Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM15361![]() ((1aR,2Z,4E,14R,15aR)-8-chloro-9,11-dihydroxy-14-me...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 150 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Vernalis (R&D) Ltd | Assay Description The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90... | Bioorg Med Chem Lett 15: 5187-91 (2005) Article DOI: 10.1016/j.bmcl.2005.08.092 BindingDB Entry DOI: 10.7270/Q2HH6H9Z | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM15410![]() (N-[4-hydroxy-3-(2-hydroxynaphthalen-1-yl)phenyl]th...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 600 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Vernalis (R&D) Ltd | Assay Description The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90... | Bioorg Med Chem Lett 15: 5187-91 (2005) Article DOI: 10.1016/j.bmcl.2005.08.092 BindingDB Entry DOI: 10.7270/Q2HH6H9Z | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM15408![]() (2,5-dichloro-N-[4-hydroxy-3-(2-hydroxynaphthalen-1...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 700 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Vernalis (R&D) Ltd | Assay Description The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90... | Bioorg Med Chem Lett 15: 5187-91 (2005) Article DOI: 10.1016/j.bmcl.2005.08.092 BindingDB Entry DOI: 10.7270/Q2HH6H9Z | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM15359![]() ((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.27E+3 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Vernalis (R&D) Ltd | Assay Description The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90... | Bioorg Med Chem Lett 15: 5187-91 (2005) Article DOI: 10.1016/j.bmcl.2005.08.092 BindingDB Entry DOI: 10.7270/Q2HH6H9Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM15404![]() (4-chloro-N-[4-hydroxy-3-(2-hydroxynaphthalen-1-yl)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Vernalis (R&D) Ltd | Assay Description The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90... | Bioorg Med Chem Lett 15: 5187-91 (2005) Article DOI: 10.1016/j.bmcl.2005.08.092 BindingDB Entry DOI: 10.7270/Q2HH6H9Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM15402![]() (N-[4-hydroxy-3-(2-hydroxy-1-naphthalenyl)phenyl]be...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Vernalis (R&D) Ltd | Assay Description The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90... | Bioorg Med Chem Lett 15: 5187-91 (2005) Article DOI: 10.1016/j.bmcl.2005.08.092 BindingDB Entry DOI: 10.7270/Q2HH6H9Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM15405![]() (4-bromo-N-[4-hydroxy-3-(2-hydroxynaphthalen-1-yl)p...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.10E+3 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Vernalis (R&D) Ltd | Assay Description The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90... | Bioorg Med Chem Lett 15: 5187-91 (2005) Article DOI: 10.1016/j.bmcl.2005.08.092 BindingDB Entry DOI: 10.7270/Q2HH6H9Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM15406![]() (4-ethyl-N-[4-hydroxy-3-(2-hydroxynaphthalen-1-yl)p...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.60E+3 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Vernalis (R&D) Ltd | Assay Description The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90... | Bioorg Med Chem Lett 15: 5187-91 (2005) Article DOI: 10.1016/j.bmcl.2005.08.092 BindingDB Entry DOI: 10.7270/Q2HH6H9Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM15403![]() (4-fluoro-N-[4-hydroxy-3-(2-hydroxynaphthalen-1-yl)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8.80E+3 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Vernalis (R&D) Ltd | Assay Description The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90... | Bioorg Med Chem Lett 15: 5187-91 (2005) Article DOI: 10.1016/j.bmcl.2005.08.092 BindingDB Entry DOI: 10.7270/Q2HH6H9Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM15409![]() (N-[4-hydroxy-3-(2-hydroxynaphthalen-1-yl)phenyl]-2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.52E+4 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Vernalis (R&D) Ltd | Assay Description The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90... | Bioorg Med Chem Lett 15: 5187-91 (2005) Article DOI: 10.1016/j.bmcl.2005.08.092 BindingDB Entry DOI: 10.7270/Q2HH6H9Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM15407![]() (4-tert-butyl-N-[4-hydroxy-3-(2-hydroxynaphthalen-1...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.64E+4 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Vernalis (R&D) Ltd | Assay Description The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90... | Bioorg Med Chem Lett 15: 5187-91 (2005) Article DOI: 10.1016/j.bmcl.2005.08.092 BindingDB Entry DOI: 10.7270/Q2HH6H9Z | |||||||||||
More data for this Ligand-Target Pair |