Compile Data Set for Download or QSAR

Found 61 hits Enz. Inhib. hit(s) with all data for entry = 1049   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM8365 (N-[6-(3-chloro-4-hydroxyphenyl)-1H-pyrazolo[3,4-b]...) Show SMILES Oc1ccc(cc1Cl)-c1ccc2c(NC(=O)C3CC3)n[nH]c2n1 Show InChI InChI=1S/C16H13ClN4O2/c17-11-7-9(3-6-13(11)22)12-5-4-10-14(18-12)20-21-15(10)19-16(23)8-1-2-8/h3-8,22H,1-2H2,(H2,18,19,20,21,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM8364 (CHEMBL260416 | N-[6-(3-bromo-4-hydroxyphenyl)-1H-p...) Show SMILES Oc1ccc(cc1Br)-c1ccc2c(NC(=O)C3CC3)n[nH]c2n1 Show InChI InChI=1S/C16H13BrN4O2/c17-11-7-9(3-6-13(11)22)12-5-4-10-14(18-12)20-21-15(10)19-16(23)8-1-2-8/h3-8,22H,1-2H2,(H2,18,19,20,21,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair				3D Structure (docked)
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM8370 (N-[6-(4-hydroxyphenyl)-1H-indazol-3-yl]cyclopropan...) Show SMILES Oc1ccc(cc1)-c1ccc2c(NC(=O)C3CC3)n[nH]c2c1 Show InChI InChI=1S/C17H15N3O2/c21-13-6-3-10(4-7-13)12-5-8-14-15(9-12)19-20-16(14)18-17(22)11-1-2-11/h3-9,11,21H,1-2H2,(H2,18,19,20,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM8348 (6-aryl-pyrazolo[3,4-b]pyridine analogue 12 | CHEMB...) Show SMILES Oc1ccc(cc1)-c1nc2[nH]nc(NC(=O)C3CC3)c2cc1-c1ccccc1 Show InChI InChI=1S/C22H18N4O2/c27-16-10-8-14(9-11-16)19-17(13-4-2-1-3-5-13)12-18-20(23-19)25-26-21(18)24-22(28)15-6-7-15/h1-5,8-12,15,27H,6-7H2,(H2,23,24,25,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM8349 (6-aryl-pyrazolo[3,4-b]pyridine analogue 13 | CHEMB...) Show SMILES Oc1ccc(cc1)-c1nc2[nH]nc(NC(=O)C3CC3)c2cc1Br Show InChI InChI=1S/C16H13BrN4O2/c17-12-7-11-14(18-13(12)8-3-5-10(22)6-4-8)20-21-15(11)19-16(23)9-1-2-9/h3-7,9,22H,1-2H2,(H2,18,19,20,21,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 alpha (Homo sapiens (Human))	BDBM8392 (CHEMBL408564 | N-[5-bromo-6-(furan-2-yl)-1H-pyrazo...) Show SMILES Brc1cc2c(NC(=O)C3CC3)n[nH]c2nc1-c1ccco1 Show InChI InChI=1S/C14H11BrN4O2/c15-9-6-8-12(16-11(9)10-2-1-5-21-10)18-19-13(8)17-14(20)7-3-4-7/h1-2,5-7H,3-4H2,(H2,16,17,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 alpha (Homo sapiens (Human))	BDBM8390 (CHEMBL407980 | N-[5-bromo-6-(thiophen-2-yl)-1H-pyr...) Show SMILES Brc1cc2c(NC(=O)C3CCCC3)n[nH]c2nc1-c1cccs1 Show InChI InChI=1S/C16H15BrN4OS/c17-11-8-10-14(18-13(11)12-6-3-7-23-12)20-21-15(10)19-16(22)9-4-1-2-5-9/h3,6-9H,1-2,4-5H2,(H2,18,19,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM8341 (6-aryl-pyrazolo[3,4-b]pyridine analogue 5 | N-[6-(...) Show SMILES Oc1ccc(cc1)-c1ccc2c(NC(=O)C3CC3)n[nH]c2n1 Show InChI InChI=1S/C16H14N4O2/c21-11-5-3-9(4-6-11)13-8-7-12-14(17-13)19-20-15(12)18-16(22)10-1-2-10/h3-8,10,21H,1-2H2,(H2,17,18,19,20,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 alpha (Homo sapiens (Human))	BDBM8396 (1-benzyl-N-[5-bromo-6-(furan-2-yl)-1H-pyrazolo[3,4...) Show SMILES Brc1cc2c(NC(=O)C3CCN(Cc4ccccc4)C3)n[nH]c2nc1-c1ccco1 Show InChI InChI=1S/C22H20BrN5O2/c23-17-11-16-20(24-19(17)18-7-4-10-30-18)26-27-21(16)25-22(29)15-8-9-28(13-15)12-14-5-2-1-3-6-14/h1-7,10-11,15H,8-9,12-13H2,(H2,24,25,26,27,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 alpha (Homo sapiens (Human))	BDBM8394 (CHEMBL406644 | N-[5-bromo-6-(1,3-thiazol-2-yl)-1H-...) Show SMILES Brc1cc2c(NC(=O)C3CCCC3)n[nH]c2nc1-c1nccs1 Show InChI InChI=1S/C15H14BrN5OS/c16-10-7-9-12(18-11(10)15-17-5-6-23-15)20-21-13(9)19-14(22)8-3-1-2-4-8/h5-8H,1-4H2,(H2,18,19,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 alpha (Homo sapiens (Human))	BDBM8395 (CHEMBL101747 | N-[5-bromo-6-(thiophen-2-yl)-1H-pyr...) Show SMILES CCN1CCC(CC(=O)Nc2n[nH]c3nc(-c4cccs4)c(Br)cc23)CC1 Show InChI InChI=1S/C19H22BrN5OS/c1-2-25-7-5-12(6-8-25)10-16(26)21-18-13-11-14(20)17(15-4-3-9-27-15)22-19(13)24-23-18/h3-4,9,11-12H,2,5-8,10H2,1H3,(H2,21,22,23,24,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 alpha (Homo sapiens (Human))	BDBM8386 (CHEMBL260243 | N-[6-(furan-3-yl)-1H-indazol-3-yl]c...) Show SMILES O=C(Nc1n[nH]c2cc(ccc12)-c1ccoc1)C1CC1 Show InChI InChI=1S/C15H13N3O2/c19-15(9-1-2-9)16-14-12-4-3-10(7-13(12)17-18-14)11-5-6-20-8-11/h3-9H,1-2H2,(H2,16,17,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 alpha (Homo sapiens (Human))	BDBM8389 (CHEMBL260231 | N-[5-bromo-6-(thiophen-2-yl)-1H-pyr...) Show SMILES Brc1cc2c(NC(=O)C3CC3)n[nH]c2nc1-c1cccs1 Show InChI InChI=1S/C14H11BrN4OS/c15-9-6-8-12(16-11(9)10-2-1-5-21-10)18-19-13(8)17-14(20)7-3-4-7/h1-2,5-7H,3-4H2,(H2,16,17,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 alpha (Homo sapiens (Human))	BDBM8385 (CHEMBL421207 | N-[6-(furan-2-yl)-1H-indazol-3-yl]c...) Show SMILES O=C(Nc1n[nH]c2cc(ccc12)-c1ccco1)C1CC1 Show InChI InChI=1S/C15H13N3O2/c19-15(9-3-4-9)16-14-11-6-5-10(8-12(11)17-18-14)13-2-1-7-20-13/h1-2,5-9H,3-4H2,(H2,16,17,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	7.0	22
GlaxoSmithKline					Assay Description The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM8357 (6-aryl-pyrazolo[3,4-b]pyridine analogue 21 | CHEMB...) Show SMILES CCN1CCN(CCCC(=O)Nc2n[nH]c3nc(c(Br)cc23)-c2ccc(O)cc2)CC1 Show InChI InChI=1S/C22H27BrN6O2/c1-2-28-10-12-29(13-11-28)9-3-4-19(31)24-21-17-14-18(23)20(25-22(17)27-26-21)15-5-7-16(30)8-6-15/h5-8,14,30H,2-4,9-13H2,1H3,(H2,24,25,26,27,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM8344 (6-aryl-pyrazolo[3,4-b]pyridine analogue 8 | CHEMBL...) Show SMILES Oc1cccc(c1)-c1ccc2c(NC(=O)C3CC3)n[nH]c2n1 Show InChI InChI=1S/C16H14N4O2/c21-11-3-1-2-10(8-11)13-7-6-12-14(17-13)19-20-15(12)18-16(22)9-4-5-9/h1-3,6-9,21H,4-5H2,(H2,17,18,19,20,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	62	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 alpha (Homo sapiens (Human))	BDBM8393 (CHEMBL261690 | N-[5-bromo-6-(1,3-thiazol-2-yl)-1H-...) Show SMILES Brc1cc2c(NC(=O)C3CC3)n[nH]c2nc1-c1nccs1 Show InChI InChI=1S/C13H10BrN5OS/c14-8-5-7-10(16-9(8)13-15-3-4-21-13)18-19-11(7)17-12(20)6-1-2-6/h3-6H,1-2H2,(H2,16,17,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	99	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 alpha (Homo sapiens (Human))	BDBM8391 (CHEMBL101804 | N-[6-(furan-2-yl)-1H-pyrazolo[3,4-b...) Show SMILES O=C(Nc1n[nH]c2nc(ccc12)-c1ccco1)C1CC1 Show InChI InChI=1S/C14H12N4O2/c19-14(8-3-4-8)16-13-9-5-6-10(11-2-1-7-20-11)15-12(9)17-18-13/h1-2,5-8H,3-4H2,(H2,15,16,17,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	141	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 alpha (Homo sapiens (Human))	BDBM8387 (CHEMBL318522 | N-[6-(thiophen-2-yl)-1H-indazol-3-y...) Show SMILES O=C(Nc1n[nH]c2cc(ccc12)-c1cccs1)C1CC1 Show InChI InChI=1S/C15H13N3OS/c19-15(9-3-4-9)16-14-11-6-5-10(8-12(11)17-18-14)13-2-1-7-20-13/h1-2,5-9H,3-4H2,(H2,16,17,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	215	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 alpha (Homo sapiens (Human))	BDBM8384 (CHEMBL260929 | N-[6-(1H-pyrrol-2-yl)-1H-indazol-3-...) Show SMILES O=C(Nc1n[nH]c2cc(ccc12)-c1ccc[nH]1)C1CC1 Show InChI InChI=1S/C15H14N4O/c20-15(9-3-4-9)17-14-11-6-5-10(8-13(11)18-19-14)12-2-1-7-16-12/h1-2,5-9,16H,3-4H2,(H2,17,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	7.0	22
GlaxoSmithKline					Assay Description The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 alpha (Homo sapiens (Human))	BDBM8388 (CHEMBL260928 | N-[6-(thiophen-3-yl)-1H-indazol-3-y...) Show SMILES O=C(Nc1n[nH]c2cc(ccc12)-c1ccsc1)C1CC1 Show InChI InChI=1S/C15H13N3OS/c19-15(9-1-2-9)16-14-12-4-3-10(7-13(12)17-18-14)11-5-6-20-8-11/h3-9H,1-2H2,(H2,16,17,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	329	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM8387 (CHEMBL318522 | N-[6-(thiophen-2-yl)-1H-indazol-3-y...) Show SMILES O=C(Nc1n[nH]c2cc(ccc12)-c1cccs1)C1CC1 Show InChI InChI=1S/C15H13N3OS/c19-15(9-3-4-9)16-14-11-6-5-10(8-12(11)17-18-14)13-2-1-7-20-13/h1-2,5-9H,3-4H2,(H2,16,17,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	341	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 alpha (Homo sapiens (Human))	BDBM8374 (CHEMBL407113 | N-[6-(3-sulfamoylphenyl)-1H-indazol...) Show SMILES NS(=O)(=O)c1cccc(c1)-c1ccc2c(NC(=O)C3CC3)n[nH]c2c1 Show InChI InChI=1S/C17H16N4O3S/c18-25(23,24)13-3-1-2-11(8-13)12-6-7-14-15(9-12)20-21-16(14)19-17(22)10-4-5-10/h1-3,6-10H,4-5H2,(H2,18,23,24)(H2,19,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	481	n/a	n/a	n/a	n/a	7.0	22
GlaxoSmithKline					Assay Description The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM8388 (CHEMBL260928 | N-[6-(thiophen-3-yl)-1H-indazol-3-y...) Show SMILES O=C(Nc1n[nH]c2cc(ccc12)-c1ccsc1)C1CC1 Show InChI InChI=1S/C15H13N3OS/c19-15(9-1-2-9)16-14-12-4-3-10(7-13(12)17-18-14)11-5-6-20-8-11/h3-9H,1-2H2,(H2,16,17,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	484	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM8384 (CHEMBL260929 | N-[6-(1H-pyrrol-2-yl)-1H-indazol-3-...) Show SMILES O=C(Nc1n[nH]c2cc(ccc12)-c1ccc[nH]1)C1CC1 Show InChI InChI=1S/C15H14N4O/c20-15(9-3-4-9)17-14-11-6-5-10(8-13(11)18-19-14)12-2-1-7-16-12/h1-2,5-9,16H,3-4H2,(H2,17,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	497	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM8385 (CHEMBL421207 | N-[6-(furan-2-yl)-1H-indazol-3-yl]c...) Show SMILES O=C(Nc1n[nH]c2cc(ccc12)-c1ccco1)C1CC1 Show InChI InChI=1S/C15H13N3O2/c19-15(9-3-4-9)16-14-11-6-5-10(8-12(11)17-18-14)13-2-1-7-20-13/h1-2,5-9H,3-4H2,(H2,16,17,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	631	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM8389 (CHEMBL260231 | N-[5-bromo-6-(thiophen-2-yl)-1H-pyr...) Show SMILES Brc1cc2c(NC(=O)C3CC3)n[nH]c2nc1-c1cccs1 Show InChI InChI=1S/C14H11BrN4OS/c15-9-6-8-12(16-11(9)10-2-1-5-21-10)18-19-13(8)17-14(20)7-3-4-7/h1-2,5-7H,3-4H2,(H2,16,17,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	639	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 alpha (Homo sapiens (Human))	BDBM8382 (CHEMBL261660 | N-[6-(3-fluorophenyl)-1H-indazol-3-...) Show SMILES Fc1cccc(c1)-c1ccc2c(NC(=O)C3CC3)n[nH]c2c1 Show InChI InChI=1S/C17H14FN3O/c18-13-3-1-2-11(8-13)12-6-7-14-15(9-12)20-21-16(14)19-17(22)10-4-5-10/h1-3,6-10H,4-5H2,(H2,19,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	828	n/a	n/a	n/a	n/a	7.0	22
GlaxoSmithKline					Assay Description The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM8392 (CHEMBL408564 | N-[5-bromo-6-(furan-2-yl)-1H-pyrazo...) Show SMILES Brc1cc2c(NC(=O)C3CC3)n[nH]c2nc1-c1ccco1 Show InChI InChI=1S/C14H11BrN4O2/c15-9-6-8-12(16-11(9)10-2-1-5-21-10)18-19-13(8)17-14(20)7-3-4-7/h1-2,5-7H,3-4H2,(H2,16,17,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM8393 (CHEMBL261690 | N-[5-bromo-6-(1,3-thiazol-2-yl)-1H-...) Show SMILES Brc1cc2c(NC(=O)C3CC3)n[nH]c2nc1-c1nccs1 Show InChI InChI=1S/C13H10BrN5OS/c14-8-5-7-10(16-9(8)13-15-3-4-21-13)18-19-11(7)17-12(20)6-1-2-6/h3-6H,1-2H2,(H2,16,17,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM8394 (CHEMBL406644 | N-[5-bromo-6-(1,3-thiazol-2-yl)-1H-...) Show SMILES Brc1cc2c(NC(=O)C3CCCC3)n[nH]c2nc1-c1nccs1 Show InChI InChI=1S/C15H14BrN5OS/c16-10-7-9-12(18-11(10)15-17-5-6-23-15)20-21-13(9)19-14(22)8-3-1-2-4-8/h5-8H,1-4H2,(H2,18,19,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM8395 (CHEMBL101747 | N-[5-bromo-6-(thiophen-2-yl)-1H-pyr...) Show SMILES CCN1CCC(CC(=O)Nc2n[nH]c3nc(-c4cccs4)c(Br)cc23)CC1 Show InChI InChI=1S/C19H22BrN5OS/c1-2-25-7-5-12(6-8-25)10-16(26)21-18-13-11-14(20)17(15-4-3-9-27-15)22-19(13)24-23-18/h3-4,9,11-12H,2,5-8,10H2,1H3,(H2,21,22,23,24,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM8391 (CHEMBL101804 | N-[6-(furan-2-yl)-1H-pyrazolo[3,4-b...) Show SMILES O=C(Nc1n[nH]c2nc(ccc12)-c1ccco1)C1CC1 Show InChI InChI=1S/C14H12N4O2/c19-14(8-3-4-8)16-13-9-5-6-10(11-2-1-7-20-11)15-12(9)17-18-13/h1-2,5-8H,3-4H2,(H2,15,16,17,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM8390 (CHEMBL407980 | N-[5-bromo-6-(thiophen-2-yl)-1H-pyr...) Show SMILES Brc1cc2c(NC(=O)C3CCCC3)n[nH]c2nc1-c1cccs1 Show InChI InChI=1S/C16H15BrN4OS/c17-11-8-10-14(18-13(11)12-6-3-7-23-12)20-21-15(10)19-16(22)9-4-1-2-5-9/h3,6-9H,1-2,4-5H2,(H2,18,19,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM8386 (CHEMBL260243 | N-[6-(furan-3-yl)-1H-indazol-3-yl]c...) Show SMILES O=C(Nc1n[nH]c2cc(ccc12)-c1ccoc1)C1CC1 Show InChI InChI=1S/C15H13N3O2/c19-15(9-1-2-9)16-14-12-4-3-10(7-13(12)17-18-14)11-5-6-20-8-11/h3-9H,1-2H2,(H2,16,17,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM8383 (N-[6-(4-fluorophenyl)-1H-indazol-3-yl]cyclopropane...) Show SMILES Fc1ccc(cc1)-c1ccc2c(NC(=O)C3CC3)n[nH]c2c1 Show InChI InChI=1S/C17H14FN3O/c18-13-6-3-10(4-7-13)12-5-8-14-15(9-12)20-21-16(14)19-17(22)11-1-2-11/h3-9,11H,1-2H2,(H2,19,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM8382 (CHEMBL261660 | N-[6-(3-fluorophenyl)-1H-indazol-3-...) Show SMILES Fc1cccc(c1)-c1ccc2c(NC(=O)C3CC3)n[nH]c2c1 Show InChI InChI=1S/C17H14FN3O/c18-13-3-1-2-11(8-13)12-6-7-14-15(9-12)20-21-16(14)19-17(22)10-4-5-10/h1-3,6-10H,4-5H2,(H2,19,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM8381 (N-[6-(2,3-difluorophenyl)-1H-indazol-3-yl]cyclopro...) Show SMILES Fc1cccc(-c2ccc3c(NC(=O)C4CC4)n[nH]c3c2)c1F Show InChI InChI=1S/C17H13F2N3O/c18-13-3-1-2-11(15(13)19)10-6-7-12-14(8-10)21-22-16(12)20-17(23)9-4-5-9/h1-3,6-9H,4-5H2,(H2,20,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM8380 (N-[6-(3,4-difluorophenyl)-1H-indazol-3-yl]cyclopro...) Show SMILES Fc1ccc(cc1F)-c1ccc2c(NC(=O)C3CC3)n[nH]c2c1 Show InChI InChI=1S/C17H13F2N3O/c18-13-6-4-10(7-14(13)19)11-3-5-12-15(8-11)21-22-16(12)20-17(23)9-1-2-9/h3-9H,1-2H2,(H2,20,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM8379 (N-[6-(2,5-difluorophenyl)-1H-indazol-3-yl]cyclopro...) Show SMILES Fc1ccc(F)c(c1)-c1ccc2c(NC(=O)C3CC3)n[nH]c2c1 Show InChI InChI=1S/C17H13F2N3O/c18-11-4-6-14(19)13(8-11)10-3-5-12-15(7-10)21-22-16(12)20-17(23)9-1-2-9/h3-9H,1-2H2,(H2,20,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM8378 (N-[6-(2-fluorophenyl)-1H-indazol-3-yl]cyclopropane...) Show SMILES Fc1ccccc1-c1ccc2c(NC(=O)C3CC3)n[nH]c2c1 Show InChI InChI=1S/C17H14FN3O/c18-14-4-2-1-3-12(14)11-7-8-13-15(9-11)20-21-16(13)19-17(22)10-5-6-10/h1-4,7-10H,5-6H2,(H2,19,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM8377 (N-[6-(6-oxo-1,6-dihydropyridin-3-yl)-1H-indazol-3-...) Show SMILES O=C(Nc1n[nH]c2cc(ccc12)-c1ccc(=O)[nH]c1)C1CC1 Show InChI InChI=1S/C16H14N4O2/c21-14-6-4-11(8-17-14)10-3-5-12-13(7-10)19-20-15(12)18-16(22)9-1-2-9/h3-9H,1-2H2,(H,17,21)(H2,18,19,20,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM8376 (N-[6-(4-methanesulfonamidophenyl)-1H-indazol-3-yl]...) Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1ccc2c(NC(=O)C3CC3)n[nH]c2c1 Show InChI InChI=1S/C18H18N4O3S/c1-26(24,25)22-14-7-4-11(5-8-14)13-6-9-15-16(10-13)20-21-17(15)19-18(23)12-2-3-12/h4-10,12,22H,2-3H2,1H3,(H2,19,20,21,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM8375 (N-[6-(3-methanesulfonamidophenyl)-1H-indazol-3-yl]...) Show SMILES CS(=O)(=O)Nc1cccc(c1)-c1ccc2c(NC(=O)C3CC3)n[nH]c2c1 Show InChI InChI=1S/C18H18N4O3S/c1-26(24,25)22-14-4-2-3-12(9-14)13-7-8-15-16(10-13)20-21-17(15)19-18(23)11-5-6-11/h2-4,7-11,22H,5-6H2,1H3,(H2,19,20,21,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM8374 (CHEMBL407113 | N-[6-(3-sulfamoylphenyl)-1H-indazol...) Show SMILES NS(=O)(=O)c1cccc(c1)-c1ccc2c(NC(=O)C3CC3)n[nH]c2c1 Show InChI InChI=1S/C17H16N4O3S/c18-25(23,24)13-3-1-2-11(8-13)12-6-7-14-15(9-12)20-21-16(14)19-17(22)10-4-5-10/h1-3,6-10H,4-5H2,(H2,18,23,24)(H2,19,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM8373 (N-[6-(4-sulfamoylphenyl)-1H-indazol-3-yl]cycloprop...) Show SMILES NS(=O)(=O)c1ccc(cc1)-c1ccc2c(NC(=O)C3CC3)n[nH]c2c1 Show InChI InChI=1S/C17H16N4O3S/c18-25(23,24)13-6-3-10(4-7-13)12-5-8-14-15(9-12)20-21-16(14)19-17(22)11-1-2-11/h3-9,11H,1-2H2,(H2,18,23,24)(H2,19,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM8372 (N-[6-(quinolin-6-yl)-1H-indazol-3-yl]cyclopropanec...) Show SMILES O=C(Nc1n[nH]c2cc(ccc12)-c1ccc2ncccc2c1)C1CC1 Show InChI InChI=1S/C20H16N4O/c25-20(12-3-4-12)22-19-16-7-5-14(11-18(16)23-24-19)13-6-8-17-15(10-13)2-1-9-21-17/h1-2,5-12H,3-4H2,(H2,22,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM8371 (CHEMBL261659 | N-[6-(1H-indol-5-yl)-1H-indazol-3-y...) Show SMILES O=C(Nc1n[nH]c2cc(ccc12)-c1ccc2[nH]ccc2c1)C1CC1 Show InChI InChI=1S/C19H16N4O/c24-19(11-1-2-11)21-18-15-5-3-13(10-17(15)22-23-18)12-4-6-16-14(9-12)7-8-20-16/h3-11,20H,1-2H2,(H2,21,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM8369 (CHEMBL405021 | N-(6-phenyl-1H-indazol-3-yl)cyclopr...) Show SMILES O=C(Nc1n[nH]c2cc(ccc12)-c1ccccc1)C1CC1 Show InChI InChI=1S/C17H15N3O/c21-17(12-6-7-12)18-16-14-9-8-13(10-15(14)19-20-16)11-4-2-1-3-5-11/h1-5,8-10,12H,6-7H2,(H2,18,19,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM8353 (6-aryl-pyrazolo[3,4-b]pyridine analogue 17 | CHEMB...) Show SMILES Brc1cc2c(NC(=O)C3CC3)n[nH]c2nc1-c1ccccc1 Show InChI InChI=1S/C16H13BrN4O/c17-12-8-11-14(18-13(12)9-4-2-1-3-5-9)20-21-15(11)19-16(22)10-6-7-10/h1-5,8,10H,6-7H2,(H2,18,19,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...				Bioorg Med Chem Lett 13: 3059-62 (2003) Article DOI: 10.1016/s0960-894x(03)00646-2 BindingDB Entry DOI: 10.7270/Q2348HKS
					More data for this Ligand-Target Pair

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