BindingDB PrimarySearch

Found 22 hits of ec50 for UniProtKB: Q9QYN8
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50408756 (CHEMBL2145444) Show SMILES CC(C)CCOCCCc1cnc[nH]1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	0.220	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description In vitro intrinsic activity against histamine H3 receptor from synaptosomes of rat cerebral cortex				J Med Chem 42: 4269-74 (1999) BindingDB Entry DOI: 10.7270/Q2B85799
Freie Universität Berlin Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50408755 (CHEMBL2145442) Show SMILES CC(C)CCCOCCCc1cnc[nH]1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	0.25	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description In vitro intrinsic activity against histamine H3 receptor from synaptosomes of rat cerebral cortex				J Med Chem 42: 4269-74 (1999) BindingDB Entry DOI: 10.7270/Q2B85799
Freie Universität Berlin Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50118156 (4-[3-(3,3-Dimethyl-butoxy)-propyl]-1H-imidazole \| ...) Show SMILES CC(C)(C)CCOCCCc1cnc[nH]1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	0.550	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description In vitro intrinsic activity against histamine H3 receptor from synaptosomes of rat cerebral cortex				J Med Chem 42: 4269-74 (1999) BindingDB Entry DOI: 10.7270/Q2B85799
Freie Universität Berlin Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50224191 ((R)-2-(1-(6-ethoxypyridazin-3-yl)-5-methyl-1H-pyra...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.740	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Agonist activity at rat histamine H3 receptor expressed in HEK239 cells assessed as reduction of basal [35S]GTPgammaS binding				J Med Chem 50: 5439-48 (2007) Article DOI: 10.1021/jm0705051 BindingDB Entry DOI: 10.7270/Q25M65G0
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM22911 (2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide \|...) Show SMILES NC(=N)SCCc1cnc[nH]1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description The compound was evaluated for agonistic effect on release of [3H]-histamine from rat brain cortical slices with L-[3H]-histidine at 0.3 microM				Bioorg Med Chem Lett 2: 1231-1234 (1992) Article DOI: 10.1016/S0960-894X(00)80219-X BindingDB Entry DOI: 10.7270/Q2J38SGF
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM22911 (2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide \|...) Show SMILES NC(=N)SCCc1cnc[nH]1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description In vitro intrinsic activity against histamine H3 receptor from synaptosomes of rat cerebral cortex				J Med Chem 42: 4269-74 (1999) BindingDB Entry DOI: 10.7270/Q2B85799
Freie Universität Berlin Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50350021 (CHEMBL1813067) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	2	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inverse agonist activity at rat histamine H3 receptor assessed as inhibition of R-alpha-methylhistamine induced [35S]GTPgammaS binding				J Med Chem 54: 4781-92 (2011) Article DOI: 10.1021/jm200401v BindingDB Entry DOI: 10.7270/Q2W66MRB
Cephalon, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50350023 (CHEMBL1813065) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	2.10	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inverse agonist activity at rat histamine H3 receptor assessed as inhibition of R-alpha-methylhistamine induced [35S]GTPgammaS binding				J Med Chem 54: 4781-92 (2011) Article DOI: 10.1021/jm200401v BindingDB Entry DOI: 10.7270/Q2W66MRB
Cephalon, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50350022 (CHEMBL1813057) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	2.20	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inverse agonist activity at rat histamine H3 receptor assessed as inhibition of R-alpha-methylhistamine induced [35S]GTPgammaS binding				J Med Chem 54: 4781-92 (2011) Article DOI: 10.1021/jm200401v BindingDB Entry DOI: 10.7270/Q2W66MRB
Cephalon, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM22911 (2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide \|...) Show SMILES NC(=N)SCCc1cnc[nH]1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	2.80	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description In vitro binding affinity against histamine H3 receptor from synaptosomes of rat cerebral cortex				J Med Chem 42: 4269-74 (1999) BindingDB Entry DOI: 10.7270/Q2B85799
Freie Universität Berlin Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50224189 ((R)-2-(4-methyl-2-(pyrrolidin-1-yl)pyrimidin-5-yl)...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	3.02	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Agonist activity at rat histamine H3 receptor expressed in HEK239 cells assessed as reduction of basal [35S]GTPgammaS binding				J Med Chem 50: 5439-48 (2007) Article DOI: 10.1021/jm0705051 BindingDB Entry DOI: 10.7270/Q25M65G0
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50224187 ((R)-2-(5-methyl-1-(pyridin-2-yl)-1H-pyrazol-4-yl)-...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.63	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Agonist activity at rat histamine H3 receptor expressed in HEK239 cells assessed as reduction of basal [35S]GTPgammaS binding				J Med Chem 50: 5439-48 (2007) Article DOI: 10.1021/jm0705051 BindingDB Entry DOI: 10.7270/Q25M65G0
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50280120 ((R)-2-(1H-Imidazol-4-yl)-propylamine; hydrobromide...) Show SMILES C[C@H](CN)c1cnc[nH]1 \|r\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	n/a	n/a	4	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was evaluated for agonistic effect on release of [3H]-histamine from rat brain cortical slices with L-[3H]-histidine at 0.3 microM				Bioorg Med Chem Lett 2: 1231-1234 (1992) Article DOI: 10.1016/S0960-894X(00)80219-X BindingDB Entry DOI: 10.7270/Q2J38SGF
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50224192 ((R)-2-(2,7-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)-...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	5.01	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Agonist activity at rat histamine H3 receptor expressed in HEK239 cells assessed as reduction of basal [35S]GTPgammaS binding				J Med Chem 50: 5439-48 (2007) Article DOI: 10.1021/jm0705051 BindingDB Entry DOI: 10.7270/Q25M65G0
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50224190 ((R)-2-(1,3-dimethyl-1H-pyrazol-4-yl)-6-(2-(2-methy...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	5.75	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Agonist activity at rat histamine H3 receptor expressed in HEK239 cells assessed as reduction of basal [35S]GTPgammaS binding				J Med Chem 50: 5439-48 (2007) Article DOI: 10.1021/jm0705051 BindingDB Entry DOI: 10.7270/Q25M65G0
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50224188 ((R)-2-methyl-3-(6-(2-(2-methylpyrrolidin-1-yl)ethy...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	7.24	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Agonist activity at rat histamine H3 receptor expressed in HEK239 cells assessed as reduction of basal [35S]GTPgammaS binding				J Med Chem 50: 5439-48 (2007) Article DOI: 10.1021/jm0705051 BindingDB Entry DOI: 10.7270/Q25M65G0
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50280119 (2-[2-(1H-Imidazol-4-yl)-ethyl]-1-methyl-isothioure...) Show SMILES CN=C(N)SCCc1cnc[nH]1 \|w:1.0\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	n/a	n/a	15	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description The compound was evaluated for agonistic effect on release of [3H]-histamine from rat brain cortical slices with L-[3H]-histidine at 0.3 microM				Bioorg Med Chem Lett 2: 1231-1234 (1992) Article DOI: 10.1016/S0960-894X(00)80219-X BindingDB Entry DOI: 10.7270/Q2J38SGF
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50139391 ((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	17.4	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Agonist activity at rat histamine H3 receptor expressed in HEK239 cells assessed as reduction of basal [35S]GTPgammaS binding				J Med Chem 50: 5439-48 (2007) Article DOI: 10.1021/jm0705051 BindingDB Entry DOI: 10.7270/Q25M65G0
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50327477 ((R)-2-(cyclopropylmethyl)-8-(1-isopropylpiperidin-...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	18	n/a	n/a	n/a	n/a
F Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Inverse agonist activity at rat histamine H3 receptor				Bioorg Med Chem Lett 20: 5713-7 (2010) Article DOI: 10.1016/j.bmcl.2010.08.009 BindingDB Entry DOI: 10.7270/Q2571C7N
F Hoffmann-La Roche Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50118156 (4-[3-(3,3-Dimethyl-butoxy)-propyl]-1H-imidazole \| ...) Show SMILES CC(C)(C)CCOCCCc1cnc[nH]1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	45	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description In vitro binding affinity against histamine H3 receptor from synaptosomes of rat cerebral cortex				J Med Chem 42: 4269-74 (1999) BindingDB Entry DOI: 10.7270/Q2B85799
Freie Universität Berlin Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM7966 (2-(1H-imidazol-4-yl)ethan-1-amine \| CHEMBL544208 \|...) Show SMILES NCCc1cnc[nH]1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article	n/a	n/a	n/a	n/a	62	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was evaluated for antagonistic effect on release of [3H]-histamine from rat brain cortical slices with L-[3H]-histidine at 0.3 microM				Bioorg Med Chem Lett 2: 1231-1234 (1992) Article DOI: 10.1016/S0960-894X(00)80219-X BindingDB Entry DOI: 10.7270/Q2J38SGF
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50408756 (CHEMBL2145444) Show SMILES CC(C)CCOCCCc1cnc[nH]1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	128	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description In vitro binding affinity against histamine H3 receptor from synaptosomes of rat cerebral cortex				J Med Chem 42: 4269-74 (1999) BindingDB Entry DOI: 10.7270/Q2B85799
Freie Universität Berlin Curated by ChEMBL					More data for this Ligand-Target Pair