Found 185 hits of ic50 for UniProtKB: P97639 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50383522
(CHEMBL2032049)Show SMILES C[C@@H]1[C@H]2CN(CCC3(CCCCC3)C(O)=O)CC[C@@H]2Cc2[nH]c3ccc(cc3c12)C(F)(F)F |r| Show InChI InChI=1S/C26H33F3N2O2/c1-16-20-15-31(12-10-25(24(32)33)8-3-2-4-9-25)11-7-17(20)13-22-23(16)19-14-18(26(27,28)29)5-6-21(19)30-22/h5-6,14,16-17,20,30H,2-4,7-13,15H2,1H3,(H,32,33)/t16-,17-,20-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen San Francisco
Curated by ChEMBL
| Assay Description Antagonist activity at rat MCHR1 assessed inhibition of MCH-mediated intracellular Ca2+ calcium mobilization |
Bioorg Med Chem Lett 22: 3781-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.04.006 BindingDB Entry DOI: 10.7270/Q2542PMN |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50383112
(CHEMBL2029372)Show SMILES Cc1c(NC(=O)c2ccc(cc2)-c2ccc(F)cc2)ccc2cc(CN3CCCC3)cnc12 Show InChI InChI=1S/C28H26FN3O/c1-19-26(13-10-24-16-20(17-30-27(19)24)18-32-14-2-3-15-32)31-28(33)23-6-4-21(5-7-23)22-8-11-25(29)12-9-22/h4-13,16-17H,2-3,14-15,18H2,1H3,(H,31,33) | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Displacement of [125I]MCH from rat MCHR1 expressed in CHO cells after 60 mins by liquid scintillation counting |
J Med Chem 55: 4336-51 (2012)
Article DOI: 10.1021/jm300167z BindingDB Entry DOI: 10.7270/Q2JS9RHR |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50388442
(CHEMBL2059408)Show SMILES CCCCOc1ccc(cc1)C(=O)Nc1ccc2cc(CN3CCCC3)cnc2c1C Show InChI InChI=1S/C26H31N3O2/c1-3-4-15-31-23-10-7-21(8-11-23)26(30)28-24-12-9-22-16-20(17-27-25(22)19(24)2)18-29-13-5-6-14-29/h7-12,16-17H,3-6,13-15,18H2,1-2H3,(H,28,30) | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Displacement of [125I]MCH from rat MCHR1 expressed in CHO cells after 60 mins by liquid scintillation counting |
J Med Chem 55: 4336-51 (2012)
Article DOI: 10.1021/jm300167z BindingDB Entry DOI: 10.7270/Q2JS9RHR |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50388443
(CHEMBL2059409)Show SMILES Cc1c(NC(=O)c2ccc(OCC3CC3)cc2)ccc2cc(CN3CCCC3)cnc12 Show InChI InChI=1S/C26H29N3O2/c1-18-24(28-26(30)21-6-9-23(10-7-21)31-17-19-4-5-19)11-8-22-14-20(15-27-25(18)22)16-29-12-2-3-13-29/h6-11,14-15,19H,2-5,12-13,16-17H2,1H3,(H,28,30) | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Displacement of [125I]MCH from rat MCHR1 expressed in CHO cells after 60 mins by liquid scintillation counting |
J Med Chem 55: 4336-51 (2012)
Article DOI: 10.1021/jm300167z BindingDB Entry DOI: 10.7270/Q2JS9RHR |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50383112
(CHEMBL2029372)Show SMILES Cc1c(NC(=O)c2ccc(cc2)-c2ccc(F)cc2)ccc2cc(CN3CCCC3)cnc12 Show InChI InChI=1S/C28H26FN3O/c1-19-26(13-10-24-16-20(17-30-27(19)24)18-32-14-2-3-15-32)31-28(33)23-6-4-21(5-7-23)22-8-11-25(29)12-9-22/h4-13,16-17H,2-3,14-15,18H2,1H3,(H,31,33) | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
| Assay Description Displacement of [125I]MCH from rat MCHR1 expressed in CHO cells after 1 hr by scintillation counting |
J Med Chem 55: 2353-66 (2012)
Article DOI: 10.1021/jm201596h BindingDB Entry DOI: 10.7270/Q2GH9JZQ |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50219047
(CHEMBL245231 | N-(3-(1-(4-(3,4-difluorophenoxy)ben...)Show SMILES CC(C)C(=O)Nc1cccc(c1)C1CCN(Cc2ccc(Oc3ccc(F)c(F)c3)cc2)CC1 Show InChI InChI=1S/C28H30F2N2O2/c1-19(2)28(33)31-23-5-3-4-22(16-23)21-12-14-32(15-13-21)18-20-6-8-24(9-7-20)34-25-10-11-26(29)27(30)17-25/h3-11,16-17,19,21H,12-15,18H2,1-2H3,(H,31,33) | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description Inhibition of rat MCH1R receptor |
Bioorg Med Chem Lett 19: 5339-45 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.132 BindingDB Entry DOI: 10.7270/Q27P90BK |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50388452
(CHEMBL2059420)Show SMILES C[C@@H](N1CCCC1)c1cnc2c(C)c(NC(=O)c3ccc(OCC4CC4)cc3)ccc2c1 |r| Show InChI InChI=1S/C27H31N3O2/c1-18-25(29-27(31)21-7-10-24(11-8-21)32-17-20-5-6-20)12-9-22-15-23(16-28-26(18)22)19(2)30-13-3-4-14-30/h7-12,15-16,19-20H,3-6,13-14,17H2,1-2H3,(H,29,31)/t19-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Displacement of [125I]MCH from rat MCHR1 expressed in CHO cells after 60 mins by liquid scintillation counting |
J Med Chem 55: 4336-51 (2012)
Article DOI: 10.1021/jm300167z BindingDB Entry DOI: 10.7270/Q2JS9RHR |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50388444
(CHEMBL2059410)Show SMILES Cc1c(NC(=O)c2ccc(OCCC3CC3)cc2)ccc2cc(CN3CCCC3)cnc12 Show InChI InChI=1S/C27H31N3O2/c1-19-25(11-8-23-16-21(17-28-26(19)23)18-30-13-2-3-14-30)29-27(31)22-6-9-24(10-7-22)32-15-12-20-4-5-20/h6-11,16-17,20H,2-5,12-15,18H2,1H3,(H,29,31) | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Displacement of [125I]MCH from rat MCHR1 expressed in CHO cells after 60 mins by liquid scintillation counting |
J Med Chem 55: 4336-51 (2012)
Article DOI: 10.1021/jm300167z BindingDB Entry DOI: 10.7270/Q2JS9RHR |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50351312
(CHEMBL1818800)Show SMILES Clc1ccc(cc1)-c1ccc(cc1)C(=O)Nc1ccc2C=C(CN3CCCC3)CCc2c1 |t:22| Show InChI InChI=1S/C28H27ClN2O/c29-26-12-9-22(10-13-26)21-5-7-23(8-6-21)28(32)30-27-14-11-24-17-20(3-4-25(24)18-27)19-31-15-1-2-16-31/h5-14,17-18H,1-4,15-16,19H2,(H,30,32) | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
| Assay Description Displacement of [125I]-MCH from rat MCHR1 expressed in CHO cells after 60 mins by scintillation counting |
Bioorg Med Chem 19: 5539-52 (2011)
Article DOI: 10.1016/j.bmc.2011.07.038 BindingDB Entry DOI: 10.7270/Q26H4HT4 |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50351322
(CHEMBL1818810)Show SMILES Cc1ccc(cc1)-c1ccc(cc1)C(=O)Nc1ccc2C=C(CN3CCCC3)CCc2c1 |t:22| Show InChI InChI=1S/C29H30N2O/c1-21-4-7-23(8-5-21)24-10-12-25(13-11-24)29(32)30-28-15-14-26-18-22(6-9-27(26)19-28)20-31-16-2-3-17-31/h4-5,7-8,10-15,18-19H,2-3,6,9,16-17,20H2,1H3,(H,30,32) | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
| Assay Description Displacement of [125I]-MCH from rat MCHR1 expressed in CHO cells after 60 mins by scintillation counting |
Bioorg Med Chem 19: 5539-52 (2011)
Article DOI: 10.1016/j.bmc.2011.07.038 BindingDB Entry DOI: 10.7270/Q26H4HT4 |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50388460
(CHEMBL2059513)Show SMILES C[C@@H](NCCNC(C)=O)c1cnc2c(C)c(NC(=O)c3ccc(OCC4CC4)cc3)ccc2c1 |r| Show InChI InChI=1S/C27H32N4O3/c1-17-25(31-27(33)21-6-9-24(10-7-21)34-16-20-4-5-20)11-8-22-14-23(15-30-26(17)22)18(2)28-12-13-29-19(3)32/h6-11,14-15,18,20,28H,4-5,12-13,16H2,1-3H3,(H,29,32)(H,31,33)/t18-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Displacement of [125I]MCH from rat MCHR1 expressed in CHO cells after 60 mins by liquid scintillation counting |
J Med Chem 55: 4336-51 (2012)
Article DOI: 10.1021/jm300167z BindingDB Entry DOI: 10.7270/Q2JS9RHR |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50351313
(CHEMBL1818801)Show SMILES Clc1ccc(cc1)-c1ccc(cc1)C(=O)Nc1ccc2C=C(CN3CCCCC3)CCc2c1 |t:22| Show InChI InChI=1S/C29H29ClN2O/c30-27-13-10-23(11-14-27)22-6-8-24(9-7-22)29(33)31-28-15-12-25-18-21(4-5-26(25)19-28)20-32-16-2-1-3-17-32/h6-15,18-19H,1-5,16-17,20H2,(H,31,33) | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
| Assay Description Displacement of [125I]-MCH from rat MCHR1 expressed in CHO cells after 60 mins by scintillation counting |
Bioorg Med Chem 19: 5539-52 (2011)
Article DOI: 10.1016/j.bmc.2011.07.038 BindingDB Entry DOI: 10.7270/Q26H4HT4 |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50388457
(CHEMBL2059426)Show SMILES CC(NCC(C)(C)O)c1cnc2c(C)c(NC(=O)c3ccc(OCC4CC4)cc3)ccc2c1 Show InChI InChI=1S/C27H33N3O3/c1-17-24(30-26(31)20-7-10-23(11-8-20)33-15-19-5-6-19)12-9-21-13-22(14-28-25(17)21)18(2)29-16-27(3,4)32/h7-14,18-19,29,32H,5-6,15-16H2,1-4H3,(H,30,31) | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Displacement of [125I]MCH from rat MCHR1 expressed in CHO cells after 60 mins by liquid scintillation counting |
J Med Chem 55: 4336-51 (2012)
Article DOI: 10.1021/jm300167z BindingDB Entry DOI: 10.7270/Q2JS9RHR |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50351308
(CHEMBL1818795)Show SMILES CN(C)CC1=Cc2ccc(NC(=O)c3ccc(cc3)-c3ccc(Cl)cc3)cc2CC1 |t:4| Show InChI InChI=1S/C26H25ClN2O/c1-29(2)17-18-3-4-23-16-25(14-11-22(23)15-18)28-26(30)21-7-5-19(6-8-21)20-9-12-24(27)13-10-20/h5-16H,3-4,17H2,1-2H3,(H,28,30) | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
| Assay Description Displacement of [125I]-MCH from rat MCHR1 expressed in CHO cells after 60 mins by scintillation counting |
Bioorg Med Chem 19: 5539-52 (2011)
Article DOI: 10.1016/j.bmc.2011.07.038 BindingDB Entry DOI: 10.7270/Q26H4HT4 |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50388458
(CHEMBL2059511)Show SMILES CC(NCCNC(C)=O)c1cnc2c(C)c(NC(=O)c3ccc(OCC4CC4)cc3)ccc2c1 Show InChI InChI=1S/C27H32N4O3/c1-17-25(31-27(33)21-6-9-24(10-7-21)34-16-20-4-5-20)11-8-22-14-23(15-30-26(17)22)18(2)28-12-13-29-19(3)32/h6-11,14-15,18,20,28H,4-5,12-13,16H2,1-3H3,(H,29,32)(H,31,33) | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Displacement of [125I]MCH from rat MCHR1 expressed in CHO cells after 60 mins by liquid scintillation counting |
J Med Chem 55: 4336-51 (2012)
Article DOI: 10.1021/jm300167z BindingDB Entry DOI: 10.7270/Q2JS9RHR |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50351323
(CHEMBL1818811)Show SMILES COc1ccc(cc1)-c1ccc(cc1)C(=O)Nc1ccc2C=C(CN3CCCC3)CCc2c1 |t:23| Show InChI InChI=1S/C29H30N2O2/c1-33-28-14-11-23(12-15-28)22-6-8-24(9-7-22)29(32)30-27-13-10-25-18-21(4-5-26(25)19-27)20-31-16-2-3-17-31/h6-15,18-19H,2-5,16-17,20H2,1H3,(H,30,32) | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
| Assay Description Displacement of [125I]-MCH from rat MCHR1 expressed in CHO cells after 60 mins by scintillation counting |
Bioorg Med Chem 19: 5539-52 (2011)
Article DOI: 10.1016/j.bmc.2011.07.038 BindingDB Entry DOI: 10.7270/Q26H4HT4 |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50358743
(CHEMBL1922270)Show SMILES C[C@@H]1[C@H]2CN(CCCC3CCOCC3)CC[C@@H]2Cc2[nH]c3ccc(cc3c12)C(F)(F)F |r| Show InChI InChI=1S/C25H33F3N2O/c1-16-21-15-30(9-2-3-17-7-11-31-12-8-17)10-6-18(21)13-23-24(16)20-14-19(25(26,27)28)4-5-22(20)29-23/h4-5,14,16-18,21,29H,2-3,6-13,15H2,1H3/t16-,18-,21-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen
Curated by ChEMBL
| Assay Description Antagonist activity at rat MCHR1 expressed in HEK293 cells by aequorin bioluminescence assay |
Bioorg Med Chem Lett 21: 7001-5 (2011)
Article DOI: 10.1016/j.bmcl.2011.09.110 BindingDB Entry DOI: 10.7270/Q29887FX |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50351324
(CHEMBL1818901)Show SMILES Fc1ccc(cc1)-c1ccc(cc1)C(=O)Nc1ccc2C=C(CN3CCCC3)CCc2c1 |t:22| Show InChI InChI=1S/C28H27FN2O/c29-26-12-9-22(10-13-26)21-5-7-23(8-6-21)28(32)30-27-14-11-24-17-20(3-4-25(24)18-27)19-31-15-1-2-16-31/h5-14,17-18H,1-4,15-16,19H2,(H,30,32) | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
| Assay Description Displacement of [125I]-MCH from rat MCHR1 expressed in CHO cells after 60 mins by scintillation counting |
Bioorg Med Chem 19: 5539-52 (2011)
Article DOI: 10.1016/j.bmc.2011.07.038 BindingDB Entry DOI: 10.7270/Q26H4HT4 |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50388450
(CHEMBL2059418)Show SMILES CC(N1CCCC1)c1cnc2c(C)c(NC(=O)c3ccc(OCC4CC4)cc3)ccc2c1 Show InChI InChI=1S/C27H31N3O2/c1-18-25(29-27(31)21-7-10-24(11-8-21)32-17-20-5-6-20)12-9-22-15-23(16-28-26(18)22)19(2)30-13-3-4-14-30/h7-12,15-16,19-20H,3-6,13-14,17H2,1-2H3,(H,29,31) | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Displacement of [125I]MCH from rat MCHR1 expressed in CHO cells after 60 mins by liquid scintillation counting |
J Med Chem 55: 4336-51 (2012)
Article DOI: 10.1021/jm300167z BindingDB Entry DOI: 10.7270/Q2JS9RHR |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50351314
(CHEMBL1818802)Show SMILES CN1CCN(CC2=Cc3ccc(NC(=O)c4ccc(cc4)-c4ccc(Cl)cc4)cc3CC2)CC1 |t:6| Show InChI InChI=1S/C29H30ClN3O/c1-32-14-16-33(17-15-32)20-21-2-3-26-19-28(13-10-25(26)18-21)31-29(34)24-6-4-22(5-7-24)23-8-11-27(30)12-9-23/h4-13,18-19H,2-3,14-17,20H2,1H3,(H,31,34) | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 5.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
| Assay Description Displacement of [125I]-MCH from rat MCHR1 expressed in CHO cells after 60 mins by scintillation counting |
Bioorg Med Chem 19: 5539-52 (2011)
Article DOI: 10.1016/j.bmc.2011.07.038 BindingDB Entry DOI: 10.7270/Q26H4HT4 |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50351297
(CHEMBL1818783)Show SMILES CN(C)CC1CCc2cc(NC(=O)c3ccc(cc3)-c3ccc(Cl)cc3)ccc2C1 Show InChI InChI=1S/C26H27ClN2O/c1-29(2)17-18-3-4-23-16-25(14-11-22(23)15-18)28-26(30)21-7-5-19(6-8-21)20-9-12-24(27)13-10-20/h5-14,16,18H,3-4,15,17H2,1-2H3,(H,28,30) | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 5.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
| Assay Description Displacement of [125I]-MCH from rat MCHR1 expressed in CHO cells after 60 mins by scintillation counting |
Bioorg Med Chem 19: 5539-52 (2011)
Article DOI: 10.1016/j.bmc.2011.07.038 BindingDB Entry DOI: 10.7270/Q26H4HT4 |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50388454
(CHEMBL2059422)Show SMILES CC(N1CCCCCC1)c1cnc2c(C)c(NC(=O)c3ccc(OCC4CC4)cc3)ccc2c1 Show InChI InChI=1S/C29H35N3O2/c1-20-27(31-29(33)23-9-12-26(13-10-23)34-19-22-7-8-22)14-11-24-17-25(18-30-28(20)24)21(2)32-15-5-3-4-6-16-32/h9-14,17-18,21-22H,3-8,15-16,19H2,1-2H3,(H,31,33) | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Displacement of [125I]MCH from rat MCHR1 expressed in CHO cells after 60 mins by liquid scintillation counting |
J Med Chem 55: 4336-51 (2012)
Article DOI: 10.1021/jm300167z BindingDB Entry DOI: 10.7270/Q2JS9RHR |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50391543
(CHEMBL2147477)Show SMILES [#6]-[#6@@H](-[#6]-[#7]-[#6]-c1ccccc1)-[#7]-1-[#6]-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7](-[#6]-[#6]-c2cccc(F)c2)-[#6]-1=S |r| Show InChI InChI=1S/C25H35FN6S/c1-19(16-29-17-21-7-3-2-4-8-21)32-18-23(11-6-13-30-24(27)28)31(25(32)33)14-12-20-9-5-10-22(26)15-20/h2-5,7-10,15,19,23,29H,6,11-14,16-18H2,1H3,(H4,27,28,30)/t19-,23-/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 6.10 | n/a | n/a | n/a | n/a | n/a | n/a |
LEO Pharma
Curated by ChEMBL
| Assay Description Antagonist activity at rat MCH1 receptor expressed in HEK 293T cells assessed as inhibition of MCH-induced Ca2+ mobilization after 10 mins by FLIPR a... |
Bioorg Med Chem Lett 22: 6039-47 (2012)
Article DOI: 10.1016/j.bmcl.2012.08.025 BindingDB Entry DOI: 10.7270/Q2T72JHK |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50351318
(CHEMBL1818806)Show SMILES CCC(=O)N(C)CC1=Cc2ccc(NC(=O)c3ccc(cc3)-c3ccc(Cl)cc3)cc2CC1 |t:7| Show InChI InChI=1S/C28H27ClN2O2/c1-3-27(32)31(2)18-19-4-5-24-17-26(15-12-23(24)16-19)30-28(33)22-8-6-20(7-9-22)21-10-13-25(29)14-11-21/h6-17H,3-5,18H2,1-2H3,(H,30,33) | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
| Assay Description Displacement of [125I]-MCH from rat MCHR1 expressed in CHO cells after 60 mins by scintillation counting |
Bioorg Med Chem 19: 5539-52 (2011)
Article DOI: 10.1016/j.bmc.2011.07.038 BindingDB Entry DOI: 10.7270/Q26H4HT4 |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50149456
(CHEMBL3769702)Show SMILES Cc1c(nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cn12)C1CC1 Show InChI InChI=1S/C20H18F3N3O3/c1-12-19(13-2-3-13)25-17-9-4-14(10-26(12)17)24-18(27)11-28-15-5-7-16(8-6-15)29-20(21,22)23/h4-10,13H,2-3,11H2,1H3,(H,24,27) | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis |
J Med Chem 59: 1116-39 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01704 BindingDB Entry DOI: 10.7270/Q2V40X2T |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50357508
(CHEMBL1914637)Show SMILES CCS(=O)(=O)N1CCc2ccc(cc2CC1)C(=O)CCCN1CCC(CC1)c1ccc(Cl)cc1 Show InChI InChI=1S/C27H35ClN2O3S/c1-2-34(32,33)30-18-13-22-5-6-25(20-24(22)14-19-30)27(31)4-3-15-29-16-11-23(12-17-29)21-7-9-26(28)10-8-21/h5-10,20,23H,2-4,11-19H2,1H3 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Displacement of [125I]-MCH(4-19) from rat MCHR1 expressed in CHO cells |
Bioorg Med Chem 19: 6261-73 (2011)
Article DOI: 10.1016/j.bmc.2011.09.007 BindingDB Entry DOI: 10.7270/Q26T0N2H |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50388445
(CHEMBL2059411)Show SMILES CC(C)COc1ccc(cc1)C(=O)Nc1ccc2cc(CN3CCCC3)cnc2c1C Show InChI InChI=1S/C26H31N3O2/c1-18(2)17-31-23-9-6-21(7-10-23)26(30)28-24-11-8-22-14-20(15-27-25(22)19(24)3)16-29-12-4-5-13-29/h6-11,14-15,18H,4-5,12-13,16-17H2,1-3H3,(H,28,30) | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Displacement of [125I]MCH from rat MCHR1 expressed in CHO cells after 60 mins by liquid scintillation counting |
J Med Chem 55: 4336-51 (2012)
Article DOI: 10.1021/jm300167z BindingDB Entry DOI: 10.7270/Q2JS9RHR |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50388449
(CHEMBL2059417)Show SMILES CC1CCCN1Cc1cnc2c(C)c(NC(=O)c3ccc(OCC4CC4)cc3)ccc2c1 Show InChI InChI=1S/C27H31N3O2/c1-18-4-3-13-30(18)16-21-14-23-9-12-25(19(2)26(23)28-15-21)29-27(31)22-7-10-24(11-8-22)32-17-20-5-6-20/h7-12,14-15,18,20H,3-6,13,16-17H2,1-2H3,(H,29,31) | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Displacement of [125I]MCH from rat MCHR1 expressed in CHO cells after 60 mins by liquid scintillation counting |
J Med Chem 55: 4336-51 (2012)
Article DOI: 10.1021/jm300167z BindingDB Entry DOI: 10.7270/Q2JS9RHR |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50357504
(CHEMBL1914633)Show SMILES Clc1ccc(cc1)C1CCN(CCCC(=O)c2ccc3CCN(CCc3c2)C(=O)C2CC2)CC1 Show InChI InChI=1S/C29H35ClN2O2/c30-27-9-7-21(8-10-27)23-11-16-31(17-12-23)15-1-2-28(33)26-6-3-22-13-18-32(19-14-25(22)20-26)29(34)24-4-5-24/h3,6-10,20,23-24H,1-2,4-5,11-19H2 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Displacement of [125I]-MCH(4-19) from rat MCHR1 expressed in CHO cells |
Bioorg Med Chem 19: 6261-73 (2011)
Article DOI: 10.1016/j.bmc.2011.09.007 BindingDB Entry DOI: 10.7270/Q26T0N2H |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50149462
(CHEMBL3771182)Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2csc(Cl)c2)cc1=O)C1CC1 Show InChI InChI=1S/C21H18ClN3O2S/c1-13-21(15-2-3-15)23-19-5-4-16(10-25(13)19)24-7-6-17(9-20(24)26)27-11-14-8-18(22)28-12-14/h4-10,12,15H,2-3,11H2,1H3 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis |
J Med Chem 59: 1116-39 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01704 BindingDB Entry DOI: 10.7270/Q2V40X2T |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50357503
(CHEMBL1914632)Show SMILES CCCC(=O)N1CCc2ccc(cc2CC1)C(=O)CCCN1CCC(CC1)c1ccc(Cl)cc1 Show InChI InChI=1S/C29H37ClN2O2/c1-2-4-29(34)32-19-14-23-6-7-26(21-25(23)15-20-32)28(33)5-3-16-31-17-12-24(13-18-31)22-8-10-27(30)11-9-22/h6-11,21,24H,2-5,12-20H2,1H3 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Displacement of [125I]-MCH(4-19) from rat MCHR1 expressed in CHO cells |
Bioorg Med Chem 19: 6261-73 (2011)
Article DOI: 10.1016/j.bmc.2011.09.007 BindingDB Entry DOI: 10.7270/Q26T0N2H |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50189576
((R)-6-(6-(3-(methylamino)pyrrolidin-1-yl)pyridin-3...)Show SMILES CN[C@@H]1CCN(C1)c1ccc(cn1)-n1ncc2cc(sc2c1=O)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C23H20F3N5OS/c1-27-17-8-9-30(13-17)20-7-6-18(12-28-20)31-22(32)21-15(11-29-31)10-19(33-21)14-2-4-16(5-3-14)23(24,25)26/h2-7,10-12,17,27H,8-9,13H2,1H3/t17-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description Activity at chimeric rat/human MCH1R by accumulation of GTPgammaS |
J Med Chem 49: 3753-6 (2006)
Article DOI: 10.1021/jm051263c BindingDB Entry DOI: 10.7270/Q2Z037SN |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50149457
(CHEMBL3771335)Show SMILES Cc1nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cn2c1C Show InChI InChI=1S/C18H16F3N3O3/c1-11-12(2)24-9-13(3-8-16(24)22-11)23-17(25)10-26-14-4-6-15(7-5-14)27-18(19,20)21/h3-9H,10H2,1-2H3,(H,23,25) | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis |
J Med Chem 59: 1116-39 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01704 BindingDB Entry DOI: 10.7270/Q2V40X2T |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50388451
(CHEMBL2059419)Show SMILES C[C@H](N1CCCC1)c1cnc2c(C)c(NC(=O)c3ccc(OCC4CC4)cc3)ccc2c1 |r| Show InChI InChI=1S/C27H31N3O2/c1-18-25(29-27(31)21-7-10-24(11-8-21)32-17-20-5-6-20)12-9-22-15-23(16-28-26(18)22)19(2)30-13-3-4-14-30/h7-12,15-16,19-20H,3-6,13-14,17H2,1-2H3,(H,29,31)/t19-/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Displacement of [125I]MCH from rat MCHR1 expressed in CHO cells after 60 mins by liquid scintillation counting |
J Med Chem 55: 4336-51 (2012)
Article DOI: 10.1021/jm300167z BindingDB Entry DOI: 10.7270/Q2JS9RHR |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50351297
(CHEMBL1818783)Show SMILES CN(C)CC1CCc2cc(NC(=O)c3ccc(cc3)-c3ccc(Cl)cc3)ccc2C1 Show InChI InChI=1S/C26H27ClN2O/c1-29(2)17-18-3-4-23-16-25(14-11-22(23)15-18)28-26(30)21-7-5-19(6-8-21)20-9-12-24(27)13-10-20/h5-14,16,18H,3-4,15,17H2,1-2H3,(H,28,30) | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
| Assay Description Displacement of [125I]-MCH from rat MCHR1 expressed in CHO cells after 60 mins by scintillation counting |
Bioorg Med Chem 19: 5539-52 (2011)
Article DOI: 10.1016/j.bmc.2011.07.038 BindingDB Entry DOI: 10.7270/Q26H4HT4 |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50351297
(CHEMBL1818783)Show SMILES CN(C)CC1CCc2cc(NC(=O)c3ccc(cc3)-c3ccc(Cl)cc3)ccc2C1 Show InChI InChI=1S/C26H27ClN2O/c1-29(2)17-18-3-4-23-16-25(14-11-22(23)15-18)28-26(30)21-7-5-19(6-8-21)20-9-12-24(27)13-10-20/h5-14,16,18H,3-4,15,17H2,1-2H3,(H,28,30) | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
| Assay Description Displacement of [125I]-MCH from rat MCHR1 expressed in CHO cells after 60 mins by scintillation counting |
Bioorg Med Chem 19: 5539-52 (2011)
Article DOI: 10.1016/j.bmc.2011.07.038 BindingDB Entry DOI: 10.7270/Q26H4HT4 |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50388441
(CHEMBL2059514)Show SMILES Cc1c(NC(=O)c2ccc(OCC3CC3)cc2)ccc2cc(cnc12)C(C)(C)N1CCCC1 Show InChI InChI=1S/C28H33N3O2/c1-19-25(30-27(32)21-8-11-24(12-9-21)33-18-20-6-7-20)13-10-22-16-23(17-29-26(19)22)28(2,3)31-14-4-5-15-31/h8-13,16-17,20H,4-7,14-15,18H2,1-3H3,(H,30,32) | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Displacement of [125I]MCH from rat MCHR1 expressed in CHO cells after 60 mins by liquid scintillation counting |
J Med Chem 55: 4336-51 (2012)
Article DOI: 10.1021/jm300167z BindingDB Entry DOI: 10.7270/Q2JS9RHR |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50388453
(CHEMBL2059421)Show SMILES CC(N1CCCCC1)c1cnc2c(C)c(NC(=O)c3ccc(OCC4CC4)cc3)ccc2c1 Show InChI InChI=1S/C28H33N3O2/c1-19-26(30-28(32)22-8-11-25(12-9-22)33-18-21-6-7-21)13-10-23-16-24(17-29-27(19)23)20(2)31-14-4-3-5-15-31/h8-13,16-17,20-21H,3-7,14-15,18H2,1-2H3,(H,30,32) | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Displacement of [125I]MCH from rat MCHR1 expressed in CHO cells after 60 mins by liquid scintillation counting |
J Med Chem 55: 4336-51 (2012)
Article DOI: 10.1021/jm300167z BindingDB Entry DOI: 10.7270/Q2JS9RHR |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50357502
(CHEMBL1914631)Show SMILES CCC(=O)N1CCc2ccc(cc2CC1)C(=O)CCCN1CCC(CC1)c1ccc(Cl)cc1 Show InChI InChI=1S/C28H35ClN2O2/c1-2-28(33)31-18-13-22-5-6-25(20-24(22)14-19-31)27(32)4-3-15-30-16-11-23(12-17-30)21-7-9-26(29)10-8-21/h5-10,20,23H,2-4,11-19H2,1H3 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Displacement of [125I]-MCH(4-19) from rat MCHR1 expressed in CHO cells |
Bioorg Med Chem 19: 6261-73 (2011)
Article DOI: 10.1016/j.bmc.2011.09.007 BindingDB Entry DOI: 10.7270/Q26T0N2H |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50357507
(CHEMBL1914636)Show SMILES CS(=O)(=O)N1CCc2ccc(cc2CC1)C(=O)CCCN1CCC(CC1)c1ccc(Cl)cc1 Show InChI InChI=1S/C26H33ClN2O3S/c1-33(31,32)29-17-12-21-4-5-24(19-23(21)13-18-29)26(30)3-2-14-28-15-10-22(11-16-28)20-6-8-25(27)9-7-20/h4-9,19,22H,2-3,10-18H2,1H3 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Displacement of [125I]-MCH(4-19) from rat MCHR1 expressed in CHO cells |
Bioorg Med Chem 19: 6261-73 (2011)
Article DOI: 10.1016/j.bmc.2011.09.007 BindingDB Entry DOI: 10.7270/Q26T0N2H |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50189581
((S)-6-(4-chlorophenyl)-2-(6-(3-(methylamino)pyrrol...)Show SMILES CN[C@H]1CCN(C1)c1ccc(cn1)-n1ncc2cc(ccc2c1=O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C24H22ClN5O/c1-26-20-10-11-29(15-20)23-9-7-21(14-27-23)30-24(31)22-8-4-17(12-18(22)13-28-30)16-2-5-19(25)6-3-16/h2-9,12-14,20,26H,10-11,15H2,1H3/t20-/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description Activity at chimeric rat/human MCH1R by accumulation of GTPgammaS |
J Med Chem 49: 3753-6 (2006)
Article DOI: 10.1021/jm051263c BindingDB Entry DOI: 10.7270/Q2Z037SN |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50351315
(CHEMBL1818803)Show SMILES CNCC1=Cc2ccc(NC(=O)c3ccc(cc3)-c3ccc(Cl)cc3)cc2CC1 |t:3| Show InChI InChI=1S/C25H23ClN2O/c1-27-16-17-2-3-22-15-24(13-10-21(22)14-17)28-25(29)20-6-4-18(5-7-20)19-8-11-23(26)12-9-19/h4-15,27H,2-3,16H2,1H3,(H,28,29) | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
| Assay Description Displacement of [125I]-MCH from rat MCHR1 expressed in CHO cells after 60 mins by scintillation counting |
Bioorg Med Chem 19: 5539-52 (2011)
Article DOI: 10.1016/j.bmc.2011.07.038 BindingDB Entry DOI: 10.7270/Q26H4HT4 |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50301708
((Z)-1'-((6-((3,4-difluorophenyl)(ethoxyimino)methy...)Show SMILES CCO\N=C(\c1ccc(F)c(F)c1)c1ccc(CN2CCC3(CC2)OCc2cn(C)c(=O)cc32)cn1 Show InChI InChI=1S/C27H28F2N4O3/c1-3-36-31-26(19-5-6-22(28)23(29)12-19)24-7-4-18(14-30-24)15-33-10-8-27(9-11-33)21-13-25(34)32(2)16-20(21)17-35-27/h4-7,12-14,16H,3,8-11,15,17H2,1-2H3/b31-26- | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description Inhibition of rat MCH1R receptor |
Bioorg Med Chem Lett 19: 5339-45 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.132 BindingDB Entry DOI: 10.7270/Q27P90BK |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50149443
(CHEMBL3771307)Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2ccc(Br)cc2)cc1=O)C1CC1 Show InChI InChI=1S/C23H20BrN3O2/c1-15-23(17-4-5-17)25-21-9-8-19(13-27(15)21)26-11-10-20(12-22(26)28)29-14-16-2-6-18(24)7-3-16/h2-3,6-13,17H,4-5,14H2,1H3 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis |
J Med Chem 59: 1116-39 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01704 BindingDB Entry DOI: 10.7270/Q2V40X2T |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50163480
(CHEMBL3792707)Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2csc(Cl)c2)cc1=O)C1CC1 Show InChI InChI=1S/C21H18ClN3O2S/c1-24-18-9-15(4-5-17(18)23-21(24)14-2-3-14)25-7-6-16(10-20(25)26)27-11-13-8-19(22)28-12-13/h4-10,12,14H,2-3,11H2,1H3 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Displacement of [125I]-MCH(4-19) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting |
Bioorg Med Chem 24: 2486-503 (2016)
Article DOI: 10.1016/j.bmc.2016.04.011 BindingDB Entry DOI: 10.7270/Q2862JB1 |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50351324
(CHEMBL1818901)Show SMILES Fc1ccc(cc1)-c1ccc(cc1)C(=O)Nc1ccc2C=C(CN3CCCC3)CCc2c1 |t:22| Show InChI InChI=1S/C28H27FN2O/c29-26-12-9-22(10-13-26)21-5-7-23(8-6-21)28(32)30-27-14-11-24-17-20(3-4-25(24)18-27)19-31-15-1-2-16-31/h5-14,17-18H,1-4,15-16,19H2,(H,30,32) | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
| Assay Description Antagonist activity at rat MCHR1 expressed in CHO cells assessed as inhibition of MCH-induced GTPgammaS binding after 60 mins by scintillation counti... |
Bioorg Med Chem 19: 5539-52 (2011)
Article DOI: 10.1016/j.bmc.2011.07.038 BindingDB Entry DOI: 10.7270/Q26H4HT4 |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50357526
(CHEMBL1914852)Show SMILES CC(=O)N1CCc2ccc(cc2C1)C(=O)CCCN1CCC(CC1)c1ccc(Cl)cc1 Show InChI InChI=1S/C26H31ClN2O2/c1-19(30)29-16-12-21-4-5-23(17-24(21)18-29)26(31)3-2-13-28-14-10-22(11-15-28)20-6-8-25(27)9-7-20/h4-9,17,22H,2-3,10-16,18H2,1H3 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Displacement of [125I]-MCH(4-19) from rat MCHR1 expressed in CHO cells |
Bioorg Med Chem 19: 6261-73 (2011)
Article DOI: 10.1016/j.bmc.2011.09.007 BindingDB Entry DOI: 10.7270/Q26T0N2H |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50357505
(CHEMBL1914634)Show SMILES CCCCC(=O)N1CCc2ccc(cc2CC1)C(=O)CCCN1CCC(CC1)c1ccc(Cl)cc1 Show InChI InChI=1S/C30H39ClN2O2/c1-2-3-6-30(35)33-20-15-24-7-8-27(22-26(24)16-21-33)29(34)5-4-17-32-18-13-25(14-19-32)23-9-11-28(31)12-10-23/h7-12,22,25H,2-6,13-21H2,1H3 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Displacement of [125I]-MCH(4-19) from rat MCHR1 expressed in CHO cells |
Bioorg Med Chem 19: 6261-73 (2011)
Article DOI: 10.1016/j.bmc.2011.09.007 BindingDB Entry DOI: 10.7270/Q26T0N2H |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50357510
(CHEMBL1914639)Show SMILES CCNC(=O)N1CCc2ccc(cc2CC1)C(=O)CCCN1CCC(CC1)c1ccc(Cl)cc1 Show InChI InChI=1S/C28H36ClN3O2/c1-2-30-28(34)32-18-13-22-5-6-25(20-24(22)14-19-32)27(33)4-3-15-31-16-11-23(12-17-31)21-7-9-26(29)10-8-21/h5-10,20,23H,2-4,11-19H2,1H3,(H,30,34) | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Displacement of [125I]-MCH(4-19) from rat MCHR1 expressed in CHO cells |
Bioorg Med Chem 19: 6261-73 (2011)
Article DOI: 10.1016/j.bmc.2011.09.007 BindingDB Entry DOI: 10.7270/Q26T0N2H |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50149444
(CHEMBL3770706)Show SMILES Cc1c(nc2ccc(cn12)-n1ccc2oc(cc2c1=O)-c1ccc(Cl)cc1)C1CC1 Show InChI InChI=1S/C24H18ClN3O2/c1-14-23(16-2-3-16)26-22-9-8-18(13-28(14)22)27-11-10-20-19(24(27)29)12-21(30-20)15-4-6-17(25)7-5-15/h4-13,16H,2-3H2,1H3 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis |
J Med Chem 59: 1116-39 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01704 BindingDB Entry DOI: 10.7270/Q2V40X2T |
More data for this Ligand-Target Pair | |