Found 259 hits Enz. Inhib. hit(s) with Target = 'Dual specificity mitogen-activated protein kinase kinase 4' AND taxid = 9606 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM2579
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r| Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of Mitogen activated protein kinase kinase 4 |
J Med Chem 45: 3772-93 (2002)
BindingDB Entry DOI: 10.7270/Q2WW7JD9 |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM50567689
(CHEMBL4790247)Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2n[nH]c3ncc(cc23)-c2ccc(cc2)S(=O)(=O)NC(C)=O)c1F | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of MKK4 (unknown origin) by PanQinase assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113371 BindingDB Entry DOI: 10.7270/Q2ZG6X0K |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM50559798
(CHEMBL4758063 | US11370770, Compound 6ff) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2HX1GWD |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM50559798
(CHEMBL4758063 | US11370770, Compound 6ff) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of MEK4 (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmcl.2020.127203 BindingDB Entry DOI: 10.7270/Q2028W77 |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM558862
(US11370770, Compound 6n)Show SMILES OC(=O)c1ccc(cc1)-c1n[nH]c2ccc(cc12)C(F)(F)F | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2HX1GWD |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM50577661
(CHEMBL4879048) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 61 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant full length N-terminal GST tagged MEK4 expressed in Sf21 cells using p38 alpha as substrate pre-incubated for 30 mins... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00376 BindingDB Entry DOI: 10.7270/Q20C50MC |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM558880
(US11370770, Compound 6ee) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2HX1GWD |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM50559798
(CHEMBL4758063 | US11370770, Compound 6ff) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 66 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2HX1GWD |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM50577689
(CHEMBL4866649)Show SMILES NC(=O)c1ccc(NS(=O)(=O)c2cccc(c2)-c2n[nH]c3cc(F)ccc23)cc1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 83 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant full length N-terminal GST tagged MEK4 expressed in Sf21 cells using p38 alpha as substrate pre-incubated for 30 mins... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00376 BindingDB Entry DOI: 10.7270/Q20C50MC |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM50567688
(CHEMBL4784779)Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2n[nH]c3ncc(cc23)-c2ccc(cc2)S(N)(=O)=O)c1F | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 89 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of MKK4 (unknown origin) by PanQinase assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113371 BindingDB Entry DOI: 10.7270/Q2ZG6X0K |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM50577657
(CHEMBL4848865) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 96 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant full length N-terminal GST tagged MEK4 expressed in Sf21 cells using p38 alpha as substrate pre-incubated for 30 mins... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00376 BindingDB Entry DOI: 10.7270/Q20C50MC |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM558875
(US11370770, Compound 6z)Show SMILES OC(=O)c1ccc(cc1)-c1n[nH]c2cc(ccc12)C(F)(F)F | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2HX1GWD |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM50559798
(CHEMBL4758063 | US11370770, Compound 6ff) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2HX1GWD |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM558864
(US11370770, Compound 6p) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2HX1GWD |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM558878
(US11370770, Compound 6cc) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2HX1GWD |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM558862
(US11370770, Compound 6n)Show SMILES OC(=O)c1ccc(cc1)-c1n[nH]c2ccc(cc12)C(F)(F)F | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2HX1GWD |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM50585046
(CHEMBL5086263)Show SMILES CN1Cc2nn(C)c(C#N)c2-c2cnc3[nH]c(F)c(-c4cn(CCCC1=O)nc4C(F)(F)F)c3c2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 132 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of MEK4 (unknown origin) at 1 uM by kinome scan method |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00630 BindingDB Entry DOI: 10.7270/Q2183BDB |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM50567686
(CHEMBL4798975)Show SMILES NS(=O)(=O)c1ccc(cc1)-c1cnc2[nH]nc(C(=O)c3c(F)ccc(NS(=O)(=O)Cc4ccccc4)c3F)c2c1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 146 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of MKK4 (unknown origin) by PanQinase assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113371 BindingDB Entry DOI: 10.7270/Q2ZG6X0K |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM558867
(US11370770, Compound 6s) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2HX1GWD |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM50585045
(CHEMBL5093741)Show SMILES CN1Cc2nn(C)c(C#N)c2-c2cnc3[nH]cc(-c4cn(CCCC1=O)nc4C(F)(F)F)c3c2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 173 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of MEK4 (unknown origin) at 1 uM by kinome scan method |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00630 BindingDB Entry DOI: 10.7270/Q2183BDB |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM558848
(US11370770, Compound 6a) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2HX1GWD |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM558867
(US11370770, Compound 6s) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2HX1GWD |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM50559799
(CHEMBL4748767) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of MEK4 (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmcl.2020.127203 BindingDB Entry DOI: 10.7270/Q2028W77 |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM558866
(US11370770, Compound 6r) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2HX1GWD |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM558865
(US11370770, Compound 6q) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2HX1GWD |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM558867
(US11370770, Compound 6s) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2HX1GWD |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM558858
(US11370770, Compound 6j) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 240 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2HX1GWD |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM558858
(US11370770, Compound 6j) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2HX1GWD |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM558880
(US11370770, Compound 6ee) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 260 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2HX1GWD |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM50607924
(CHEMBL5278864) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | 281 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM50577686
(CHEMBL4865159)Show SMILES CS(=O)(=O)c1ccc(NS(=O)(=O)c2cccc(c2)-c2n[nH]c3cc(F)ccc23)cc1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 290 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant full length N-terminal GST tagged MEK4 expressed in Sf21 cells using p38 alpha as substrate pre-incubated for 30 mins... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00376 BindingDB Entry DOI: 10.7270/Q20C50MC |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM50577647
(CHEMBL4849172) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 310 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant full length N-terminal GST tagged MEK4 expressed in Sf21 cells using p38 alpha as substrate pre-incubated for 30 mins... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00376 BindingDB Entry DOI: 10.7270/Q20C50MC |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM50577671
(CHEMBL4872723)Show SMILES Fc1ccc2c(n[nH]c2c1)-c1cccc(c1)S(=O)(=O)Nc1ccccc1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 310 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant full length N-terminal GST tagged MEK4 expressed in Sf21 cells using p38 alpha as substrate pre-incubated for 30 mins... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00376 BindingDB Entry DOI: 10.7270/Q20C50MC |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM558875
(US11370770, Compound 6z)Show SMILES OC(=O)c1ccc(cc1)-c1n[nH]c2cc(ccc12)C(F)(F)F | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 360 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2HX1GWD |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM50577673
(CHEMBL4858450)Show SMILES Fc1ccc2c(n[nH]c2c1)-c1cccc(c1)S(=O)(=O)NC1CC1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant full length N-terminal GST tagged MEK4 expressed in Sf21 cells using p38 alpha as substrate pre-incubated for 30 mins... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00376 BindingDB Entry DOI: 10.7270/Q20C50MC |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM50577682
(CHEMBL4846360)Show SMILES COc1ccc(NS(=O)(=O)c2cccc(c2)-c2n[nH]c3cc(F)ccc23)cc1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 390 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant full length N-terminal GST tagged MEK4 expressed in Sf21 cells using p38 alpha as substrate pre-incubated for 30 mins... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00376 BindingDB Entry DOI: 10.7270/Q20C50MC |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM558863
(US11370770, Compound 6o) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 390 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2HX1GWD |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM19459
(5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one...)Show InChI InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-13-6-10(17)5-12(18)14(13)15(11)19/h1-7,16-18H | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human MEK4 (14 to 377 residues) after 5 mins by Western blot analysis |
Citation and Details
Article DOI: 10.1016/j.bmcl.2020.127203 BindingDB Entry DOI: 10.7270/Q2028W77 |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM558864
(US11370770, Compound 6p) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2HX1GWD |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM558865
(US11370770, Compound 6q) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2HX1GWD |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM50577680
(CHEMBL4874017)Show SMILES COc1ccccc1NS(=O)(=O)c1cccc(c1)-c1n[nH]c2cc(F)ccc12 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant full length N-terminal GST tagged MEK4 expressed in Sf21 cells using p38 alpha as substrate pre-incubated for 30 mins... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00376 BindingDB Entry DOI: 10.7270/Q20C50MC |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM558879
(US11370770, Compound 6dd) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2HX1GWD |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM50577674
(CHEMBL4871499)Show SMILES Fc1ccc2c(n[nH]c2c1)-c1cccc(c1)S(=O)(=O)Nc1cccnc1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 450 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant full length N-terminal GST tagged MEK4 expressed in Sf21 cells using p38 alpha as substrate pre-incubated for 30 mins... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00376 BindingDB Entry DOI: 10.7270/Q20C50MC |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM558848
(US11370770, Compound 6a) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 460 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2HX1GWD |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM558876
(US11370770, Compound 6aa) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 460 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2HX1GWD |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM50577685
(CHEMBL4854291)Show SMILES Fc1ccc2c(n[nH]c2c1)-c1cccc(c1)S(=O)(=O)Nc1ccc(cc1)C#N | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 470 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant full length N-terminal GST tagged MEK4 expressed in Sf21 cells using p38 alpha as substrate pre-incubated for 30 mins... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00376 BindingDB Entry DOI: 10.7270/Q20C50MC |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM558862
(US11370770, Compound 6n)Show SMILES OC(=O)c1ccc(cc1)-c1n[nH]c2ccc(cc12)C(F)(F)F | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 470 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2HX1GWD |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM50577659
(CHEMBL4860404) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 480 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant full length N-terminal GST tagged MEK4 expressed in Sf21 cells using p38 alpha as substrate pre-incubated for 30 mins... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00376 BindingDB Entry DOI: 10.7270/Q20C50MC |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM558866
(US11370770, Compound 6r) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 510 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2HX1GWD |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 4
(Homo sapiens (Human)) | BDBM558864
(US11370770, Compound 6p) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 560 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2HX1GWD |
More data for this Ligand-Target Pair | |