Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Gag-Pol polyprotein [489-587,G537V,H558K,V571A] (Human immunodeficiency virus) | BDBM50422052 (CHEMBL109952 | L-700417) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | MMDB Article PubMed | 0.370 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CSIR-National Chemical Laboratory Curated by ChEMBL | Assay Description Inhibition of recombinant HIV protease expressed in inclusion bodies of Escherichia coli BL21 (DE3) | J Med Chem 61: 3779-3798 (2018) Article DOI: 10.1021/acs.jmedchem.7b00718 BindingDB Entry DOI: 10.7270/Q2GT5QTK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gag-Pol polyprotein [489-587,G537V,H558K,V571A] (Human immunodeficiency virus) | BDBM50067593 (CHEBI:44032 | Crixivan | Indinavir | L-735524 | MK...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 0.380 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CSIR-National Chemical Laboratory Curated by ChEMBL | Assay Description Inhibition of recombinant HIV protease expressed in inclusion bodies of Escherichia coli BL21 (DE3) | J Med Chem 61: 3779-3798 (2018) Article DOI: 10.1021/acs.jmedchem.7b00718 BindingDB Entry DOI: 10.7270/Q2GT5QTK | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Gag-Pol polyprotein [489-587,G537V,H558K,V571A] (Human immunodeficiency virus) | BDBM84460 (HIV-1 PR Inhibitor, compound 6) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | MMDB PC cid PC sid UniChem | MMDB Article PubMed | 1.70 | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute | Assay Description The inhibition activity against HIV-1 PR and three mutants (G48V, V82F, V82A)were done in 96 well microtiter plate and were assayed. Wells that show... | Chembiochem 4: 1246-8 (2003) Article DOI: 10.1002/cbic.200300724 BindingDB Entry DOI: 10.7270/Q23N21XC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gag-Pol polyprotein [489-587,G537V,H558K,V571A] (Human immunodeficiency virus) | BDBM50462131 (CHEMBL2182010) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CSIR-National Chemical Laboratory Curated by ChEMBL | Assay Description Inhibition of HIV protease | J Med Chem 61: 3779-3798 (2018) Article DOI: 10.1021/acs.jmedchem.7b00718 BindingDB Entry DOI: 10.7270/Q2GT5QTK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gag-Pol polyprotein [489-587,G537V,H558K,V571A] (Human immunodeficiency virus) | BDBM84461 (HIV-1 PR Inhibitor, compound 8) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem | MMDB PDB Article PubMed | 4 | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute | Assay Description The inhibition activity against HIV-1 PR and three mutants (G48V, V82F, V82A)were done in 96 well microtiter plate and were assayed. Wells that show... | Chembiochem 4: 1246-8 (2003) Article DOI: 10.1002/cbic.200300724 BindingDB Entry DOI: 10.7270/Q23N21XC | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Gag-Pol polyprotein [489-587,G537V,H558K,V571A] (Human immunodeficiency virus) | BDBM84461 (HIV-1 PR Inhibitor, compound 8) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem | MMDB PDB Article PubMed | 9.70 | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute | Assay Description The inhibition activity against HIV-1 PR and three mutants (G48V, V82F, V82A)were done in 96 well microtiter plate and were assayed. Wells that show... | Chembiochem 4: 1246-8 (2003) Article DOI: 10.1002/cbic.200300724 BindingDB Entry DOI: 10.7270/Q23N21XC | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Gag-Pol polyprotein [489-587,G537V,H558K,V571A] (Human immunodeficiency virus) | BDBM84460 (HIV-1 PR Inhibitor, compound 6) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | MMDB PC cid PC sid UniChem | MMDB Article PubMed | 10 | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute | Assay Description The inhibition activity against HIV-1 PR and three mutants (G48V, V82F, V82A)were done in 96 well microtiter plate and were assayed. Wells that show... | Chembiochem 4: 1246-8 (2003) Article DOI: 10.1002/cbic.200300724 BindingDB Entry DOI: 10.7270/Q23N21XC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gag-Pol polyprotein [489-587,G537V,H558K,V571A] (Human immunodeficiency virus) | BDBM84461 (HIV-1 PR Inhibitor, compound 8) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem | MMDB PDB Article PubMed | 13 | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute | Assay Description The inhibition activity against HIV-1 PR and three mutants (G48V, V82F, V82A)were done in 96 well microtiter plate and were assayed. Wells that show... | Chembiochem 4: 1246-8 (2003) Article DOI: 10.1002/cbic.200300724 BindingDB Entry DOI: 10.7270/Q23N21XC | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Gag-Pol polyprotein [489-587,G537V,H558K,V571A] (Human immunodeficiency virus) | BDBM84460 (HIV-1 PR Inhibitor, compound 6) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | MMDB PC cid PC sid UniChem | MMDB Article PubMed | 22 | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute | Assay Description The inhibition activity against HIV-1 PR and three mutants (G48V, V82F, V82A)were done in 96 well microtiter plate and were assayed. Wells that show... | Chembiochem 4: 1246-8 (2003) Article DOI: 10.1002/cbic.200300724 BindingDB Entry DOI: 10.7270/Q23N21XC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gag-Pol polyprotein [489-587,G537V,H558K,V571A] (Human immunodeficiency virus) | BDBM84460 (HIV-1 PR Inhibitor, compound 6) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | MMDB PC cid PC sid UniChem | MMDB Article PubMed | 27 | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute | Assay Description The inhibition activity against HIV-1 PR and three mutants (G48V, V82F, V82A)were done in 96 well microtiter plate and were assayed. Wells that show... | Chembiochem 4: 1246-8 (2003) Article DOI: 10.1002/cbic.200300724 BindingDB Entry DOI: 10.7270/Q23N21XC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gag-Pol polyprotein [489-587,G537V,H558K,V571A] (Human immunodeficiency virus) | BDBM84461 (HIV-1 PR Inhibitor, compound 8) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem | MMDB PDB Article PubMed | 30 | n/a | 52 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute | Assay Description The inhibition activity against HIV-1 PR and three mutants (G48V, V82F, V82A)were done in 96 well microtiter plate and were assayed. Wells that show... | Chembiochem 4: 1246-8 (2003) Article DOI: 10.1002/cbic.200300724 BindingDB Entry DOI: 10.7270/Q23N21XC | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |