanGAP-SUMO2 substrate preincubated for 1...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112553 BindingDB Entry DOI: 10.7270/Q2H135RP
					More data for this Ligand-Target Pair
Sentrin-specific protease 2 (Homo sapiens (Human))	BDBM103829 (SPI-04 | US11041859, Code SPI-04 | US9791447, Comp...) Show SMILES Nc1ccc(\N=N\c2ccc(\C=C\c3ccc(cc3S(O)(=O)=O)\N=N\c3ccc(N)c4ccc(cc34)S([O-])(=O)=O)c(c2)S(O)(=O)=O)c2cc(ccc12)S(O)(=O)=O Show InChI InChI=1S/C34H26N6O12S4/c35-29-11-13-31(27-17-23(53(41,42)43)7-9-25(27)29)39-37-21-5-3-19(33(15-21)55(47,48)49)1-2-20-4-6-22(16-34(20)56(50,51)52)38-40-32-14-12-30(36)26-10-8-24(18-28(26)32)54(44,45)46/h1-18H,35-36H2,(H,41,42,43)(H,44,45,46)(H,47,48,49)(H,50,51,52)/p-1/b2-1+,39-37+,40-38+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
City of Hope US Patent					Assay Description The binding of SPI-01 to the enzyme-substrate complex was investigated. CSP analysis was carried out on the 40 kDa complex of 15N-labeled full length...				US Patent US9791447 (2017) BindingDB Entry DOI: 10.7270/Q2J67K27
					More data for this Ligand-Target Pair
Sentrin-specific protease 2 (Homo sapiens (Human))	BDBM103829 (SPI-04 | US11041859, Code SPI-04 | US9791447, Comp...) Show SMILES Nc1ccc(\N=N\c2ccc(\C=C\c3ccc(cc3S(O)(=O)=O)\N=N\c3ccc(N)c4ccc(cc34)S([O-])(=O)=O)c(c2)S(O)(=O)=O)c2cc(ccc12)S(O)(=O)=O Show InChI InChI=1S/C34H26N6O12S4/c35-29-11-13-31(27-17-23(53(41,42)43)7-9-25(27)29)39-37-21-5-3-19(33(15-21)55(47,48)49)1-2-20-4-6-22(16-34(20)56(50,51)52)38-40-32-14-12-30(36)26-10-8-24(18-28(26)32)54(44,45)46/h1-18H,35-36H2,(H,41,42,43)(H,44,45,46)(H,47,48,49)(H,50,51,52)/p-1/b2-1+,39-37+,40-38+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...				Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JKM
					More data for this Ligand-Target Pair
Sentrin-specific protease 2 (Homo sapiens (Human))	BDBM50565382 (CHEMBL4778045) Show SMILES O=C(NCc1cccc(NC(=O)c2cc3ccccc3s2)c1)c1sc2ccccc2c1OCc1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human SNEP2 (365 to 589 residues) expressed in Escherichia coli (DE3) cells using RanGAP-SUMO2 substrate preincubated for 1...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112553 BindingDB Entry DOI: 10.7270/Q2H135RP
					More data for this Ligand-Target Pair
Sentrin-specific protease 2 (Homo sapiens (Human))	BDBM50421693 (CHEMBL5269877) Show SMILES CCc1c(OC)cc(Cc2cnc(N)nc2N)cc1OC Show InChI InChI=1S/C15H20N4O2/c1-4-11-12(20-2)6-9(7-13(11)21-3)5-10-8-18-15(17)19-14(10)16/h6-8H,4-5H2,1-3H3,(H4,16,17,18,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars		n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sentrin-specific protease 2 (Homo sapiens (Human))	BDBM348885 (NSC8676 | US9791447, Compound SPI-03) Show SMILES Cc1cc(ccc1-c1ccc(cc1C)\N=N\c1cc(c2ccccc2c1N)S([O-])(=O)=O)\N=N\c1cc(c2ccccc2c1N)S(O)(=O)=O Show InChI InChI=1S/C34H28N6O6S2/c1-19-15-21(37-39-29-17-31(47(41,42)43)25-7-3-5-9-27(25)33(29)35)11-13-23(19)24-14-12-22(16-20(24)2)38-40-30-18-32(48(44,45)46)26-8-4-6-10-28(26)34(30)36/h3-18H,35-36H2,1-2H3,(H,41,42,43)(H,44,45,46)/p-1/b39-37+,40-38+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
City of Hope US Patent					Assay Description The binding of SPI-01 to the enzyme-substrate complex was investigated. CSP analysis was carried out on the 40 kDa complex of 15N-labeled full length...				US Patent US9791447 (2017) BindingDB Entry DOI: 10.7270/Q2J67K27
					More data for this Ligand-Target Pair
Sentrin-specific protease 2 (Homo sapiens (Human))	BDBM103828 (SPI-03 | US11041859, Code SPI-03) Show SMILES Cc1cc(ccc1-c1ccc(cc1C)\N=N\c1cc(c2ccccc2c1N)S(O)(=O)=O)\N=N\c1cc(c2ccccc2c1N)S(O)(=O)=O Show InChI InChI=1S/C34H28N6O6S2/c1-19-15-21(37-39-29-17-31(47(41,42)43)25-7-3-5-9-27(25)33(29)35)11-13-23(19)24-14-12-22(16-20(24)2)38-40-30-18-32(48(44,45)46)26-8-4-6-10-28(26)34(30)36/h3-18H,35-36H2,1-2H3,(H,41,42,43)(H,44,45,46)/b39-37+,40-38+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...				Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JKM
					More data for this Ligand-Target Pair
Sentrin-specific protease 2 (Homo sapiens (Human))	BDBM50565396 (CHEMBL4783695) Show SMILES ClCC(=O)Nc1ccc2sc(C(=O)NCc3cccc(NC(=O)c4cccs4)c3)c(OCc3ccccc3)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human SNEP2 (365 to 589 residues) expressed in Escherichia coli (DE3) cells using RanGAP-SUMO2 substrate preincubated for 1...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112553 BindingDB Entry DOI: 10.7270/Q2H135RP
					More data for this Ligand-Target Pair
Sentrin-specific protease 2 (Homo sapiens (Human))	BDBM103828 (SPI-03 | US11041859, Code SPI-03) Show SMILES Cc1cc(ccc1-c1ccc(cc1C)\N=N\c1cc(c2ccccc2c1N)S(O)(=O)=O)\N=N\c1cc(c2ccccc2c1N)S(O)(=O)=O Show InChI InChI=1S/C34H28N6O6S2/c1-19-15-21(37-39-29-17-31(47(41,42)43)25-7-3-5-9-27(25)33(29)35)11-13-23(19)24-14-12-22(16-20(24)2)38-40-30-18-32(48(44,45)46)26-8-4-6-10-28(26)34(30)36/h3-18H,35-36H2,1-2H3,(H,41,42,43)(H,44,45,46)/b39-37+,40-38+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars		n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sentrin-specific protease 2 (Homo sapiens (Human))	BDBM103835 (SPI-10 | US11041859, Code SPI-10 | US9791447, Comp...) Show SMILES Nc1ccc(\N=N\c2cccc(c2)S([O-])(=O)=O)c2ccccc12 Show InChI InChI=1S/C16H13N3O3S/c17-15-8-9-16(14-7-2-1-6-13(14)15)19-18-11-4-3-5-12(10-11)23(20,21)22/h1-10H,17H2,(H,20,21,22)/p-1/b19-18+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
City of Hope US Patent					Assay Description The binding of SPI-01 to the enzyme-substrate complex was investigated. CSP analysis was carried out on the 40 kDa complex of 15N-labeled full length...				US Patent US9791447 (2017) BindingDB Entry DOI: 10.7270/Q2J67K27
					More data for this Ligand-Target Pair
Sentrin-specific protease 2 (Homo sapiens (Human))	BDBM103835 (SPI-10 | US11041859, Code SPI-10 | US9791447, Comp...) Show SMILES Nc1ccc(\N=N\c2cccc(c2)S([O-])(=O)=O)c2ccccc12 Show InChI InChI=1S/C16H13N3O3S/c17-15-8-9-16(14-7-2-1-6-13(14)15)19-18-11-4-3-5-12(10-11)23(20,21)22/h1-10H,17H2,(H,20,21,22)/p-1/b19-18+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...				Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JKM
					More data for this Ligand-Target Pair
Sentrin-specific protease 2 (Homo sapiens (Human))	BDBM50565378 (CHEMBL4793952) Show SMILES O=C(NCc1cccc(NC(=O)c2cccs2)c1)c1sc2ccccc2c1OCc1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human SNEP2 (365 to 589 residues) expressed in Escherichia coli (DE3) cells using RanGAP-SUMO2 substrate preincubated for 1...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112553 BindingDB Entry DOI: 10.7270/Q2H135RP
					More data for this Ligand-Target Pair
Sentrin-specific protease 2 (Homo sapiens (Human))	BDBM50421692 (CHEMBL5287963) Show SMILES COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OCCCN1C(=O)c2ccccc2C1=O Show InChI InChI=1S/C24H25N5O5/c1-32-18-11-14(10-15-13-27-24(26)28-21(15)25)12-19(33-2)20(18)34-9-5-8-29-22(30)16-6-3-4-7-17(16)23(29)31/h3-4,6-7,11-13H,5,8-10H2,1-2H3,(H4,25,26,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars		n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sentrin-specific protease 2 (Homo sapiens (Human))	BDBM103827 (SPI-02 | US11041859, Code SPI-02 | US9791447, Comp...) Show SMILES Cc1cc(ccc1\N=N\c1c(N)ccc2cc(ccc12)S(O)(=O)=O)-c1ccc(\N=N\c2c(N)c(cc3cc(ccc23)S(O)(=O)=O)S(O)(=O)=O)c(C)c1 Show InChI InChI=1S/C34H28N6O9S3/c1-18-13-20(4-11-29(18)37-39-33-26-8-6-24(50(41,42)43)15-22(26)3-10-28(33)35)21-5-12-30(19(2)14-21)38-40-34-27-9-7-25(51(44,45)46)16-23(27)17-31(32(34)36)52(47,48)49/h3-17H,35-36H2,1-2H3,(H,41,42,43)(H,44,45,46)(H,47,48,49)/b39-37+,40-38+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	7.4	n/a
Beckman Research Institute of the City of Hope					Assay Description Assays were performedby incubating SENPs with various concentrations of the inhibitor (0−60 μM) at RT for 10 min in assay buffer (50 mM Tr...				ACS Chem Biol 8: 1435-41 (2013) Article DOI: 10.1021/cb400177q BindingDB Entry DOI: 10.7270/Q2KH0KZN
					More data for this Ligand-Target Pair
Sentrin-specific protease 2 (Homo sapiens (Human))	BDBM50164846 (CHEMBL3799152) Show SMILES O=C(Nc1cccc(CNC(=O)c2cccc(c2)-c2ccccc2)c1)\C=C\c1ccccc1 Show InChI InChI=1S/C29H24N2O2/c32-28(18-17-22-9-3-1-4-10-22)31-27-16-7-11-23(19-27)21-30-29(33)26-15-8-14-25(20-26)24-12-5-2-6-13-24/h1-20H,21H2,(H,30,33)(H,31,32)/b18-17+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Shanghai Jiao Tong University Curated by ChEMBL					Assay Description Inhibition of human recombinant His-tagged SENP2 (363 to 589 residues) expressed in Escherichia coli BL21 (DE3) using RanGAP-SUMO as substrate incuba...				Bioorg Med Chem Lett 26: 2124-8 (2016) Article DOI: 10.1016/j.bmcl.2016.03.080 BindingDB Entry DOI: 10.7270/Q2BR8V2K
					More data for this Ligand-Target Pair
Sentrin-specific protease 2 (Homo sapiens (Human))	BDBM50164846 (CHEMBL3799152) Show SMILES O=C(Nc1cccc(CNC(=O)c2cccc(c2)-c2ccccc2)c1)\C=C\c1ccccc1 Show InChI InChI=1S/C29H24N2O2/c32-28(18-17-22-9-3-1-4-10-22)31-27-16-7-11-23(19-27)21-30-29(33)26-15-8-14-25(20-26)24-12-5-2-6-13-24/h1-20H,21H2,(H,30,33)(H,31,32)/b18-17+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Shanghai Jiao Tong University Curated by ChEMBL					Assay Description Inhibition of human recombinant His-tagged SENP2 (363 to 589 residues) expressed in Escherichia coli BL21 (DE3) using RanGAP-SUMO as substrate incuba...				Bioorg Med Chem Lett 26: 2124-8 (2016) Article DOI: 10.1016/j.bmcl.2016.03.080 BindingDB Entry DOI: 10.7270/Q2BR8V2K
					More data for this Ligand-Target Pair
Sentrin-specific protease 2 (Homo sapiens (Human))	BDBM103826 (SPI-01 | US11041859, Code SPI-01 | US9791447, Comp...) Show SMILES Nc1ccc2ccccc2c1\N=N\c1ccc(\C=C\c2ccc(cc2S(O)(=O)=O)\N=N\c2c(N)ccc3ccccc23)c(c1)S(O)(=O)=O Show InChI InChI=1S/C34H26N6O6S2/c35-29-17-13-21-5-1-3-7-27(21)33(29)39-37-25-15-11-23(31(19-25)47(41,42)43)9-10-24-12-16-26(20-32(24)48(44,45)46)38-40-34-28-8-4-2-6-22(28)14-18-30(34)36/h1-20H,35-36H2,(H,41,42,43)(H,44,45,46)/b10-9+,39-37+,40-38+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
City of Hope US Patent					Assay Description The binding of SPI-01 to the enzyme-substrate complex was investigated. CSP analysis was carried out on the 40 kDa complex of 15N-labeled full length...				US Patent US9791447 (2017) BindingDB Entry DOI: 10.7270/Q2J67K27
					More data for this Ligand-Target Pair
Sentrin-specific protease 2 (Homo sapiens (Human))	BDBM103826 (SPI-01 | US11041859, Code SPI-01 | US9791447, Comp...) Show SMILES Nc1ccc2ccccc2c1\N=N\c1ccc(\C=C\c2ccc(cc2S(O)(=O)=O)\N=N\c2c(N)ccc3ccccc23)c(c1)S(O)(=O)=O Show InChI InChI=1S/C34H26N6O6S2/c35-29-17-13-21-5-1-3-7-27(21)33(29)39-37-25-15-11-23(31(19-25)47(41,42)43)9-10-24-12-16-26(20-32(24)48(44,45)46)38-40-34-28-8-4-2-6-22(28)14-18-30(34)36/h1-20H,35-36H2,(H,41,42,43)(H,44,45,46)/b10-9+,39-37+,40-38+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...				Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JKM
					More data for this Ligand-Target Pair
Sentrin-specific protease 2 (Homo sapiens (Human))	BDBM103826 (SPI-01 | US11041859, Code SPI-01 | US9791447, Comp...) Show SMILES Nc1ccc2ccccc2c1\N=N\c1ccc(\C=C\c2ccc(cc2S(O)(=O)=O)\N=N\c2c(N)ccc3ccccc23)c(c1)S(O)(=O)=O Show InChI InChI=1S/C34H26N6O6S2/c35-29-17-13-21-5-1-3-7-27(21)33(29)39-37-25-15-11-23(31(19-25)47(41,42)43)9-10-24-12-16-26(20-32(24)48(44,45)46)38-40-34-28-8-4-2-6-22(28)14-18-30(34)36/h1-20H,35-36H2,(H,41,42,43)(H,44,45,46)/b10-9+,39-37+,40-38+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars		n/a	n/a	2.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sentrin-specific protease 2 (Homo sapiens (Human))	BDBM103828 (SPI-03 | US11041859, Code SPI-03) Show SMILES Cc1cc(ccc1-c1ccc(cc1C)\N=N\c1cc(c2ccccc2c1N)S(O)(=O)=O)\N=N\c1cc(c2ccccc2c1N)S(O)(=O)=O Show InChI InChI=1S/C34H28N6O6S2/c1-19-15-21(37-39-29-17-31(47(41,42)43)25-7-3-5-9-27(25)33(29)35)11-13-23(19)24-14-12-22(16-20(24)2)38-40-30-18-32(48(44,45)46)26-8-4-6-10-28(26)34(30)36/h3-18H,35-36H2,1-2H3,(H,41,42,43)(H,44,45,46)/b39-37+,40-38+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	7.4	n/a
Beckman Research Institute of the City of Hope					Assay Description Assays were performedby incubating SENPs with various concentrations of the inhibitor (0−60 μM) at RT for 10 min in assay buffer (50 mM Tr...				ACS Chem Biol 8: 1435-41 (2013) Article DOI: 10.1021/cb400177q BindingDB Entry DOI: 10.7270/Q2KH0KZN
					More data for this Ligand-Target Pair
Sentrin-specific protease 2/Small ubiquitin-related modifier 1 (Homo sapiens (Human))	BDBM103827 (SPI-02 | US11041859, Code SPI-02 | US9791447, Comp...) Show SMILES Cc1cc(ccc1\N=N\c1c(N)ccc2cc(ccc12)S(O)(=O)=O)-c1ccc(\N=N\c2c(N)c(cc3cc(ccc23)S(O)(=O)=O)S(O)(=O)=O)c(C)c1 Show InChI InChI=1S/C34H28N6O9S3/c1-18-13-20(4-11-29(18)37-39-33-26-8-6-24(50(41,42)43)15-22(26)3-10-28(33)35)21-5-12-30(19(2)14-21)38-40-34-27-9-7-25(51(44,45)46)16-23(27)17-31(32(34)36)52(47,48)49/h3-17H,35-36H2,1-2H3,(H,41,42,43)(H,44,45,46)(H,47,48,49)/b39-37+,40-38+	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.42E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...				Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JKM
					More data for this Ligand-Target Pair
Sentrin-specific protease 2 (Homo sapiens (Human))	BDBM103827 (SPI-02 | US11041859, Code SPI-02 | US9791447, Comp...) Show SMILES Cc1cc(ccc1\N=N\c1c(N)ccc2cc(ccc12)S(O)(=O)=O)-c1ccc(\N=N\c2c(N)c(cc3cc(ccc23)S(O)(=O)=O)S(O)(=O)=O)c(C)c1 Show InChI InChI=1S/C34H28N6O9S3/c1-18-13-20(4-11-29(18)37-39-33-26-8-6-24(50(41,42)43)15-22(26)3-10-28(33)35)21-5-12-30(19(2)14-21)38-40-34-27-9-7-25(51(44,45)46)16-23(27)17-31(32(34)36)52(47,48)49/h3-17H,35-36H2,1-2H3,(H,41,42,43)(H,44,45,46)(H,47,48,49)/b39-37+,40-38+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.42E+3	n/a	n/a	n/a	n/a	7.4	n/a
Beckman Research Institute of the City of Hope					Assay Description Assays were performedby incubating SENPs with various concentrations of the inhibitor (0−60 μM) at RT for 10 min in assay buffer (50 mM Tr...				ACS Chem Biol 8: 1435-41 (2013) Article DOI: 10.1021/cb400177q BindingDB Entry DOI: 10.7270/Q2KH0KZN
					More data for this Ligand-Target Pair
Sentrin-specific protease 2 (Homo sapiens (Human))	BDBM50565352 (CHEMBL4791044) Show SMILES [O-][N+](=O)c1cccc(COc2c(sc3ccccc23)C(=O)NCc2cccc(NC(=O)c3ccccc3)c2)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human SNEP2 (365 to 589 residues) expressed in Escherichia coli (DE3) cells using RanGAP-SUMO2 substrate preincubated for 1...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112553 BindingDB Entry DOI: 10.7270/Q2H135RP
					More data for this Ligand-Target Pair
Sentrin-specific protease 2 (Homo sapiens (Human))	BDBM50565397 (CHEMBL4796293) Show SMILES C=CC(=O)Nc1ccc2sc(C(=O)NCc3cccc(NC(=O)c4cccs4)c3)c(OCc3ccccc3)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human SNEP2 (365 to 589 residues) expressed in Escherichia coli (DE3) cells using RanGAP-SUMO2 substrate preincubated for 1...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112553 BindingDB Entry DOI: 10.7270/Q2H135RP
					More data for this Ligand-Target Pair
Sentrin-specific protease 2/Small ubiquitin-related modifier 1 (Homo sapiens (Human))	BDBM348888 (NSC70551 | US11041859, Code SPI-06 | US9791447, Co...) Show SMILES Cc1ccccc1\N=N\c1cc(c2ccccc2c1N)S([O-])(=O)=O Show InChI InChI=1S/C17H15N3O3S/c1-11-6-2-5-9-14(11)19-20-15-10-16(24(21,22)23)12-7-3-4-8-13(12)17(15)18/h2-10H,18H2,1H3,(H,21,22,23)/p-1/b20-19+	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.62E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...				Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JKM
					More data for this Ligand-Target Pair
Sentrin-specific protease 2 (Homo sapiens (Human))	BDBM103831 (SPI-06) Show SMILES Cc1ccccc1\N=N\c1cc(c2ccccc2c1N)S(O)(=O)=O Show InChI InChI=1S/C17H15N3O3S/c1-11-6-2-5-9-14(11)19-20-15-10-16(24(21,22)23)12-7-3-4-8-13(12)17(15)18/h2-10H,18H2,1H3,(H,21,22,23)/b20-19+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.62E+3	n/a	n/a	n/a	n/a	7.4	n/a
Beckman Research Institute of the City of Hope					Assay Description Assays were performedby incubating SENPs with various concentrations of the inhibitor (0−60 μM) at RT for 10 min in assay buffer (50 mM Tr...				ACS Chem Biol 8: 1435-41 (2013) Article DOI: 10.1021/cb400177q BindingDB Entry DOI: 10.7270/Q2KH0KZN
					More data for this Ligand-Target Pair
Sentrin-specific protease 2 (Homo sapiens (Human))	BDBM81511 (VEA-260) Show SMILES OC(=O)c1cccc(c1)C(=O)NCc1ccc(cc1)C(=O)NNC(=O)[C@H]1O[C@@H]1C(=O)N(Cc1cccc2ccccc12)Cc1cccc2ccccc12 |r| Show InChI InChI=1S/C42H34N4O7/c47-38(30-12-7-13-31(22-30)42(51)52)43-23-26-18-20-29(21-19-26)39(48)44-45-40(49)36-37(53-36)41(50)46(24-32-14-5-10-27-8-1-3-16-34(27)32)25-33-15-6-11-28-9-2-4-17-35(28)33/h1-22,36-37H,23-25H2,(H,43,47)(H,44,48)(H,45,49)(H,51,52)/t36-,37-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	8.0	37
Stanford University					Assay Description The fluorogenic substrate library screen was performed with hSENP1 in low salt tris buffer at final concentration of 2uM. Fluorophore release (AFC) ...				Chem Biol 18: 722-32 (2011) Article DOI: 10.1016/j.chembiol.2011.05.008 BindingDB Entry DOI: 10.7270/Q2542M2N
					More data for this Ligand-Target Pair
Sentrin-specific protease 2 (Homo sapiens (Human))	BDBM348888 (NSC70551 | US11041859, Code SPI-06 | US9791447, Co...) Show SMILES Cc1ccccc1\N=N\c1cc(c2ccccc2c1N)S([O-])(=O)=O Show InChI InChI=1S/C17H15N3O3S/c1-11-6-2-5-9-14(11)19-20-15-10-16(24(21,22)23)12-7-3-4-8-13(12)17(15)18/h2-10H,18H2,1H3,(H,21,22,23)/p-1/b20-19+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
City of Hope US Patent					Assay Description The binding of SPI-01 to the enzyme-substrate complex was investigated. CSP analysis was carried out on the 40 kDa complex of 15N-labeled full length...				US Patent US9791447 (2017) BindingDB Entry DOI: 10.7270/Q2J67K27
					More data for this Ligand-Target Pair
Sentrin-specific protease 2 (Homo sapiens (Human))	BDBM348888 (NSC70551 | US11041859, Code SPI-06 | US9791447, Co...) Show SMILES Cc1ccccc1\N=N\c1cc(c2ccccc2c1N)S([O-])(=O)=O Show InChI InChI=1S/C17H15N3O3S/c1-11-6-2-5-9-14(11)19-20-15-10-16(24(21,22)23)12-7-3-4-8-13(12)17(15)18/h2-10H,18H2,1H3,(H,21,22,23)/p-1/b20-19+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...				Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JKM
					More data for this Ligand-Target Pair
Sentrin-specific protease 2 (Homo sapiens (Human))	BDBM50591764 (CHEMBL5207368) Show SMILES OC(=O)c1cccc(c1)C(=O)NCc1ccc(cc1)C(=O)NNC(=O)[C@H]1O[C@@H]1C(=O)C(Cc1cccc2ccccc12)Cc1cccc2ccccc12 |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2022.114227 BindingDB Entry DOI: 10.7270/Q2T43Z3H
					More data for this Ligand-Target Pair
Sentrin-specific protease 2 (Homo sapiens (Human))	BDBM50591766 (CHEMBL5188918) Show SMILES Cc1cc(OCC(=O)Nc2nonc2NC(=O)COc2ccc(Cl)c(C)c2)ccc1Cl Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2022.114227 BindingDB Entry DOI: 10.7270/Q2T43Z3H
					More data for this Ligand-Target Pair
Sentrin-specific protease 2 (Homo sapiens (Human))	BDBM103831 (SPI-06) Show SMILES Cc1ccccc1\N=N\c1cc(c2ccccc2c1N)S(O)(=O)=O Show InChI InChI=1S/C17H15N3O3S/c1-11-6-2-5-9-14(11)19-20-15-10-16(24(21,22)23)12-7-3-4-8-13(12)17(15)18/h2-10H,18H2,1H3,(H,21,22,23)/b20-19+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars		n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair

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