Compile Data Set for Download or QSAR

Found 58 hits Enz. Inhib. hit(s) with all data for entry = 50006973   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50505140 (CHEMBL4526884) Show SMILES Fc1cc(ccc1Cl)N1CCN(CC1)C(=O)C(=O)Nc1ccc2[nH]c(=O)oc2c1 Show InChI InChI=1S/C19H16ClFN4O4/c20-13-3-2-12(10-14(13)21)24-5-7-25(8-6-24)18(27)17(26)22-11-1-4-15-16(9-11)29-19(28)23-15/h1-4,9-10H,5-8H2,(H,22,26)(H,23,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B receptor expressed in HEK293 cells co-expressing NR1 subunit assessed as reduction in glutamic acid/glycine-induced...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50505124 (CHEMBL4534333) Show SMILES Fc1cc(ccc1C(F)(F)F)N1CCN(CC1)C(=O)C(=O)Nc1ccc2[nH]c(=O)oc2c1 Show InChI InChI=1S/C20H16F4N4O4/c21-14-10-12(2-3-13(14)20(22,23)24)27-5-7-28(8-6-27)18(30)17(29)25-11-1-4-15-16(9-11)32-19(31)26-15/h1-4,9-10H,5-8H2,(H,25,29)(H,26,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B receptor expressed in HEK293 cells co-expressing NR1 subunit assessed as reduction in glutamic acid/glycine-induced...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50505122 (CHEMBL4583880) Show SMILES C[C@@H]1CN(CCN1C(=O)C(=O)Nc1ccc2[nH]c(=O)oc2c1)c1ccc(Cl)c(F)c1 |r| Show InChI InChI=1S/C20H18ClFN4O4/c1-11-10-25(13-3-4-14(21)15(22)9-13)6-7-26(11)19(28)18(27)23-12-2-5-16-17(8-12)30-20(29)24-16/h2-5,8-9,11H,6-7,10H2,1H3,(H,23,27)(H,24,29)/t11-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B receptor expressed in HEK293 cells co-expressing NR1 subunit assessed as reduction in glutamic acid/glycine-induced...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50149684 (2-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-2-oxo-N-(2-...) Show SMILES Fc1ccc(CC2CCN(CC2)C(=O)C(=O)Nc2ccc3[nH]c(=O)oc3c2)cc1 Show InChI InChI=1S/C21H20FN3O4/c22-15-3-1-13(2-4-15)11-14-7-9-25(10-8-14)20(27)19(26)23-16-5-6-17-18(12-16)29-21(28)24-17/h1-6,12,14H,7-11H2,(H,23,26)(H,24,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B receptor expressed in HEK293 cells co-expressing NR1 subunit assessed as reduction in glutamic acid/glycine-induced...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50505146 (CHEMBL4470637) Show SMILES C[C@@H]1CN(CCN1c1ccc(Cl)c(F)c1)C(=O)C(=O)Nc1ccc2[nH]c(=O)oc2c1 |r| Show InChI InChI=1S/C20H18ClFN4O4/c1-11-10-25(6-7-26(11)13-3-4-14(21)15(22)9-13)19(28)18(27)23-12-2-5-16-17(8-12)30-20(29)24-16/h2-5,8-9,11H,6-7,10H2,1H3,(H,23,27)(H,24,29)/t11-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B receptor expressed in HEK293 cells co-expressing NR1 subunit assessed as reduction in glutamic acid/glycine-induced...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50505121 (CHEMBL4454495) Show SMILES FC(F)(F)c1ccc(cc1)N1CCN(CC1)C(=O)C(=O)Nc1ccc2[nH]c(=O)oc2c1 Show InChI InChI=1S/C20H17F3N4O4/c21-20(22,23)12-1-4-14(5-2-12)26-7-9-27(10-8-26)18(29)17(28)24-13-3-6-15-16(11-13)31-19(30)25-15/h1-6,11H,7-10H2,(H,24,28)(H,25,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.30	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B receptor expressed in HEK293 cells co-expressing NR1 subunit assessed as reduction in glutamic acid/glycine-induced...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50505126 (CHEMBL4442519) Show SMILES C[C@@H]1CN(CCN1c1ccc(Cl)cc1)C(=O)C(=O)Nc1ccc2[nH]c(=O)oc2c1 |r| Show InChI InChI=1S/C20H19ClN4O4/c1-12-11-24(8-9-25(12)15-5-2-13(21)3-6-15)19(27)18(26)22-14-4-7-16-17(10-14)29-20(28)23-16/h2-7,10,12H,8-9,11H2,1H3,(H,22,26)(H,23,28)/t12-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.30	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B receptor expressed in HEK293 cells co-expressing NR1 subunit assessed as reduction in glutamic acid/glycine-induced...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50505145 (CHEMBL4474892) Show SMILES C[C@@H]1CN(CCN1C(=O)C(=O)Nc1ccc2[nH]c(=O)oc2c1)c1ccc(F)c(F)c1 |r| Show InChI InChI=1S/C20H18F2N4O4/c1-11-10-25(13-3-4-14(21)15(22)9-13)6-7-26(11)19(28)18(27)23-12-2-5-16-17(8-12)30-20(29)24-16/h2-5,8-9,11H,6-7,10H2,1H3,(H,23,27)(H,24,29)/t11-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.30	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B receptor expressed in HEK293 cells co-expressing NR1 subunit assessed as reduction in glutamic acid/glycine-induced...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50505125 (CHEMBL4464831) Show SMILES C[C@@H]1CN(CCN1C(=O)C(=O)Nc1ccc2[nH]c(=O)oc2c1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C20H19ClN4O4/c1-12-11-24(15-5-2-13(21)3-6-15)8-9-25(12)19(27)18(26)22-14-4-7-16-17(10-14)29-20(28)23-16/h2-7,10,12H,8-9,11H2,1H3,(H,22,26)(H,23,28)/t12-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.30	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B receptor expressed in HEK293 cells co-expressing NR1 subunit assessed as reduction in glutamic acid/glycine-induced...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50505147 (CHEMBL4451442) Show SMILES Clc1ccc(cc1)N1CCN(CC1)C(=O)C(=O)Nc1ccc2[nH]c(=O)oc2c1 Show InChI InChI=1S/C19H17ClN4O4/c20-12-1-4-14(5-2-12)23-7-9-24(10-8-23)18(26)17(25)21-13-3-6-15-16(11-13)28-19(27)22-15/h1-6,11H,7-10H2,(H,21,25)(H,22,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.90	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B receptor expressed in HEK293 cells co-expressing NR1 subunit assessed as reduction in glutamic acid/glycine-induced...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50505123 (CHEMBL4460939) Show SMILES Fc1ccc(cc1Cl)N1CCN(CC1)C(=O)C(=O)Nc1ccc2[nH]c(=O)oc2c1 Show InChI InChI=1S/C19H16ClFN4O4/c20-13-10-12(2-3-14(13)21)24-5-7-25(8-6-24)18(27)17(26)22-11-1-4-15-16(9-11)29-19(28)23-15/h1-4,9-10H,5-8H2,(H,22,26)(H,23,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B receptor expressed in HEK293 cells co-expressing NR1 subunit assessed as reduction in glutamic acid/glycine-induced...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50505118 (CHEMBL4463054) Show SMILES C[C@@H]1CN(CCN1c1ccc(F)c(F)c1)C(=O)C(=O)Nc1ccc2[nH]c(=O)oc2c1 |r| Show InChI InChI=1S/C20H18F2N4O4/c1-11-10-25(6-7-26(11)13-3-4-14(21)15(22)9-13)19(28)18(27)23-12-2-5-16-17(8-12)30-20(29)24-16/h2-5,8-9,11H,6-7,10H2,1H3,(H,23,27)(H,24,29)/t11-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B receptor expressed in HEK293 cells co-expressing NR1 subunit assessed as reduction in glutamic acid/glycine-induced...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50505136 (CHEMBL4460020) Show SMILES Fc1ccc(cc1F)N1CCN(CC1)C(=O)C(=O)Nc1ccc2[nH]c(=O)oc2c1 Show InChI InChI=1S/C19H16F2N4O4/c20-13-3-2-12(10-14(13)21)24-5-7-25(8-6-24)18(27)17(26)22-11-1-4-15-16(9-11)29-19(28)23-15/h1-4,9-10H,5-8H2,(H,22,26)(H,23,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B receptor expressed in HEK293 cells co-expressing NR1 subunit assessed as reduction in glutamic acid/glycine-induced...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50505134 (CHEMBL4455039) Show SMILES Clc1ccc(CC2CCN(CC2)C(=O)c2cc(on2)-c2ccc(=O)[nH]c2)cc1 Show InChI InChI=1S/C21H20ClN3O3/c22-17-4-1-14(2-5-17)11-15-7-9-25(10-8-15)21(27)18-12-19(28-24-18)16-3-6-20(26)23-13-16/h1-6,12-13,15H,7-11H2,(H,23,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B receptor expressed in HEK293 cells co-expressing NR1 subunit assessed as reduction in glutamic acid/glycine-induced...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50505135 (CHEMBL4453597) Show SMILES O[C@@]1(Cc2cc(on2)-c2cn[nH]c2)CC[C@H](Cc2ccc(cc2)C(F)(F)F)CC1 |r,wU:15.17,1.1,(40.37,-25.74,;40.37,-27.28,;39.04,-26.5,;37.71,-27.27,;36.3,-26.63,;35.27,-27.77,;36.03,-29.11,;37.54,-28.8,;33.73,-27.77,;32.81,-26.51,;31.35,-26.98,;31.34,-28.53,;32.81,-29.01,;40.37,-28.82,;41.7,-29.6,;43.03,-28.84,;44.36,-29.61,;45.7,-28.84,;45.7,-27.29,;47.03,-26.52,;48.36,-27.29,;48.37,-28.84,;47.03,-29.61,;49.69,-26.51,;51.03,-27.28,;49.69,-24.97,;51.02,-25.73,;43.04,-27.29,;41.71,-26.52,)| Show InChI InChI=1S/C21H22F3N3O2/c22-21(23,24)17-3-1-14(2-4-17)9-15-5-7-20(28,8-6-15)11-18-10-19(29-27-18)16-12-25-26-13-16/h1-4,10,12-13,15,28H,5-9,11H2,(H,25,26)/t15-,20-	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B receptor expressed in HEK293 cells co-expressing NR1 subunit assessed as reduction in glutamic acid/glycine-induced...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50505140 (CHEMBL4526884) Show SMILES Fc1cc(ccc1Cl)N1CCN(CC1)C(=O)C(=O)Nc1ccc2[nH]c(=O)oc2c1 Show InChI InChI=1S/C19H16ClFN4O4/c20-13-3-2-12(10-14(13)21)24-5-7-25(8-6-24)18(27)17(26)22-11-1-4-15-16(9-11)29-19(28)23-15/h1-4,9-10H,5-8H2,(H,22,26)(H,23,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B receptor in rat brain cerebral cortex membranes incubated for 120 mins by liquid scintillation counting met...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50505122 (CHEMBL4583880) Show SMILES C[C@@H]1CN(CCN1C(=O)C(=O)Nc1ccc2[nH]c(=O)oc2c1)c1ccc(Cl)c(F)c1 |r| Show InChI InChI=1S/C20H18ClFN4O4/c1-11-10-25(13-3-4-14(21)15(22)9-13)6-7-26(11)19(28)18(27)23-12-2-5-16-17(8-12)30-20(29)24-16/h2-5,8-9,11H,6-7,10H2,1H3,(H,23,27)(H,24,29)/t11-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B receptor in rat brain cerebral cortex membranes incubated for 120 mins by liquid scintillation counting met...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50505144 (CHEMBL4531810) Show SMILES COc1ccc(cc1F)N1CCN(CC1)C(=O)C(=O)Nc1ccc2[nH]c(=O)oc2c1 Show InChI InChI=1S/C20H19FN4O5/c1-29-16-5-3-13(11-14(16)21)24-6-8-25(9-7-24)19(27)18(26)22-12-2-4-15-17(10-12)30-20(28)23-15/h2-5,10-11H,6-9H2,1H3,(H,22,26)(H,23,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B receptor in rat brain cerebral cortex membranes incubated for 120 mins by liquid scintillation counting met...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50505144 (CHEMBL4531810) Show SMILES COc1ccc(cc1F)N1CCN(CC1)C(=O)C(=O)Nc1ccc2[nH]c(=O)oc2c1 Show InChI InChI=1S/C20H19FN4O5/c1-29-16-5-3-13(11-14(16)21)24-6-8-25(9-7-24)19(27)18(26)22-12-2-4-15-17(10-12)30-20(28)23-15/h2-5,10-11H,6-9H2,1H3,(H,22,26)(H,23,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B receptor expressed in HEK293 cells co-expressing NR1 subunit assessed as reduction in glutamic acid/glycine-induced...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50505124 (CHEMBL4534333) Show SMILES Fc1cc(ccc1C(F)(F)F)N1CCN(CC1)C(=O)C(=O)Nc1ccc2[nH]c(=O)oc2c1 Show InChI InChI=1S/C20H16F4N4O4/c21-14-10-12(2-3-13(14)20(22,23)24)27-5-7-28(8-6-27)18(30)17(29)25-11-1-4-15-16(9-11)32-19(31)26-15/h1-4,9-10H,5-8H2,(H,25,29)(H,26,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B receptor in rat brain cerebral cortex membranes incubated for 120 mins by liquid scintillation counting met...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50505147 (CHEMBL4451442) Show SMILES Clc1ccc(cc1)N1CCN(CC1)C(=O)C(=O)Nc1ccc2[nH]c(=O)oc2c1 Show InChI InChI=1S/C19H17ClN4O4/c20-12-1-4-14(5-2-12)23-7-9-24(10-8-23)18(26)17(25)21-13-3-6-15-16(11-13)28-19(27)22-15/h1-6,11H,7-10H2,(H,21,25)(H,22,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B receptor in rat brain cerebral cortex membranes incubated for 120 mins by liquid scintillation counting met...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50505136 (CHEMBL4460020) Show SMILES Fc1ccc(cc1F)N1CCN(CC1)C(=O)C(=O)Nc1ccc2[nH]c(=O)oc2c1 Show InChI InChI=1S/C19H16F2N4O4/c20-13-3-2-12(10-14(13)21)24-5-7-25(8-6-24)18(27)17(26)22-11-1-4-15-16(9-11)29-19(28)23-15/h1-4,9-10H,5-8H2,(H,22,26)(H,23,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B receptor in rat brain cerebral cortex membranes incubated for 120 mins by liquid scintillation counting met...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50505134 (CHEMBL4455039) Show SMILES Clc1ccc(CC2CCN(CC2)C(=O)c2cc(on2)-c2ccc(=O)[nH]c2)cc1 Show InChI InChI=1S/C21H20ClN3O3/c22-17-4-1-14(2-5-17)11-15-7-9-25(10-8-15)21(27)18-12-19(28-24-18)16-3-6-20(26)23-13-16/h1-6,12-13,15H,7-11H2,(H,23,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B receptor in rat brain cerebral cortex membranes incubated for 120 mins by liquid scintillation counting met...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50505121 (CHEMBL4454495) Show SMILES FC(F)(F)c1ccc(cc1)N1CCN(CC1)C(=O)C(=O)Nc1ccc2[nH]c(=O)oc2c1 Show InChI InChI=1S/C20H17F3N4O4/c21-20(22,23)12-1-4-14(5-2-12)26-7-9-27(10-8-26)18(29)17(28)24-13-3-6-15-16(11-13)31-19(30)25-15/h1-6,11H,7-10H2,(H,24,28)(H,25,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B receptor in rat brain cerebral cortex membranes incubated for 120 mins by liquid scintillation counting met...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50149684 (2-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-2-oxo-N-(2-...) Show SMILES Fc1ccc(CC2CCN(CC2)C(=O)C(=O)Nc2ccc3[nH]c(=O)oc3c2)cc1 Show InChI InChI=1S/C21H20FN3O4/c22-15-3-1-13(2-4-15)11-14-7-9-25(10-8-14)20(27)19(26)23-16-5-6-17-18(12-16)29-21(28)24-17/h1-6,12,14H,7-11H2,(H,23,26)(H,24,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B receptor in rat brain cerebral cortex membranes incubated for 120 mins by liquid scintillation counting met...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50505123 (CHEMBL4460939) Show SMILES Fc1ccc(cc1Cl)N1CCN(CC1)C(=O)C(=O)Nc1ccc2[nH]c(=O)oc2c1 Show InChI InChI=1S/C19H16ClFN4O4/c20-13-10-12(2-3-14(13)21)24-5-7-25(8-6-24)18(27)17(26)22-11-1-4-15-16(9-11)29-19(28)23-15/h1-4,9-10H,5-8H2,(H,22,26)(H,23,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B receptor in rat brain cerebral cortex membranes incubated for 120 mins by liquid scintillation counting met...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50505125 (CHEMBL4464831) Show SMILES C[C@@H]1CN(CCN1C(=O)C(=O)Nc1ccc2[nH]c(=O)oc2c1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C20H19ClN4O4/c1-12-11-24(15-5-2-13(21)3-6-15)8-9-25(12)19(27)18(26)22-14-4-7-16-17(10-14)29-20(28)23-16/h2-7,10,12H,8-9,11H2,1H3,(H,22,26)(H,23,28)/t12-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B receptor in rat brain cerebral cortex membranes incubated for 120 mins by liquid scintillation counting met...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50505128 (CHEMBL4451235) Show SMILES Clc1ccc(CC2CCN(CC2)C(=O)c2cc(on2)-c2cn[nH]c2)cc1 Show InChI InChI=1S/C19H19ClN4O2/c20-16-3-1-13(2-4-16)9-14-5-7-24(8-6-14)19(25)17-10-18(26-23-17)15-11-21-22-12-15/h1-4,10-12,14H,5-9H2,(H,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B receptor expressed in HEK293 cells co-expressing NR1 subunit assessed as reduction in glutamic acid/glycine-induced...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50505138 (CHEMBL4463106) Show SMILES Fc1ccc(CC2CCN(CC2)C(=O)c2cc(on2)-c2ccc(=O)[nH]c2)cc1 Show InChI InChI=1S/C21H20FN3O3/c22-17-4-1-14(2-5-17)11-15-7-9-25(10-8-15)21(27)18-12-19(28-24-18)16-3-6-20(26)23-13-16/h1-6,12-13,15H,7-11H2,(H,23,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B receptor expressed in HEK293 cells co-expressing NR1 subunit assessed as reduction in glutamic acid/glycine-induced...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50505142 (CHEMBL4462628) Show SMILES O=C(N1CCC(Cc2ccccc2)CC1)c1cc(on1)-c1cn[nH]c1 Show InChI InChI=1S/C19H20N4O2/c24-19(17-11-18(25-22-17)16-12-20-21-13-16)23-8-6-15(7-9-23)10-14-4-2-1-3-5-14/h1-5,11-13,15H,6-10H2,(H,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B receptor expressed in HEK293 cells co-expressing NR1 subunit assessed as reduction in glutamic acid/glycine-induced...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50505146 (CHEMBL4470637) Show SMILES C[C@@H]1CN(CCN1c1ccc(Cl)c(F)c1)C(=O)C(=O)Nc1ccc2[nH]c(=O)oc2c1 |r| Show InChI InChI=1S/C20H18ClFN4O4/c1-11-10-25(6-7-26(11)13-3-4-14(21)15(22)9-13)19(28)18(27)23-12-2-5-16-17(8-12)30-20(29)24-16/h2-5,8-9,11H,6-7,10H2,1H3,(H,23,27)(H,24,29)/t11-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B receptor in rat brain cerebral cortex membranes incubated for 120 mins by liquid scintillation counting met...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50505145 (CHEMBL4474892) Show SMILES C[C@@H]1CN(CCN1C(=O)C(=O)Nc1ccc2[nH]c(=O)oc2c1)c1ccc(F)c(F)c1 |r| Show InChI InChI=1S/C20H18F2N4O4/c1-11-10-25(13-3-4-14(21)15(22)9-13)6-7-26(11)19(28)18(27)23-12-2-5-16-17(8-12)30-20(29)24-16/h2-5,8-9,11H,6-7,10H2,1H3,(H,23,27)(H,24,29)/t11-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B receptor in rat brain cerebral cortex membranes incubated for 120 mins by liquid scintillation counting met...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50505138 (CHEMBL4463106) Show SMILES Fc1ccc(CC2CCN(CC2)C(=O)c2cc(on2)-c2ccc(=O)[nH]c2)cc1 Show InChI InChI=1S/C21H20FN3O3/c22-17-4-1-14(2-5-17)11-15-7-9-25(10-8-15)21(27)18-12-19(28-24-18)16-3-6-20(26)23-13-16/h1-6,12-13,15H,7-11H2,(H,23,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B receptor in rat brain cerebral cortex membranes incubated for 120 mins by liquid scintillation counting met...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50505119 (CHEMBL4449793) Show SMILES Clc1ccc(CN2CCN(CC2)C(=O)C(=O)Nc2ccc3[nH]c(=O)oc3c2)cc1 Show InChI InChI=1S/C20H19ClN4O4/c21-14-3-1-13(2-4-14)12-24-7-9-25(10-8-24)19(27)18(26)22-15-5-6-16-17(11-15)29-20(28)23-16/h1-6,11H,7-10,12H2,(H,22,26)(H,23,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	63	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B receptor expressed in HEK293 cells co-expressing NR1 subunit assessed as reduction in glutamic acid/glycine-induced...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50505120 (CHEMBL4435364) Show SMILES O=C(N1CCC(Cc2ccccc2)CC1)c1cc(on1)-c1ccc(=O)[nH]c1 Show InChI InChI=1S/C21H21N3O3/c25-20-7-6-17(14-22-20)19-13-18(23-27-19)21(26)24-10-8-16(9-11-24)12-15-4-2-1-3-5-15/h1-7,13-14,16H,8-12H2,(H,22,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	63	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B receptor expressed in HEK293 cells co-expressing NR1 subunit assessed as reduction in glutamic acid/glycine-induced...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50505126 (CHEMBL4442519) Show SMILES C[C@@H]1CN(CCN1c1ccc(Cl)cc1)C(=O)C(=O)Nc1ccc2[nH]c(=O)oc2c1 |r| Show InChI InChI=1S/C20H19ClN4O4/c1-12-11-24(8-9-25(12)15-5-2-13(21)3-6-15)19(27)18(26)22-14-4-7-16-17(10-14)29-20(28)23-16/h2-7,10,12H,8-9,11H2,1H3,(H,22,26)(H,23,28)/t12-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	63	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B receptor in rat brain cerebral cortex membranes incubated for 120 mins by liquid scintillation counting met...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50505127 (CHEMBL4471369) Show SMILES Fc1ccc(CC2CCN(CC2)C(=O)c2cc(on2)-c2cn[nH]c2)cc1 Show InChI InChI=1S/C19H19FN4O2/c20-16-3-1-13(2-4-16)9-14-5-7-24(8-6-14)19(25)17-10-18(26-23-17)15-11-21-22-12-15/h1-4,10-12,14H,5-9H2,(H,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	63	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B receptor expressed in HEK293 cells co-expressing NR1 subunit assessed as reduction in glutamic acid/glycine-induced...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50505128 (CHEMBL4451235) Show SMILES Clc1ccc(CC2CCN(CC2)C(=O)c2cc(on2)-c2cn[nH]c2)cc1 Show InChI InChI=1S/C19H19ClN4O2/c20-16-3-1-13(2-4-16)9-14-5-7-24(8-6-14)19(25)17-10-18(26-23-17)15-11-21-22-12-15/h1-4,10-12,14H,5-9H2,(H,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	63	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B receptor in rat brain cerebral cortex membranes incubated for 120 mins by liquid scintillation counting met...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50505118 (CHEMBL4463054) Show SMILES C[C@@H]1CN(CCN1c1ccc(F)c(F)c1)C(=O)C(=O)Nc1ccc2[nH]c(=O)oc2c1 |r| Show InChI InChI=1S/C20H18F2N4O4/c1-11-10-25(6-7-26(11)13-3-4-14(21)15(22)9-13)19(28)18(27)23-12-2-5-16-17(8-12)30-20(29)24-16/h2-5,8-9,11H,6-7,10H2,1H3,(H,23,27)(H,24,29)/t11-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	63	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B receptor in rat brain cerebral cortex membranes incubated for 120 mins by liquid scintillation counting met...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50505120 (CHEMBL4435364) Show SMILES O=C(N1CCC(Cc2ccccc2)CC1)c1cc(on1)-c1ccc(=O)[nH]c1 Show InChI InChI=1S/C21H21N3O3/c25-20-7-6-17(14-22-20)19-13-18(23-27-19)21(26)24-10-8-16(9-11-24)12-15-4-2-1-3-5-15/h1-7,13-14,16H,8-12H2,(H,22,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	63	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B receptor in rat brain cerebral cortex membranes incubated for 120 mins by liquid scintillation counting met...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50505127 (CHEMBL4471369) Show SMILES Fc1ccc(CC2CCN(CC2)C(=O)c2cc(on2)-c2cn[nH]c2)cc1 Show InChI InChI=1S/C19H19FN4O2/c20-16-3-1-13(2-4-16)9-14-5-7-24(8-6-14)19(25)17-10-18(26-23-17)15-11-21-22-12-15/h1-4,10-12,14H,5-9H2,(H,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	79	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B receptor in rat brain cerebral cortex membranes incubated for 120 mins by liquid scintillation counting met...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50505142 (CHEMBL4462628) Show SMILES O=C(N1CCC(Cc2ccccc2)CC1)c1cc(on1)-c1cn[nH]c1 Show InChI InChI=1S/C19H20N4O2/c24-19(17-11-18(25-22-17)16-12-20-21-13-16)23-8-6-15(7-9-23)10-14-4-2-1-3-5-14/h1-5,11-13,15H,6-10H2,(H,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	79	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B receptor in rat brain cerebral cortex membranes incubated for 120 mins by liquid scintillation counting met...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50505137 (CHEMBL4457441) Show SMILES Fc1cc(F)cc(c1)N1CCN(CC1)C(=O)C(=O)Nc1ccc2[nH]c(=O)oc2c1 Show InChI InChI=1S/C19H16F2N4O4/c20-11-7-12(21)9-14(8-11)24-3-5-25(6-4-24)18(27)17(26)22-13-1-2-15-16(10-13)29-19(28)23-15/h1-2,7-10H,3-6H2,(H,22,26)(H,23,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B receptor expressed in HEK293 cells co-expressing NR1 subunit assessed as reduction in glutamic acid/glycine-induced...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50505135 (CHEMBL4453597) Show SMILES O[C@@]1(Cc2cc(on2)-c2cn[nH]c2)CC[C@H](Cc2ccc(cc2)C(F)(F)F)CC1 |r,wU:15.17,1.1,(40.37,-25.74,;40.37,-27.28,;39.04,-26.5,;37.71,-27.27,;36.3,-26.63,;35.27,-27.77,;36.03,-29.11,;37.54,-28.8,;33.73,-27.77,;32.81,-26.51,;31.35,-26.98,;31.34,-28.53,;32.81,-29.01,;40.37,-28.82,;41.7,-29.6,;43.03,-28.84,;44.36,-29.61,;45.7,-28.84,;45.7,-27.29,;47.03,-26.52,;48.36,-27.29,;48.37,-28.84,;47.03,-29.61,;49.69,-26.51,;51.03,-27.28,;49.69,-24.97,;51.02,-25.73,;43.04,-27.29,;41.71,-26.52,)| Show InChI InChI=1S/C21H22F3N3O2/c22-21(23,24)17-3-1-14(2-4-17)9-15-5-7-20(28,8-6-15)11-18-10-19(29-27-18)16-12-25-26-13-16/h1-4,10,12-13,15,28H,5-9,11H2,(H,25,26)/t15-,20-	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B receptor in rat brain cerebral cortex membranes incubated for 120 mins by liquid scintillation counting met...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50505141 (CHEMBL4448851) Show SMILES C[C@H]1CN(CCN1c1ccc(Cl)cc1)C(=O)C(=O)Nc1ccc2[nH]c(=O)oc2c1 |r| Show InChI InChI=1S/C20H19ClN4O4/c1-12-11-24(8-9-25(12)15-5-2-13(21)3-6-15)19(27)18(26)22-14-4-7-16-17(10-14)29-20(28)23-16/h2-7,10,12H,8-9,11H2,1H3,(H,22,26)(H,23,28)/t12-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B receptor expressed in HEK293 cells co-expressing NR1 subunit assessed as reduction in glutamic acid/glycine-induced...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50505131 (CHEMBL4456965) Show SMILES Fc1ccc(cc1)N1CCN(CC1)C(=O)C(=O)Nc1ccc2[nH]c(=O)oc2c1 Show InChI InChI=1S/C19H17FN4O4/c20-12-1-4-14(5-2-12)23-7-9-24(10-8-23)18(26)17(25)21-13-3-6-15-16(11-13)28-19(27)22-15/h1-6,11H,7-10H2,(H,21,25)(H,22,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	126	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B receptor in rat brain cerebral cortex membranes incubated for 120 mins by liquid scintillation counting met...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50505131 (CHEMBL4456965) Show SMILES Fc1ccc(cc1)N1CCN(CC1)C(=O)C(=O)Nc1ccc2[nH]c(=O)oc2c1 Show InChI InChI=1S/C19H17FN4O4/c20-12-1-4-14(5-2-12)23-7-9-24(10-8-23)18(26)17(25)21-13-3-6-15-16(11-13)28-19(27)22-15/h1-6,11H,7-10H2,(H,21,25)(H,22,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	126	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B receptor expressed in HEK293 cells co-expressing NR1 subunit assessed as reduction in glutamic acid/glycine-induced...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50505137 (CHEMBL4457441) Show SMILES Fc1cc(F)cc(c1)N1CCN(CC1)C(=O)C(=O)Nc1ccc2[nH]c(=O)oc2c1 Show InChI InChI=1S/C19H16F2N4O4/c20-11-7-12(21)9-14(8-11)24-3-5-25(6-4-24)18(27)17(26)22-13-1-2-15-16(10-13)29-19(28)23-15/h1-2,7-10H,3-6H2,(H,22,26)(H,23,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	158	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B receptor in rat brain cerebral cortex membranes incubated for 120 mins by liquid scintillation counting met...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50505132 (CHEMBL4438058) Show SMILES COc1ccc(cc1)N1CCN(CC1)C(=O)C(=O)Nc1ccc2[nH]c(=O)oc2c1 Show InChI InChI=1S/C20H20N4O5/c1-28-15-5-3-14(4-6-15)23-8-10-24(11-9-23)19(26)18(25)21-13-2-7-16-17(12-13)29-20(27)22-16/h2-7,12H,8-11H2,1H3,(H,21,25)(H,22,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B receptor expressed in HEK293 cells co-expressing NR1 subunit assessed as reduction in glutamic acid/glycine-induced...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50505132 (CHEMBL4438058) Show SMILES COc1ccc(cc1)N1CCN(CC1)C(=O)C(=O)Nc1ccc2[nH]c(=O)oc2c1 Show InChI InChI=1S/C20H20N4O5/c1-28-15-5-3-14(4-6-15)23-8-10-24(11-9-23)19(26)18(25)21-13-2-7-16-17(12-13)29-20(27)22-16/h2-7,12H,8-11H2,1H3,(H,21,25)(H,22,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	251	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi & Co., Ltd Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B receptor in rat brain cerebral cortex membranes incubated for 120 mins by liquid scintillation counting met...				Bioorg Med Chem Lett 29: 1143-1147 (2019) Article DOI: 10.1016/j.bmcl.2019.02.017 BindingDB Entry DOI: 10.7270/Q2P55RSV
					More data for this Ligand-Target Pair

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