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Compile Data Set for Download or QSAR

Found 50 hits Enz. Inhib. hit(s) with all data for entry = 50002772   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Cytochrome P450 1A2


(Homo sapiens (Human))		BDBM50462745
PNG
(CHEMBL4250214)
Show SMILES Cc1nn(C)c2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C15H14N6/c1-9-11-6-5-10(8-13(11)21(2)20-9)17-15-14-12(18-19-15)4-3-7-16-14/h3-8H,1-2H3,(H2,17,18,19)
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n/an/a<100n/an/an/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Inhibition of CYP1A2 in human liver microsomes

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair
Cytochrome P450 1A2


(Homo sapiens (Human))		BDBM186216
PNG
(US9163015, 2)
Show SMILES Fc1ccc(Nc2n[nH]c3cccnc23)cc1Cl
Show InChI InChI=1S/C12H8ClFN4/c13-8-6-7(3-4-9(8)14)16-12-11-10(17-18-12)2-1-5-15-11/h1-6H,(H2,16,17,18)
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n/an/a<100n/an/an/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Inhibition of CYP1A2 in human liver microsomes

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair
Cytochrome P450 1A2


(Homo sapiens (Human))		BDBM50462741
PNG
(CHEMBL4239399)
Show SMILES Cn1ncc2ccc(Nc3n[nH]c4cccnc34)cc12
Show InChI InChI=1S/C14H12N6/c1-20-12-7-10(5-4-9(12)8-16-20)17-14-13-11(18-19-14)3-2-6-15-13/h2-8H,1H3,(H2,17,18,19)
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n/an/a 110n/an/an/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Inhibition of CYP1A2 in human liver microsomes

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair
Cytochrome P450 1A2


(Homo sapiens (Human))		BDBM50462763
PNG
(CHEMBL4242079)
Show SMILES C1CC1c1n[nH]c2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C16H14N6/c1-2-12-15(17-7-1)16(22-19-12)18-10-5-6-11-13(8-10)20-21-14(11)9-3-4-9/h1-2,5-9H,3-4H2,(H,20,21)(H2,18,19,22)
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n/an/a 280n/an/an/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Inhibition of CYP1A2 in human liver microsomes

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair
Cytochrome P450 1A2


(Homo sapiens (Human))		BDBM50462746
PNG
(CHEMBL4239430)
Show SMILES Cn1nc(C2CC2)c2ccc(Nc3n[nH]c4cccnc34)cc12
Show InChI InChI=1S/C17H16N6/c1-23-14-9-11(6-7-12(14)15(22-23)10-4-5-10)19-17-16-13(20-21-17)3-2-8-18-16/h2-3,6-10H,4-5H2,1H3,(H2,19,20,21)
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n/an/a 350n/an/an/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Inhibition of CYP1A2 in human liver microsomes

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair
Cytochrome P450 1A2


(Homo sapiens (Human))		BDBM50462753
PNG
(CHEMBL4247943)
Show SMILES Cn1nc(C2CC2)c2ccc(Nc3n[nH]c4nccnc34)cc12
Show InChI InChI=1S/C16H15N7/c1-23-12-8-10(4-5-11(12)13(22-23)9-2-3-9)19-16-14-15(20-21-16)18-7-6-17-14/h4-9H,2-3H2,1H3,(H2,18,19,20,21)
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Vanderbilt University

Curated by ChEMBL


Assay Description
Inhibition of CYP1A2 in human liver microsomes

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair
Cytochrome P450 1A2


(Homo sapiens (Human))		BDBM50462750
PNG
(CHEMBL4243630)
Show SMILES Cn1ncc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C14H12N6/c1-20-12-5-4-10(7-9(12)8-16-20)17-14-13-11(18-19-14)3-2-6-15-13/h2-8H,1H3,(H2,17,18,19)
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n/an/a 530n/an/an/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Inhibition of CYP1A2 in human liver microsomes

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair
Cytochrome P450 1A2


(Homo sapiens (Human))		BDBM50462749
PNG
(CHEMBL4241489)
Show SMILES Cn1nc(C2CC2)c2ccc(Nc3n[nH]c4ncccc34)cc12
Show InChI InChI=1S/C17H16N6/c1-23-14-9-11(6-7-12(14)15(22-23)10-4-5-10)19-17-13-3-2-8-18-16(13)20-21-17/h2-3,6-10H,4-5H2,1H3,(H2,18,19,20,21)
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n/an/a 2.60E+3n/an/an/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Inhibition of CYP1A2 in human liver microsomes

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50462748
PNG
(CHEMBL4249099 | US10508105, Compound 14)
Show SMILES Cn1nc(OCC2CCCCO2)c2ccc(Nc3n[nH]c4cccnc34)cc12
Show InChI InChI=1S/C20H22N6O2/c1-26-17-11-13(22-19-18-16(23-24-19)6-4-9-21-18)7-8-15(17)20(25-26)28-12-14-5-2-3-10-27-14/h4,6-9,11,14H,2-3,5,10,12H2,1H3,(H2,22,23,24)
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Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50462750
PNG
(CHEMBL4243630)
Show SMILES Cn1ncc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C14H12N6/c1-20-12-5-4-10(7-9(12)8-16-20)17-14-13-11(18-19-14)3-2-6-15-13/h2-8H,1H3,(H2,17,18,19)
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n/an/an/an/a 870n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50462751
PNG
(CHEMBL4237744)
Show SMILES Cn1nnc2ccc(Nc3n[nH]c4cccnc34)cc12
Show InChI InChI=1S/C13H11N7/c1-20-11-7-8(4-5-9(11)17-19-20)15-13-12-10(16-18-13)3-2-6-14-12/h2-7H,1H3,(H2,15,16,18)
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n/an/an/an/a 1.43E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50462752
PNG
(CHEMBL4238452)
Show SMILES CCc1nn(C)c2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C16H16N6/c1-3-12-11-7-6-10(9-14(11)22(2)21-12)18-16-15-13(19-20-16)5-4-8-17-15/h4-9H,3H2,1-2H3,(H2,18,19,20)
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n/an/an/an/a 38n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50462753
PNG
(CHEMBL4247943)
Show SMILES Cn1nc(C2CC2)c2ccc(Nc3n[nH]c4nccnc34)cc12
Show InChI InChI=1S/C16H15N7/c1-23-12-8-10(4-5-11(12)13(22-23)9-2-3-9)19-16-14-15(20-21-16)18-7-6-17-14/h4-9H,2-3H2,1H3,(H2,18,19,20,21)
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Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50462754
PNG
(CHEMBL4237497)
Show SMILES Cn1nc(c2ccc(Nc3n[nH]c4cccnc34)cc12)C1(C)CC1
Show InChI InChI=1S/C18H18N6/c1-18(7-8-18)16-12-6-5-11(10-14(12)24(2)23-16)20-17-15-13(21-22-17)4-3-9-19-15/h3-6,9-10H,7-8H2,1-2H3,(H2,20,21,22)
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n/an/an/an/a 68n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50462755
PNG
(CHEMBL4241532)
Show SMILES Cc1nn(CC2CCC2)c2ccc(Nc3n[nH]c4cccnc34)cc12
Show InChI InChI=1S/C19H20N6/c1-12-15-10-14(21-19-18-16(22-23-19)6-3-9-20-18)7-8-17(15)25(24-12)11-13-4-2-5-13/h3,6-10,13H,2,4-5,11H2,1H3,(H2,21,22,23)
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n/an/an/an/a 47n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50462756
PNG
(CHEMBL4237293)
Show SMILES Cn1nc(C(=O)N2CC[C@H](F)C2)c2ccc(Nc3n[nH]c4cccnc34)cc12 |r|
Show InChI InChI=1S/C19H18FN7O/c1-26-15-9-12(22-18-17-14(23-24-18)3-2-7-21-17)4-5-13(15)16(25-26)19(28)27-8-6-11(20)10-27/h2-5,7,9,11H,6,8,10H2,1H3,(H2,22,23,24)/t11-/m0/s1
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n/an/an/an/a 764n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50462757
PNG
(CHEMBL4249226)
Show SMILES Cn1nc(C(=O)NC2CCC2)c2ccc(Nc3n[nH]c4cccnc34)cc12
Show InChI InChI=1S/C19H19N7O/c1-26-15-10-12(21-18-17-14(23-24-18)6-3-9-20-17)7-8-13(15)16(25-26)19(27)22-11-4-2-5-11/h3,6-11H,2,4-5H2,1H3,(H,22,27)(H2,21,23,24)
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n/an/an/an/a 653n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50293743
PNG
(CHEMBL556667 | N-(3-chlorophenyl)picolinamide | ci...)
Show SMILES Clc1cccc(NC(=O)c2ccccn2)c1
Show InChI InChI=1S/C12H9ClN2O/c13-9-4-3-5-10(8-9)15-12(16)11-6-1-2-7-14-11/h1-8H,(H,15,16)
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n/an/an/an/a 1.10E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50462758
PNG
(CHEMBL4250557)
Show SMILES Cn1cnc2ccc(Nc3n[nH]c4cccnc34)cc12
Show InChI InChI=1S/C14H12N6/c1-20-8-16-10-5-4-9(7-12(10)20)17-14-13-11(18-19-14)3-2-6-15-13/h2-8H,1H3,(H2,17,18,19)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50462759
PNG
(CHEMBL4243164)
Show SMILES Cn1ccc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C15H13N5/c1-20-8-6-10-9-11(4-5-13(10)20)17-15-14-12(18-19-15)3-2-7-16-14/h2-9H,1H3,(H2,17,18,19)
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n/an/an/an/a 3.59E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50462745
PNG
(CHEMBL4250214)
Show SMILES Cc1nn(C)c2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C15H14N6/c1-9-11-6-5-10(8-13(11)21(2)20-9)17-15-14-12(18-19-15)4-3-7-16-14/h3-8H,1-2H3,(H2,17,18,19)
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n/an/an/an/a 78n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50462760
PNG
(CHEMBL4249753)
Show SMILES Cc1nn(C)c2ccc(Nc3n[nH]c4cccnc34)cc12
Show InChI InChI=1S/C15H14N6/c1-9-11-8-10(5-6-13(11)21(2)20-9)17-15-14-12(18-19-15)4-3-7-16-14/h3-8H,1-2H3,(H2,17,18,19)
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n/an/an/an/a 345n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50462761
PNG
(CHEMBL4239644)
Show SMILES CCn1nc(Cl)c2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C15H13ClN6/c1-2-22-12-6-5-9(8-10(12)14(16)21-22)18-15-13-11(19-20-15)4-3-7-17-13/h3-8H,2H2,1H3,(H2,18,19,20)
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n/an/an/an/a 815n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50462762
PNG
(CHEMBL4246041)
Show SMILES Cn1nc(c2ccc(Nc3n[nH]c4cccnc34)cc12)C(F)(F)F
Show InChI InChI=1S/C15H11F3N6/c1-24-11-7-8(4-5-9(11)13(23-24)15(16,17)18)20-14-12-10(21-22-14)3-2-6-19-12/h2-7H,1H3,(H2,20,21,22)
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n/an/an/an/a 119n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50462763
PNG
(CHEMBL4242079)
Show SMILES C1CC1c1n[nH]c2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C16H14N6/c1-2-12-15(17-7-1)16(22-19-12)18-10-5-6-11-13(8-10)20-21-14(11)9-3-4-9/h1-2,5-9H,3-4H2,(H,20,21)(H2,18,19,22)
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n/an/an/an/a 452n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50462749
PNG
(CHEMBL4241489)
Show SMILES Cn1nc(C2CC2)c2ccc(Nc3n[nH]c4ncccc34)cc12
Show InChI InChI=1S/C17H16N6/c1-23-14-9-11(6-7-12(14)15(22-23)10-4-5-10)19-17-13-3-2-8-18-16(13)20-21-17/h2-3,6-10H,4-5H2,1H3,(H2,18,19,20,21)
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n/an/an/an/a 43n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50462764
PNG
(CHEMBL4245437)
Show SMILES CCn1nc(C2CC2)c2ccc(Nc3n[nH]c4cccnc34)cc12
Show InChI InChI=1S/C18H18N6/c1-2-24-15-10-12(7-8-13(15)16(23-24)11-5-6-11)20-18-17-14(21-22-18)4-3-9-19-17/h3-4,7-11H,2,5-6H2,1H3,(H2,20,21,22)
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n/an/an/an/a 1.21E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50462764
PNG
(CHEMBL4245437)
Show SMILES CCn1nc(C2CC2)c2ccc(Nc3n[nH]c4cccnc34)cc12
Show InChI InChI=1S/C18H18N6/c1-2-24-15-10-12(7-8-13(15)16(23-24)11-5-6-11)20-18-17-14(21-22-18)4-3-9-19-17/h3-4,7-11H,2,5-6H2,1H3,(H2,20,21,22)
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n/an/an/an/a 36n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50462765
PNG
(CHEMBL4251433)
Show SMILES Cn1nc(c2ccc(Nc3n[nH]c4ncccc34)cc12)C1(C)CC1
Show InChI InChI=1S/C18H18N6/c1-18(7-8-18)15-12-6-5-11(10-14(12)24(2)23-15)20-17-13-4-3-9-19-16(13)21-22-17/h3-6,9-10H,7-8H2,1-2H3,(H2,19,20,21,22)
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n/an/an/an/a 129n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50462766
PNG
(CHEMBL4247139)
Show SMILES Cn1nc(c2ccc(Nc3n[nH]c4nccnc34)cc12)C1(C)CC1
Show InChI InChI=1S/C17H17N7/c1-17(5-6-17)14-11-4-3-10(9-12(11)24(2)23-14)20-16-13-15(21-22-16)19-8-7-18-13/h3-4,7-9H,5-6H2,1-2H3,(H2,19,20,21,22)
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n/an/an/an/a 25n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50462767
PNG
(CHEMBL4249560)
Show SMILES Cc1nn(C2CCCC2)c2ccc(Nc3n[nH]c4cccnc34)cc12
Show InChI InChI=1S/C19H20N6/c1-12-15-11-13(21-19-18-16(22-23-19)7-4-10-20-18)8-9-17(15)25(24-12)14-5-2-3-6-14/h4,7-11,14H,2-3,5-6H2,1H3,(H2,21,22,23)
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n/an/an/an/a 265n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50462768
PNG
(CHEMBL4238603 | US10508105, Compound 3)
Show SMILES CC(C)COc1nn(C)c2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C18H20N6O/c1-11(2)10-25-18-13-7-6-12(9-15(13)24(3)23-18)20-17-16-14(21-22-17)5-4-8-19-16/h4-9,11H,10H2,1-3H3,(H2,20,21,22)
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n/an/an/an/a 231n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50462769
PNG
(CHEMBL4242783 | US10508105, Compound 2)
Show SMILES Cc1cc(COc2nn(C)c3cc(Nc4n[nH]c5cccnc45)ccc23)on1
Show InChI InChI=1S/C19H17N7O2/c1-11-8-13(28-25-11)10-27-19-14-6-5-12(9-16(14)26(2)24-19)21-18-17-15(22-23-18)4-3-7-20-17/h3-9H,10H2,1-2H3,(H2,21,22,23)
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n/an/an/an/a 104n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50462770
PNG
(CHEMBL4248724)
Show SMILES Cn1nc(C(=O)N2CCCC2)c2ccc(Nc3n[nH]c4cccnc34)cc12
Show InChI InChI=1S/C19H19N7O/c1-25-15-11-12(21-18-17-14(22-23-18)5-4-8-20-17)6-7-13(15)16(24-25)19(27)26-9-2-3-10-26/h4-8,11H,2-3,9-10H2,1H3,(H2,21,22,23)
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n/an/an/an/a 827n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50462771
PNG
(CHEMBL4247308)
Show SMILES Cn1nc(C(=O)N2CC[C@@H](F)C2)c2ccc(Nc3n[nH]c4cccnc34)cc12 |r|
Show InChI InChI=1S/C19H18FN7O/c1-26-15-9-12(22-18-17-14(23-24-18)3-2-7-21-17)4-5-13(15)16(25-26)19(28)27-8-6-11(20)10-27/h2-5,7,9,11H,6,8,10H2,1H3,(H2,22,23,24)/t11-/m1/s1
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n/an/an/an/a 907n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50462772
PNG
(CHEMBL4241027)
Show SMILES Cn1nc(C(=O)N2CCC(F)(F)C2)c2ccc(Nc3n[nH]c4cccnc34)cc12
Show InChI InChI=1S/C19H17F2N7O/c1-27-14-9-11(23-17-16-13(24-25-17)3-2-7-22-16)4-5-12(14)15(26-27)18(29)28-8-6-19(20,21)10-28/h2-5,7,9H,6,8,10H2,1H3,(H2,23,24,25)
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n/an/an/an/a 289n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50462773
PNG
(CHEMBL4240579)
Show SMILES Cn1nc(C(=O)NC2CC(F)(F)C2)c2ccc(Nc3n[nH]c4cccnc34)cc12
Show InChI InChI=1S/C19H17F2N7O/c1-28-14-7-10(23-17-16-13(25-26-17)3-2-6-22-16)4-5-12(14)15(27-28)18(29)24-11-8-19(20,21)9-11/h2-7,11H,8-9H2,1H3,(H,24,29)(H2,23,25,26)
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n/an/an/an/a 116n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50462774
PNG
(CHEMBL4248576)
Show SMILES Cn1nc(C(=O)N2CCC(F)(F)CC2)c2ccc(Nc3n[nH]c4cccnc34)cc12
Show InChI InChI=1S/C20H19F2N7O/c1-28-15-11-12(24-18-17-14(25-26-18)3-2-8-23-17)4-5-13(15)16(27-28)19(30)29-9-6-20(21,22)7-10-29/h2-5,8,11H,6-7,9-10H2,1H3,(H2,24,25,26)
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n/an/an/an/a 498n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50462775
PNG
(CHEMBL4248273 | US10508105, Compound 20)
Show SMILES Cn1nc(OC2CCOCC2)c2ccc(Nc3n[nH]c4cccnc34)cc12
Show InChI InChI=1S/C19H20N6O2/c1-25-16-11-12(21-18-17-15(22-23-18)3-2-8-20-17)4-5-14(16)19(24-25)27-13-6-9-26-10-7-13/h2-5,8,11,13H,6-7,9-10H2,1H3,(H2,21,22,23)
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n/an/an/an/a 45n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50462776
PNG
(CHEMBL4240046)
Show SMILES Cn1nc(C(=O)NC2CC(F)C2)c2ccc(Nc3n[nH]c4cccnc34)cc12 |(18.31,-40.83,;17.4,-39.59,;17.87,-38.12,;16.62,-37.22,;16.61,-35.68,;15.27,-34.91,;17.94,-34.9,;17.93,-33.36,;19.01,-32.28,;17.92,-31.19,;17.91,-29.65,;16.83,-32.29,;15.37,-38.13,;13.85,-37.82,;12.84,-38.97,;13.32,-40.43,;12.3,-41.58,;10.79,-41.26,;10.16,-39.86,;8.63,-40.03,;8.32,-41.54,;6.99,-42.31,;6.99,-43.85,;8.32,-44.62,;9.66,-43.85,;9.65,-42.3,;14.83,-40.74,;15.86,-39.59,)|
Show InChI InChI=1S/C19H18FN7O/c1-27-15-9-11(22-18-17-14(24-25-18)3-2-6-21-17)4-5-13(15)16(26-27)19(28)23-12-7-10(20)8-12/h2-6,9-10,12H,7-8H2,1H3,(H,23,28)(H2,22,24,25)
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n/an/an/an/a 794n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50462777
PNG
(CHEMBL4242608)
Show SMILES CCn1nc(C)c2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C16H16N6/c1-3-22-14-7-6-11(9-12(14)10(2)21-22)18-16-15-13(19-20-16)5-4-8-17-15/h4-9H,3H2,1-2H3,(H2,18,19,20)
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n/an/an/an/a 95n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50462747
PNG
(CHEMBL4245763 | US10508105, Compound 1)
Show SMILES CC(C)Oc1nn(C)c2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C17H18N6O/c1-10(2)24-17-12-7-6-11(9-14(12)23(3)22-17)19-16-15-13(20-21-16)5-4-8-18-15/h4-10H,1-3H3,(H2,19,20,21)
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n/an/an/an/a 413n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50462746
PNG
(CHEMBL4239430)
Show SMILES Cn1nc(C2CC2)c2ccc(Nc3n[nH]c4cccnc34)cc12
Show InChI InChI=1S/C17H16N6/c1-23-14-9-11(6-7-12(14)15(22-23)10-4-5-10)19-17-16-13(20-21-17)3-2-8-18-16/h2-3,6-10H,4-5H2,1H3,(H2,19,20,21)
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n/an/an/an/a 43n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM186216
PNG
(US9163015, 2)
Show SMILES Fc1ccc(Nc2n[nH]c3cccnc23)cc1Cl
Show InChI InChI=1S/C12H8ClFN4/c13-8-6-7(3-4-9(8)14)16-12-11-10(17-18-12)2-1-5-15-11/h1-6H,(H2,16,17,18)
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n/an/an/an/a 68n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50462744
PNG
(CHEMBL4245399)
Show SMILES Cn1nc(C2CC2)c2ncc(Nc3n[nH]c4cccnc34)cc12
Show InChI InChI=1S/C16H15N7/c1-23-12-7-10(8-18-15(12)13(22-23)9-4-5-9)19-16-14-11(20-21-16)3-2-6-17-14/h2-3,6-9H,4-5H2,1H3,(H2,19,20,21)
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n/an/an/an/a 468n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50462743
PNG
(CHEMBL4241662)
Show SMILES [2H]C([2H])([2H])Cn1nc(C2CC2)c2ccc(Nc3n[nH]c4ncccc34)cc12
Show InChI InChI=1S/C18H18N6/c1-2-24-15-10-12(7-8-13(15)16(23-24)11-5-6-11)20-18-14-4-3-9-19-17(14)21-22-18/h3-4,7-11H,2,5-6H2,1H3,(H2,19,20,21,22)
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n/an/an/an/a 160n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50462742
PNG
(CHEMBL4242145)
Show SMILES CC(C)n1nc(C)c2ccc(Nc3n[nH]c4cccnc34)cc12
Show InChI InChI=1S/C17H18N6/c1-10(2)23-15-9-12(6-7-13(15)11(3)22-23)19-17-16-14(20-21-17)5-4-8-18-16/h4-10H,1-3H3,(H2,19,20,21)
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n/an/an/an/a 9.89E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50462778
PNG
(CHEMBL4245306)
Show SMILES Cn1nc(CC(F)(F)F)c2ccc(Nc3n[nH]c4cccnc34)cc12
Show InChI InChI=1S/C16H13F3N6/c1-25-13-7-9(4-5-10(13)12(24-25)8-16(17,18)19)21-15-14-11(22-23-15)3-2-6-20-14/h2-7H,8H2,1H3,(H2,21,22,23)
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n/an/an/an/a 96n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50462740
PNG
(CHEMBL4244458)
Show SMILES CN1CCC(CC1)Oc1nn(C)c2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C20H23N7O/c1-26-10-7-14(8-11-26)28-20-15-6-5-13(12-17(15)27(2)25-20)22-19-18-16(23-24-19)4-3-9-21-18/h3-6,9,12,14H,7-8,10-11H2,1-2H3,(H2,22,23,24)
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n/an/an/an/a 1.88E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50462741
PNG
(CHEMBL4239399)
Show SMILES Cn1ncc2ccc(Nc3n[nH]c4cccnc34)cc12
Show InChI InChI=1S/C14H12N6/c1-20-12-7-10(5-4-9(12)8-16-20)17-14-13-11(18-19-14)3-2-6-15-13/h2-8H,1H3,(H2,17,18,19)
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n/an/an/an/a 257n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...

Bioorg Med Chem Lett 28: 2641-2646 (2018)


Article DOI: 10.1016/j.bmcl.2018.06.034
BindingDB Entry DOI: 10.7270/Q2DR2Z5H
More data for this
Ligand-Target Pair