Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50123246 ((S)-2-Benzenesulfonylamino-3-{[5-(4-guanidino-phen...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.00130 | n/a | n/a | n/a | n/a | n/a | n/a |
Shire BioChem Inc. Curated by ChEMBL | Assay Description Inhibition of vitronectin binding to HT-29 cells expressing integrin alphaV-beta5 | Bioorg Med Chem Lett 13: 503-6 (2003) BindingDB Entry DOI: 10.7270/Q25T3JVD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50123251 ((S)-2-Benzenesulfonylamino-3-{[5-(2-guanidinomethy...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.00580 | n/a | n/a | n/a | n/a | n/a | n/a |
Shire BioChem Inc. Curated by ChEMBL | Assay Description Inhibition of fibrinogen binding to integrin alphaV-beta3 receptor | Bioorg Med Chem Lett 13: 503-6 (2003) BindingDB Entry DOI: 10.7270/Q25T3JVD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50104592 ((S)-3-{[3-(2-Piperidin-4-yl-ethyl)-5,6,7,8-tetrahy...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 0.0160 | n/a | n/a | n/a | n/a | n/a | n/a |
The R. W. Johnson Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of biotinylated fibrinogen binding to immobilized integrin GPIIb/IIIa | Bioorg Med Chem Lett 11: 2619-22 (2001) BindingDB Entry DOI: 10.7270/Q2DB8141 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50346317 ((S)-3-(3-chloro-4-(4-(1,4,5,6-tetrahydropyrimidin-...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.0230 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Tokyo Curated by ChEMBL | Assay Description Antagonist activity at alpha2bbeta3 integrin receptor | J Med Chem 54: 1539-54 (2011) Article DOI: 10.1021/jm101356p BindingDB Entry DOI: 10.7270/Q27S7P30 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50104598 (2-Benzyloxycarbonylamino-3-{[(R)-1-(3-piperidin-4-...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.0270 | n/a | n/a | n/a | n/a | n/a | n/a |
The R. W. Johnson Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of thrombin-induced human gel-filtered platelet aggregation | Bioorg Med Chem Lett 11: 2619-22 (2001) BindingDB Entry DOI: 10.7270/Q2DB8141 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50104602 (2-Benzyloxycarbonylamino-3-{[3-(2-piperidin-4-yl-v...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.0410 | n/a | n/a | n/a | n/a | n/a | n/a |
The R. W. Johnson Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of biotinylated fibrinogen binding to immobilized integrin GPIIb/IIIa | Bioorg Med Chem Lett 11: 2619-22 (2001) BindingDB Entry DOI: 10.7270/Q2DB8141 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50104595 (2-Phenylmethanesulfonylamino-3-{[3-(2-piperidin-4-...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | 0.0430 | n/a | n/a | n/a | n/a | n/a | n/a |
The R. W. Johnson Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of biotinylated fibrinogen binding to immobilized integrin GPIIb/IIIa | Bioorg Med Chem Lett 11: 2619-22 (2001) BindingDB Entry DOI: 10.7270/Q2DB8141 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50104591 ((S)-3-{[3-((E)-2-Piperidin-4-yl-vinyl)-5,6,7,8-tet...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.0570 | n/a | n/a | n/a | n/a | n/a | n/a |
The R. W. Johnson Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of thrombin-induced human gel-filtered platelet aggregation | Bioorg Med Chem Lett 11: 2619-22 (2001) BindingDB Entry DOI: 10.7270/Q2DB8141 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50104600 ((S)-3-{[(R)-1-(3-Piperidin-4-yl-propionyl)-piperid...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL MCE PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.0600 | n/a | n/a | n/a | n/a | n/a | n/a |
The R. W. Johnson Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of biotinylated fibrinogen binding to immobilized integrin GPIIb/IIIa | Bioorg Med Chem Lett 11: 2619-22 (2001) BindingDB Entry DOI: 10.7270/Q2DB8141 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50104597 ((S)-3-{[3-((E)-2-Piperidin-4-yl-vinyl)-5,6,7,8-tet...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.0610 | n/a | n/a | n/a | n/a | n/a | n/a |
The R. W. Johnson Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of thrombin-induced human gel-filtered platelet aggregation | Bioorg Med Chem Lett 11: 2619-22 (2001) BindingDB Entry DOI: 10.7270/Q2DB8141 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50104594 (2-Benzyloxycarbonylamino-3-{[3-(2-piperidin-4-yl-e...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.0680 | n/a | n/a | n/a | n/a | n/a | n/a |
The R. W. Johnson Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of biotinylated fibrinogen binding to immobilized integrin GPIIb/IIIa | Bioorg Med Chem Lett 11: 2619-22 (2001) BindingDB Entry DOI: 10.7270/Q2DB8141 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50067222 (CHEMBL128906 | [6-(4-Carbamimidoyl-benzoylamino)-c...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.0730 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsui Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibition of Fibronogen binding to Immobilized Human Fibrinogen Receptor. | J Med Chem 41: 4036-52 (1998) Article DOI: 10.1021/jm9801859 BindingDB Entry DOI: 10.7270/Q24M93N7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50098965 (3-{2-[(Z)-4-Carbamimidoyl-benzoylimino]-3,4-dimeth...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | 0.0900 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co. Ltd. Curated by ChEMBL | Assay Description Affinity for purified activated GPIIb/IIIa fibrinogen receptor in ELISA | Bioorg Med Chem Lett 11: 1031-5 (2001) BindingDB Entry DOI: 10.7270/Q29G5M2G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50098971 (3-({3-Benzyl-2-[(Z)-4-carbamimidoyl-benzoylimino]-...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.0900 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co. Ltd. Curated by ChEMBL | Assay Description Affinity for purified activated GPIIb/IIIa fibrinogen receptor in ELISA | Bioorg Med Chem Lett 11: 1031-5 (2001) BindingDB Entry DOI: 10.7270/Q29G5M2G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50067216 (CHEMBL129877 | {6-[4-(Imino-morpholin-4-yl-methyl)...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.0980 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsui Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibition of Fibronogen binding to Immobilized Human Fibrinogen Receptor. | J Med Chem 41: 4036-52 (1998) Article DOI: 10.1021/jm9801859 BindingDB Entry DOI: 10.7270/Q24M93N7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50287978 ((S)-3-{[(R)-1-(3-Piperidin-4-yl-propionyl)-piperid...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description In vitro inhibition of biotinylated fibrinogen binding to immobilized integrin alpha IIb beta3 | Bioorg Med Chem Lett 6: 2371-2376 (1996) Article DOI: 10.1016/0960-894X(96)00438-6 BindingDB Entry DOI: 10.7270/Q26M36T2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50287969 ((S)-3-{[(R)-1-(3-Piperidin-4-yl-propionyl)-piperid...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description In vitro inhibition of biotinylated fibrinogen binding to immobilized integrin alpha IIb beta3 | Bioorg Med Chem Lett 6: 2371-2376 (1996) Article DOI: 10.1016/0960-894X(96)00438-6 BindingDB Entry DOI: 10.7270/Q26M36T2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50083469 ((R)-3-(5-Chloro-thiophen-2-yl)-3-{[(R)-1-(3-piperi...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
The R. W. Johnson Pharmaceutical Research Institute Curated by ChEMBL | Assay Description In vitro inhibition of biotinylated fibrinogen binding to immobolized fibrinogen receptor. | J Med Chem 42: 5254-65 (2000) BindingDB Entry DOI: 10.7270/Q2BV7FT4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50083490 ((R)-3-{[(R)-1-(3-Piperidin-4-yl-propionyl)-piperid...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
The R. W. Johnson Pharmaceutical Research Institute Curated by ChEMBL | Assay Description In vitro inhibition of biotinylated fibrinogen binding to immobolized fibrinogen receptor. | J Med Chem 42: 5254-65 (2000) BindingDB Entry DOI: 10.7270/Q2BV7FT4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50104596 (3-{[3-(2-Piperidin-4-yl-vinyl)-5,6,7,8-tetrahydro-...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | 0.120 | n/a | n/a | n/a | n/a | n/a | n/a |
The R. W. Johnson Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of thrombin-induced human gel-filtered platelet aggregation | Bioorg Med Chem Lett 11: 2619-22 (2001) BindingDB Entry DOI: 10.7270/Q2DB8141 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50098967 (3-({2-[(Z)-4-Carbamimidoyl-benzoylimino]-3-ethyl-4...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.120 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co. Ltd. Curated by ChEMBL | Assay Description Inhibition of immobilized HUVEC adhesion on fibronectin | Bioorg Med Chem Lett 11: 1031-5 (2001) BindingDB Entry DOI: 10.7270/Q29G5M2G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50067217 (CHEMBL323649 | {(S)-6-[4-(Imino-morpholin-4-yl-met...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.120 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsui Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibition of Fibronogen binding to Immobilized Human Fibrinogen Receptor. | J Med Chem 41: 4036-52 (1998) Article DOI: 10.1021/jm9801859 BindingDB Entry DOI: 10.7270/Q24M93N7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50067228 (CHEMBL131823 | [7-(4-Carbamimidoyl-benzoylamino)-1...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.120 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsui Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibition of Fibronogen binding to Immobilized Human Fibrinogen Receptor. | J Med Chem 41: 4036-52 (1998) Article DOI: 10.1021/jm9801859 BindingDB Entry DOI: 10.7270/Q24M93N7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50083492 ((S)-3-(6-Methyl-pyridin-3-yl)-3-{[(R)-1-(3-piperid...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 0.130 | n/a | n/a | n/a | n/a | n/a | n/a |
The R. W. Johnson Pharmaceutical Research Institute Curated by ChEMBL | Assay Description In vitro inhibition of biotinylated fibrinogen binding to immobolized fibrinogen receptor. | J Med Chem 42: 5254-65 (2000) BindingDB Entry DOI: 10.7270/Q2BV7FT4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50067220 (CHEMBL130405 | {7-[4-(N-Propylcarbamimidoyl)-benzo...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.130 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsui Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibition of Fibronogen binding to Immobilized Human Fibrinogen Receptor. | J Med Chem 41: 4036-52 (1998) Article DOI: 10.1021/jm9801859 BindingDB Entry DOI: 10.7270/Q24M93N7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50098964 (3-({3-Butyl-2-[(Z)-4-carbamimidoyl-benzoylimino]-4...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.130 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co. Ltd. Curated by ChEMBL | Assay Description Binding to [125I]- fibrinogen by washed platelet fibrinogen receptor | Bioorg Med Chem Lett 11: 1031-5 (2001) BindingDB Entry DOI: 10.7270/Q29G5M2G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50067224 (CHEMBL130437 | {6-[4-(N-Prop-2-ynylcarbamimidoyl)-...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.130 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsui Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibition of Fibronogen binding to Immobilized Human Fibrinogen Receptor. | J Med Chem 41: 4036-52 (1998) Article DOI: 10.1021/jm9801859 BindingDB Entry DOI: 10.7270/Q24M93N7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50083453 ((S)-3-(6-Chloro-pyridin-3-yl)-3-{[(R)-1-(3-piperid...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.140 | n/a | n/a | n/a | n/a | n/a | n/a |
The R. W. Johnson Pharmaceutical Research Institute Curated by ChEMBL | Assay Description In vitro inhibition of biotinylated fibrinogen binding to immobolized fibrinogen receptor. | J Med Chem 42: 5254-65 (2000) BindingDB Entry DOI: 10.7270/Q2BV7FT4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50067218 (CHEMBL130878 | {7-[4-(Imino-morpholin-4-yl-methyl)...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.150 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsui Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibition of Fibronogen binding to Immobilized Human Fibrinogen Receptor. | J Med Chem 41: 4036-52 (1998) Article DOI: 10.1021/jm9801859 BindingDB Entry DOI: 10.7270/Q24M93N7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50104600 ((S)-3-{[(R)-1-(3-Piperidin-4-yl-propionyl)-piperid...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.150 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL | Assay Description Inhibition of human Biotinylated Fg binding to immobilized Alpha II beta-3 | Bioorg Med Chem Lett 14: 5227-32 (2004) Article DOI: 10.1016/j.bmcl.2004.06.061 BindingDB Entry DOI: 10.7270/Q2TH8M5Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50067223 (CHEMBL130892 | {7-[4-(N-Prop-2-ynylcarbamimidoyl)-...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.160 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsui Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibition of Fibronogen binding to Immobilized Human Fibrinogen Receptor. | J Med Chem 41: 4036-52 (1998) Article DOI: 10.1021/jm9801859 BindingDB Entry DOI: 10.7270/Q24M93N7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50123253 ((S)-3-{[5-(3-Guanidinomethyl-phenyl)-thiophene-2-c...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.160 | n/a | n/a | n/a | n/a | n/a | n/a |
Shire BioChem Inc. Curated by ChEMBL | Assay Description Inhibition of fibrinogen binding to K562 cells expressing integrin alphaV-beta3 | Bioorg Med Chem Lett 13: 503-6 (2003) BindingDB Entry DOI: 10.7270/Q25T3JVD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50104598 (2-Benzyloxycarbonylamino-3-{[(R)-1-(3-piperidin-4-...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.170 | n/a | n/a | n/a | n/a | n/a | n/a |
The R. W. Johnson Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of biotinylated fibrinogen binding to immobilized integrin GPIIb/IIIa | Bioorg Med Chem Lett 11: 2619-22 (2001) BindingDB Entry DOI: 10.7270/Q2DB8141 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50346319 ((S)-3-(3-fluoro-4-(4-(1,4,5,6-tetrahydropyrimidin-...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.180 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Tokyo Curated by ChEMBL | Assay Description Antagonist activity at alpha2bbeta3 integrin receptor | J Med Chem 54: 1539-54 (2011) Article DOI: 10.1021/jm101356p BindingDB Entry DOI: 10.7270/Q27S7P30 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50497715 (CHEMBL1180976) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bradford Curated by ChEMBL | Assay Description Antagonist activity at alpha2bbeta3 integrin receptor (unknown origin) by cell-free ELISA | J Med Chem 57: 6301-15 (2014) Article DOI: 10.1021/jm5000547 BindingDB Entry DOI: 10.7270/Q2NS0XW8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50067227 (CHEMBL128539 | {7-[4-(N-Furan-2-ylmethyl-carbamimi...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsui Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibition of Fibronogen binding to Immobilized Human Fibrinogen Receptor. | J Med Chem 41: 4036-52 (1998) Article DOI: 10.1021/jm9801859 BindingDB Entry DOI: 10.7270/Q24M93N7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50104597 ((S)-3-{[3-((E)-2-Piperidin-4-yl-vinyl)-5,6,7,8-tet...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.210 | n/a | n/a | n/a | n/a | n/a | n/a |
The R. W. Johnson Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of biotinylated fibrinogen binding to immobilized integrin GPIIb/IIIa | Bioorg Med Chem Lett 11: 2619-22 (2001) BindingDB Entry DOI: 10.7270/Q2DB8141 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50083456 ((S)-3-(5-Bromo-pyridin-3-yl)-3-{[(R)-1-(3-piperidi...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.210 | n/a | n/a | n/a | n/a | n/a | n/a |
The R. W. Johnson Pharmaceutical Research Institute Curated by ChEMBL | Assay Description In vitro inhibition of biotinylated fibrinogen binding to immobolized fibrinogen receptor. | J Med Chem 42: 5254-65 (2000) BindingDB Entry DOI: 10.7270/Q2BV7FT4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50346318 ((S)-3-(3-fluoro-4-(4-(1,4,5,6-tetrahydropyrimidin-...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.210 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Tokyo Curated by ChEMBL | Assay Description Antagonist activity at alpha2bbeta3 integrin receptor | J Med Chem 54: 1539-54 (2011) Article DOI: 10.1021/jm101356p BindingDB Entry DOI: 10.7270/Q27S7P30 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50062810 (3-{(S)-1-[2-(4-Carbamimidoyl-benzoylamino)-acetyl]...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.210 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Chemical Industries, Ltd. Curated by ChEMBL | Assay Description Ability to inhibit binding of biotin-labeled human fibrinogen to immobilized fibrinogen receptor purified from human erythroleukemia(HEL) cells. | J Med Chem 41: 489-502 (1998) Article DOI: 10.1021/jm970235u BindingDB Entry DOI: 10.7270/Q2571B4W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50083479 ((R)-5-Phenyl-3-{[(R)-1-(3-piperidin-4-yl-propionyl...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.220 | n/a | n/a | n/a | n/a | n/a | n/a |
The R. W. Johnson Pharmaceutical Research Institute Curated by ChEMBL | Assay Description In vitro inhibition of biotinylated fibrinogen binding to immobolized fibrinogen receptor. | J Med Chem 42: 5254-65 (2000) BindingDB Entry DOI: 10.7270/Q2BV7FT4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50083455 ((S)-3-(5-Ethynyl-pyridin-3-yl)-3-{[(R)-1-(3-piperi...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.240 | n/a | n/a | n/a | n/a | n/a | n/a |
The R. W. Johnson Pharmaceutical Research Institute Curated by ChEMBL | Assay Description In vitro inhibition of biotinylated fibrinogen binding to immobolized fibrinogen receptor. | J Med Chem 42: 5254-65 (2000) BindingDB Entry DOI: 10.7270/Q2BV7FT4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50083496 ((R)-3-Benzo[1,3]dioxol-5-yl-3-({(R)-1-[3-(1-methyl...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.240 | n/a | n/a | n/a | n/a | n/a | n/a |
The R. W. Johnson Pharmaceutical Research Institute Curated by ChEMBL | Assay Description In vitro inhibition of biotinylated fibrinogen binding to immobolized fibrinogen receptor. | J Med Chem 42: 5254-65 (2000) BindingDB Entry DOI: 10.7270/Q2BV7FT4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50058855 ((S)-2-Butoxycarbonylamino-3-{2-[(R)-3-(4-carbamimi...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 0.25 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Merck Pharmaceutical Company Curated by ChEMBL | Assay Description Inhibition of [125I]fibrinogen binding to purified platelet Fibrinogen Receptor | J Med Chem 40: 2064-84 (1997) Article DOI: 10.1021/jm960799i BindingDB Entry DOI: 10.7270/Q2DB82HC | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50123252 ((S)-2-Benzenesulfonylamino-3-{[5-(2-guanidino-phen...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.25 | n/a | n/a | n/a | n/a | n/a | n/a |
Shire BioChem Inc. Curated by ChEMBL | Assay Description Inhibition of fibrinogen binding to K562 cells expressing integrin alpha5-beta1 | Bioorg Med Chem Lett 13: 503-6 (2003) BindingDB Entry DOI: 10.7270/Q25T3JVD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50058855 ((S)-2-Butoxycarbonylamino-3-{2-[(R)-3-(4-carbamimi...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB PubMed | n/a | n/a | 0.25 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Pharmaceuticals Company Curated by ChEMBL | Assay Description Inhbition of platelet aggregation in heparin treated human platelet rich plasma (PRP) | Bioorg Med Chem Lett 9: 123-6 (1999) BindingDB Entry DOI: 10.7270/Q2P55MND | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50067230 (CHEMBL131593 | {7-[4-(N-Allylcarbamimidoyl)-benzoy...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.260 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsui Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibition of Fibronogen binding to Immobilized Human Fibrinogen Receptor. | J Med Chem 41: 4036-52 (1998) Article DOI: 10.1021/jm9801859 BindingDB Entry DOI: 10.7270/Q24M93N7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50083467 ((S)-5-Phenyl-3-{[(R)-1-(3-piperidin-4-yl-propionyl...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.290 | n/a | n/a | n/a | n/a | n/a | n/a |
The R. W. Johnson Pharmaceutical Research Institute Curated by ChEMBL | Assay Description In vitro inhibition of biotinylated fibrinogen binding to immobolized fibrinogen receptor. | J Med Chem 42: 5254-65 (2000) BindingDB Entry DOI: 10.7270/Q2BV7FT4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50062797 (3-{(S)-1-[2-(4-Carbamimidoyl-benzoylamino)-acetyl]...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.290 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Chemical Industries, Ltd. Curated by ChEMBL | Assay Description Ability to inhibit binding of biotin-labeled human fibrinogen to immobilized fibrinogen receptor purified from human erythroleukemia(HEL) cells. | J Med Chem 41: 489-502 (1998) Article DOI: 10.1021/jm970235u BindingDB Entry DOI: 10.7270/Q2571B4W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin alpha-IIb/beta-3 (Homo sapiens (Human)) | BDBM50123248 ((S)-2-Benzenesulfonylamino-3-{[5-(3-guanidinomethy...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bradford Curated by ChEMBL | Assay Description Antagonist activity at alpha2bbeta3 integrin receptor (unknown origin) by cell-free ELISA | J Med Chem 57: 6301-15 (2014) Article DOI: 10.1021/jm5000547 BindingDB Entry DOI: 10.7270/Q2NS0XW8 | |||||||||||
More data for this Ligand-Target Pair |
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