BindingDB PrimarySearch

Found 7 hits Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 4' and Ligand = 'BDBM50293743'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50293743 (CHEMBL556667 \| N-(3-chlorophenyl)picolinamide \| ci...) Show SMILES Clc1cccc(NC(=O)c2ccccn2)c1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB PCBioAssay	n/a	n/a	n/a	n/a	1.09E+3	n/a	n/a	n/a	n/a
Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters Curated by PubChem BioAssay					Assay Description Assay Provider: Colleen Niswender Assay Provider Affiliation: Vanderbilt University The primary pathophysiological change giving rise to the symptoms...				PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2VT1QHF
					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50293743 (CHEMBL556667 \| N-(3-chlorophenyl)picolinamide \| ci...) Show SMILES Clc1cccc(NC(=O)c2ccccn2)c1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human mGlu4 receptor				Bioorg Med Chem Lett 25: 3956-60 (2015) Article DOI: 10.1016/j.bmcl.2015.07.031 BindingDB Entry DOI: 10.7270/Q28C9Z1B
Massachusetts General Hospital Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat))	BDBM50293743 (CHEMBL556667 \| N-(3-chlorophenyl)picolinamide \| ci...) Show SMILES Clc1cccc(NC(=O)c2ccccn2)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	330	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Positive allosteric modulator activity at rat mGlu4 receptor				Bioorg Med Chem Lett 25: 3956-60 (2015) Article DOI: 10.1016/j.bmcl.2015.07.031 BindingDB Entry DOI: 10.7270/Q28C9Z1B
Massachusetts General Hospital Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50293743 (CHEMBL556667 \| N-(3-chlorophenyl)picolinamide \| ci...) Show SMILES Clc1cccc(NC(=O)c2ccccn2)c1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2022.114378 BindingDB Entry DOI: 10.7270/Q2377DQ0
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50293743 (CHEMBL556667 \| N-(3-chlorophenyl)picolinamide \| ci...) Show SMILES Clc1cccc(NC(=O)c2ccccn2)c1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Activity at human mGluR4 receptor expressed in CHO cells assessed as effect on calcium mobilization				J Med Chem 52: 4115-8 (2009) Article DOI: 10.1021/jm9005065 BindingDB Entry DOI: 10.7270/Q2RJ4JHT
Vanderbilt University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50293743 (CHEMBL556667 \| N-(3-chlorophenyl)picolinamide \| ci...) Show SMILES Clc1cccc(NC(=O)c2ccccn2)c1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGluR4 expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium flux prein...				Bioorg Med Chem Lett 28: 2641-2646 (2018) Article DOI: 10.1016/j.bmcl.2018.06.034 BindingDB Entry DOI: 10.7270/Q2DR2Z5H
Vanderbilt University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat))	BDBM50293743 (CHEMBL556667 \| N-(3-chlorophenyl)picolinamide \| ci...) Show SMILES Clc1cccc(NC(=O)c2ccccn2)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	290	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Activity at rat mGluR4 receptor expressed in HEK293 cells assessed as effect on thallium flux				J Med Chem 52: 4115-8 (2009) Article DOI: 10.1021/jm9005065 BindingDB Entry DOI: 10.7270/Q2RJ4JHT
Vanderbilt University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)