Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Epidermal growth factor receptor [1-18,20-1210] (Homo sapiens (Human)) | BDBM112499![]() (DACOMITINIB | US8623883, No. 2 | WO2022090481, Exa...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB WIPO WO2022090481 | n/a | n/a | 0.0100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Epidermal growth factor receptor [1-18,20-1210] (Homo sapiens (Human)) | BDBM50322823![]() ((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB WIPO WO2022090481 | n/a | n/a | 0.0200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Epidermal growth factor receptor [L858R] (Homo sapiens (Human)) | BDBM50322823![]() ((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB WIPO WO2022090481 | n/a | n/a | 0.0200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Epidermal growth factor receptor [L858R] (Homo sapiens (Human)) | BDBM112499![]() (DACOMITINIB | US8623883, No. 2 | WO2022090481, Exa...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB WIPO WO2022090481 | n/a | n/a | 0.0300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Epidermal growth factor receptor [1-18,20-1210] (Homo sapiens (Human)) | BDBM50029668![]() (AZD-9291 | Osimertinib | US10085983, Compound AZD-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | PDB WIPO WO2022090481 | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S] (Homo sapiens (Human)) | BDBM547815![]() (WO2022090481, Example I-030) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022090481 | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Ba/F3 cells were ordered from DSMZ (ACC300, Lot17) and grown in RPMI-1640 (ATCC 30-2001) + 10 % FCS + 10 ng/ml IL-3 at 37 °C in 5 % CO2 atmosphere. ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S] (Homo sapiens (Human)) | BDBM547877![]() (WO2022090481, Example I-096) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022090481 | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Ba/F3 cells were ordered from DSMZ (ACC300, Lot17) and grown in RPMI-1640 (ATCC 30-2001) + 10 % FCS + 10 ng/ml IL-3 at 37 °C in 5 % CO2 atmosphere. ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S] (Homo sapiens (Human)) | BDBM547876![]() (WO2022090481, Example I-095) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022090481 | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Ba/F3 cells were ordered from DSMZ (ACC300, Lot17) and grown in RPMI-1640 (ATCC 30-2001) + 10 % FCS + 10 ng/ml IL-3 at 37 °C in 5 % CO2 atmosphere. ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM50322823![]() ((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB WIPO WO2022090481 | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM112499![]() (DACOMITINIB | US8623883, No. 2 | WO2022090481, Exa...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB WIPO WO2022090481 | n/a | n/a | 0.640 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S] (Homo sapiens (Human)) | BDBM547878![]() (WO2022090481, Example I-097) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022090481 | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Ba/F3 cells were ordered from DSMZ (ACC300, Lot17) and grown in RPMI-1640 (ATCC 30-2001) + 10 % FCS + 10 ng/ml IL-3 at 37 °C in 5 % CO2 atmosphere. ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S] (Homo sapiens (Human)) | BDBM547814![]() (WO2022090481, Example I-029) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022090481 | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Ba/F3 cells were ordered from DSMZ (ACC300, Lot17) and grown in RPMI-1640 (ATCC 30-2001) + 10 % FCS + 10 ng/ml IL-3 at 37 °C in 5 % CO2 atmosphere. ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S] (Homo sapiens (Human)) | BDBM547879![]() (WO2022090481, Example I-098) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022090481 | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Ba/F3 cells were ordered from DSMZ (ACC300, Lot17) and grown in RPMI-1640 (ATCC 30-2001) + 10 % FCS + 10 ng/ml IL-3 at 37 °C in 5 % CO2 atmosphere. ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S] (Homo sapiens (Human)) | BDBM547880![]() (WO2022090481, Example I-099) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022090481 | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Ba/F3 cells were ordered from DSMZ (ACC300, Lot17) and grown in RPMI-1640 (ATCC 30-2001) + 10 % FCS + 10 ng/ml IL-3 at 37 °C in 5 % CO2 atmosphere. ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S] (Homo sapiens (Human)) | BDBM547807![]() (WO2022090481, Example I-022 | WO2022090481, Exampl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022090481 | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Ba/F3 cells were ordered from DSMZ (ACC300, Lot17) and grown in RPMI-1640 (ATCC 30-2001) + 10 % FCS + 10 ng/ml IL-3 at 37 °C in 5 % CO2 atmosphere. ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-1210] (Homo sapiens (Human)) | BDBM547941![]() (WO2022090481, Example I-162) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | MCE PC cid PC sid UniChem | WIPO WO2022090481 | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S] (Homo sapiens (Human)) | BDBM547838![]() (WO2022090481, Example I-053) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022090481 | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Ba/F3 cells were ordered from DSMZ (ACC300, Lot17) and grown in RPMI-1640 (ATCC 30-2001) + 10 % FCS + 10 ng/ml IL-3 at 37 °C in 5 % CO2 atmosphere. ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-1210] (Homo sapiens (Human)) | BDBM50160870![]() (CHEMBL3787344 | US11896597, Compound EGF816 | WO20...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem | WIPO WO2022090481 | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S] (Homo sapiens (Human)) | BDBM547810![]() (WO2022090481, Example I-025) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022090481 | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Ba/F3 cells were ordered from DSMZ (ACC300, Lot17) and grown in RPMI-1640 (ATCC 30-2001) + 10 % FCS + 10 ng/ml IL-3 at 37 °C in 5 % CO2 atmosphere. ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S] (Homo sapiens (Human)) | BDBM547862![]() (WO2022090481, Example I-080) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022090481 | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Ba/F3 cells were ordered from DSMZ (ACC300, Lot17) and grown in RPMI-1640 (ATCC 30-2001) + 10 % FCS + 10 ng/ml IL-3 at 37 °C in 5 % CO2 atmosphere. ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S] (Homo sapiens (Human)) | BDBM547882![]() (WO2022090481, Example I-101) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022090481 | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Ba/F3 cells were ordered from DSMZ (ACC300, Lot17) and grown in RPMI-1640 (ATCC 30-2001) + 10 % FCS + 10 ng/ml IL-3 at 37 °C in 5 % CO2 atmosphere. ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S] (Homo sapiens (Human)) | BDBM547881![]() (WO2022090481, Example I-100) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022090481 | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Ba/F3 cells were ordered from DSMZ (ACC300, Lot17) and grown in RPMI-1640 (ATCC 30-2001) + 10 % FCS + 10 ng/ml IL-3 at 37 °C in 5 % CO2 atmosphere. ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S] (Homo sapiens (Human)) | BDBM547863![]() (WO2022090481, Example I-081) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022090481 | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Ba/F3 cells were ordered from DSMZ (ACC300, Lot17) and grown in RPMI-1640 (ATCC 30-2001) + 10 % FCS + 10 ng/ml IL-3 at 37 °C in 5 % CO2 atmosphere. ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [L858R] (Homo sapiens (Human)) | BDBM50029668![]() (AZD-9291 | Osimertinib | US10085983, Compound AZD-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | PDB WIPO WO2022090481 | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Epidermal growth factor receptor [1-18,20-1210,C797S] (Homo sapiens (Human)) | BDBM547941![]() (WO2022090481, Example I-162) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | MCE PC cid PC sid UniChem | WIPO WO2022090481 | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S] (Homo sapiens (Human)) | BDBM547883![]() (WO2022090481, Example I-102) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022090481 | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Ba/F3 cells were ordered from DSMZ (ACC300, Lot17) and grown in RPMI-1640 (ATCC 30-2001) + 10 % FCS + 10 ng/ml IL-3 at 37 °C in 5 % CO2 atmosphere. ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S] (Homo sapiens (Human)) | BDBM547885![]() (WO2022090481, Example I-104) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022090481 | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Ba/F3 cells were ordered from DSMZ (ACC300, Lot17) and grown in RPMI-1640 (ATCC 30-2001) + 10 % FCS + 10 ng/ml IL-3 at 37 °C in 5 % CO2 atmosphere. ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S] (Homo sapiens (Human)) | BDBM547884![]() (WO2022090481, Example I-103) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022090481 | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Ba/F3 cells were ordered from DSMZ (ACC300, Lot17) and grown in RPMI-1640 (ATCC 30-2001) + 10 % FCS + 10 ng/ml IL-3 at 37 °C in 5 % CO2 atmosphere. ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S] (Homo sapiens (Human)) | BDBM547865![]() (WO2022090481, Example I-084) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022090481 | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Ba/F3 cells were ordered from DSMZ (ACC300, Lot17) and grown in RPMI-1640 (ATCC 30-2001) + 10 % FCS + 10 ng/ml IL-3 at 37 °C in 5 % CO2 atmosphere. ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S] (Homo sapiens (Human)) | BDBM547816![]() (WO2022090481, Example I-031) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022090481 | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Ba/F3 cells were ordered from DSMZ (ACC300, Lot17) and grown in RPMI-1640 (ATCC 30-2001) + 10 % FCS + 10 ng/ml IL-3 at 37 °C in 5 % CO2 atmosphere. ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S] (Homo sapiens (Human)) | BDBM547866![]() (WO2022090481, Example I-085) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022090481 | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Ba/F3 cells were ordered from DSMZ (ACC300, Lot17) and grown in RPMI-1640 (ATCC 30-2001) + 10 % FCS + 10 ng/ml IL-3 at 37 °C in 5 % CO2 atmosphere. ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S] (Homo sapiens (Human)) | BDBM547886![]() (WO2022090481, Example I-105) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022090481 | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Ba/F3 cells were ordered from DSMZ (ACC300, Lot17) and grown in RPMI-1640 (ATCC 30-2001) + 10 % FCS + 10 ng/ml IL-3 at 37 °C in 5 % CO2 atmosphere. ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S] (Homo sapiens (Human)) | BDBM547867![]() (WO2022090481, Example I-086) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022090481 | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Ba/F3 cells were ordered from DSMZ (ACC300, Lot17) and grown in RPMI-1640 (ATCC 30-2001) + 10 % FCS + 10 ng/ml IL-3 at 37 °C in 5 % CO2 atmosphere. ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S] (Homo sapiens (Human)) | BDBM547908![]() (WO2022090481, Example I-128) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022090481 | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Ba/F3 cells were ordered from DSMZ (ACC300, Lot17) and grown in RPMI-1640 (ATCC 30-2001) + 10 % FCS + 10 ng/ml IL-3 at 37 °C in 5 % CO2 atmosphere. ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S] (Homo sapiens (Human)) | BDBM547789![]() (WO2022090481, Example I-004) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022090481 | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Ba/F3 cells were ordered from DSMZ (ACC300, Lot17) and grown in RPMI-1640 (ATCC 30-2001) + 10 % FCS + 10 ng/ml IL-3 at 37 °C in 5 % CO2 atmosphere. ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S] (Homo sapiens (Human)) | BDBM547788![]() (WO2022090481, Example I-001) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022090481 | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Ba/F3 cells were ordered from DSMZ (ACC300, Lot17) and grown in RPMI-1640 (ATCC 30-2001) + 10 % FCS + 10 ng/ml IL-3 at 37 °C in 5 % CO2 atmosphere. ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S] (Homo sapiens (Human)) | BDBM547887![]() (WO2022090481, Example I-106) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022090481 | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Ba/F3 cells were ordered from DSMZ (ACC300, Lot17) and grown in RPMI-1640 (ATCC 30-2001) + 10 % FCS + 10 ng/ml IL-3 at 37 °C in 5 % CO2 atmosphere. ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S] (Homo sapiens (Human)) | BDBM547839![]() (WO2022090481, Example I-054) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022090481 | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Ba/F3 cells were ordered from DSMZ (ACC300, Lot17) and grown in RPMI-1640 (ATCC 30-2001) + 10 % FCS + 10 ng/ml IL-3 at 37 °C in 5 % CO2 atmosphere. ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S] (Homo sapiens (Human)) | BDBM547800![]() (WO2022090481, Example I-015) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022090481 | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Ba/F3 cells were ordered from DSMZ (ACC300, Lot17) and grown in RPMI-1640 (ATCC 30-2001) + 10 % FCS + 10 ng/ml IL-3 at 37 °C in 5 % CO2 atmosphere. ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S] (Homo sapiens (Human)) | BDBM547914![]() (WO2022090481, Example I-135) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022090481 | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Ba/F3 cells were ordered from DSMZ (ACC300, Lot17) and grown in RPMI-1640 (ATCC 30-2001) + 10 % FCS + 10 ng/ml IL-3 at 37 °C in 5 % CO2 atmosphere. ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S] (Homo sapiens (Human)) | BDBM547801![]() (WO2022090481, Example I-016) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022090481 | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Ba/F3 cells were ordered from DSMZ (ACC300, Lot17) and grown in RPMI-1640 (ATCC 30-2001) + 10 % FCS + 10 ng/ml IL-3 at 37 °C in 5 % CO2 atmosphere. ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-1210,C797S] (Homo sapiens (Human)) | BDBM112499![]() (DACOMITINIB | US8623883, No. 2 | WO2022090481, Exa...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB WIPO WO2022090481 | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S] (Homo sapiens (Human)) | BDBM547888![]() (WO2022090481, Example I-107) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022090481 | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Ba/F3 cells were ordered from DSMZ (ACC300, Lot17) and grown in RPMI-1640 (ATCC 30-2001) + 10 % FCS + 10 ng/ml IL-3 at 37 °C in 5 % CO2 atmosphere. ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S] (Homo sapiens (Human)) | BDBM547868![]() (WO2022090481, Example I-087) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022090481 | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Ba/F3 cells were ordered from DSMZ (ACC300, Lot17) and grown in RPMI-1640 (ATCC 30-2001) + 10 % FCS + 10 ng/ml IL-3 at 37 °C in 5 % CO2 atmosphere. ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S] (Homo sapiens (Human)) | BDBM547920![]() (WO2022090481, Example I-141) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022090481 | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Ba/F3 cells were ordered from DSMZ (ACC300, Lot17) and grown in RPMI-1640 (ATCC 30-2001) + 10 % FCS + 10 ng/ml IL-3 at 37 °C in 5 % CO2 atmosphere. ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S] (Homo sapiens (Human)) | BDBM547790![]() (WO2022090481, Example I-005) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022090481 | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Ba/F3 cells were ordered from DSMZ (ACC300, Lot17) and grown in RPMI-1640 (ATCC 30-2001) + 10 % FCS + 10 ng/ml IL-3 at 37 °C in 5 % CO2 atmosphere. ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-1210,T790M] (Homo sapiens (Human)) | BDBM50029668![]() (AZD-9291 | Osimertinib | US10085983, Compound AZD-...) | PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | PDB WIPO WO2022090481 | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S] (Homo sapiens (Human)) | BDBM547889![]() (WO2022090481, Example I-108) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022090481 | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Ba/F3 cells were ordered from DSMZ (ACC300, Lot17) and grown in RPMI-1640 (ATCC 30-2001) + 10 % FCS + 10 ng/ml IL-3 at 37 °C in 5 % CO2 atmosphere. ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S] (Homo sapiens (Human)) | BDBM547840![]() (WO2022090481, Example I-056) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | WIPO WO2022090481 | n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Ba/F3 cells were ordered from DSMZ (ACC300, Lot17) and grown in RPMI-1640 (ATCC 30-2001) + 10 % FCS + 10 ng/ml IL-3 at 37 °C in 5 % CO2 atmosphere. ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [1-18,20-1210] (Homo sapiens (Human)) | BDBM5447![]() (CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB WIPO WO2022090481 | n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19... | Citation and Details BindingDB Entry DOI: 10.7270/Q2765JH3 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |
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