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Compile Data Set for Download or QSAR

Found 95 hits Enz. Inhib. hit(s) with all data for entry = 50010340   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093652
PNG
(2-Methyl-6-pentyl-4-piperidin-1-yl-5H-pyrrolo[3,2-...)
Show SMILES CCCCCc1cc2nc(C)nc(N3CCCCC3)c2[nH]1
Show InChI InChI=1S/C17H26N4/c1-3-4-6-9-14-12-15-16(20-14)17(19-13(2)18-15)21-10-7-5-8-11-21/h12,20H,3-11H2,1-2H3
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n/an/a 0.200n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093696
PNG
(6-(3-Fluoro-phenyl)-2-methyl-4-piperidin-1-yl-5H-p...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1cccc(F)c1
Show InChI InChI=1S/C18H19FN4/c1-12-20-16-11-15(13-6-5-7-14(19)10-13)22-17(16)18(21-12)23-8-3-2-4-9-23/h5-7,10-11,22H,2-4,8-9H2,1H3
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n/an/a 0.300n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093664
PNG
(6-(4-Fluoro-phenyl)-2-methyl-4-piperidin-1-yl-5H-p...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C18H19FN4/c1-12-20-16-11-15(13-5-7-14(19)8-6-13)22-17(16)18(21-12)23-9-3-2-4-10-23/h5-8,11,22H,2-4,9-10H2,1H3
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n/an/a 0.300n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093646
PNG
(6-Benzofuran-2-yl-2-methyl-4-piperidin-1-yl-5H-pyr...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1cc2ccccc2o1
Show InChI InChI=1S/C20H20N4O/c1-13-21-16-12-15(18-11-14-7-3-4-8-17(14)25-18)23-19(16)20(22-13)24-9-5-2-6-10-24/h3-4,7-8,11-12,23H,2,5-6,9-10H2,1H3
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n/an/a 0.300n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093675
PNG
(6-(3,5-Difluoro-phenyl)-2-methyl-4-piperidin-1-yl-...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1cc(F)cc(F)c1
Show InChI InChI=1S/C18H18F2N4/c1-11-21-16-10-15(12-7-13(19)9-14(20)8-12)23-17(16)18(22-11)24-5-3-2-4-6-24/h7-10,23H,2-6H2,1H3
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n/an/a 0.400n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093691
PNG
(4-(3,6-Dihydro-2H-pyridin-1-yl)-2-methyl-6-phenyl-...)
Show SMILES Cc1nc(N2CCC=CC2)c2[nH]c(cc2n1)-c1ccccc1 |c:7|
Show InChI InChI=1S/C18H18N4/c1-13-19-16-12-15(14-8-4-2-5-9-14)21-17(16)18(20-13)22-10-6-3-7-11-22/h2-6,8-9,12,21H,7,10-11H2,1H3
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n/an/a 0.400n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093647
PNG
(2-Methyl-6-(5-methyl-furan-2-yl)-4-piperidin-1-yl-...)
Show SMILES Cc1ccc(o1)-c1cc2nc(C)nc(N3CCCCC3)c2[nH]1
Show InChI InChI=1S/C17H20N4O/c1-11-6-7-15(22-11)13-10-14-16(20-13)17(19-12(2)18-14)21-8-4-3-5-9-21/h6-7,10,20H,3-5,8-9H2,1-2H3
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n/an/a 0.5n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093697
PNG
(2-Methyl-4-piperidin-1-yl-6-p-tolyl-5H-pyrrolo[3,2...)
Show SMILES Cc1ccc(cc1)-c1cc2nc(C)nc(N3CCCCC3)c2[nH]1
Show InChI InChI=1S/C19H22N4/c1-13-6-8-15(9-7-13)16-12-17-18(22-16)19(21-14(2)20-17)23-10-4-3-5-11-23/h6-9,12,22H,3-5,10-11H2,1-2H3
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n/an/a 0.5n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093678
PNG
(2-Methyl-6-phenyl-4-pyrrolidin-1-yl-5H-pyrrolo[3,2...)
Show SMILES Cc1nc(N2CCCC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C17H18N4/c1-12-18-15-11-14(13-7-3-2-4-8-13)20-16(15)17(19-12)21-9-5-6-10-21/h2-4,7-8,11,20H,5-6,9-10H2,1H3
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n/an/a 0.700n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093673
PNG
(2-Methyl-4-piperidin-1-yl-6-(4-trifluoromethyl-phe...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C19H19F3N4/c1-12-23-16-11-15(13-5-7-14(8-6-13)19(20,21)22)25-17(16)18(24-12)26-9-3-2-4-10-26/h5-8,11,25H,2-4,9-10H2,1H3
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n/an/a 0.700n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093683
PNG
(2-Methyl-6-phenyl-4-piperidin-1-yl-5H-pyrrolo[3,2-...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C18H20N4/c1-13-19-16-12-15(14-8-4-2-5-9-14)21-17(16)18(20-13)22-10-6-3-7-11-22/h2,4-5,8-9,12,21H,3,6-7,10-11H2,1H3
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n/an/a 1.10n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093651
PNG
(6-Phenyl-4-piperidin-1-yl-5H-pyrrolo[3,2-d]pyrimid...)
Show SMILES Nc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C17H19N5/c18-17-20-14-11-13(12-7-3-1-4-8-12)19-15(14)16(21-17)22-9-5-2-6-10-22/h1,3-4,7-8,11,19H,2,5-6,9-10H2,(H2,18,20,21)
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n/an/a 1.20n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093692
PNG
(5-Methyl-2-phenyl-7-piperidin-1-yl-1H-pyrrolo[3,2-...)
Show SMILES Cc1cc(N2CCCCC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C19H21N3/c1-14-12-18(22-10-6-3-7-11-22)19-17(20-14)13-16(21-19)15-8-4-2-5-9-15/h2,4-5,8-9,12-13,21H,3,6-7,10-11H2,1H3
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n/an/a 1.70n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093616
PNG
(4-Azepan-1-yl-2-methyl-6-phenyl-5H-pyrrolo[3,2-d]p...)
Show SMILES Cc1nc(N2CCCCCC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C19H22N4/c1-14-20-17-13-16(15-9-5-4-6-10-15)22-18(17)19(21-14)23-11-7-2-3-8-12-23/h4-6,9-10,13,22H,2-3,7-8,11-12H2,1H3
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n/an/a 1.80n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093640
PNG
(4-(2,5-Dihydro-pyrrol-1-yl)-2-methyl-6-phenyl-5H-p...)
Show SMILES Cc1nc(N2CC=CC2)c2[nH]c(cc2n1)-c1ccccc1 |c:6|
Show InChI InChI=1S/C17H16N4/c1-12-18-15-11-14(13-7-3-2-4-8-13)20-16(15)17(19-12)21-9-5-6-10-21/h2-8,11,20H,9-10H2,1H3
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n/an/a 2.20n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093672
PNG
(2-Methyl-4-(2-methyl-piperidin-1-yl)-6-phenyl-5H-p...)
Show SMILES CC1CCCCN1c1nc(C)nc2cc([nH]c12)-c1ccccc1
Show InChI InChI=1S/C19H22N4/c1-13-8-6-7-11-23(13)19-18-17(20-14(2)21-19)12-16(22-18)15-9-4-3-5-10-15/h3-5,9-10,12-13,22H,6-8,11H2,1-2H3
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n/an/a 3n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093624
PNG
(2-Methyl-6-phenethyl-4-piperidin-1-yl-5H-pyrrolo[3...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(CCc3ccccc3)cc2n1
Show InChI InChI=1S/C20H24N4/c1-15-21-18-14-17(11-10-16-8-4-2-5-9-16)23-19(18)20(22-15)24-12-6-3-7-13-24/h2,4-5,8-9,14,23H,3,6-7,10-13H2,1H3
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n/an/a 5.30n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093632
PNG
(6-Cyclohexylmethyl-2-methyl-4-piperidin-1-yl-5H-py...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(CC3CCCCC3)cc2n1
Show InChI InChI=1S/C19H28N4/c1-14-20-17-13-16(12-15-8-4-2-5-9-15)22-18(17)19(21-14)23-10-6-3-7-11-23/h13,15,22H,2-12H2,1H3
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n/an/a 8.5n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093666
PNG
(6-Butyl-2-methyl-4-piperidin-1-yl-5H-pyrrolo[3,2-d...)
Show SMILES CCCCc1cc2nc(C)nc(N3CCCCC3)c2[nH]1
Show InChI InChI=1S/C16H24N4/c1-3-4-8-13-11-14-15(19-13)16(18-12(2)17-14)20-9-6-5-7-10-20/h11,19H,3-10H2,1-2H3
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n/an/a 10n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093693
PNG
(6-Cyclohexyl-2-methyl-4-piperidin-1-yl-5H-pyrrolo[...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(cc2n1)C1CCCCC1
Show InChI InChI=1S/C18H26N4/c1-13-19-16-12-15(14-8-4-2-5-9-14)21-17(16)18(20-13)22-10-6-3-7-11-22/h12,14,21H,2-11H2,1H3
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n/an/a 11n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093704
PNG
(4-(2,6-Dimethyl-piperidin-1-yl)-2-methyl-6-phenyl-...)
Show SMILES CC1CCCC(C)N1c1nc(C)nc2cc([nH]c12)-c1ccccc1
Show InChI InChI=1S/C20H24N4/c1-13-8-7-9-14(2)24(13)20-19-18(21-15(3)22-20)12-17(23-19)16-10-5-4-6-11-16/h4-6,10-14,23H,7-9H2,1-3H3
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n/an/a 17n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093633
PNG
(2-Methyl-6-phenoxymethyl-4-piperidin-1-yl-5H-pyrro...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(COc3ccccc3)cc2n1
Show InChI InChI=1S/C19H22N4O/c1-14-20-17-12-15(13-24-16-8-4-2-5-9-16)22-18(17)19(21-14)23-10-6-3-7-11-23/h2,4-5,8-9,12,22H,3,6-7,10-11,13H2,1H3
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n/an/a 18n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093679
PNG
(2-Ethyl-6-phenyl-4-piperidin-1-yl-5H-pyrrolo[3,2-d...)
Show SMILES CCc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C19H22N4/c1-2-17-20-16-13-15(14-9-5-3-6-10-14)21-18(16)19(22-17)23-11-7-4-8-12-23/h3,5-6,9-10,13,21H,2,4,7-8,11-12H2,1H3
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n/an/a 20n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093700
PNG
(6-Phenyl-4-piperidin-1-yl-2-propyl-5H-pyrrolo[3,2-...)
Show SMILES CCCc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C20H24N4/c1-2-9-18-21-17-14-16(15-10-5-3-6-11-15)22-19(17)20(23-18)24-12-7-4-8-13-24/h3,5-6,10-11,14,22H,2,4,7-9,12-13H2,1H3
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n/an/a 28n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093662
PNG
(CHEMBL136650 | Methyl-(6-phenyl-4-piperidin-1-yl-5...)
Show SMILES CNc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C18H21N5/c1-19-18-21-15-12-14(13-8-4-2-5-9-13)20-16(15)17(22-18)23-10-6-3-7-11-23/h2,4-5,8-9,12,20H,3,6-7,10-11H2,1H3,(H,19,21,22)
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n/an/a 29n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093658
PNG
(2-Methyl-6-phenyl-4-piperidin-1-yl-furo[3,2-d]pyri...)
Show SMILES Cc1nc(N2CCCCC2)c2oc(cc2n1)-c1ccccc1
Show InChI InChI=1S/C18H19N3O/c1-13-19-15-12-16(14-8-4-2-5-9-14)22-17(15)18(20-13)21-10-6-3-7-11-21/h2,4-5,8-9,12H,3,6-7,10-11H2,1H3
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n/an/a 30n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093684
PNG
(2-Cyclopropyl-6-phenyl-4-piperidin-1-yl-5H-pyrrolo...)
Show SMILES C1CC1c1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C20H22N4/c1-3-7-14(8-4-1)16-13-17-18(21-16)20(24-11-5-2-6-12-24)23-19(22-17)15-9-10-15/h1,3-4,7-8,13,15,21H,2,5-6,9-12H2
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n/an/a 32n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093614
PNG
(CHEMBL337152 | Diethyl-(2-methyl-6-phenyl-5H-pyrro...)
Show SMILES CCN(CC)c1nc(C)nc2cc([nH]c12)-c1ccccc1
Show InChI InChI=1S/C17H20N4/c1-4-21(5-2)17-16-15(18-12(3)19-17)11-14(20-16)13-9-7-6-8-10-13/h6-11,20H,4-5H2,1-3H3
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n/an/a 36n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093613
PNG
(6-(4-Methoxy-phenyl)-2-methyl-4-piperidin-1-yl-5H-...)
Show SMILES COc1ccc(cc1)-c1cc2nc(C)nc(N3CCCCC3)c2[nH]1
Show InChI InChI=1S/C19H22N4O/c1-13-20-17-12-16(14-6-8-15(24-2)9-7-14)22-18(17)19(21-13)23-10-4-3-5-11-23/h6-9,12,22H,3-5,10-11H2,1-2H3
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n/an/a 41n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093618
PNG
(6-(2-Fluoro-phenyl)-2-methyl-4-piperidin-1-yl-5H-p...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1ccccc1F
Show InChI InChI=1S/C18H19FN4/c1-12-20-16-11-15(13-7-3-4-8-14(13)19)22-17(16)18(21-12)23-9-5-2-6-10-23/h3-4,7-8,11,22H,2,5-6,9-10H2,1H3
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n/an/a 44n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093674
PNG
(6-Adamantan-1-yl-2-methyl-4-piperidin-1-yl-5H-pyrr...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(cc2n1)C12C[C@H]3C[C@H](C[C@H](C3)C1)C2 |TLB:23:22:25:17.18.19,23:18:25:24.22.21|
Show InChI InChI=1S/C22H30N4/c1-14-23-18-10-19(22-11-15-7-16(12-22)9-17(8-15)13-22)25-20(18)21(24-14)26-5-3-2-4-6-26/h10,15-17,25H,2-9,11-13H2,1H3/t15-,16+,17-,22?
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n/an/a 45n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093657
PNG
(CHEMBL137613 | Furan-2-ylmethyl-methyl-(2-methyl-6...)
Show SMILES CN(Cc1ccco1)c1nc(C)nc2cc([nH]c12)-c1ccccc1
Show InChI InChI=1S/C19H18N4O/c1-13-20-17-11-16(14-7-4-3-5-8-14)22-18(17)19(21-13)23(2)12-15-9-6-10-24-15/h3-11,22H,12H2,1-2H3
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n/an/a 52n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093629
PNG
(2,7-Dimethyl-6-phenyl-4-piperidin-1-yl-5H-pyrrolo[...)
Show SMILES Cc1c([nH]c2c(nc(C)nc12)N1CCCCC1)-c1ccccc1
Show InChI InChI=1S/C19H22N4/c1-13-16(15-9-5-3-6-10-15)22-18-17(13)20-14(2)21-19(18)23-11-7-4-8-12-23/h3,5-6,9-10,22H,4,7-8,11-12H2,1-2H3
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n/an/a 53n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093649
PNG
(4-Azetidin-1-yl-2-methyl-6-phenyl-5H-pyrrolo[3,2-d...)
Show SMILES Cc1nc(N2CCC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C16H16N4/c1-11-17-14-10-13(12-6-3-2-4-7-12)19-15(14)16(18-11)20-8-5-9-20/h2-4,6-7,10,19H,5,8-9H2,1H3
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n/an/a 57n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093706
PNG
(2-Methyl-4-piperidin-1-yl-6-propyl-5H-pyrrolo[3,2-...)
Show SMILES CCCc1cc2nc(C)nc(N3CCCCC3)c2[nH]1
Show InChI InChI=1S/C15H22N4/c1-3-7-12-10-13-14(18-12)15(17-11(2)16-13)19-8-5-4-6-9-19/h10,18H,3-9H2,1-2H3
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n/an/a 66n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093667
PNG
(4-(2-Ethyl-piperidin-1-yl)-2-methyl-6-phenyl-5H-py...)
Show SMILES CCC1CCCCN1c1nc(C)nc2cc([nH]c12)-c1ccccc1
Show InChI InChI=1S/C20H24N4/c1-3-16-11-7-8-12-24(16)20-19-18(21-14(2)22-20)13-17(23-19)15-9-5-4-6-10-15/h4-6,9-10,13,16,23H,3,7-8,11-12H2,1-2H3
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n/an/a 74n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093644
PNG
(6-(2,5-Difluoro-phenyl)-2-methyl-4-piperidin-1-yl-...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1cc(F)ccc1F
Show InChI InChI=1S/C18H18F2N4/c1-11-21-16-10-15(13-9-12(19)5-6-14(13)20)23-17(16)18(22-11)24-7-3-2-4-8-24/h5-6,9-10,23H,2-4,7-8H2,1H3
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n/an/a 79n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093702
PNG
(2-Methyl-4-piperidin-1-yl-6-thiophen-2-yl-5H-pyrro...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1cccs1
Show InChI InChI=1S/C16H18N4S/c1-11-17-13-10-12(14-6-5-9-21-14)19-15(13)16(18-11)20-7-3-2-4-8-20/h5-6,9-10,19H,2-4,7-8H2,1H3
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n/an/a 100n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093639
PNG
(2-Methyl-4-morpholin-4-yl-6-phenyl-5H-pyrrolo[3,2-...)
Show SMILES Cc1nc(N2CCOCC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C17H18N4O/c1-12-18-15-11-14(13-5-3-2-4-6-13)20-16(15)17(19-12)21-7-9-22-10-8-21/h2-6,11,20H,7-10H2,1H3
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n/an/a 100n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093698
PNG
((6-Phenyl-4-piperidin-1-yl-5H-pyrrolo[3,2-d]pyrimi...)
Show SMILES CCCNc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C20H25N5/c1-2-11-21-20-23-17-14-16(15-9-5-3-6-10-15)22-18(17)19(24-20)25-12-7-4-8-13-25/h3,5-6,9-10,14,22H,2,4,7-8,11-13H2,1H3,(H,21,23,24)
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n/an/a 120n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093659
PNG
(6-Benzo[b]thiophen-2-yl-2-methyl-4-piperidin-1-yl-...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1cc2ccccc2s1
Show InChI InChI=1S/C20H20N4S/c1-13-21-16-12-15(18-11-14-7-3-4-8-17(14)25-18)23-19(16)20(22-13)24-9-5-2-6-10-24/h3-4,7-8,11-12,23H,2,5-6,9-10H2,1H3
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n/an/a 140n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093689
PNG
(2-Methyl-4-piperidin-1-yl-6-pyridin-2-yl-5H-pyrrol...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1ccccn1
Show InChI InChI=1S/C17H19N5/c1-12-19-15-11-14(13-7-3-4-8-18-13)21-16(15)17(20-12)22-9-5-2-6-10-22/h3-4,7-8,11,21H,2,5-6,9-10H2,1H3
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n/an/a 150n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093628
PNG
(6-[2-(4-Methoxy-phenyl)-ethyl]-2-methyl-4-piperidi...)
Show SMILES COc1ccc(CCc2cc3nc(C)nc(N4CCCCC4)c3[nH]2)cc1
Show InChI InChI=1S/C21H26N4O/c1-15-22-19-14-17(9-6-16-7-10-18(26-2)11-8-16)24-20(19)21(23-15)25-12-4-3-5-13-25/h7-8,10-11,14,24H,3-6,9,12-13H2,1-2H3
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093654
PNG
(2,6-Dimethyl-4-piperidin-1-yl-5H-pyrrolo[3,2-d]pyr...)
Show SMILES Cc1cc2nc(C)nc(N3CCCCC3)c2[nH]1
Show InChI InChI=1S/C13H18N4/c1-9-8-11-12(14-9)13(16-10(2)15-11)17-6-4-3-5-7-17/h8,14H,3-7H2,1-2H3
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093653
PNG
(2-Methyl-4-piperidin-1-yl-6-(3-trifluoromethyl-ben...)
Show SMILES Cc1nc(N2CCCCC2)c2[nH]c(Cc3cccc(c3)C(F)(F)F)cc2n1
Show InChI InChI=1S/C20H21F3N4/c1-13-24-17-12-16(11-14-6-5-7-15(10-14)20(21,22)23)26-18(17)19(25-13)27-8-3-2-4-9-27/h5-7,10,12,26H,2-4,8-9,11H2,1H3
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093695
PNG
(4-(3,5-Dimethyl-piperidin-1-yl)-2-methyl-6-phenyl-...)
Show SMILES CC1CC(C)CN(C1)c1nc(C)nc2cc([nH]c12)-c1ccccc1
Show InChI InChI=1S/C20H24N4/c1-13-9-14(2)12-24(11-13)20-19-18(21-15(3)22-20)10-17(23-19)16-7-5-4-6-8-16/h4-8,10,13-14,23H,9,11-12H2,1-3H3
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093663
PNG
(2-Methyl-6-phenyl-4-piperidin-1-yl-thieno[3,2-d]py...)
Show SMILES Cc1nc(N2CCCCC2)c2sc(cc2n1)-c1ccccc1
Show InChI InChI=1S/C18H19N3S/c1-13-19-15-12-16(14-8-4-2-5-9-14)22-17(15)18(20-13)21-10-6-3-7-11-21/h2,4-5,8-9,12H,3,6-7,10-11H2,1H3
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093623
PNG
(2-(2-Methyl-6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-4-...)
Show SMILES Cc1nc(N2CCc3ccccc3C2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C22H20N4/c1-15-23-20-13-19(17-8-3-2-4-9-17)25-21(20)22(24-15)26-12-11-16-7-5-6-10-18(16)14-26/h2-10,13,25H,11-12,14H2,1H3
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093641
PNG
(1-(2-Methyl-6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-4-...)
Show SMILES Cc1nc(N2CCC(O)CC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C18H20N4O/c1-12-19-16-11-15(13-5-3-2-4-6-13)21-17(16)18(20-12)22-9-7-14(23)8-10-22/h2-6,11,14,21,23H,7-10H2,1H3
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Homo sapiens (Human))
BDBM50093699
PNG
(CHEMBL138278 | Dimethyl-(6-phenyl-4-piperidin-1-yl...)
Show SMILES CN(C)c1nc(N2CCCCC2)c2[nH]c(cc2n1)-c1ccccc1
Show InChI InChI=1S/C19H23N5/c1-23(2)19-21-16-13-15(14-9-5-3-6-10-14)20-17(16)18(22-19)24-11-7-4-8-12-24/h3,5-6,9-10,13,20H,4,7-8,11-12H2,1-2H3
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n/an/a 280n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay


J Med Chem 43: 4288-312 (2000)


BindingDB Entry DOI: 10.7270/Q2C828J1
More data for this
Ligand-Target Pair
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