Found 14 hits Enz. Inhib. hit(s) with all data for entry = 50028904 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Prostaglandin G/H synthase 1/2
(RAT) | BDBM22971
(2-[(2,6-dichloro-3-methylphenyl)amino]benzoic acid...)Show InChI InChI=1S/C14H11Cl2NO2/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19/h2-7,17H,1H3,(H,18,19) | PDB MMDB
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
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| PDB Article
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Compound was evaluated in an intact RBL-1 cell line for inhibition of 5-Cyclooxygenase |
Bioorg Med Chem Lett 2: 69-72 (1992)
Article DOI: 10.1016/S0960-894X(00)80657-5 BindingDB Entry DOI: 10.7270/Q29K4B4Q |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Prostaglandin G/H synthase 1/2
(RAT) | BDBM50280051
(5-[2-(3-Trifluoromethyl-phenylamino)-pyridin-3-yl]...)Show InChI InChI=1S/C14H9F3N4OS/c15-14(16,17)8-3-1-4-9(7-8)19-11-10(5-2-6-18-11)12-20-21-13(23)22-12/h1-7H,(H,18,19)(H,21,23) | PDB MMDB
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| CHEMBL PC cid PC sid UniChem
| Article
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against Cyclooxygenase was determined |
Bioorg Med Chem Lett 2: 69-72 (1992)
Article DOI: 10.1016/S0960-894X(00)80657-5 BindingDB Entry DOI: 10.7270/Q29K4B4Q |
More data for this Ligand-Target Pair | |
Prostaglandin G/H synthase 1/2
(RAT) | BDBM50048004
(5-(2-(3-(trifluoromethyl)phenylamino)phenyl)-1,3,4...)Show InChI InChI=1S/C15H10F3N3OS/c16-15(17,18)9-4-3-5-10(8-9)19-12-7-2-1-6-11(12)13-20-21-14(23)22-13/h1-8,19H,(H,21,23) | PDB MMDB
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| CHEMBL PC cid PC sid UniChem
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| Article
| n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against Cyclooxygenase was determined |
Bioorg Med Chem Lett 2: 69-72 (1992)
Article DOI: 10.1016/S0960-894X(00)80657-5 BindingDB Entry DOI: 10.7270/Q29K4B4Q |
More data for this Ligand-Target Pair | |
Prostaglandin G/H synthase 1/2
(RAT) | BDBM50048003
(5-[2-(2,3-Dimethyl-phenylamino)-phenyl]-3H-[1,3,4]...)Show InChI InChI=1S/C16H15N3OS/c1-10-6-5-9-13(11(10)2)17-14-8-4-3-7-12(14)15-18-19-16(21)20-15/h3-9,17H,1-2H3,(H,19,21) | PDB MMDB
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| CHEMBL PC cid PC sid UniChem
Patents
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| Article
| n/a | n/a | 610 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against Cyclooxygenase was determined |
Bioorg Med Chem Lett 2: 69-72 (1992)
Article DOI: 10.1016/S0960-894X(00)80657-5 BindingDB Entry DOI: 10.7270/Q29K4B4Q |
More data for this Ligand-Target Pair | |
Prostaglandin G/H synthase 1/2
(RAT) | BDBM50048007
(5-[2-(2,6-Dichloro-3-methyl-phenylamino)-phenyl]-3...)Show InChI InChI=1S/C15H11Cl2N3OS/c1-8-6-7-10(16)13(12(8)17)18-11-5-3-2-4-9(11)14-19-20-15(22)21-14/h2-7,18H,1H3,(H,20,22) | PDB MMDB
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| CHEMBL PC cid PC sid UniChem
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| Article
| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Tested for inhibition of contractile effects of Tachykinin receptor 1 in guinea pig ileum preparation. |
Bioorg Med Chem Lett 2: 69-72 (1992)
Article DOI: 10.1016/S0960-894X(00)80657-5 BindingDB Entry DOI: 10.7270/Q29K4B4Q |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50048007
(5-[2-(2,6-Dichloro-3-methyl-phenylamino)-phenyl]-3...)Show InChI InChI=1S/C15H11Cl2N3OS/c1-8-6-7-10(16)13(12(8)17)18-11-5-3-2-4-9(11)14-19-20-15(22)21-14/h2-7,18H,1H3,(H,20,22) | PDB MMDB
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| CHEMBL PC cid PC sid UniChem
Patents
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| Article
| n/a | n/a | 740 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibitory activity of the compound against 5-lipoxygenase was determined |
Bioorg Med Chem Lett 2: 69-72 (1992)
Article DOI: 10.1016/S0960-894X(00)80657-5 BindingDB Entry DOI: 10.7270/Q29K4B4Q |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50048004
(5-(2-(3-(trifluoromethyl)phenylamino)phenyl)-1,3,4...)Show InChI InChI=1S/C15H10F3N3OS/c16-15(17,18)9-4-3-5-10(8-9)19-12-7-2-1-6-11(12)13-20-21-14(23)22-13/h1-8,19H,(H,21,23) | PDB MMDB
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| CHEMBL PC cid PC sid UniChem
Patents
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| Article
| n/a | n/a | 770 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibitory activity of the compound against 5-lipoxygenase was determined |
Bioorg Med Chem Lett 2: 69-72 (1992)
Article DOI: 10.1016/S0960-894X(00)80657-5 BindingDB Entry DOI: 10.7270/Q29K4B4Q |
More data for this Ligand-Target Pair | |
Prostaglandin G/H synthase 1/2
(RAT) | BDBM50047998
(5-(2-(3-(trifluoromethyl)phenylamino)phenyl)-1,3,4...)Show InChI InChI=1S/C15H10F3N3S2/c16-15(17,18)9-4-3-5-10(8-9)19-12-7-2-1-6-11(12)13-20-21-14(22)23-13/h1-8,19H,(H,21,22) | PDB MMDB
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UniProtKB/SwissProt
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| CHEMBL PC cid PC sid UniChem
Patents
| Article
| n/a | n/a | 850 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against Cyclooxygenase was determined |
Bioorg Med Chem Lett 2: 69-72 (1992)
Article DOI: 10.1016/S0960-894X(00)80657-5 BindingDB Entry DOI: 10.7270/Q29K4B4Q |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50047998
(5-(2-(3-(trifluoromethyl)phenylamino)phenyl)-1,3,4...)Show InChI InChI=1S/C15H10F3N3S2/c16-15(17,18)9-4-3-5-10(8-9)19-12-7-2-1-6-11(12)13-20-21-14(22)23-13/h1-8,19H,(H,21,22) | PDB MMDB
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UniProtKB/SwissProt
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| CHEMBL PC cid PC sid UniChem
Patents
| Article
| n/a | n/a | 870 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibitory activity of the compound against 5-lipoxygenase was determined |
Bioorg Med Chem Lett 2: 69-72 (1992)
Article DOI: 10.1016/S0960-894X(00)80657-5 BindingDB Entry DOI: 10.7270/Q29K4B4Q |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50280051
(5-[2-(3-Trifluoromethyl-phenylamino)-pyridin-3-yl]...)Show InChI InChI=1S/C14H9F3N4OS/c15-14(16,17)8-3-1-4-9(7-8)19-11-10(5-2-6-18-11)12-20-21-13(23)22-12/h1-7H,(H,18,19)(H,21,23) | PDB MMDB
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| CHEMBL PC cid PC sid UniChem
| Article
| n/a | n/a | 990 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibitory activity of the compound against 5-lipoxygenase was determined |
Bioorg Med Chem Lett 2: 69-72 (1992)
Article DOI: 10.1016/S0960-894X(00)80657-5 BindingDB Entry DOI: 10.7270/Q29K4B4Q |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50048003
(5-[2-(2,3-Dimethyl-phenylamino)-phenyl]-3H-[1,3,4]...)Show InChI InChI=1S/C16H15N3OS/c1-10-6-5-9-13(11(10)2)17-14-8-4-3-7-12(14)15-18-19-16(21)20-15/h3-9,17H,1-2H3,(H,19,21) | PDB MMDB
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UniProtKB/SwissProt
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| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibitory activity of the compound against 5-lipoxygenase was determined |
Bioorg Med Chem Lett 2: 69-72 (1992)
Article DOI: 10.1016/S0960-894X(00)80657-5 BindingDB Entry DOI: 10.7270/Q29K4B4Q |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50048009
(5-[2-(2,6-Dichloro-3-methyl-phenylamino)-phenyl]-3...)Show InChI InChI=1S/C15H11Cl2N3S2/c1-8-6-7-10(16)13(12(8)17)18-11-5-3-2-4-9(11)14-19-20-15(21)22-14/h2-7,18H,1H3,(H,20,21) | PDB MMDB
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| CHEMBL PC cid PC sid UniChem
| Article
| n/a | n/a | 1.39E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibitory activity of the compound against 5-lipoxygenase was determined |
Bioorg Med Chem Lett 2: 69-72 (1992)
Article DOI: 10.1016/S0960-894X(00)80657-5 BindingDB Entry DOI: 10.7270/Q29K4B4Q |
More data for this Ligand-Target Pair | |
Prostaglandin G/H synthase 1/2
(RAT) | BDBM50048009
(5-[2-(2,6-Dichloro-3-methyl-phenylamino)-phenyl]-3...)Show InChI InChI=1S/C15H11Cl2N3S2/c1-8-6-7-10(16)13(12(8)17)18-11-5-3-2-4-9(11)14-19-20-15(21)22-14/h2-7,18H,1H3,(H,20,21) | PDB MMDB
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UniProtKB/SwissProt
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| CHEMBL PC cid PC sid UniChem
| Article
| n/a | n/a | 1.75E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against Cyclooxygenase was determined |
Bioorg Med Chem Lett 2: 69-72 (1992)
Article DOI: 10.1016/S0960-894X(00)80657-5 BindingDB Entry DOI: 10.7270/Q29K4B4Q |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM22971
(2-[(2,6-dichloro-3-methylphenyl)amino]benzoic acid...)Show InChI InChI=1S/C14H11Cl2NO2/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19/h2-7,17H,1H3,(H,18,19) | PDB MMDB
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
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| Article
| n/a | n/a | 2.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Compound was evaluated in an intact RBL-1 cell line for inhibition of 5-lipoxygenase |
Bioorg Med Chem Lett 2: 69-72 (1992)
Article DOI: 10.1016/S0960-894X(00)80657-5 BindingDB Entry DOI: 10.7270/Q29K4B4Q |
More data for this Ligand-Target Pair | |