Compile Data Set for Download or QSAR

Found 298 hits Enz. Inhib. hit(s) with Target = 'Glycogen synthase kinase-3 beta' AND taxid = 9913   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glycogen synthase kinase-3 beta (Bos taurus (cattle))	BDBM155160 (US9006232, 1.106) Show SMILES COc1cccc(c1)N1CCCC(C1)Oc1nc(cc(=O)n1C)-c1ccncn1 Show InChI InChI=1S/C21H23N5O3/c1-25-20(27)12-19(18-8-9-22-14-23-18)24-21(25)29-17-7-4-10-26(13-17)15-5-3-6-16(11-15)28-2/h3,5-6,8-9,11-12,14,17H,4,7,10,13H2,1-2H3	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	6.5	25
Mitsubishi Tanabe Pharma Corporation US Patent					Assay Description A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...				US Patent US9006232 (2015) BindingDB Entry DOI: 10.7270/Q25T3J7B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta/[Tau protein] kinase (Sus scrofa)	BDBM50012188 (6BIO) Show SMILES O\N=C1\C(\Nc2ccccc\12)=C1\C(=O)Nc2cc(Br)ccc12 Show InChI InChI=1S/C16H10BrN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,18,22H,(H,19,21)/b15-13-,20-14+	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2021.113652 BindingDB Entry DOI: 10.7270/Q27H1PN4
					More data for this Ligand-Target Pair				3D Structure (crystal)
Glycogen synthase kinase-3 beta (Bos taurus (cattle))	BDBM155169 (US9006232, 1.203) Show SMILES CN1CCN(Cc2ccc(cc2)N2CCC(CC2)Oc2nc(cc(=O)n2C)-c2ccncn2)CC1 Show InChI InChI=1S/C26H33N7O2/c1-30-13-15-32(16-14-30)18-20-3-5-21(6-4-20)33-11-8-22(9-12-33)35-26-29-24(17-25(34)31(26)2)23-7-10-27-19-28-23/h3-7,10,17,19,22H,8-9,11-16,18H2,1-2H3	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.40	n/a	n/a	n/a	n/a	6.5	25
Mitsubishi Tanabe Pharma Corporation US Patent					Assay Description A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...				US Patent US9006232 (2015) BindingDB Entry DOI: 10.7270/Q25T3J7B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta/[Tau protein] kinase (Sus scrofa)	BDBM50523276 (CHEMBL4443989) Show SMILES [H][C@]12CCCCN1C(=O)c1cccc(NC(=O)Nc3cc(ccn3)-c3cn(CCNc4c5CCCCc5nc5ccccc45)nn3)c21 |r| Show InChI InChI=1S/C35H35N9O2/c45-34-25-10-7-13-28(32(25)30-14-5-6-18-44(30)34)39-35(46)40-31-20-22(15-16-36-31)29-21-43(42-41-29)19-17-37-33-23-8-1-3-11-26(23)38-27-12-4-2-9-24(27)33/h1,3,7-8,10-11,13,15-16,20-21,30H,2,4-6,9,12,14,17-19H2,(H,37,38)(H2,36,39,40,46)/t30-/m1/s1	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
CNRS Curated by ChEMBL					Assay Description Inhibition of native porcine brain GSK-3alpha/beta using GS-1 as substrate incubated for 30 mins in presence of [gamma-33P]ATP by liquid scintillatio...				Eur J Med Chem 168: 58-77 (2019) Article DOI: 10.1016/j.ejmech.2018.12.063 BindingDB Entry DOI: 10.7270/Q2J969S0
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Bos taurus (cattle))	BDBM155226 (US9006232, 1.903) Show SMILES CN1CCN(Cc2ccc(cc2)[C@H]2CC[C@@H](CC2)Oc2nc(cc(=O)n2C)-c2ccncn2)CC1 |r,wU:12.12,wD:15.19,(-10,-.77,;-8.67,,;-8.67,1.54,;-7.34,2.31,;-6,1.54,;-4.67,2.31,;-3.33,1.54,;-2,2.31,;-.67,1.54,;-.67,,;-2,-.77,;-3.33,,;.67,-.77,;2,,;3.33,-.77,;3.33,-2.31,;2,-3.08,;.67,-2.31,;4.67,-3.08,;6,-2.31,;6,-.77,;7.34,,;8.67,-.77,;8.67,-2.31,;10,-3.08,;7.34,-3.08,;7.34,-4.62,;7.34,1.54,;6,2.31,;6,3.85,;7.34,4.62,;8.67,3.85,;8.67,2.31,;-6,,;-7.34,-.77,)| Show InChI InChI=1S/C27H34N6O2/c1-31-13-15-33(16-14-31)18-20-3-5-21(6-4-20)22-7-9-23(10-8-22)35-27-30-25(17-26(34)32(27)2)24-11-12-28-19-29-24/h3-6,11-12,17,19,22-23H,7-10,13-16,18H2,1-2H3/t22-,23-	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.80	n/a	n/a	n/a	n/a	6.5	25
Mitsubishi Tanabe Pharma Corporation US Patent					Assay Description A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...				US Patent US9006232 (2015) BindingDB Entry DOI: 10.7270/Q25T3J7B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta/[Tau protein] kinase (Sus scrofa)	BDBM50523265 (CHEMBL4531222) Show SMILES O=C(Nc1cc(COCc2cn(CCCc3ccccc3)nn2)ccn1)Nc1cccc2C(=O)N3CCCCC3c12 Show InChI InChI=1S/C31H33N7O3/c39-30-25-11-6-12-26(29(25)27-13-4-5-17-38(27)30)33-31(40)34-28-18-23(14-15-32-28)20-41-21-24-19-37(36-35-24)16-7-10-22-8-2-1-3-9-22/h1-3,6,8-9,11-12,14-15,18-19,27H,4-5,7,10,13,16-17,20-21H2,(H2,32,33,34,40)	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
CNRS Curated by ChEMBL					Assay Description Inhibition of native porcine brain GSK-3alpha/beta using GS-1 as substrate incubated for 30 mins in presence of [gamma-33P]ATP by liquid scintillatio...				Eur J Med Chem 168: 58-77 (2019) Article DOI: 10.1016/j.ejmech.2018.12.063 BindingDB Entry DOI: 10.7270/Q2J969S0
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Bos taurus (cattle))	BDBM155185 (US9006232, 1.219) Show SMILES Cn1c(OC2CCN(CC2)c2ccc(CN3Cc4ccccc4C3)cc2)nc(cc1=O)-c1ccncn1 Show InChI InChI=1S/C29H30N6O2/c1-33-28(36)16-27(26-10-13-30-20-31-26)32-29(33)37-25-11-14-35(15-12-25)24-8-6-21(7-9-24)17-34-18-22-4-2-3-5-23(22)19-34/h2-10,13,16,20,25H,11-12,14-15,17-19H2,1H3	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.40	n/a	n/a	n/a	n/a	6.5	25
Mitsubishi Tanabe Pharma Corporation US Patent					Assay Description A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...				US Patent US9006232 (2015) BindingDB Entry DOI: 10.7270/Q25T3J7B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Bos taurus (cattle))	BDBM155158 (US9006232, 1.104) Show SMILES Cn1c(OC2CCCN(C2)c2cccc(F)c2)nc(cc1=O)-c1ccncn1 Show InChI InChI=1S/C20H20FN5O2/c1-25-19(27)11-18(17-7-8-22-13-23-17)24-20(25)28-16-6-3-9-26(12-16)15-5-2-4-14(21)10-15/h2,4-5,7-8,10-11,13,16H,3,6,9,12H2,1H3	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.90	n/a	n/a	n/a	n/a	6.5	25
Mitsubishi Tanabe Pharma Corporation US Patent					Assay Description A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...				US Patent US9006232 (2015) BindingDB Entry DOI: 10.7270/Q25T3J7B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Bos taurus (cattle))	BDBM155155 (US9006232, 1.101) Show SMILES Cn1c(OC2CCCN(C2)c2ccccc2)nc(cc1=O)-c1ccncn1 Show InChI InChI=1S/C20H21N5O2/c1-24-19(26)12-18(17-9-10-21-14-22-17)23-20(24)27-16-8-5-11-25(13-16)15-6-3-2-4-7-15/h2-4,6-7,9-10,12,14,16H,5,8,11,13H2,1H3	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9.40	n/a	n/a	n/a	n/a	6.5	25
Mitsubishi Tanabe Pharma Corporation US Patent					Assay Description A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...				US Patent US9006232 (2015) BindingDB Entry DOI: 10.7270/Q25T3J7B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Bos taurus (cattle))	BDBM155191 (US9006232, 1.225) Show SMILES Cn1c(OC2CCN(CC2)c2ccc3CNCc3c2)nc(cc1=O)-c1ccncn1 Show InChI InChI=1S/C22H24N6O2/c1-27-21(29)11-20(19-4-7-23-14-25-19)26-22(27)30-18-5-8-28(9-6-18)17-3-2-15-12-24-13-16(15)10-17/h2-4,7,10-11,14,18,24H,5-6,8-9,12-13H2,1H3	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9.40	n/a	n/a	n/a	n/a	6.5	25
Mitsubishi Tanabe Pharma Corporation US Patent					Assay Description A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...				US Patent US9006232 (2015) BindingDB Entry DOI: 10.7270/Q25T3J7B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Bos taurus (cattle))	BDBM38219 (US9006232, 1.223) Show SMILES Cn1c(OC2CCN(CC2)c2cccc(CN3CCCCC3)c2)nc(cc1=O)-c1ccncn1 Show InChI InChI=1S/C20H17F6N3OS/c1-18(6-7-31-17(27)29-18)13-8-14(20(24,25)26)10-15(9-13)28-16(30)11-2-4-12(5-3-11)19(21,22)23/h2-5,8-10H,6-7H2,1H3,(H2,27,29)(H,28,30)	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9.40	n/a	n/a	n/a	n/a	6.5	25
Mitsubishi Tanabe Pharma Corporation US Patent					Assay Description A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...				US Patent US9006232 (2015) BindingDB Entry DOI: 10.7270/Q25T3J7B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta/[Tau protein] kinase (Sus scrofa)	BDBM50523277 (CHEMBL4516356) Show SMILES O=C(Nc1cc(COCc2cn(CCNc3c4CCCCc4nc4ccccc34)nn2)ccn1)Nc1cccc2C(=O)N3CCCCC3c12 Show InChI InChI=1S/C37H39N9O3/c47-36-28-10-7-13-31(34(28)32-14-5-6-18-46(32)36)41-37(48)42-33-20-24(15-16-38-33)22-49-23-25-21-45(44-43-25)19-17-39-35-26-8-1-3-11-29(26)40-30-12-4-2-9-27(30)35/h1,3,7-8,10-11,13,15-16,20-21,32H,2,4-6,9,12,14,17-19,22-23H2,(H,39,40)(H2,38,41,42,48)	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
CNRS Curated by ChEMBL					Assay Description Inhibition of native porcine brain GSK-3alpha/beta using GS-1 as substrate incubated for 30 mins in presence of [gamma-33P]ATP by liquid scintillatio...				Eur J Med Chem 168: 58-77 (2019) Article DOI: 10.1016/j.ejmech.2018.12.063 BindingDB Entry DOI: 10.7270/Q2J969S0
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta/[Tau protein] kinase (Sus scrofa)	BDBM50523269 (CHEMBL4446287) Show SMILES CN(Cc1cn(CCNc2c3CCCCc3nc3ccccc23)nn1)Cc1ccnc(NC(=O)Nc2cccc3C(=O)N4CCCCC4c23)c1 Show InChI InChI=1S/C38H42N10O2/c1-46(23-26-24-47(45-44-26)20-18-40-36-27-9-2-4-12-30(27)41-31-13-5-3-10-28(31)36)22-25-16-17-39-34(21-25)43-38(50)42-32-14-8-11-29-35(32)33-15-6-7-19-48(33)37(29)49/h2,4,8-9,11-12,14,16-17,21,24,33H,3,5-7,10,13,15,18-20,22-23H2,1H3,(H,40,41)(H2,39,42,43,50)	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
CNRS Curated by ChEMBL					Assay Description Inhibition of native porcine brain GSK-3alpha/beta using GS-1 as substrate incubated for 30 mins in presence of [gamma-33P]ATP by liquid scintillatio...				Eur J Med Chem 168: 58-77 (2019) Article DOI: 10.1016/j.ejmech.2018.12.063 BindingDB Entry DOI: 10.7270/Q2J969S0
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Bos taurus (cattle))	BDBM155174 (US9006232, 1.208) Show SMILES Cn1c(OC2CCN(CC2)c2ccc(cc2)N2CCNCC2)nc(cc1=O)-c1ccncn1 Show InChI InChI=1S/C24H29N7O2/c1-29-23(32)16-22(21-6-9-26-17-27-21)28-24(29)33-20-7-12-30(13-8-20)18-2-4-19(5-3-18)31-14-10-25-11-15-31/h2-6,9,16-17,20,25H,7-8,10-15H2,1H3	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10.7	n/a	n/a	n/a	n/a	6.5	25
Mitsubishi Tanabe Pharma Corporation US Patent					Assay Description A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...				US Patent US9006232 (2015) BindingDB Entry DOI: 10.7270/Q25T3J7B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Bos taurus (cattle))	BDBM155182 (US9006232, 1.216) Show SMILES Cn1c(OC2CCN(CC2)c2ccc(CN3CCCCC3)cc2)nc(cc1=O)-c1ccncc1F Show InChI InChI=1S/C27H32FN5O2/c1-31-26(34)17-25(23-9-12-29-18-24(23)28)30-27(31)35-22-10-15-33(16-11-22)21-7-5-20(6-8-21)19-32-13-3-2-4-14-32/h5-9,12,17-18,22H,2-4,10-11,13-16,19H2,1H3	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10.9	n/a	n/a	n/a	n/a	6.5	25
Mitsubishi Tanabe Pharma Corporation US Patent					Assay Description A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...				US Patent US9006232 (2015) BindingDB Entry DOI: 10.7270/Q25T3J7B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta/[Tau protein] kinase (Sus scrofa)	BDBM50523266 (CHEMBL4444585) Show SMILES CN(CC#C)Cc1ccnc(NC(=O)Nc2cccc3C(=O)N4CCCCC4c23)c1 Show InChI InChI=1S/C23H25N5O2/c1-3-12-27(2)15-16-10-11-24-20(14-16)26-23(30)25-18-8-6-7-17-21(18)19-9-4-5-13-28(19)22(17)29/h1,6-8,10-11,14,19H,4-5,9,12-13,15H2,2H3,(H2,24,25,26,30)	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
CNRS Curated by ChEMBL					Assay Description Inhibition of native porcine brain GSK-3alpha/beta using GS-1 as substrate incubated for 30 mins in presence of [gamma-33P]ATP by liquid scintillatio...				Eur J Med Chem 168: 58-77 (2019) Article DOI: 10.1016/j.ejmech.2018.12.063 BindingDB Entry DOI: 10.7270/Q2J969S0
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Bos taurus (cattle))	BDBM155162 (US9006232, 1.108) Show SMILES Cn1c(OC2CCCN(C2)c2ccccn2)nc(cc1=O)-c1ccncn1 Show InChI InChI=1S/C19H20N6O2/c1-24-18(26)11-16(15-7-9-20-13-22-15)23-19(24)27-14-5-4-10-25(12-14)17-6-2-3-8-21-17/h2-3,6-9,11,13-14H,4-5,10,12H2,1H3	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11.7	n/a	n/a	n/a	n/a	6.5	25
Mitsubishi Tanabe Pharma Corporation US Patent					Assay Description A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...				US Patent US9006232 (2015) BindingDB Entry DOI: 10.7270/Q25T3J7B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Bos taurus (cattle))	BDBM155183 (US9006232, 1.217) Show SMILES Cn1c(OC2CCN(CC2)c2ccc(CN3CCCC3)cc2)nc(cc1=O)-c1ccncn1 Show InChI InChI=1S/C25H30N6O2/c1-29-24(32)16-23(22-8-11-26-18-27-22)28-25(29)33-21-9-14-31(15-10-21)20-6-4-19(5-7-20)17-30-12-2-3-13-30/h4-8,11,16,18,21H,2-3,9-10,12-15,17H2,1H3	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	6.5	25
Mitsubishi Tanabe Pharma Corporation US Patent					Assay Description A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...				US Patent US9006232 (2015) BindingDB Entry DOI: 10.7270/Q25T3J7B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Bos taurus (cattle))	BDBM155197 (US9006232, 1.231) Show SMILES Cn1c(OC2CCN(C2)c2ccc(CN3CCCCC3)cc2)nc(cc1=O)-c1ccncn1 Show InChI InChI=1S/C25H30N6O2/c1-29-24(32)15-23(22-9-11-26-18-27-22)28-25(29)33-21-10-14-31(17-21)20-7-5-19(6-8-20)16-30-12-3-2-4-13-30/h5-9,11,15,18,21H,2-4,10,12-14,16-17H2,1H3	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12.8	n/a	n/a	n/a	n/a	6.5	25
Mitsubishi Tanabe Pharma Corporation US Patent					Assay Description A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...				US Patent US9006232 (2015) BindingDB Entry DOI: 10.7270/Q25T3J7B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Bos taurus (cattle))	BDBM155168 (US9006232, 1.202) Show SMILES Cn1c(OC2CCN(CC2)c2ccc(CN3CCNCC3)cc2)nc(cc1=O)-c1ccncn1 Show InChI InChI=1S/C25H31N7O2/c1-30-24(33)16-23(22-6-9-27-18-28-22)29-25(30)34-21-7-12-32(13-8-21)20-4-2-19(3-5-20)17-31-14-10-26-11-15-31/h2-6,9,16,18,21,26H,7-8,10-15,17H2,1H3	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	6.5	25
Mitsubishi Tanabe Pharma Corporation US Patent					Assay Description A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...				US Patent US9006232 (2015) BindingDB Entry DOI: 10.7270/Q25T3J7B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Bos taurus (cattle))	BDBM155202 (US9006232, 1.302) Show SMILES CN1CCN(Cc2ccccc2N2CCC(CC2)Oc2nc(cc(=O)n2C)-c2ccncn2)CC1 Show InChI InChI=1S/C26H33N7O2/c1-30-13-15-32(16-14-30)18-20-5-3-4-6-24(20)33-11-8-21(9-12-33)35-26-29-23(17-25(34)31(26)2)22-7-10-27-19-28-22/h3-7,10,17,19,21H,8-9,11-16,18H2,1-2H3	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	14.9	n/a	n/a	n/a	n/a	6.5	25
Mitsubishi Tanabe Pharma Corporation US Patent					Assay Description A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...				US Patent US9006232 (2015) BindingDB Entry DOI: 10.7270/Q25T3J7B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta/[Tau protein] kinase (Sus scrofa)	BDBM50523282 (CHEMBL4515295) Show SMILES O=C(Nc1cc(CCC#C)ccn1)Nc1cccc2C(=O)N3CCCCC3c12 Show InChI InChI=1S/C22H22N4O2/c1-2-3-7-15-11-12-23-19(14-15)25-22(28)24-17-9-6-8-16-20(17)18-10-4-5-13-26(18)21(16)27/h1,6,8-9,11-12,14,18H,3-5,7,10,13H2,(H2,23,24,25,28)	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
CNRS Curated by ChEMBL					Assay Description Inhibition of native porcine brain GSK-3alpha/beta using GS-1 as substrate incubated for 30 mins in presence of [gamma-33P]ATP by liquid scintillatio...				Eur J Med Chem 168: 58-77 (2019) Article DOI: 10.1016/j.ejmech.2018.12.063 BindingDB Entry DOI: 10.7270/Q2J969S0
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Bos taurus (cattle))	BDBM155200 (US9006232, 1.234) Show SMILES Cn1c(OCC2CCN(CC2)c2ccc(CN3CCCCC3)cc2)nc(cc1=O)-c1ccncc1F Show InChI InChI=1S/C28H34FN5O2/c1-32-27(35)17-26(24-9-12-30-18-25(24)29)31-28(32)36-20-22-10-15-34(16-11-22)23-7-5-21(6-8-23)19-33-13-3-2-4-14-33/h5-9,12,17-18,22H,2-4,10-11,13-16,19-20H2,1H3	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	15.6	n/a	n/a	n/a	n/a	6.5	25
Mitsubishi Tanabe Pharma Corporation US Patent					Assay Description A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...				US Patent US9006232 (2015) BindingDB Entry DOI: 10.7270/Q25T3J7B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Bos taurus (cattle))	BDBM155193 (US9006232, 1.227) Show SMILES Cn1c(OC2CCN(CC2)c2ccc3CN(Cc4ccccc4)Cc3c2)nc(cc1=O)-c1ccncn1 Show InChI InChI=1S/C29H30N6O2/c1-33-28(36)16-27(26-9-12-30-20-31-26)32-29(33)37-25-10-13-35(14-11-25)24-8-7-22-18-34(19-23(22)15-24)17-21-5-3-2-4-6-21/h2-9,12,15-16,20,25H,10-11,13-14,17-19H2,1H3	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	6.5	25
Mitsubishi Tanabe Pharma Corporation US Patent					Assay Description A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...				US Patent US9006232 (2015) BindingDB Entry DOI: 10.7270/Q25T3J7B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta/[Tau protein] kinase (Sus scrofa)	BDBM50523267 (CHEMBL4559936) Show SMILES O=C(Nc1cc(ccn1)-c1cn(CCNc2c3CCCCc3nc3ccccc23)nn1)Nc1cccc2C(=O)N3CCCCC3c12 Show InChI InChI=1S/C35H35N9O2/c45-34-25-10-7-13-28(32(25)30-14-5-6-18-44(30)34)39-35(46)40-31-20-22(15-16-36-31)29-21-43(42-41-29)19-17-37-33-23-8-1-3-11-26(23)38-27-12-4-2-9-24(27)33/h1,3,7-8,10-11,13,15-16,20-21,30H,2,4-6,9,12,14,17-19H2,(H,37,38)(H2,36,39,40,46)	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
CNRS Curated by ChEMBL					Assay Description Inhibition of native porcine brain GSK-3alpha/beta using GS-1 as substrate incubated for 30 mins in presence of [gamma-33P]ATP by liquid scintillatio...				Eur J Med Chem 168: 58-77 (2019) Article DOI: 10.1016/j.ejmech.2018.12.063 BindingDB Entry DOI: 10.7270/Q2J969S0
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Bos taurus (cattle))	BDBM155180 (US9006232, 1.214) Show SMILES Cn1c(OC2CCN(CC2)c2ccc(CN3CCCCC3)cc2)nc(cc1=O)-c1ccncn1 Show InChI InChI=1S/C26H32N6O2/c1-30-25(33)17-24(23-9-12-27-19-28-23)29-26(30)34-22-10-15-32(16-11-22)21-7-5-20(6-8-21)18-31-13-3-2-4-14-31/h5-9,12,17,19,22H,2-4,10-11,13-16,18H2,1H3	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	16.1	n/a	n/a	n/a	n/a	6.5	25
Mitsubishi Tanabe Pharma Corporation US Patent					Assay Description A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...				US Patent US9006232 (2015) BindingDB Entry DOI: 10.7270/Q25T3J7B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Bos taurus (cattle))	BDBM155175 (US9006232, 1.209) Show SMILES CN1CCN(CC1)c1ccc(cc1)N1CCC(CC1)Oc1nc(cc(=O)n1C)-c1ccncn1 Show InChI InChI=1S/C25H31N7O2/c1-29-13-15-32(16-14-29)20-5-3-19(4-6-20)31-11-8-21(9-12-31)34-25-28-23(17-24(33)30(25)2)22-7-10-26-18-27-22/h3-7,10,17-18,21H,8-9,11-16H2,1-2H3	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	17.9	n/a	n/a	n/a	n/a	6.5	25
Mitsubishi Tanabe Pharma Corporation US Patent					Assay Description A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...				US Patent US9006232 (2015) BindingDB Entry DOI: 10.7270/Q25T3J7B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Bos taurus (cattle))	BDBM155237 (US9006232, 2.205) Show SMILES Cn1c(OC[C@@H]2CCCN2c2ccc(F)cc2)nc(cc1=O)-c1ccncc1F |r| Show InChI InChI=1S/C21H20F2N4O2/c1-26-20(28)11-19(17-8-9-24-12-18(17)23)25-21(26)29-13-16-3-2-10-27(16)15-6-4-14(22)5-7-15/h4-9,11-12,16H,2-3,10,13H2,1H3/t16-/m0/s1	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	18.4	n/a	n/a	n/a	n/a	6.5	25
Mitsubishi Tanabe Pharma Corporation US Patent					Assay Description A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...				US Patent US9006232 (2015) BindingDB Entry DOI: 10.7270/Q25T3J7B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta/[Tau protein] kinase (Sus scrofa)	BDBM50523262 (CHEMBL4443468) Show SMILES [H][C@@]12CCCCN1C(=O)c1cccc(NC(=O)Nc3cc(ccn3)-c3cn(CCNc4c5CCCCc5nc5ccccc45)nn3)c21 |r| Show InChI InChI=1S/C35H35N9O2/c45-34-25-10-7-13-28(32(25)30-14-5-6-18-44(30)34)39-35(46)40-31-20-22(15-16-36-31)29-21-43(42-41-29)19-17-37-33-23-8-1-3-11-26(23)38-27-12-4-2-9-24(27)33/h1,3,7-8,10-11,13,15-16,20-21,30H,2,4-6,9,12,14,17-19H2,(H,37,38)(H2,36,39,40,46)/t30-/m0/s1	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
CNRS Curated by ChEMBL					Assay Description Inhibition of native porcine brain GSK-3alpha/beta using GS-1 as substrate incubated for 30 mins in presence of [gamma-33P]ATP by liquid scintillatio...				Eur J Med Chem 168: 58-77 (2019) Article DOI: 10.1016/j.ejmech.2018.12.063 BindingDB Entry DOI: 10.7270/Q2J969S0
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Bos taurus (cattle))	BDBM155167 (US9006232, 1.201) Show SMILES Cn1c(OC2CCN(CC2)c2ccc(CN3CCN(CC3)C(=O)OC(C)(C)C)cc2)nc(cc1=O)-c1ccncn1 Show InChI InChI=1S/C30H39N7O4/c1-30(2,3)41-29(39)37-17-15-35(16-18-37)20-22-5-7-23(8-6-22)36-13-10-24(11-14-36)40-28-33-26(19-27(38)34(28)4)25-9-12-31-21-32-25/h5-9,12,19,21,24H,10-11,13-18,20H2,1-4H3	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	19.1	n/a	n/a	n/a	n/a	6.5	25
Mitsubishi Tanabe Pharma Corporation US Patent					Assay Description A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...				US Patent US9006232 (2015) BindingDB Entry DOI: 10.7270/Q25T3J7B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Bos taurus (cattle))	BDBM155179 (US9006232, 1.213) Show SMILES Cn1c(OC2CCN(CC2)c2ccc(CN3CCOCC3)cc2)nc(cc1=O)-c1ccncn1 Show InChI InChI=1S/C25H30N6O3/c1-29-24(32)16-23(22-6-9-26-18-27-22)28-25(29)34-21-7-10-31(11-8-21)20-4-2-19(3-5-20)17-30-12-14-33-15-13-30/h2-6,9,16,18,21H,7-8,10-15,17H2,1H3	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	19.4	n/a	n/a	n/a	n/a	6.5	25
Mitsubishi Tanabe Pharma Corporation US Patent					Assay Description A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...				US Patent US9006232 (2015) BindingDB Entry DOI: 10.7270/Q25T3J7B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Bos taurus (cattle))	BDBM155244 (US9006232, 2.301) Show SMILES Cn1c(OCC(=O)c2ccccc2)nc(cc1=O)-c1ccncn1 Show InChI InChI=1S/C17H14N4O3/c1-21-16(23)9-14(13-7-8-18-11-19-13)20-17(21)24-10-15(22)12-5-3-2-4-6-12/h2-9,11H,10H2,1H3	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	6.5	25
Mitsubishi Tanabe Pharma Corporation US Patent					Assay Description A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...				US Patent US9006232 (2015) BindingDB Entry DOI: 10.7270/Q25T3J7B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta/[Tau protein] kinase (Sus scrofa)	BDBM50523268 (CHEMBL4593316) Show SMILES O=C(Nc1cc(CCc2cn(CCNc3c4CCCCc4nc4ccccc34)nn2)ccn1)Nc1cccc2C(=O)N3CCCCC3c12 Show InChI InChI=1S/C37H39N9O2/c47-36-28-10-7-13-31(34(28)32-14-5-6-20-46(32)36)41-37(48)42-33-22-24(17-18-38-33)15-16-25-23-45(44-43-25)21-19-39-35-26-8-1-3-11-29(26)40-30-12-4-2-9-27(30)35/h1,3,7-8,10-11,13,17-18,22-23,32H,2,4-6,9,12,14-16,19-21H2,(H,39,40)(H2,38,41,42,48)	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
CNRS Curated by ChEMBL					Assay Description Inhibition of native porcine brain GSK-3alpha/beta using GS-1 as substrate incubated for 30 mins in presence of [gamma-33P]ATP by liquid scintillatio...				Eur J Med Chem 168: 58-77 (2019) Article DOI: 10.1016/j.ejmech.2018.12.063 BindingDB Entry DOI: 10.7270/Q2J969S0
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Bos taurus (cattle))	BDBM155186 (US9006232, 1.220) Show SMILES CN(C)Cc1ccc(cc1)N1CCC(CC1)Oc1nc(cc(=O)n1C)-c1ccncn1 Show InChI InChI=1S/C23H28N6O2/c1-27(2)15-17-4-6-18(7-5-17)29-12-9-19(10-13-29)31-23-26-21(14-22(30)28(23)3)20-8-11-24-16-25-20/h4-8,11,14,16,19H,9-10,12-13,15H2,1-3H3	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	21.2	n/a	n/a	n/a	n/a	6.5	25
Mitsubishi Tanabe Pharma Corporation US Patent					Assay Description A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...				US Patent US9006232 (2015) BindingDB Entry DOI: 10.7270/Q25T3J7B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Bos taurus (cattle))	BDBM155188 (US9006232, 1.222) Show SMILES CN1CCN(Cc2cccc(c2)N2CCC(CC2)Oc2nc(cc(=O)n2C)-c2ccncn2)CC1 Show InChI InChI=1S/C26H33N7O2/c1-30-12-14-32(15-13-30)18-20-4-3-5-21(16-20)33-10-7-22(8-11-33)35-26-29-24(17-25(34)31(26)2)23-6-9-27-19-28-23/h3-6,9,16-17,19,22H,7-8,10-15,18H2,1-2H3	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	21.5	n/a	n/a	n/a	n/a	6.5	25
Mitsubishi Tanabe Pharma Corporation US Patent					Assay Description A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...				US Patent US9006232 (2015) BindingDB Entry DOI: 10.7270/Q25T3J7B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta/[Tau protein] kinase (Sus scrofa)	BDBM50166289 (CHEBI:43645 | CHEMBL216543) Show SMILES O\N=C1\C(\Nc2ccccc\12)=C1\C(=O)Nc2ccccc12 Show InChI InChI=1S/C16H11N3O2/c20-16-13(9-5-1-3-7-11(9)18-16)15-14(19-21)10-6-2-4-8-12(10)17-15/h1-8,17,21H,(H,18,20)/b15-13-,19-14+	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2021.113652 BindingDB Entry DOI: 10.7270/Q27H1PN4
					More data for this Ligand-Target Pair				3D Structure (crystal)
Glycogen synthase kinase-3 beta/[Tau protein] kinase (Sus scrofa)	BDBM50399310 (CHEMBL2180854) Show SMILES Brc1ccnc(NC(=O)Nc2cccc3C(=O)N4CCCCC4c23)c1 Show InChI InChI=1S/C18H17BrN4O2/c19-11-7-8-20-15(10-11)22-18(25)21-13-5-3-4-12-16(13)14-6-1-2-9-23(14)17(12)24/h3-5,7-8,10,14H,1-2,6,9H2,(H2,20,21,22,25)	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
CNRS Curated by ChEMBL					Assay Description Inhibition of native porcine brain GSK-3alpha/beta using GS-1 as substrate incubated for 30 mins in presence of [gamma-33P]ATP by liquid scintillatio...				Eur J Med Chem 168: 58-77 (2019) Article DOI: 10.1016/j.ejmech.2018.12.063 BindingDB Entry DOI: 10.7270/Q2J969S0
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Bos taurus (cattle))	BDBM155215 (US9006232, 1.802) Show SMILES Cn1c(OC2CCCCC2)nc(cc1=O)-c1ccncn1 Show InChI InChI=1S/C15H18N4O2/c1-19-14(20)9-13(12-7-8-16-10-17-12)18-15(19)21-11-5-3-2-4-6-11/h7-11H,2-6H2,1H3	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	22.6	n/a	n/a	n/a	n/a	6.5	25
Mitsubishi Tanabe Pharma Corporation US Patent					Assay Description A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...				US Patent US9006232 (2015) BindingDB Entry DOI: 10.7270/Q25T3J7B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Bos taurus (cattle))	BDBM155192 (US9006232, 1.226) Show SMILES CN1Cc2ccc(cc2C1)N1CCC(CC1)Oc1nc(cc(=O)n1C)-c1ccncn1 Show InChI InChI=1S/C23H26N6O2/c1-27-13-16-3-4-18(11-17(16)14-27)29-9-6-19(7-10-29)31-23-26-21(12-22(30)28(23)2)20-5-8-24-15-25-20/h3-5,8,11-12,15,19H,6-7,9-10,13-14H2,1-2H3	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	23.7	n/a	n/a	n/a	n/a	6.5	25
Mitsubishi Tanabe Pharma Corporation US Patent					Assay Description A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...				US Patent US9006232 (2015) BindingDB Entry DOI: 10.7270/Q25T3J7B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta/[Tau protein] kinase (Sus scrofa)	BDBM50523274 (CHEMBL4537142) Show SMILES Cn1cc(COCc2ccnc(NC(=O)Nc3cccc4C(=O)N5CCCCC5c34)c2)nn1 Show InChI InChI=1S/C23H25N7O3/c1-29-12-16(27-28-29)14-33-13-15-8-9-24-20(11-15)26-23(32)25-18-6-4-5-17-21(18)19-7-2-3-10-30(19)22(17)31/h4-6,8-9,11-12,19H,2-3,7,10,13-14H2,1H3,(H2,24,25,26,32)	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
CNRS Curated by ChEMBL					Assay Description Inhibition of native porcine brain GSK-3alpha/beta using GS-1 as substrate incubated for 30 mins in presence of [gamma-33P]ATP by liquid scintillatio...				Eur J Med Chem 168: 58-77 (2019) Article DOI: 10.1016/j.ejmech.2018.12.063 BindingDB Entry DOI: 10.7270/Q2J969S0
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Bos taurus (cattle))	BDBM155204 (US9006232, 1.304) Show SMILES Cn1c(OC2CCN(CC2)c2ccccc2CN2Cc3ccccc3C2)nc(cc1=O)-c1ccncn1 Show InChI InChI=1S/C29H30N6O2/c1-33-28(36)16-26(25-10-13-30-20-31-25)32-29(33)37-24-11-14-35(15-12-24)27-9-5-4-8-23(27)19-34-17-21-6-2-3-7-22(21)18-34/h2-10,13,16,20,24H,11-12,14-15,17-19H2,1H3	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	25.2	n/a	n/a	n/a	n/a	6.5	25
Mitsubishi Tanabe Pharma Corporation US Patent					Assay Description A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...				US Patent US9006232 (2015) BindingDB Entry DOI: 10.7270/Q25T3J7B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Bos taurus (cattle))	BDBM155246 (US9006232, 2.303) Show SMILES Cn1c(OCC(=O)c2ccc(Br)cc2)nc(cc1=O)-c1ccncc1F Show InChI InChI=1S/C18H13BrFN3O3/c1-23-17(25)8-15(13-6-7-21-9-14(13)20)22-18(23)26-10-16(24)11-2-4-12(19)5-3-11/h2-9H,10H2,1H3	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	6.5	25
Mitsubishi Tanabe Pharma Corporation US Patent					Assay Description A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...				US Patent US9006232 (2015) BindingDB Entry DOI: 10.7270/Q25T3J7B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Bos taurus (cattle))	BDBM155176 (US9006232, 1.210) Show SMILES CC(=O)N1CCN(CC1)c1ccc(cc1)N1CCC(CC1)Oc1nc(cc(=O)n1C)-c1ccncn1 Show InChI InChI=1S/C26H31N7O3/c1-19(34)31-13-15-33(16-14-31)21-5-3-20(4-6-21)32-11-8-22(9-12-32)36-26-29-24(17-25(35)30(26)2)23-7-10-27-18-28-23/h3-7,10,17-18,22H,8-9,11-16H2,1-2H3	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	27.4	n/a	n/a	n/a	n/a	6.5	25
Mitsubishi Tanabe Pharma Corporation US Patent					Assay Description A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...				US Patent US9006232 (2015) BindingDB Entry DOI: 10.7270/Q25T3J7B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Bos taurus (cattle))	BDBM155156 (US9006232, 1.102) Show SMILES COC(=O)N1CCCC(C1)Oc1nc(cc(=O)n1C)-c1ccncn1 Show InChI InChI=1S/C16H19N5O4/c1-20-14(22)8-13(12-5-6-17-10-18-12)19-15(20)25-11-4-3-7-21(9-11)16(23)24-2/h5-6,8,10-11H,3-4,7,9H2,1-2H3	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	28.2	n/a	n/a	n/a	n/a	6.5	25
Mitsubishi Tanabe Pharma Corporation US Patent					Assay Description A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...				US Patent US9006232 (2015) BindingDB Entry DOI: 10.7270/Q25T3J7B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Bos taurus (cattle))	BDBM155190 (US9006232, 1.224) Show SMILES Cn1c(OC2CCN(CC2)c2cccnc2)nc(cc1=O)-c1ccncn1 Show InChI InChI=1S/C19H20N6O2/c1-24-18(26)11-17(16-4-8-21-13-22-16)23-19(24)27-15-5-9-25(10-6-15)14-3-2-7-20-12-14/h2-4,7-8,11-13,15H,5-6,9-10H2,1H3	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	29.8	n/a	n/a	n/a	n/a	6.5	25
Mitsubishi Tanabe Pharma Corporation US Patent					Assay Description A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...				US Patent US9006232 (2015) BindingDB Entry DOI: 10.7270/Q25T3J7B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta/[Tau protein] kinase (Sus scrofa)	BDBM50523273 (CHEMBL4459540) Show SMILES O=C(Nc1cc(COCc2cn(CCNc3ccncc3)nn2)ccn1)Nc1cccc2C(=O)N3CCCCC3c12 Show InChI InChI=1S/C29H31N9O3/c39-28-23-4-3-5-24(27(23)25-6-1-2-14-38(25)28)33-29(40)34-26-16-20(7-12-32-26)18-41-19-22-17-37(36-35-22)15-13-31-21-8-10-30-11-9-21/h3-5,7-12,16-17,25H,1-2,6,13-15,18-19H2,(H,30,31)(H2,32,33,34,40)	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
CNRS Curated by ChEMBL					Assay Description Inhibition of native porcine brain GSK-3alpha/beta using GS-1 as substrate incubated for 30 mins in presence of [gamma-33P]ATP by liquid scintillatio...				Eur J Med Chem 168: 58-77 (2019) Article DOI: 10.1016/j.ejmech.2018.12.063 BindingDB Entry DOI: 10.7270/Q2J969S0
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta/[Tau protein] kinase (Sus scrofa)	BDBM2605 ((Arylindolyl)maleimide deriv. 27 | 3-(1-methyl-1H-...) Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(C)c3ncccc23)c2ccccc12 |t:4| Show InChI InChI=1S/C21H16N4O2/c1-24-10-14(12-6-3-4-8-16(12)24)17-18(21(27)23-20(17)26)15-11-25(2)19-13(15)7-5-9-22-19/h3-11H,1-2H3,(H,23,26,27)	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
University College Cork Curated by ChEMBL					Assay Description Inhibition of domestic porcine brain full length GSK-3alpha/beta using GS-1 as substrate in presence of [gamma-33P]ATP				Bioorg Med Chem 26: 4209-4224 (2018) Article DOI: 10.1016/j.bmc.2018.07.012 BindingDB Entry DOI: 10.7270/Q270843T
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Bos taurus (cattle))	BDBM155227 (US9006232, 1.904) Show SMILES CN1CCN(Cc2ccc(cc2)[C@@H]2CC[C@@H](CC2)Oc2nc(cc(=O)n2C)-c2ccncn2)CC1 |r,wU:15.19,12.12,(-10,-.77,;-8.67,,;-8.67,1.54,;-7.34,2.31,;-6,1.54,;-4.67,2.31,;-3.33,1.54,;-2,2.31,;-.67,1.54,;-.67,,;-2,-.77,;-3.33,,;.67,-.77,;.67,-2.31,;2,-3.08,;3.33,-2.31,;3.33,-.77,;2,,;4.67,-3.08,;6,-2.31,;6,-.77,;7.34,,;8.67,-.77,;8.67,-2.31,;10,-3.08,;7.34,-3.08,;7.34,-4.62,;7.34,1.54,;6,2.31,;6,3.85,;7.34,4.62,;8.67,3.85,;8.67,2.31,;-6,,;-7.34,-.77,)| Show InChI InChI=1S/C27H34N6O2/c1-31-13-15-33(16-14-31)18-20-3-5-21(6-4-20)22-7-9-23(10-8-22)35-27-30-25(17-26(34)32(27)2)24-11-12-28-19-29-24/h3-6,11-12,17,19,22-23H,7-10,13-16,18H2,1-2H3/t22-,23+	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	30.3	n/a	n/a	n/a	n/a	6.5	25
Mitsubishi Tanabe Pharma Corporation US Patent					Assay Description A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...				US Patent US9006232 (2015) BindingDB Entry DOI: 10.7270/Q25T3J7B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Bos taurus (cattle))	BDBM155213 (US9006232, 1.701) Show SMILES Cn1c(OC2CCCN(CC2)c2ccc(cc2)C#N)nc(cc1=O)-c1ccncn1 Show InChI InChI=1S/C22H22N6O2/c1-27-21(29)13-20(19-8-10-24-15-25-19)26-22(27)30-18-3-2-11-28(12-9-18)17-6-4-16(14-23)5-7-17/h4-8,10,13,15,18H,2-3,9,11-12H2,1H3	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	30.3	n/a	n/a	n/a	n/a	6.5	25
Mitsubishi Tanabe Pharma Corporation US Patent					Assay Description A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...				US Patent US9006232 (2015) BindingDB Entry DOI: 10.7270/Q25T3J7B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Bos taurus (cattle))	BDBM155187 (US9006232, 1.221) Show SMILES Cn1c(OC2CCN(CC2)c2cccc(CN3CCOCC3)c2)nc(cc1=O)-c1ccncn1 Show InChI InChI=1S/C25H30N6O3/c1-29-24(32)16-23(22-5-8-26-18-27-22)28-25(29)34-21-6-9-31(10-7-21)20-4-2-3-19(15-20)17-30-11-13-33-14-12-30/h2-5,8,15-16,18,21H,6-7,9-14,17H2,1H3	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	31.5	n/a	n/a	n/a	n/a	6.5	25
Mitsubishi Tanabe Pharma Corporation US Patent					Assay Description A mixture containing 100 mM MES-sodium hydroxide (pH 6.5), 1 mM magnesium acetate, 0.5 mM EGTA, 5 mM, .beta.-mercaptoethanol, 0.02% Tween 20, 10% gly...				US Patent US9006232 (2015) BindingDB Entry DOI: 10.7270/Q25T3J7B
					More data for this Ligand-Target Pair

Displayed 1 to 50 (of 298 total )  |  Next  |  Last  >>

Jump to: