Found 11 hits Enz. Inhib. hit(s) with Target = 'Protein kinase C gamma type' AND taxid = 10116 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Protein kinase C gamma type
(Rattus norvegicus) | BDBM50064089
(4-hydroxymethyl-7,10-diisopropyl-8,10,13-trimethyl...)Show SMILES CC(C)[C@@H]1N(C)c2cc3c(c4[nH]cc(C[C@@H](CO)NC1=O)c24)[C@](C)(CC[C@]3(C)C(C)C)C=C |r| Show InChI InChI=1S/C28H41N3O2/c1-9-27(6)10-11-28(7,17(4)5)20-13-21-22-18(14-29-24(22)23(20)27)12-19(15-32)30-26(33)25(16(2)3)31(21)8/h9,13-14,16-17,19,25,29,32H,1,10-12,15H2,2-8H3,(H,30,33)/t19-,25-,27-,28+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]- PDBu binding to peptide C, rat brain PKC gamma |
Bioorg Med Chem Lett 6: 353-356 (1996)
Article DOI: 10.1016/0960-894X(96)00026-1 BindingDB Entry DOI: 10.7270/Q2NG4QMM |
More data for this Ligand-Target Pair | |
Protein kinase C gamma type
(Rattus norvegicus) | BDBM50057512
((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)Show SMILES CCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@@]3(O)CC(CO)=C[C@H]2[C@@H]2C(C)(C)[C@]12OC(=O)CCC |c:23,t:12| Show InChI InChI=1S/C28H40O8/c1-7-9-20(30)35-24-16(4)27(34)18(22-25(5,6)28(22,24)36-21(31)10-8-2)12-17(14-29)13-26(33)19(27)11-15(3)23(26)32/h11-12,16,18-19,22,24,29,33-34H,7-10,13-14H2,1-6H3/t16-,18+,19-,22?,24-,26-,27-,28-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| Article
| 53 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]- PDBu binding to peptide C, rat brain PKC gamma |
Bioorg Med Chem Lett 6: 353-356 (1996)
Article DOI: 10.1016/0960-894X(96)00026-1 BindingDB Entry DOI: 10.7270/Q2NG4QMM |
More data for this Ligand-Target Pair | |
Protein kinase C gamma type
(Rattus norvegicus) | BDBM50280454
((10S,13S)-13-Hydroxymethyl-10-isopropyl-9-methyl-3...)Show SMILES CC(C)[C@@H]1N(C)c2cccc3NCC(C[C@@H](CO)NC1=O)c23 Show InChI InChI=1S/C17H25N3O2/c1-10(2)16-17(22)19-12(9-21)7-11-8-18-13-5-4-6-14(15(11)13)20(16)3/h4-6,10-12,16,18,21H,7-9H2,1-3H3,(H,19,22)/t11?,12-,16-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article
| 1.03E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]- PDBu binding to peptide C, rat brain PKC gamma |
Bioorg Med Chem Lett 6: 353-356 (1996)
Article DOI: 10.1016/0960-894X(96)00026-1 BindingDB Entry DOI: 10.7270/Q2NG4QMM |
More data for this Ligand-Target Pair | |
Protein kinase C gamma type
(Rattus norvegicus) | BDBM50015677
((S)-1-hydroxymethyl-2-octanoyloxy-ethyl ester | 1,...)Show InChI InChI=1S/C19H36O5/c1-3-5-7-9-11-13-18(21)23-16-17(15-20)24-19(22)14-12-10-8-6-4-2/h17,20H,3-16H2,1-2H3/t17-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
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CHEMBL KEGG PC cid PC sid UniChem
Patents
Similars
| Article
| 2.93E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]- PDBu binding to peptide C, rat brain PKC gamma |
Bioorg Med Chem Lett 6: 353-356 (1996)
Article DOI: 10.1016/0960-894X(96)00026-1 BindingDB Entry DOI: 10.7270/Q2NG4QMM |
More data for this Ligand-Target Pair | |
Protein kinase C gamma type
(Rattus norvegicus) | BDBM50282632
(3-((3aR,10aR)-2-Methyl-2,3,3a,4,10,10a-hexahydro-1...)Show SMILES CN1C[C@@H]2Cc3c(C4=C(C(=O)NC4=O)c4cn(C)c5ccccc45)c4ccccc4n3C[C@H]2C1 |r,t:7| Show InChI InChI=1S/C28H26N4O2/c1-30-12-16-11-23-24(19-8-4-6-10-22(19)32(23)14-17(16)13-30)26-25(27(33)29-28(26)34)20-15-31(2)21-9-5-3-7-18(20)21/h3-10,15-17H,11-14H2,1-2H3,(H,29,33,34)/t16-,17+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 5.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Protein kinase C gamma (PKC) |
Bioorg Med Chem Lett 4: 1303-1308 (1994)
Article DOI: 10.1016/S0960-894X(01)80349-8 BindingDB Entry DOI: 10.7270/Q27H1JJ4 |
More data for this Ligand-Target Pair | |
Protein kinase C gamma type
(Rattus norvegicus) | BDBM50282633
((S)-3-(8-((dimethylamino)methyl)-6,7,8,9-tetrahydr...)Show SMILES CN(C)C[C@H]1CCn2c(C1)c(C1=C(C(=O)NC1=O)c1cn(C)c3ccccc13)c1ccccc21 |t:12| Show InChI InChI=1S/C28H28N4O2/c1-30(2)15-17-12-13-32-22-11-7-5-9-19(22)24(23(32)14-17)26-25(27(33)29-28(26)34)20-16-31(3)21-10-6-4-8-18(20)21/h4-11,16-17H,12-15H2,1-3H3,(H,29,33,34)/t17-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article
| n/a | n/a | 36.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Protein kinase C gamma (PKC) |
Bioorg Med Chem Lett 4: 1303-1308 (1994)
Article DOI: 10.1016/S0960-894X(01)80349-8 BindingDB Entry DOI: 10.7270/Q27H1JJ4 |
More data for this Ligand-Target Pair | |
Protein kinase C gamma type
(Rattus norvegicus) | BDBM50213062
(CHEMBL342866)Show SMILES [H][C@@]1(C)Cc2ccc3[nH]cc4C[C@@H](CO)NC(=O)[C@H](C(C)C)N1c2c34 Show InChI InChI=1S/C19H25N3O2/c1-10(2)17-19(24)21-14(9-23)7-13-8-20-15-5-4-12-6-11(3)22(17)18(12)16(13)15/h4-5,8,10-11,14,17,20,23H,6-7,9H2,1-3H3,(H,21,24)/t11-,14+,17+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| | n/a | n/a | 1.26E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of [3H]phorbol-12,13-dibutyrate (PDBu) binding to rat brain protein kinase C gamma regulatory domain |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GM89G6 |
More data for this Ligand-Target Pair | |
Protein kinase C gamma type
(Rattus norvegicus) | BDBM50057511
((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...)Show SMILES CC(C)[C@@H]1N(C)c2cccc3[nH]cc(C[C@@H](CO)NC1=O)c23 Show InChI InChI=1S/C17H23N3O2/c1-10(2)16-17(22)19-12(9-21)7-11-8-18-13-5-4-6-14(15(11)13)20(16)3/h4-6,8,10,12,16,18,21H,7,9H2,1-3H3,(H,19,22)/t12-,16-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| | n/a | n/a | 2.75E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of [3H]phorbol-12,13-dibutyrate (PDBu) binding to rat brain protein kinase C gamma regulatory domain |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GM89G6 |
More data for this Ligand-Target Pair | |
Protein kinase C gamma type
(Rattus norvegicus) | BDBM50213063
(CHEMBL342131)Show SMILES CC(C)[C@H]1C(=O)N[C@H](CO)Cc2c[nH]c3ccc4cc(C)n1c4c23 Show InChI InChI=1S/C19H23N3O2/c1-10(2)17-19(24)21-14(9-23)7-13-8-20-15-5-4-12-6-11(3)22(17)18(12)16(13)15/h4-6,8,10,14,17,20,23H,7,9H2,1-3H3,(H,21,24)/t14-,17-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of [3H]phorbol-12,13-dibutyrate (PDBu) binding to rat brain protein kinase C gamma regulatory domain |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GM89G6 |
More data for this Ligand-Target Pair | |
Protein kinase C gamma type
(Rattus norvegicus) | BDBM50213064
(CHEMBL342147)Show SMILES [H][C@]1(C)Cc2ccc3[nH]cc4C[C@@H](CO)NC(=O)[C@H](C(C)C)N1c2c34 Show InChI InChI=1S/C19H25N3O2/c1-10(2)17-19(24)21-14(9-23)7-13-8-20-15-5-4-12-6-11(3)22(17)18(12)16(13)15/h4-5,8,10-11,14,17,20,23H,6-7,9H2,1-3H3,(H,21,24)/t11-,14-,17-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| | n/a | n/a | 2.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of [3H]phorbol-12,13-dibutyrate (PDBu) binding to rat brain protein kinase C gamma regulatory domain |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GM89G6 |
More data for this Ligand-Target Pair | |
Protein kinase C gamma type
(Rattus norvegicus) | BDBM50213040
(CHEMBL141695)Show SMILES CC(C)[C@@H]1N(C)c2c(C)ccc3[nH]cc(C[C@@H](CO)NC1=O)c23 Show InChI InChI=1S/C18H25N3O2/c1-10(2)16-18(23)20-13(9-22)7-12-8-19-14-6-5-11(3)17(15(12)14)21(16)4/h5-6,8,10,13,16,19,22H,7,9H2,1-4H3,(H,20,23)/t13-,16-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of [3H]phorbol-12,13-dibutyrate (PDBu) binding to rat brain protein kinase C gamma regulatory domain |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GM89G6 |
More data for this Ligand-Target Pair | |