Found 21 hits Enz. Inhib. hit(s) with Target = 'Transcription factor ETV6' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Transcription factor ETV6/Tyrosine-protein kinase receptor UFO
(Homo sapiens (Human)) | BDBM50531864
(CHEMBL4524568)Show SMILES CCc1nc(C(N)=O)c(Nc2ccc3CCN(CCc3c2)C2CCCC2)nc1NC1CCOCC1 Show InChI InChI=1S/C27H38N6O2/c1-2-23-26(29-20-11-15-35-16-12-20)32-27(24(31-23)25(28)34)30-21-8-7-18-9-13-33(14-10-19(18)17-21)22-5-3-4-6-22/h7-8,17,20,22H,2-6,9-16H2,1H3,(H2,28,34)(H2,29,30,32) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai University
Curated by ChEMBL
| Assay Description
Inhibition of TEL/AXL (unknown origin) expressed in mouse BA/F3 cells assessed as growth inhibition after 72 hrs by SRB assay |
Bioorg Med Chem Lett 29: 836-838 (2019)
Article DOI: 10.1016/j.bmcl.2019.01.018
BindingDB Entry DOI: 10.7270/Q25B05Z7 |
More data for this
Ligand-Target Pair | |
Transcription factor ETV6/Tyrosine-protein kinase receptor UFO
(Homo sapiens (Human)) | BDBM50531860
(CHEMBL4581972)Show SMILES CCc1nc(C(N)=O)c(Nc2ccc3CCN(CCc3c2)C2CC2)nc1NC1CCOCC1 Show InChI InChI=1S/C25H34N6O2/c1-2-21-24(27-18-9-13-33-14-10-18)30-25(22(29-21)23(26)32)28-19-4-3-16-7-11-31(20-5-6-20)12-8-17(16)15-19/h3-4,15,18,20H,2,5-14H2,1H3,(H2,26,32)(H2,27,28,30) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai University
Curated by ChEMBL
| Assay Description
Inhibition of TEL/AXL (unknown origin) expressed in mouse BA/F3 cells assessed as growth inhibition after 72 hrs by SRB assay |
Bioorg Med Chem Lett 29: 836-838 (2019)
Article DOI: 10.1016/j.bmcl.2019.01.018
BindingDB Entry DOI: 10.7270/Q25B05Z7 |
More data for this
Ligand-Target Pair | |
Transcription factor ETV6/Tyrosine-protein kinase receptor UFO
(Homo sapiens (Human)) | BDBM50531858
(CHEMBL4576727)Show SMILES CCc1nc(C(N)=O)c(Nc2ccc3CCC(CCc3c2)N2CCCC2)nc1NC1CCOCC1 Show InChI InChI=1S/C27H38N6O2/c1-2-23-26(29-20-11-15-35-16-12-20)32-27(24(31-23)25(28)34)30-21-8-5-18-6-9-22(10-7-19(18)17-21)33-13-3-4-14-33/h5,8,17,20,22H,2-4,6-7,9-16H2,1H3,(H2,28,34)(H2,29,30,32) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai University
Curated by ChEMBL
| Assay Description
Inhibition of TEL/AXL (unknown origin) expressed in mouse BA/F3 cells assessed as growth inhibition after 72 hrs by SRB assay |
Bioorg Med Chem Lett 29: 836-838 (2019)
Article DOI: 10.1016/j.bmcl.2019.01.018
BindingDB Entry DOI: 10.7270/Q25B05Z7 |
More data for this
Ligand-Target Pair | |
Transcription factor ETV6/Tyrosine-protein kinase receptor UFO
(Homo sapiens (Human)) | BDBM144315
(Gilteritinib | US11512074, Example T-9 | US8969336...)Show SMILES CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(CC3)N3CCN(C)CC3)c(OC)c2)nc1NC1CCOCC1 Show InChI InChI=1S/C29H44N8O3/c1-4-23-28(31-20-9-17-40-18-10-20)34-29(26(33-23)27(30)38)32-21-5-6-24(25(19-21)39-3)37-11-7-22(8-12-37)36-15-13-35(2)14-16-36/h5-6,19-20,22H,4,7-18H2,1-3H3,(H2,30,38)(H2,31,32,34) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai University
Curated by ChEMBL
| Assay Description
Inhibition of TEL/AXL (unknown origin) expressed in mouse BA/F3 cells assessed as growth inhibition after 72 hrs by SRB assay |
Bioorg Med Chem Lett 29: 836-838 (2019)
Article DOI: 10.1016/j.bmcl.2019.01.018
BindingDB Entry DOI: 10.7270/Q25B05Z7 |
More data for this
Ligand-Target Pair | |
Transcription factor ETV6/Tyrosine-protein kinase receptor UFO
(Homo sapiens (Human)) | BDBM50531865
(CHEMBL4516515)Show SMILES CCC1CCC(C1)N1CCc2ccc(Nc3nc(NC4CCOCC4)c(CC)nc3C(N)=O)cc2CC1 Show InChI InChI=1S/C29H42N6O2/c1-3-19-5-8-24(17-19)35-13-9-20-6-7-23(18-21(20)10-14-35)32-29-26(27(30)36)33-25(4-2)28(34-29)31-22-11-15-37-16-12-22/h6-7,18-19,22,24H,3-5,8-17H2,1-2H3,(H2,30,36)(H2,31,32,34) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 9.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai University
Curated by ChEMBL
| Assay Description
Inhibition of TEL/AXL (unknown origin) expressed in mouse BA/F3 cells assessed as growth inhibition after 72 hrs by SRB assay |
Bioorg Med Chem Lett 29: 836-838 (2019)
Article DOI: 10.1016/j.bmcl.2019.01.018
BindingDB Entry DOI: 10.7270/Q25B05Z7 |
More data for this
Ligand-Target Pair | |
Transcription factor ETV6/Tyrosine-protein kinase receptor UFO
(Homo sapiens (Human)) | BDBM50531862
(CHEMBL4529955)Show SMILES CCc1nc(C(N)=O)c(Nc2ccc3CCN(CCc3c2)C(=O)C2(N)CC2)nc1NC1CCOCC1 Show InChI InChI=1S/C26H35N7O3/c1-2-20-23(29-18-7-13-36-14-8-18)32-24(21(31-20)22(27)34)30-19-4-3-16-5-11-33(12-6-17(16)15-19)25(35)26(28)9-10-26/h3-4,15,18H,2,5-14,28H2,1H3,(H2,27,34)(H2,29,30,32) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 103 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai University
Curated by ChEMBL
| Assay Description
Inhibition of TEL/AXL (unknown origin) expressed in mouse BA/F3 cells assessed as growth inhibition after 72 hrs by SRB assay |
Bioorg Med Chem Lett 29: 836-838 (2019)
Article DOI: 10.1016/j.bmcl.2019.01.018
BindingDB Entry DOI: 10.7270/Q25B05Z7 |
More data for this
Ligand-Target Pair | |
Transcription factor ETV6/Tyrosine-protein kinase receptor UFO
(Homo sapiens (Human)) | BDBM50531859
(CHEMBL4475960)Show SMILES CCc1nc(C(N)=O)c(Nc2ccc3OCC4CN(CCN4C(=O)c3c2)C(C)C)nc1NC1CCOCC1 Show InChI InChI=1S/C27H37N7O4/c1-4-21-25(29-17-7-11-37-12-8-17)32-26(23(31-21)24(28)35)30-18-5-6-22-20(13-18)27(36)34-10-9-33(16(2)3)14-19(34)15-38-22/h5-6,13,16-17,19H,4,7-12,14-15H2,1-3H3,(H2,28,35)(H2,29,30,32) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >200 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai University
Curated by ChEMBL
| Assay Description
Inhibition of TEL/AXL (unknown origin) expressed in mouse BA/F3 cells assessed as growth inhibition after 72 hrs by SRB assay |
Bioorg Med Chem Lett 29: 836-838 (2019)
Article DOI: 10.1016/j.bmcl.2019.01.018
BindingDB Entry DOI: 10.7270/Q25B05Z7 |
More data for this
Ligand-Target Pair | |
Transcription factor ETV6/Tyrosine-protein kinase receptor UFO
(Homo sapiens (Human)) | BDBM50531863
(CHEMBL4592943)Show SMILES CCc1nc(C(N)=O)c(Nc2ccc3OCC4CN(C)CCN4C(=O)c3c2)nc1NC1CCOCC1 Show InChI InChI=1S/C25H33N7O4/c1-3-19-23(27-15-6-10-35-11-7-15)30-24(21(29-19)22(26)33)28-16-4-5-20-18(12-16)25(34)32-9-8-31(2)13-17(32)14-36-20/h4-5,12,15,17H,3,6-11,13-14H2,1-2H3,(H2,26,33)(H2,27,28,30) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >200 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai University
Curated by ChEMBL
| Assay Description
Inhibition of TEL/AXL (unknown origin) expressed in mouse BA/F3 cells assessed as growth inhibition after 72 hrs by SRB assay |
Bioorg Med Chem Lett 29: 836-838 (2019)
Article DOI: 10.1016/j.bmcl.2019.01.018
BindingDB Entry DOI: 10.7270/Q25B05Z7 |
More data for this
Ligand-Target Pair | |
Transcription factor ETV6/Tyrosine-protein kinase receptor UFO
(Homo sapiens (Human)) | BDBM50531866
(CHEMBL4578043)Show SMILES CCc1nc(C(N)=O)c(Nc2ccc3CCC(CCc3c2)N2CC3CNCC3C2)nc1NC1CCOCC1 Show InChI InChI=1S/C29H41N7O2/c1-2-25-28(32-22-9-11-38-12-10-22)35-29(26(34-25)27(30)37)33-23-6-3-18-4-7-24(8-5-19(18)13-23)36-16-20-14-31-15-21(20)17-36/h3,6,13,20-22,24,31H,2,4-5,7-12,14-17H2,1H3,(H2,30,37)(H2,32,33,35) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >200 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai University
Curated by ChEMBL
| Assay Description
Inhibition of TEL/AXL (unknown origin) expressed in mouse BA/F3 cells assessed as growth inhibition after 72 hrs by SRB assay |
Bioorg Med Chem Lett 29: 836-838 (2019)
Article DOI: 10.1016/j.bmcl.2019.01.018
BindingDB Entry DOI: 10.7270/Q25B05Z7 |
More data for this
Ligand-Target Pair | |
Transcription factor ETV6/Tyrosine-protein kinase receptor UFO
(Homo sapiens (Human)) | BDBM50531861
(CHEMBL4519811)Show SMILES CCc1nc(C(N)=O)c(Nc2ccc3CCN(CCc3c2)C2CCN(C)CC2)nc1NC1CCOCC1 Show InChI InChI=1S/C28H41N7O2/c1-3-24-27(30-21-10-16-37-17-11-21)33-28(25(32-24)26(29)36)31-22-5-4-19-6-14-35(15-7-20(19)18-22)23-8-12-34(2)13-9-23/h4-5,18,21,23H,3,6-17H2,1-2H3,(H2,29,36)(H2,30,31,33) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 214 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai University
Curated by ChEMBL
| Assay Description
Inhibition of TEL/AXL (unknown origin) expressed in mouse BA/F3 cells assessed as growth inhibition after 72 hrs by SRB assay |
Bioorg Med Chem Lett 29: 836-838 (2019)
Article DOI: 10.1016/j.bmcl.2019.01.018
BindingDB Entry DOI: 10.7270/Q25B05Z7 |
More data for this
Ligand-Target Pair | |
Transcription factor ETV6/Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50538516
(CHEMBL4643578)Show SMILES COC(=O)N1CCN(CC1)C(=O)c1ccc(cc1)-c1cnn2c(N)c(c(NC3CC(C)(C)N(C)C(C)(C)C3)nc12)-c1ccccc1 Show InChI InChI=1S/C35H44N8O3/c1-34(2)20-26(21-35(3,4)40(34)5)38-30-28(24-10-8-7-9-11-24)29(36)43-31(39-30)27(22-37-43)23-12-14-25(15-13-23)32(44)41-16-18-42(19-17-41)33(45)46-6/h7-15,22,26H,16-21,36H2,1-6H3,(H,38,39) | PDB
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 890 | n/a | n/a | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation
Curated by ChEMBL
| Assay Description
Inhibition of TEL/KDR (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-luc... |
ACS Med Chem Lett 11: 558-565 (2020)
Article DOI: 10.1021/acsmedchemlett.0c00015
BindingDB Entry DOI: 10.7270/Q29S1VJ7 |
More data for this
Ligand-Target Pair | |
Transcription factor ETV6/Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50538514
(CHEMBL4644274)Show SMILES COc1ccc(cc1OC)-c1cnn2c(N)c(c(NC3CC(C)(C)N(C)C(C)(C)C3)nc12)-c1ccccc1 Show InChI InChI=1S/C30H38N6O2/c1-29(2)16-21(17-30(3,4)35(29)5)33-27-25(19-11-9-8-10-12-19)26(31)36-28(34-27)22(18-32-36)20-13-14-23(37-6)24(15-20)38-7/h8-15,18,21H,16-17,31H2,1-7H3,(H,33,34) | PDB
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 990 | n/a | n/a | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation
Curated by ChEMBL
| Assay Description
Inhibition of TEL/KDR (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-luc... |
ACS Med Chem Lett 11: 558-565 (2020)
Article DOI: 10.1021/acsmedchemlett.0c00015
BindingDB Entry DOI: 10.7270/Q29S1VJ7 |
More data for this
Ligand-Target Pair | |
Transcription factor ETV6/Tyrosine-protein kinase receptor UFO
(Homo sapiens (Human)) | BDBM50531867
(CHEMBL4462288)Show SMILES CCc1nc(C(N)=O)c(Nc2ccc3OCC4CNCCN4C(=O)c3c2)nc1NC1CCOCC1 Show InChI InChI=1S/C24H31N7O4/c1-2-18-22(27-14-5-9-34-10-6-14)30-23(20(29-18)21(25)32)28-15-3-4-19-17(11-15)24(33)31-8-7-26-12-16(31)13-35-19/h3-4,11,14,16,26H,2,5-10,12-13H2,1H3,(H2,25,32)(H2,27,28,30) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai University
Curated by ChEMBL
| Assay Description
Inhibition of TEL/AXL (unknown origin) expressed in mouse BA/F3 cells assessed as growth inhibition after 72 hrs by SRB assay |
Bioorg Med Chem Lett 29: 836-838 (2019)
Article DOI: 10.1016/j.bmcl.2019.01.018
BindingDB Entry DOI: 10.7270/Q25B05Z7 |
More data for this
Ligand-Target Pair | |
Transcription factor ETV6/Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50538517
(CHEMBL4639022)Show SMILES CN1C(C)(C)CC(CC1(C)C)Nc1nc2c(cnn2c(N)c1-c1ccccc1)-c1ccc(cc1)C(=O)N1CCN(CC1)S(C)(=O)=O Show InChI InChI=1S/C34H44N8O3S/c1-33(2)20-26(21-34(3,4)39(33)5)37-30-28(24-10-8-7-9-11-24)29(35)42-31(38-30)27(22-36-42)23-12-14-25(15-13-23)32(43)40-16-18-41(19-17-40)46(6,44)45/h7-15,22,26H,16-21,35H2,1-6H3,(H,37,38) | PDB
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation
Curated by ChEMBL
| Assay Description
Inhibition of TEL/KDR (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-luc... |
ACS Med Chem Lett 11: 558-565 (2020)
Article DOI: 10.1021/acsmedchemlett.0c00015
BindingDB Entry DOI: 10.7270/Q29S1VJ7 |
More data for this
Ligand-Target Pair | |
Transcription factor ETV6/Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50538515
(CHEMBL4636056)Show SMILES [H][C@]12CN(C(=O)c3ccc(cc3)-c3cnn4c(N)c(c(NC5CC(C)(C)N(C)C(C)(C)C5)nc34)-c3ccccc3)[C@]([H])(CO1)C2 |r| Show InChI InChI=1S/C34H41N7O2/c1-33(2)16-24(17-34(3,4)39(33)5)37-30-28(22-9-7-6-8-10-22)29(35)41-31(38-30)27(18-36-41)21-11-13-23(14-12-21)32(42)40-19-26-15-25(40)20-43-26/h6-14,18,24-26H,15-17,19-20,35H2,1-5H3,(H,37,38)/t25-,26-/m0/s1 | PDB
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation
Curated by ChEMBL
| Assay Description
Inhibition of TEL/KDR (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-luc... |
ACS Med Chem Lett 11: 558-565 (2020)
Article DOI: 10.1021/acsmedchemlett.0c00015
BindingDB Entry DOI: 10.7270/Q29S1VJ7 |
More data for this
Ligand-Target Pair | |
Transcription factor ETV6/Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50538507
(CHEMBL4640601)Show SMILES COc1ccc(cc1OC)-c1cnn2c(N)c(-c3ccccc3)c(OC3CCN(C)CC3)nc12 Show InChI InChI=1S/C26H29N5O3/c1-30-13-11-19(12-14-30)34-26-23(17-7-5-4-6-8-17)24(27)31-25(29-26)20(16-28-31)18-9-10-21(32-2)22(15-18)33-3/h4-10,15-16,19H,11-14,27H2,1-3H3 | PDB
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation
Curated by ChEMBL
| Assay Description
Inhibition of TEL/KDR (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-luc... |
ACS Med Chem Lett 11: 558-565 (2020)
Article DOI: 10.1021/acsmedchemlett.0c00015
BindingDB Entry DOI: 10.7270/Q29S1VJ7 |
More data for this
Ligand-Target Pair | |
Transcription factor ETV6/Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50538511
(CHEMBL4642409)Show SMILES COc1ccc(cc1OC)-c1cnn2c(N)c(-c3ccccc3)c(OCCCN(C)C)nc12 Show InChI InChI=1S/C25H29N5O3/c1-29(2)13-8-14-33-25-22(17-9-6-5-7-10-17)23(26)30-24(28-25)19(16-27-30)18-11-12-20(31-3)21(15-18)32-4/h5-7,9-12,15-16H,8,13-14,26H2,1-4H3 | PDB
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation
Curated by ChEMBL
| Assay Description
Inhibition of TEL/KDR (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-luc... |
ACS Med Chem Lett 11: 558-565 (2020)
Article DOI: 10.1021/acsmedchemlett.0c00015
BindingDB Entry DOI: 10.7270/Q29S1VJ7 |
More data for this
Ligand-Target Pair | |
Transcription factor ETV6/Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50538512
(CHEMBL4638840)Show SMILES COc1ccc(cc1OC)-c1cnn2c(N)c(c(NC3CCN(C)CC3)nc12)-c1ccccc1 Show InChI InChI=1S/C26H30N6O2/c1-31-13-11-19(12-14-31)29-25-23(17-7-5-4-6-8-17)24(27)32-26(30-25)20(16-28-32)18-9-10-21(33-2)22(15-18)34-3/h4-10,15-16,19H,11-14,27H2,1-3H3,(H,29,30) | PDB
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
| Article
PubMed
| n/a | n/a | 3.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation
Curated by ChEMBL
| Assay Description
Inhibition of TEL/KDR (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-luc... |
ACS Med Chem Lett 11: 558-565 (2020)
Article DOI: 10.1021/acsmedchemlett.0c00015
BindingDB Entry DOI: 10.7270/Q29S1VJ7 |
More data for this
Ligand-Target Pair | |
Transcription factor ETV6
(Homo sapiens (Human)) | BDBM50436850
(CERITINIB | CHEMBL2403108 | LDK378 | US10053458, C...)Show SMILES CC(C)Oc1cc(C2CCNCC2)c(C)cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 Show InChI InChI=1S/C28H36ClN5O3S/c1-17(2)37-25-15-21(20-10-12-30-13-11-20)19(5)14-24(25)33-28-31-16-22(29)27(34-28)32-23-8-6-7-9-26(23)38(35,36)18(3)4/h6-9,14-18,20,30H,10-13H2,1-5H3,(H2,31,32,33,34) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation
Curated by ChEMBL
| Assay Description
Inhibition of wild-type TEL (unknown origin) by cell-based assay |
J Med Chem 56: 5675-90 (2014)
Article DOI: 10.1021/jm400402q
BindingDB Entry DOI: 10.7270/Q2G1627J |
More data for this
Ligand-Target Pair | |
Transcription factor ETV6/Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50538510
(CHEMBL4640989)Show SMILES COc1ccc(cc1OC)-c1cnn2c(N)c(-c3ccccc3)c(OC3CCNCC3)nc12 Show InChI InChI=1S/C25H27N5O3/c1-31-20-9-8-17(14-21(20)32-2)19-15-28-30-23(26)22(16-6-4-3-5-7-16)25(29-24(19)30)33-18-10-12-27-13-11-18/h3-9,14-15,18,27H,10-13,26H2,1-2H3 | PDB
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation
Curated by ChEMBL
| Assay Description
Inhibition of TEL/KDR (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-luc... |
ACS Med Chem Lett 11: 558-565 (2020)
Article DOI: 10.1021/acsmedchemlett.0c00015
BindingDB Entry DOI: 10.7270/Q29S1VJ7 |
More data for this
Ligand-Target Pair | |
Transcription factor ETV6/Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50538513
(CHEMBL4636800)Show SMILES COc1ccc(cc1OC)-c1cnn2c(N)c(c(NCCCN(C)C)nc12)-c1ccccc1 Show InChI InChI=1S/C25H30N6O2/c1-30(2)14-8-13-27-24-22(17-9-6-5-7-10-17)23(26)31-25(29-24)19(16-28-31)18-11-12-20(32-3)21(15-18)33-4/h5-7,9-12,15-16H,8,13-14,26H2,1-4H3,(H,27,29) | PDB
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >7.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Genomics Institute of the Novartis Research Foundation
Curated by ChEMBL
| Assay Description
Inhibition of TEL/KDR (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-luc... |
ACS Med Chem Lett 11: 558-565 (2020)
Article DOI: 10.1021/acsmedchemlett.0c00015
BindingDB Entry DOI: 10.7270/Q29S1VJ7 |
More data for this
Ligand-Target Pair | |
Search and Browse
