Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Proteasome subunit alpha type-6 (Homo sapiens (Human)) | BDBM65508![]() (CPZ analog, 2) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 6.30E+3 | n/a | n/a | 7.5 | 37 |
Michigan State University | Assay Description Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w... | ACS Chem Biol 12: 2240-2247 (2017) Article DOI: 10.1021/acschembio.7b00489 BindingDB Entry DOI: 10.7270/Q2DV1H2F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proteasome subunit alpha type-6 (Homo sapiens (Human)) | BDBM65513![]() (CPZ analog, 7) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 6.40E+3 | n/a | n/a | 7.5 | 37 |
Michigan State University | Assay Description Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w... | ACS Chem Biol 12: 2240-2247 (2017) Article DOI: 10.1021/acschembio.7b00489 BindingDB Entry DOI: 10.7270/Q2DV1H2F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proteasome subunit alpha type-6 (Homo sapiens (Human)) | BDBM67544![]() (N,N-dimethyl-3-[2-(trifluoromethyl)-10-phenothiazi...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase DrugBank MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 7.80E+3 | n/a | n/a | 7.5 | 37 |
Michigan State University | Assay Description Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w... | ACS Chem Biol 12: 2240-2247 (2017) Article DOI: 10.1021/acschembio.7b00489 BindingDB Entry DOI: 10.7270/Q2DV1H2F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proteasome subunit alpha type-6 (Homo sapiens (Human)) | BDBM65511![]() (CPZ analog, 5) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 8.90E+3 | n/a | n/a | 7.5 | 37 |
Michigan State University | Assay Description Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w... | ACS Chem Biol 12: 2240-2247 (2017) Article DOI: 10.1021/acschembio.7b00489 BindingDB Entry DOI: 10.7270/Q2DV1H2F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proteasome subunit alpha type-6 (Homo sapiens (Human)) | BDBM50001888![]() ((chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 9.90E+3 | n/a | n/a | 7.5 | 37 |
Michigan State University | Assay Description Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w... | ACS Chem Biol 12: 2240-2247 (2017) Article DOI: 10.1021/acschembio.7b00489 BindingDB Entry DOI: 10.7270/Q2DV1H2F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proteasome subunit alpha type-6 (Homo sapiens (Human)) | BDBM79211![]() (1-methyl-3-(9H-thioxanthen-9-ylmethyl)piperidine;h...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase DrugBank MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.19E+4 | n/a | n/a | 7.5 | 37 |
Michigan State University | Assay Description Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w... | ACS Chem Biol 12: 2240-2247 (2017) Article DOI: 10.1021/acschembio.7b00489 BindingDB Entry DOI: 10.7270/Q2DV1H2F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proteasome subunit alpha type-6 (Homo sapiens (Human)) | BDBM50002338![]() ((Thioridazine)10-[2-(1-Methyl-piperidin-2-yl)-ethy...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.20E+4 | n/a | n/a | 7.5 | 37 |
Michigan State University | Assay Description Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w... | ACS Chem Biol 12: 2240-2247 (2017) Article DOI: 10.1021/acschembio.7b00489 BindingDB Entry DOI: 10.7270/Q2DV1H2F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proteasome subunit alpha type-6 (Homo sapiens (Human)) | BDBM77970![]() (3-(2-chloranyl-5,6-dihydrobenzo[b][1]benzazepin-11...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.24E+4 | n/a | n/a | 7.5 | 37 |
Michigan State University | Assay Description Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w... | ACS Chem Biol 12: 2240-2247 (2017) Article DOI: 10.1021/acschembio.7b00489 BindingDB Entry DOI: 10.7270/Q2DV1H2F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proteasome subunit alpha type-6 (Homo sapiens (Human)) | BDBM50001888![]() ((chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.48E+4 | n/a | n/a | 7.5 | 37 |
Michigan State University | Assay Description Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w... | ACS Chem Biol 12: 2240-2247 (2017) Article DOI: 10.1021/acschembio.7b00489 BindingDB Entry DOI: 10.7270/Q2DV1H2F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proteasome subunit alpha type-6 (Homo sapiens (Human)) | BDBM65514![]() (CPZ analog, 8) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 1.56E+4 | n/a | n/a | 7.5 | 37 |
Michigan State University | Assay Description Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w... | ACS Chem Biol 12: 2240-2247 (2017) Article DOI: 10.1021/acschembio.7b00489 BindingDB Entry DOI: 10.7270/Q2DV1H2F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
A5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436 (Homo sapiens (Human)) | BDBM50518761![]() (CHEMBL4573271) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 2.40E+4 | n/a | n/a | n/a | n/a |
Purdue University Curated by ChEMBL | Assay Description Stimulation of human 20S proteasome using 11 amino acid FRET peptide as substrate measured every 2 mins over 1 hr by FRET assay | Bioorg Med Chem Lett 29: 420-423 (2019) Article DOI: 10.1016/j.bmcl.2018.12.030 BindingDB Entry DOI: 10.7270/Q20005FH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proteasome subunit alpha type-6 (Homo sapiens (Human)) | BDBM65512![]() (CPZ analog, 6) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | >2.50E+4 | n/a | n/a | 7.5 | 37 |
Michigan State University | Assay Description Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w... | ACS Chem Biol 12: 2240-2247 (2017) Article DOI: 10.1021/acschembio.7b00489 BindingDB Entry DOI: 10.7270/Q2DV1H2F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proteasome subunit alpha type-6 (Homo sapiens (Human)) | BDBM65510![]() (CPZ analog, 4) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | >2.50E+4 | n/a | n/a | 7.5 | 37 |
Michigan State University | Assay Description Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w... | ACS Chem Biol 12: 2240-2247 (2017) Article DOI: 10.1021/acschembio.7b00489 BindingDB Entry DOI: 10.7270/Q2DV1H2F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proteasome subunit alpha type-6 (Homo sapiens (Human)) | BDBM65507![]() (CPZ analog, 1) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | >2.50E+4 | n/a | n/a | 7.5 | 37 |
Michigan State University | Assay Description Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w... | ACS Chem Biol 12: 2240-2247 (2017) Article DOI: 10.1021/acschembio.7b00489 BindingDB Entry DOI: 10.7270/Q2DV1H2F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proteasome subunit alpha type-6 (Homo sapiens (Human)) | BDBM65509![]() (CPZ analog, 3) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | >2.50E+4 | n/a | n/a | 7.5 | 37 |
Michigan State University | Assay Description Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w... | ACS Chem Biol 12: 2240-2247 (2017) Article DOI: 10.1021/acschembio.7b00489 BindingDB Entry DOI: 10.7270/Q2DV1H2F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
A5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436 (Homo sapiens (Human)) | BDBM50054471![]() ((5Z,8Z)-Icosa-5,8,11,14-tetraenoic acid (4-hydroxy...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.80E+4 | n/a | n/a | n/a | n/a |
Purdue University Curated by ChEMBL | Assay Description Stimulation of human 20S proteasome using 11 amino acid FRET peptide as substrate measured every 2 mins over 1 hr by FRET assay | Bioorg Med Chem Lett 29: 420-423 (2019) Article DOI: 10.1016/j.bmcl.2018.12.030 BindingDB Entry DOI: 10.7270/Q20005FH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
A5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436 (Homo sapiens (Human)) | BDBM50518762![]() (CHEMBL4561568) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 3.50E+4 | n/a | n/a | n/a | n/a |
Purdue University Curated by ChEMBL | Assay Description Stimulation of human 20S proteasome using 11 amino acid FRET peptide as substrate measured every 2 mins over 1 hr by FRET assay | Bioorg Med Chem Lett 29: 420-423 (2019) Article DOI: 10.1016/j.bmcl.2018.12.030 BindingDB Entry DOI: 10.7270/Q20005FH | |||||||||||
More data for this Ligand-Target Pair |