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Found 2706 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase receptor TYRO3' AND taxid = 9606   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM50469353
PNG
(CHEMBL4283353)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(CN2CCCN(C)CC2)cc1 |r,wU:13.12,wD:16.16,3.3,(17.07,-10.92,;18.4,-10.15,;19.74,-10.92,;21.07,-10.15,;21.07,-8.61,;22.4,-10.92,;23.74,-10.15,;23.74,-8.61,;25.07,-7.84,;26.4,-8.6,;27.88,-8.12,;28.79,-9.38,;27.88,-10.63,;28.63,-11.97,;30.16,-12,;30.91,-13.35,;30.11,-14.67,;30.85,-16.02,;28.57,-14.64,;27.83,-13.29,;26.4,-10.15,;25.07,-10.92,;28.59,-6.76,;30.13,-6.7,;30.84,-5.34,;30.02,-4.03,;30.73,-2.67,;32.27,-2.6,;33,-3.97,;34.51,-4.24,;35.67,-3.22,;35.61,-1.69,;36.96,-.95,;34.36,-.79,;32.87,-1.2,;28.47,-4.1,;27.77,-5.47,)|
Show InChI InChI=1S/C30H44N6O/c1-4-6-22(2)32-30-31-19-27-28(21-36(29(27)33-30)25-11-13-26(37)14-12-25)24-9-7-23(8-10-24)20-35-16-5-15-34(3)17-18-35/h7-10,19,21-22,25-26,37H,4-6,11-18,20H2,1-3H3,(H,31,32,33)/t22-,25-,26-/m0/s1
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3.90n/an/an/an/an/an/an/an/a



UNC Eshelman School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of TYRO3 (unknown origin) using 5'-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by MCE assay


J Med Chem 61: 10242-10254 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01229
BindingDB Entry DOI: 10.7270/Q2K076ZK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497267
PNG
((2,6-dimethylpyridin-4- yl)(4-(7-((1R,4S)-4- hydro...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cc(C)nc(C)c1 |r,wU:13.12,wD:3.3,16.16,(-8.93,-2.23,;-7.59,-1.46,;-6.26,-2.23,;-4.93,-1.46,;-4.93,.08,;-3.59,-2.23,;-2.26,-1.46,;-2.26,.08,;-.93,.85,;.41,.08,;1.87,.56,;2.78,-.69,;1.87,-1.94,;2.35,-3.4,;3.85,-3.72,;4.33,-5.19,;3.3,-6.33,;3.78,-7.79,;1.79,-6.01,;1.32,-4.55,;.41,-1.46,;-.93,-2.23,;2.35,2.02,;3.85,2.34,;4.33,3.81,;3.3,4.95,;1.79,4.63,;1.32,3.16,;3.78,6.41,;3.04,7.77,;5.26,6.02,;6.35,7.1,;7.84,6.71,;8.93,7.79,;8.24,5.22,;7.15,4.13,;7.55,2.64,;5.66,4.53,)|
Show InChI InChI=1S/C30H42N6O2/c1-5-6-19(2)33-30-31-17-26-27(18-36(28(26)34-30)24-7-9-25(37)10-8-24)22-11-13-35(14-12-22)29(38)23-15-20(3)32-21(4)16-23/h15-19,22,24-25,37H,5-14H2,1-4H3,(H,31,33,34)/t19-,24-,25-/m0/s1
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19n/an/an/an/an/an/an/an/a


TBA

Assay Description
ATP competitive inhibition of TYRO3 (unknown origin)


Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113534
BindingDB Entry DOI: 10.7270/Q2M90DGJ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM50425829
PNG
(CHEMBL2312304)
Show SMILES Clc1ccc(Cl)c(CNc2ncc(C(=O)NCCCN3CCOC3=O)c(NC3CCCC3)n2)c1
Show InChI InChI=1S/C23H28Cl2N6O3/c24-16-6-7-19(25)15(12-16)13-27-22-28-14-18(20(30-22)29-17-4-1-2-5-17)21(32)26-8-3-9-31-10-11-34-23(31)33/h6-7,12,14,17H,1-5,8-11,13H2,(H,26,32)(H2,27,28,29,30)
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Similars

Article
PubMed
120n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of tracer K5 binding to NanoLuc-fused TYRO3 (unknown origin) expressed in HEK293T cells measured after 2 hrs by NanoBRET assay


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00845
BindingDB Entry DOI: 10.7270/Q2WH2TSV
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM50463483
PNG
(CHEMBL4245242)
Show SMILES O=C(Cc1cccc(OCCCC2CCNCC2)c1)Nc1nc(cs1)-c1c[nH]c2ncccc12
Show InChI InChI=1S/C26H29N5O2S/c32-24(31-26-30-23(17-34-26)22-16-29-25-21(22)7-2-10-28-25)15-19-4-1-6-20(14-19)33-13-3-5-18-8-11-27-12-9-18/h1-2,4,6-7,10,14,16-18,27H,3,5,8-9,11-13,15H2,(H,28,29)(H,30,31,32)
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>2.00E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of TYRO3 (unknown origin)


Bioorg Med Chem Lett 28: 2622-2626 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.040
BindingDB Entry DOI: 10.7270/Q2ZC85HX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM50463479
PNG
(CHEMBL4249925)
Show SMILES CS(=O)(=O)Nc1cccc(CC(=O)Nc2nc(cs2)-c2c[nH]c3ncccc23)c1
Show InChI InChI=1S/C19H17N5O3S2/c1-29(26,27)24-13-5-2-4-12(8-13)9-17(25)23-19-22-16(11-28-19)15-10-21-18-14(15)6-3-7-20-18/h2-8,10-11,24H,9H2,1H3,(H,20,21)(H,22,23,25)
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>2.00E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of TYRO3 (unknown origin)


Bioorg Med Chem Lett 28: 2622-2626 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.040
BindingDB Entry DOI: 10.7270/Q2ZC85HX
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM50557863
PNG
(CHEMBL4791034)
Show SMILES C[C@H](c1nnc2sc(nn12)-c1cnn(C)c1)c1ccc2ncccc2c1 |r|
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>4.00E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of SKY (unknown origin)


Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00094
BindingDB Entry DOI: 10.7270/Q28919JG
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM515838
PNG
(US11053225, Compound 139)
Show SMILES Cn1cc(cn1)-c1cnc(Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)nc1Nc1ccc2CCN(Cc2c1)C(=O)C(F)(F)F
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n/an/a 0.00600n/an/an/an/an/an/a


TBA

Assay Description
For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2JM2DST
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM515828
PNG
(US11053225, Compound 129 | US11053225, Compound 19...)
Show SMILES OCCn1cc(cn1)-c1cnc(Nc2cccc(Cl)c2Cl)nc1Nc1ccc2CCNCc2c1
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n/an/a 0.0100n/an/an/an/an/an/a


TBA

Assay Description
For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2JM2DST
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM515820
PNG
(US11053225, Compound 101 | US11053225, Compound 19...)
Show SMILES OCCn1cc(cn1)-c1cnc(Nc2cccc(Cl)c2)nc1Nc1ccc2CCNCc2c1
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n/an/a 0.0120n/an/an/an/an/an/a


TBA

Assay Description
For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2JM2DST
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM515870
PNG
(US11053225, Compound 172)
Show SMILES CCCn1cc(cn1)-c1cnc(Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)nc1Nc1ccc2CCNCc2c1
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n/an/a 0.0120n/an/an/an/an/an/a


TBA

Assay Description
For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2JM2DST
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM515869
PNG
(US11053225, Compound 171)
Show SMILES CCCn1cc(cn1)-c1cnc(Nc2cc(Cl)cc(Cl)c2)nc1Nc1ccc2CCNCc2c1
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n/an/a 0.0120n/an/an/an/an/an/a


TBA

Assay Description
For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2JM2DST
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM515810
PNG
(US11053225, Compound 201)
Show SMILES OCCn1cc(cn1)-c1cnc(Nc2cc(Cl)cc(Cl)c2)nc1Nc1ccc(cc1)C1CCNCC1
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n/an/a 0.0120n/an/an/an/an/an/a


TBA

Assay Description
For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2JM2DST
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM515814
PNG
(US11053225, Compound 84)
Show SMILES Cn1cc(cn1)-c1cnc(Nc2cc(Cl)cc(Cl)c2)nc1Nc1ccc2CCNCc2c1
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n/an/a 0.0410n/an/an/an/an/an/a


TBA

Assay Description
For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2JM2DST
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM515817
PNG
(US11053225, Compound 89)
Show SMILES OCCn1cc(cn1)-c1cnc(Nc2cc(Cl)cc(Cl)c2)nc1Nc1ccc2CCNCc2c1
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n/an/a 0.0410n/an/an/an/an/an/a


TBA

Assay Description
For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2JM2DST
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM515826
PNG
(US11053225, Compound 127)
Show SMILES OCCn1cc(cn1)-c1cnc(Nc2cc(F)cc(F)c2)nc1Nc1ccc2CCNCc2c1
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n/an/a 0.0520n/an/an/an/an/an/a


TBA

Assay Description
For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2JM2DST
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM515794
PNG
(US11053225, Compound 75)
Show SMILES OCCn1cc(cn1)-c1cnc(Nc2cc(Cl)cc(Cl)c2)nc1NC1CCNCC1
PDB
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n/an/a 0.0600n/an/an/an/an/an/a


TBA

Assay Description
For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2JM2DST
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM515836
PNG
(US11053225, Compound 137)
Show SMILES Cn1cc(cn1)-c1cnc(Nc2cc(F)cc(F)c2)nc1Nc1ccc2CCNCc2c1
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n/an/a 0.0970n/an/an/an/an/an/a


TBA

Assay Description
For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2JM2DST
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM515865
PNG
(US11053225, Compound 167)
Show SMILES CC(C)n1cc(cn1)-c1cnc(Nc2cccc(Cl)c2)nc1Nc1ccc2CCNCc2c1
PDB
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n/an/a 0.100n/an/an/an/an/an/a


TBA

Assay Description
For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2JM2DST
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM515847
PNG
(US11053225, Compound 148)
Show SMILES COc1cc(Nc2ncc(-c3cnn(CCO)c3)c(Nc3ccc4CCNCc4c3)n2)cc(c1)C(F)(F)F
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n/an/a 0.130n/an/an/an/an/an/a


TBA

Assay Description
For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2JM2DST
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM515871
PNG
(US11053225, Compound 173)
Show SMILES CCCn1cc(cn1)-c1cnc(Nc2cc(F)cc(F)c2)nc1Nc1ccc2CCNCc2c1
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n/an/a 0.130n/an/an/an/an/an/a


TBA

Assay Description
For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2JM2DST
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM515846
PNG
(US11053225, Compound 147)
Show SMILES OCCn1cc(cn1)-c1cnc(Nc2cc(F)cc(Cl)c2)nc1Nc1ccc2CCNCc2c1
PDB
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n/an/a 0.130n/an/an/an/an/an/a


TBA

Assay Description
For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2JM2DST
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM515812
PNG
(US11053225, Compound 205)
Show SMILES OCCn1cc(cn1)-c1cnc(Nc2cc(F)cc(F)c2)nc1Nc1ccc(cc1)C1CCNCC1
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n/an/a 0.140n/an/an/an/an/an/a


TBA

Assay Description
For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2JM2DST
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM515860
PNG
(US11053225, Compound 162)
Show SMILES CC(C)n1cc(cn1)-c1cnc(Nc2cc(F)cc(F)c2)nc1Nc1ccc2CCNCc2c1
PDB
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n/an/a 0.140n/an/an/an/an/an/a


TBA

Assay Description
For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2JM2DST
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM515830
PNG
(US11053225, Compound 131)
Show SMILES Fc1cc(F)cc(Nc2ncc(-c3cnn(c3)C3CCNCC3)c(Nc3ccc4CCNCc4c3)n2)c1
PDB
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n/an/a 0.160n/an/an/an/an/an/a


TBA

Assay Description
For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2JM2DST
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM515879
PNG
(US11053225, Compound 181)
Show SMILES CC(C)Cn1cc(cn1)-c1cnc(Nc2cc(F)cc(F)c2)nc1Nc1ccc2CCNCc2c1
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n/an/a 0.160n/an/an/an/an/an/a


TBA

Assay Description
For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2JM2DST
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM515858
PNG
(US11053225, Compound 160)
Show SMILES CC(C)n1cc(cn1)-c1cnc(Nc2cc(Cl)cc(Cl)c2)nc1Nc1ccc2CCNCc2c1
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n/an/a 0.160n/an/an/an/an/an/a


TBA

Assay Description
For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2JM2DST
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM515877
PNG
(US11053225, Compound 179)
Show SMILES CC(C)Cn1cc(cn1)-c1cnc(Nc2cc(Cl)cc(Cl)c2)nc1Nc1ccc2CCNCc2c1
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n/an/a 0.170n/an/an/an/an/an/a


TBA

Assay Description
For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2JM2DST
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM515857
PNG
(US11053225, Compound 159)
Show SMILES Cc1ccc(F)cc1Nc1ncc(-c2cnn(C)c2)c(Nc2ccc3CCNCc3c2)n1
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n/an/a 0.170n/an/an/an/an/an/a


TBA

Assay Description
For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2JM2DST
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM515867
PNG
(US11053225, Compound 169)
Show SMILES CC(C)n1cc(cn1)-c1cnc(Nc2cccc(C)c2)nc1Nc1ccc2CCNCc2c1
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n/an/a 0.170n/an/an/an/an/an/a


TBA

Assay Description
For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2JM2DST
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM515799
PNG
(US11053225, Compound 103)
Show SMILES N[C@H]1CC[C@H](CC1)Nc1nc(Nc2cc(Cl)cc(Cl)c2)ncc1-c1cnn(CCO)c1 |r,wU:4.7,1.0,(5.92,3.85,;4.58,3.08,;4.58,1.54,;3.25,.77,;1.92,1.54,;1.92,3.08,;3.25,3.85,;.58,.77,;.58,-.77,;1.92,-1.54,;1.92,-3.08,;3.25,-3.85,;4.58,-3.08,;5.92,-3.85,;7.25,-3.08,;8.59,-3.85,;7.25,-1.54,;5.92,-.77,;5.92,.77,;4.58,-1.54,;.58,-3.85,;-.75,-3.08,;-.75,-1.54,;-2.08,-.77,;-2.25,.76,;-3.75,1.08,;-4.52,-.25,;-6.01,-.65,;-7.1,.44,;-8.59,.04,;-3.49,-1.4,)|
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n/an/a 0.190n/an/an/an/an/an/a


TBA

Assay Description
For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2JM2DST
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM515831
PNG
(US11053225, Compound 132)
Show SMILES Clc1cc(Cl)cc(Nc2ncc(-c3cnn(c3)C3CCNCC3)c(Nc3ccc4CCNCc4c3)n2)c1
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n/an/a 0.200n/an/an/an/an/an/a


TBA

Assay Description
For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2JM2DST
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM515861
PNG
(US11053225, Compound 163)
Show SMILES CC(C)n1cc(cn1)-c1cnc(Nc2cc(F)cc(Cl)c2)nc1Nc1ccc2CCNCc2c1
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n/an/a 0.230n/an/an/an/an/an/a


TBA

Assay Description
For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2JM2DST
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM515876
PNG
(US11053225, Compound 178)
Show SMILES CCCn1cc(cn1)-c1cnc(Nc2cccc(Cl)c2)nc1Nc1ccc2CCNCc2c1
PDB
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n/an/a 0.270n/an/an/an/an/an/a


TBA

Assay Description
For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2JM2DST
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM515880
PNG
(US11053225, Compound 182)
Show SMILES CC(C)Cn1cc(cn1)-c1cnc(Nc2cc(F)cc(Cl)c2)nc1Nc1ccc2CCNCc2c1
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n/an/a 0.270n/an/an/an/an/an/a


TBA

Assay Description
For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2JM2DST
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM515803
PNG
(US11053225, Compound 110)
Show SMILES OCCn1cc(cn1)-c1cnc(Nc2cc(Cl)cc(Cl)c2)nc1N[C@H]1CC[C@@H](CC1)NC(=O)C(F)(F)F |r,wU:24.26,wD:27.33,(3.74,-9.89,;4.65,-8.64,;4.02,-7.23,;4.92,-5.99,;4.45,-4.52,;5.69,-3.62,;6.94,-4.52,;6.46,-5.99,;5.69,-2.08,;7.03,-1.31,;7.03,.23,;5.69,1,;5.69,2.54,;4.36,3.31,;3.03,2.54,;1.69,3.31,;.36,2.54,;1.69,4.85,;3.03,5.62,;3.03,7.16,;4.36,4.85,;4.36,.23,;4.36,-1.31,;3.03,-2.08,;1.69,-1.31,;.36,-2.08,;-.97,-1.31,;-.97,.23,;.36,1,;1.69,.23,;-2.31,1,;-2.31,2.54,;-.97,3.31,;-3.64,3.31,;-4.97,4.08,;-2.87,4.65,;-4.41,1.98,)|
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TBA

Assay Description
For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2JM2DST
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM515844
PNG
(US11053225, Compound 145)
Show SMILES Cn1cc(cn1)-c1cnc(Nc2cc(F)cc(Cl)c2)nc1Nc1ccc2CCNCc2c1
PDB
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n/an/a 0.300n/an/an/an/an/an/a


TBA

Assay Description
For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2JM2DST
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM515873
PNG
(US11053225, Compound 175)
Show SMILES CCCn1cc(cn1)-c1cnc(Nc2cc(F)cc(Cl)c2)nc1Nc1ccc2CCNCc2c1
PDB
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n/an/a 0.320n/an/an/an/an/an/a


TBA

Assay Description
For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2JM2DST
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM515864
PNG
(US11053225, Compound 166)
Show SMILES CC(C)n1cc(cn1)-c1cnc(Nc2cc(C)cc(C)c2)nc1Nc1ccc2CCNCc2c1
PDB
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n/an/a 0.340n/an/an/an/an/an/a


TBA

Assay Description
For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2JM2DST
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM515854
PNG
(US11053225, Compound 156)
Show SMILES Cc1ccccc1Nc1ncc(-c2cnn(C)c2)c(Nc2ccc3CCNCc3c2)n1
PDB
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n/an/a 0.340n/an/an/an/an/an/a


TBA

Assay Description
For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2JM2DST
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM515805
PNG
(US11053225, Compound 113)
Show SMILES N[C@H]1CC[C@@H](CC1)Nc1nc(Nc2cc(Cl)cc(Cl)c2)ncc1-c1cnn(CCO)c1 |r,wU:1.0,wD:4.7,(5.88,3.85,;4.55,3.08,;4.55,1.54,;3.22,.77,;1.88,1.54,;1.88,3.08,;3.22,3.85,;.55,.77,;.55,-.77,;1.88,-1.54,;1.88,-3.08,;3.22,-3.85,;4.55,-3.08,;5.88,-3.85,;7.22,-3.08,;8.55,-3.85,;7.22,-1.54,;5.88,-.77,;5.88,.77,;4.55,-1.54,;.55,-3.85,;-.78,-3.08,;-.78,-1.54,;-2.12,-.77,;-2.12,.77,;-3.58,1.25,;-4.49,,;-5.98,-.4,;-7.06,.69,;-8.55,.29,;-3.58,-1.25,)|
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TBA

Assay Description
For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2JM2DST
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM515821
PNG
(US11053225, Compound 102)
Show SMILES OCCn1cc(cn1)-c1cnc(Nc2cccc(F)c2)nc1Nc1ccc2CCNCc2c1
PDB
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n/an/a 0.420n/an/an/an/an/an/a


TBA

Assay Description
For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2JM2DST
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM515804
PNG
(US11053225, Compound 111)
Show SMILES N[C@H]1CC[C@H](CC1)Nc1nc(Nc2cc(Cl)cc(Cl)c2)ncc1-c1cnn(c1)C1CCNCC1 |r,wU:4.7,1.0,(6.08,3.85,;4.75,3.08,;4.75,1.54,;3.42,.77,;2.08,1.54,;2.08,3.08,;3.42,3.85,;.75,.77,;.75,-.77,;2.08,-1.54,;2.08,-3.08,;3.42,-3.85,;4.75,-3.08,;6.08,-3.85,;7.42,-3.08,;8.75,-3.85,;7.42,-1.54,;6.08,-.77,;6.08,.77,;4.75,-1.54,;.75,-3.85,;-.58,-3.08,;-.58,-1.54,;-1.92,-.77,;-1.92,.77,;-3.38,1.25,;-4.29,,;-3.38,-1.25,;-5.78,-.4,;-6.86,.69,;-8.35,.29,;-8.75,-1.2,;-7.66,-2.28,;-6.17,-1.89,)|
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TBA

Assay Description
For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2JM2DST
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM515890
PNG
(US11053225, Compound 194)
Show SMILES Cc1cc(C)cc(Nc2ncc(-c3cnn(CCO)c3)c(Nc3ccc4CCNCc4c3)n2)c1
PDB
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n/an/a 0.580n/an/an/an/an/an/a


TBA

Assay Description
For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2JM2DST
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM515820
PNG
(US11053225, Compound 101 | US11053225, Compound 19...)
Show SMILES OCCn1cc(cn1)-c1cnc(Nc2cccc(Cl)c2)nc1Nc1ccc2CCNCc2c1
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n/an/a 0.600n/an/an/an/an/an/a


TBA

Assay Description
For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2JM2DST
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM50425862
PNG
(CHEMBL2312654)
Show SMILES CN(C)C1CCC(CC1)Nc1nc(Nc2cc(Cl)cc(Cl)c2)ncc1-c1cc(C)no1 |(9.04,-43.08,;10.39,-42.35,;11.7,-43.16,;10.44,-40.81,;9.13,-40,;9.18,-38.46,;10.53,-37.74,;11.85,-38.53,;11.8,-40.08,;10.57,-36.2,;9.81,-34.87,;8.27,-34.86,;7.51,-33.53,;5.96,-33.52,;5.2,-32.19,;5.97,-30.85,;5.21,-29.52,;5.98,-28.19,;3.67,-29.52,;2.89,-30.86,;1.35,-30.86,;3.66,-32.19,;8.27,-32.2,;9.8,-32.19,;10.58,-33.53,;12.11,-33.53,;12.6,-34.99,;14.14,-34.99,;15.06,-36.23,;14.61,-33.52,;13.35,-32.62,)|
Show InChI InChI=1S/C22H26Cl2N6O/c1-13-8-20(31-29-13)19-12-25-22(27-17-10-14(23)9-15(24)11-17)28-21(19)26-16-4-6-18(7-5-16)30(2)3/h8-12,16,18H,4-7H2,1-3H3,(H2,25,26,27,28)
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Article
PubMed
n/an/a 0.700n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of Sky (unknown origin) by ELISA kinase assay in presence of 60 uM ATP


Bioorg Med Chem Lett 23: 1051-5 (2013)


Article DOI: 10.1016/j.bmcl.2012.12.028
BindingDB Entry DOI: 10.7270/Q2XW4M38
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM515798
PNG
(US11053225, Compound 100)
Show SMILES OCCn1cc(cn1)-c1cnc(Nc2cccc(Cl)c2)nc1N[C@@H]1CC[C@@H](CC1)NC(=O)C(F)(F)F |r,wD:23.25,26.32,(1.73,-9.37,;.83,-8.12,;1.45,-6.72,;.55,-5.47,;1.02,-4.01,;-.22,-3.1,;-1.47,-4.01,;-.99,-5.47,;-.22,-1.56,;-1.56,-.79,;-1.56,.75,;-.22,1.52,;-.22,3.06,;-1.56,3.83,;-1.56,5.37,;-2.89,6.14,;-4.22,5.37,;-4.22,3.83,;-5.56,3.06,;-2.89,3.06,;1.11,.75,;1.11,-.79,;2.45,-1.56,;3.78,-.79,;3.78,.75,;5.11,1.52,;6.45,.75,;6.45,-.79,;5.11,-1.56,;7.78,1.52,;9.11,.75,;9.11,-.79,;10.45,1.52,;11.78,2.29,;11.22,.19,;9.68,2.85,)|
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TBA

Assay Description
For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2JM2DST
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM515848
PNG
(US11053225, Compound 149)
Show SMILES Cn1cc(cn1)-c1cnc(Nc2cccc(Cl)c2)nc1Nc1ccc2CCNCc2c1
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Assay Description
For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2JM2DST
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM50571440
PNG
(CHEMBL4873571)
Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant human RSE (451 to end residues) using KVEKIGEGTYGVVYK as substrate incubated for 40 mins in presence of [gamma33P]ATP by sc...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c02093
BindingDB Entry DOI: 10.7270/Q2PR80SR
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM515884
PNG
(US11053225, Compound 186)
Show SMILES CC(C)Cn1cc(cn1)-c1cnc(Nc2cccc(Cl)c2)nc1Nc1ccc2CCNCc2c1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.20n/an/an/an/an/an/a


TBA

Assay Description
For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2JM2DST
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM515811
PNG
(US11053225, Compound 204)
Show SMILES OCCn1cc(cn1)-c1cnc(Nc2cccc(Cl)c2)nc1Nc1ccc(cc1)C1CCNCC1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.30n/an/an/an/an/an/a


TBA

Assay Description
For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2JM2DST
More data for this
Ligand-Target Pair
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