Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Genome polyprotein [1393-1439,E1407V]/[1476-1660,R1508K,A1566M] (Dengue virus 1(Hawaii)) | BDBM33251 (phthalazine-based compound, 2) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Novartis Institute for Tropical Diseases | Assay Description Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min.... | Anal Biochem 395: 195-204 (2009) Article DOI: 10.1016/j.ab.2009.08.013 BindingDB Entry DOI: 10.7270/Q2VM49MW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein [1393-1439,E1407V]/[1476-1660,R1508K,A1566M] (Dengue virus 1(Hawaii)) | BDBM33256 (phthalazine-based compound, 7) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.72E+3 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Novartis Institute for Tropical Diseases | Assay Description Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min.... | Anal Biochem 395: 195-204 (2009) Article DOI: 10.1016/j.ab.2009.08.013 BindingDB Entry DOI: 10.7270/Q2VM49MW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein [1393-1439,E1407V]/[1476-1660,R1508K,A1566M] (Dengue virus 1(Hawaii)) | BDBM33252 (phthalazine-based compound, 3) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.07E+4 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Novartis Institute for Tropical Diseases | Assay Description Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min.... | Anal Biochem 395: 195-204 (2009) Article DOI: 10.1016/j.ab.2009.08.013 BindingDB Entry DOI: 10.7270/Q2VM49MW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein [1393-1439,E1407V]/[1476-1660,R1508K,A1566M] (Dengue virus 1(Hawaii)) | BDBM33259 (Bz-NKRR-H | Bz-Nle-Lys-Arg-Arg-H | CHEMBL256877) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.18E+4 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Novartis Institute for Tropical Diseases | Assay Description Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min.... | Anal Biochem 395: 195-204 (2009) Article DOI: 10.1016/j.ab.2009.08.013 BindingDB Entry DOI: 10.7270/Q2VM49MW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein [1393-1439,E1407V]/[1476-1660,R1508K,A1566M] (Dengue virus 1(Hawaii)) | BDBM33254 (phthalazine-based compound, 5) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.23E+4 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Novartis Institute for Tropical Diseases | Assay Description Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min.... | Anal Biochem 395: 195-204 (2009) Article DOI: 10.1016/j.ab.2009.08.013 BindingDB Entry DOI: 10.7270/Q2VM49MW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein [1393-1439,E1407V]/[1476-1660,R1508K,A1566M] (Dengue virus 1(Hawaii)) | BDBM33257 (phthalazine-based compound, 8) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.14E+4 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Novartis Institute for Tropical Diseases | Assay Description Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min.... | Anal Biochem 395: 195-204 (2009) Article DOI: 10.1016/j.ab.2009.08.013 BindingDB Entry DOI: 10.7270/Q2VM49MW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein [1393-1439,E1407V]/[1476-1660,R1508K,A1566M] (Dengue virus 1(Hawaii)) | BDBM33250 (phthalazine-based compound, 1) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.64E+4 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Novartis Institute for Tropical Diseases | Assay Description Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min.... | Anal Biochem 395: 195-204 (2009) Article DOI: 10.1016/j.ab.2009.08.013 BindingDB Entry DOI: 10.7270/Q2VM49MW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein [1393-1439,E1407V]/[1476-1660,R1508K,A1566M] (Dengue virus 1(Hawaii)) | BDBM33258 (phthalazine-based compound, 9) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Novartis Institute for Tropical Diseases | Assay Description Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min.... | Anal Biochem 395: 195-204 (2009) Article DOI: 10.1016/j.ab.2009.08.013 BindingDB Entry DOI: 10.7270/Q2VM49MW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein [1393-1439,E1407V]/[1476-1660,R1508K,A1566M] (Dengue virus 1(Hawaii)) | BDBM33255 (phthalazine-based compound, 6) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.70E+5 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Novartis Institute for Tropical Diseases | Assay Description Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min.... | Anal Biochem 395: 195-204 (2009) Article DOI: 10.1016/j.ab.2009.08.013 BindingDB Entry DOI: 10.7270/Q2VM49MW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein [1393-1439,E1407V]/[1476-1660,R1508K,A1566M] (Dengue virus 1(Hawaii)) | BDBM33253 (phthalazine-based compound, 4) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.33E+5 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Novartis Institute for Tropical Diseases | Assay Description Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min.... | Anal Biochem 395: 195-204 (2009) Article DOI: 10.1016/j.ab.2009.08.013 BindingDB Entry DOI: 10.7270/Q2VM49MW | |||||||||||
More data for this Ligand-Target Pair |