Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM7533![]() ((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 0.460 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c02064 BindingDB Entry DOI: 10.7270/Q2SB49QV | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM50300690![]() (1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | US Patent | n/a | n/a | 0.623 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 7 For most assays, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phas... | Citation and Details BindingDB Entry DOI: 10.7270/Q2154MW8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM50300690![]() (1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | US Patent | n/a | n/a | 0.623 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 3 and 4: The HotSpot kinase profiling and screening assays were carried out using the method of Anastassiadis et al., Nat. Biotechnol. (2011) V... | Citation and Details BindingDB Entry DOI: 10.7270/Q2154MW8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM139540![]() (US10189849, staurosporine | US10307427, Staurospor...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.623 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 7 For most assays, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phas... | Citation and Details BindingDB Entry DOI: 10.7270/Q2154MW8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM50300690![]() (1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | US Patent | n/a | n/a | 0.623 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 7 For most assays, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phas... | Citation and Details BindingDB Entry DOI: 10.7270/Q2154MW8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM50377170![]() (CHEMBL256570 | US11254667, Compound I-2 | US115422...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.996 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 7 For most assays, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phas... | Citation and Details BindingDB Entry DOI: 10.7270/Q2154MW8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM139540![]() (US10189849, staurosporine | US10307427, Staurospor...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.996 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 7 For most assays, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phas... | Citation and Details BindingDB Entry DOI: 10.7270/Q2154MW8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM50377170![]() (CHEMBL256570 | US11254667, Compound I-2 | US115422...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.996 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 3 and 4: The HotSpot kinase profiling and screening assays were carried out using the method of Anastassiadis et al., Nat. Biotechnol. (2011) V... | Citation and Details BindingDB Entry DOI: 10.7270/Q2154MW8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM50539763![]() (Adagrasib | Mrtx-849 | Mrtx849) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1039/d2md00216g BindingDB Entry DOI: 10.7270/Q2DF6W53 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM50553499![]() (CHEMBL4754493) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c02064 BindingDB Entry DOI: 10.7270/Q2SB49QV | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM530357![]() (WO2022064009, Compound 136 | WO2022064009, Compoun...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022064009 | n/a | n/a | 1.38 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT... | Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM530269![]() (WO2022064009, Compound 13) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022064009 | n/a | n/a | 1.41 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT... | Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM530396![]() (WO2022064009, Compound 173) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022064009 | n/a | n/a | 1.66 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT... | Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM530309![]() (WO2022064009, Compound 70) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022064009 | n/a | n/a | 1.78 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT... | Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM50193093![]() (RGB-286638) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nebraska Medical Center Curated by ChEMBL | Assay Description Inhibition of CDK7/cyclin H (unknown origin) | J Med Chem 59: 8667-8684 (2016) Article DOI: 10.1021/acs.jmedchem.6b00150 BindingDB Entry DOI: 10.7270/Q2G73GP8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM530370![]() (WO2022064009, Compound 180a) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022064009 | n/a | n/a | 2.09 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT... | Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM530249![]() (WO2022064009, Compound 5) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022064009 | n/a | n/a | 2.14 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT... | Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM530318![]() (WO2022064009, Compound 82 | WO2022064009, Compound...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022064009 | n/a | n/a | 2.14 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT... | Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM530318![]() (WO2022064009, Compound 82 | WO2022064009, Compound...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022064009 | n/a | n/a | 2.14 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT... | Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM530297![]() (WO2022064009, Compound 58) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022064009 | n/a | n/a | 2.34 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT... | Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM530245![]() (WO2022064009, Compound 1 | WO2022064009, Compound ...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022064009 | n/a | n/a | 2.45 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT... | Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM530266![]() (WO2022064009, Compound 154 | WO2022064009, Compoun...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022064009 | n/a | n/a | 2.51 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT... | Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM530260![]() (WO2022064009, Compound 37) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022064009 | n/a | n/a | 2.51 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT... | Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM530397![]() (WO2022064009, Compound 174) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022064009 | n/a | n/a | 2.63 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT... | Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM530383![]() (WO2022064009, Compound 160) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022064009 | n/a | n/a | 2.63 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT... | Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM530252![]() (WO2022064009, Compound 8) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022064009 | n/a | n/a | 2.69 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT... | Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM530308![]() (WO2022064009, Compound 69) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022064009 | n/a | n/a | 2.69 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT... | Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM530305![]() (WO2022064009, Compound 66) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022064009 | n/a | n/a | 2.75 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT... | Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM530280![]() (WO2022064009, Compound 29) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022064009 | n/a | n/a | 2.82 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT... | Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM530401![]() (WO2022064009, Compound 188) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022064009 | n/a | n/a | 2.82 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT... | Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM530310![]() (WO2022064009, Compound 71) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022064009 | n/a | n/a | 2.88 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT... | Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM50363196![]() (CHEMBL1944698) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nebraska Medical Center Curated by ChEMBL | Assay Description Inhibition of recombinant human full length C-terminal His6-tagged CDK7/cyclin H/N-terminal GST-tagged MAT1 expressed in baculovirus infected Sf21 in... | J Med Chem 59: 8667-8684 (2016) Article DOI: 10.1021/acs.jmedchem.6b00150 BindingDB Entry DOI: 10.7270/Q2G73GP8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM530335![]() (WO2022064009, Compound 120 | WO2022064009, Compoun...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022064009 | n/a | n/a | 3.02 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT... | Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM530337![]() (WO2022064009, Compound 122b) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022064009 | n/a | n/a | 3.16 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT... | Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM530369![]() (WO2022064009, Compound 150) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022064009 | n/a | n/a | 3.16 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT... | Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM530356![]() (WO2022064009, Compound 134) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022064009 | n/a | n/a | 3.16 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT... | Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM530286![]() (WO2022064009, Compound 156 | WO2022064009, Compoun...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022064009 | n/a | n/a | 3.24 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT... | Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM530256![]() (WO2022064009, Compound 12) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022064009 | n/a | n/a | 3.24 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT... | Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM530423![]() (WO2022064009, Compound 209) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022064009 | n/a | n/a | 3.31 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT... | Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM530424![]() (WO2022064009, Compound 210) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022064009 | n/a | n/a | 3.31 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT... | Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM530299![]() (WO2022064009, Compound 60) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022064009 | n/a | n/a | 3.55 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT... | Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM530354![]() (WO2022064009, Compound 132) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022064009 | n/a | n/a | 3.63 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT... | Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM530339![]() (WO2022064009, Compound 126) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022064009 | n/a | n/a | 3.72 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT... | Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM530250![]() (WO2022064009, Compound 6) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022064009 | n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT... | Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM530316![]() (WO2022064009, Compound 78) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022064009 | n/a | n/a | 4.27 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT... | Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM530377![]() (WO2022064009, Compound 152) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022064009 | n/a | n/a | 4.37 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT... | Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM530251![]() (WO2022064009, Compound 7) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022064009 | n/a | n/a | 4.47 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT... | Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM530301![]() (WO2022064009, Compound 62 | WO2022064009, Compound...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022064009 | n/a | n/a | 4.68 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT... | Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM530426![]() (WO2022064009, Compound 212) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022064009 | n/a | n/a | 4.79 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT... | Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM530408![]() (WO2022064009, Compound 195b) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022064009 | n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT... | Citation and Details BindingDB Entry DOI: 10.7270/Q2MC936B | |||||||||||
More data for this Ligand-Target Pair |
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