Found 62 hits Enz. Inhib. hit(s) with all data for entry = 50031006 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50305149
(2-fluoro-4-{8,12,14-triazatetracyclo[8.6.1.0^{2,7}...)Show InChI InChI=1S/C20H14FN3O/c21-15-9-11(5-6-17(15)25)19-14-10-23-20-18(14)13(7-8-22-20)12-3-1-2-4-16(12)24-19/h1-10,19,24-25H,(H,22,23) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50305150
(3-fluoro-4-{8,12,14-triazatetracyclo[8.6.1.0^{2,7}...)Show SMILES Oc1ccc(C2Nc3ccccc3-c3ccnc4[nH]cc2c34)c(F)c1 Show InChI InChI=1S/C20H14FN3O/c21-16-9-11(25)5-6-14(16)19-15-10-23-20-18(15)13(7-8-22-20)12-3-1-2-4-17(12)24-19/h1-10,19,24-25H,(H,22,23) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 0.600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50305157
(3-chloro-4-{8,12,14,16-tetraazatetracyclo[8.6.1.0^...)Show SMILES Oc1ccc(c(Cl)c1)-c1nc2ccccc2c2ncnc3[nH]cc1c23 Show InChI InChI=1S/C19H11ClN4O/c20-14-7-10(25)5-6-11(14)17-13-8-21-19-16(13)18(22-9-23-19)12-3-1-2-4-15(12)24-17/h1-9,25H,(H,21,22,23) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50305156
(2-fluoro-4-{8,12,14,16-tetraazatetracyclo[8.6.1.0^...)Show InChI InChI=1S/C19H13FN4O/c20-13-7-10(5-6-15(13)25)17-12-8-21-19-16(12)18(22-9-23-19)11-3-1-2-4-14(11)24-17/h1-9,17,24-25H,(H,21,22,23) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50305155
(3-fluoro-4-{8,12,14,16-tetraazatetracyclo[8.6.1.0^...)Show SMILES Oc1ccc(C2Nc3ccccc3-c3ncnc4[nH]cc2c34)c(F)c1 Show InChI InChI=1S/C19H13FN4O/c20-14-7-10(25)5-6-11(14)17-13-8-21-19-16(13)18(22-9-23-19)12-3-1-2-4-15(12)24-17/h1-9,17,24-25H,(H,21,22,23) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50305148
(4-{8,12,14-triazatetracyclo[8.6.1.0^{2,7}.0^{13,17...)Show InChI InChI=1S/C20H15N3O/c24-13-7-5-12(6-8-13)19-16-11-22-20-18(16)15(9-10-21-20)14-3-1-2-4-17(14)23-19/h1-11,19,23-24H,(H,21,22) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 1.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50305153
(2-bromo-4-{8,12,14-triazatetracyclo[8.6.1.0^{2,7}....)Show InChI InChI=1S/C20H14BrN3O/c21-15-9-11(5-6-17(15)25)19-14-10-23-20-18(14)13(7-8-22-20)12-3-1-2-4-16(12)24-19/h1-10,19,24-25H,(H,22,23) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50305154
((4-{8,12,14-triazatetracyclo[8.6.1.0^{2,7}.0^{13,1...)Show InChI InChI=1S/C21H17N3O/c25-12-13-5-7-14(8-6-13)20-17-11-23-21-19(17)16(9-10-22-21)15-3-1-2-4-18(15)24-20/h1-11,20,24-25H,12H2,(H,22,23) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50305152
(3-chloro-4-{8,12,14-triazatetracyclo[8.6.1.0^{2,7}...)Show SMILES Oc1ccc(C2Nc3ccccc3-c3ccnc4[nH]cc2c34)c(Cl)c1 Show InChI InChI=1S/C20H14ClN3O/c21-16-9-11(25)5-6-14(16)19-15-10-23-20-18(15)13(7-8-22-20)12-3-1-2-4-17(12)24-19/h1-10,19,24-25H,(H,22,23) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50305151
((4-{8,12,14-triazatetracyclo[8.6.1.0^{2,7}.0^{13,1...)Show SMILES OB(O)c1ccc(cc1)C1Nc2ccccc2-c2ccnc3[nH]cc1c23 Show InChI InChI=1S/C20H16BN3O2/c25-21(26)13-7-5-12(6-8-13)19-16-11-23-20-18(16)15(9-10-22-20)14-3-1-2-4-17(14)24-19/h1-11,19,24-26H,(H,22,23) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50305193
(CHEMBL589387 | Methyl 9-(3-fluoro-4-hydroxyphenyl)...)Show SMILES COC(=O)C1(Nc2ccccc2-c2ccnc3[nH]cc1c23)c1ccc(O)c(F)c1 Show InChI InChI=1S/C22H16FN3O3/c1-29-21(28)22(12-6-7-18(27)16(23)10-12)15-11-25-20-19(15)14(8-9-24-20)13-4-2-3-5-17(13)26-22/h2-11,26-27H,1H3,(H,24,25) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 29 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50305196
(10-(2-fluoro-4-hydroxyphenyl)-9,13,15-triazatetrac...)Show SMILES Oc1ccc(C2NC(=O)c3ccccc3-c3ccnc4[nH]cc2c34)c(F)c1 Show InChI InChI=1S/C21H14FN3O2/c22-17-9-11(26)5-6-15(17)19-16-10-24-20-18(16)13(7-8-23-20)12-3-1-2-4-14(12)21(27)25-19/h1-10,19,26H,(H,23,24)(H,25,27) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 34 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50305178
(9-(4-methoxyphenyl)-8,12,14-triazatetracyclo[8.6.1...)Show InChI InChI=1S/C21H17N3O/c1-25-14-8-6-13(7-9-14)20-17-12-23-21-19(17)16(10-11-22-21)15-4-2-3-5-18(15)24-20/h2-12,20,24H,1H3,(H,22,23) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 42 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50305175
(9-(2,3,6-trifluorophenyl)-8,12,14-triazatetracyclo...)Show SMILES Fc1ccc(F)c(C2Nc3ccccc3-c3ccnc4[nH]cc2c34)c1F Show InChI InChI=1S/C20H12F3N3/c21-13-5-6-14(22)18(23)17(13)19-12-9-25-20-16(12)11(7-8-24-20)10-3-1-2-4-15(10)26-19/h1-9,19,26H,(H,24,25) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 56 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50305179
(4-{8,12,14-triazatetracyclo[8.6.1.0^{2,7}.0^{13,17...)Show InChI InChI=1S/C20H16N4/c21-13-7-5-12(6-8-13)19-16-11-23-20-18(16)15(9-10-22-20)14-3-1-2-4-17(14)24-19/h1-11,19,24H,21H2,(H,22,23) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 71 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50305173
(9-(2,6-difluorophenyl)-8,12,14-triazatetracyclo[8....)Show InChI InChI=1S/C20H13F2N3/c21-14-5-3-6-15(22)18(14)19-13-10-24-20-17(13)12(8-9-23-20)11-4-1-2-7-16(11)25-19/h1-10,19,25H,(H,23,24) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50305171
(9-(3-fluorophenyl)-8,12,14-triazatetracyclo[8.6.1....)Show InChI InChI=1S/C20H14FN3/c21-13-5-3-4-12(10-13)19-16-11-23-20-18(16)15(8-9-22-20)14-6-1-2-7-17(14)24-19/h1-11,19,24H,(H,22,23) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50305174
(9-(2,4-difluorophenyl)-8,12,14-triazatetracyclo[8....)Show SMILES Fc1ccc(C2Nc3ccccc3-c3ccnc4[nH]cc2c34)c(F)c1 Show InChI InChI=1S/C20H13F2N3/c21-11-5-6-14(16(22)9-11)19-15-10-24-20-18(15)13(7-8-23-20)12-3-1-2-4-17(12)25-19/h1-10,19,25H,(H,23,24) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 210 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50305192
(CHEMBL602648 | Methyl 9-(4-nitrophenyl)-8,12,14-tr...)Show SMILES COC(=O)C1(Nc2ccccc2-c2ccnc3[nH]cc1c23)c1ccc(cc1)[N+]([O-])=O Show InChI InChI=1S/C22H16N4O4/c1-30-21(27)22(13-6-8-14(9-7-13)26(28)29)17-12-24-20-19(17)16(10-11-23-20)15-4-2-3-5-18(15)25-22/h2-12,25H,1H3,(H,23,24) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 210 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50305194
(CHEMBL589632 | Methyl 9-(4-hydroxyphenyl)-8,12,14-...)Show SMILES COC(=O)C1(Nc2ccccc2-c2ccnc3[nH]cc1c23)c1ccc(O)cc1 Show InChI InChI=1S/C22H17N3O3/c1-28-21(27)22(13-6-8-14(26)9-7-13)17-12-24-20-19(17)16(10-11-23-20)15-4-2-3-5-18(15)25-22/h2-12,25-26H,1H3,(H,23,24) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 210 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50305170
(9-(2-fluorophenyl)-8,12,14-triazatetracyclo[8.6.1....)Show InChI InChI=1S/C20H14FN3/c21-16-7-3-1-6-14(16)19-15-11-23-20-18(15)13(9-10-22-20)12-5-2-4-8-17(12)24-19/h1-11,19,24H,(H,22,23) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50300198
(5-chloro-3-phenyl-1H-pyrrolo[2,3-b]pyridine | CHEM...)Show InChI InChI=1S/C13H9ClN2/c14-10-6-11-12(8-16-13(11)15-7-10)9-4-2-1-3-5-9/h1-8H,(H,15,16) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| 260 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50305176
(9-(2,3,4-trifluorophenyl)-8,12,14-triazatetracyclo...)Show SMILES Fc1ccc(C2Nc3ccccc3-c3ccnc4[nH]cc2c34)c(F)c1F Show InChI InChI=1S/C20H12F3N3/c21-14-6-5-12(17(22)18(14)23)19-13-9-25-20-16(13)11(7-8-24-20)10-3-1-2-4-15(10)26-19/h1-9,19,26H,(H,24,25) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 280 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50305169
(9-phenyl-8,12,14-triazatetracyclo[8.6.1.0^{2,7}.0^...)Show InChI InChI=1S/C20H15N3/c1-2-6-13(7-3-1)19-16-12-22-20-18(16)15(10-11-21-20)14-8-4-5-9-17(14)23-19/h1-12,19,23H,(H,21,22) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 370 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50305188
(4-{8,12,14,16-tetraazatetracyclo[8.6.1.0^{2,7}.0^{...)Show InChI InChI=1S/C17H16N4O/c22-8-4-3-7-14-12-9-18-17-15(12)16(19-10-20-17)11-5-1-2-6-13(11)21-14/h1-2,5-6,9-10,21-22H,3-4,7-8H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| 400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50305162
(CHEMBL595397 | Methyl 2-{8,12,14-triazatetracyclo[...)Show InChI InChI=1S/C17H15N3O2/c1-22-15(21)8-14-12-9-19-17-16(12)11(6-7-18-17)10-4-2-3-5-13(10)20-14/h2-7,9,14,20H,8H2,1H3,(H,18,19) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 460 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50300197
(4-phenyl-7H-pyrrolo[2,3-d]pyrimidine | CHEMBL57897...)Show InChI InChI=1S/C12H9N3/c1-2-4-9(5-3-1)11-10-6-7-13-12(10)15-8-14-11/h1-8H,(H,13,14,15) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
| Article PubMed
| 486 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50305172
(9-(4-fluorophenyl)-8,12,14-triazatetracyclo[8.6.1....)Show InChI InChI=1S/C20H14FN3/c21-13-7-5-12(6-8-13)19-16-11-23-20-18(16)15(9-10-22-20)14-3-1-2-4-17(14)24-19/h1-11,19,24H,(H,22,23) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 490 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50305195
(CHEMBL602100 | Ethyl 9-(4-hydroxyphenyl)-8,12,14,1...)Show SMILES CCOC(=O)C1(Nc2ccccc2-c2ncnc3[nH]cc1c23)c1ccc(O)cc1 Show InChI InChI=1S/C22H18N4O3/c1-2-29-21(28)22(13-7-9-14(27)10-8-13)16-11-23-20-18(16)19(24-12-25-20)15-5-3-4-6-17(15)26-22/h3-12,26-27H,2H2,1H3,(H,23,24,25) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 630 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50305163
(8,12,14-triazatetracyclo[8.6.1.0^{2,7}.0^{13,17}]h...)Show InChI InChI=1S/C14H11N3/c1-2-4-12-10(3-1)11-5-6-15-14-13(11)9(7-16-12)8-17-14/h1-6,8,16H,7H2,(H,15,17) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 750 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50305166
(9-benzyl-8,12,14-triazatetracyclo[8.6.1.0^{2,7}.0^...)Show InChI InChI=1S/C21H17N3/c1-2-6-14(7-3-1)12-19-17-13-23-21-20(17)16(10-11-22-21)15-8-4-5-9-18(15)24-19/h1-11,13,19,24H,12H2,(H,22,23) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50305177
(2-{8,12,14-triazatetracyclo[8.6.1.0^{2,7}.0^{13,17...)Show InChI InChI=1S/C20H15N3O/c24-17-8-4-2-6-14(17)19-15-11-22-20-18(15)13(9-10-21-20)12-5-1-3-7-16(12)23-19/h1-11,19,23-24H,(H,21,22) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50305183
(9-(pyridin-4-yl)-8,12,14-triazatetracyclo[8.6.1.0^...)Show InChI InChI=1S/C19H14N4/c1-2-4-16-13(3-1)14-7-10-21-19-17(14)15(11-22-19)18(23-16)12-5-8-20-9-6-12/h1-11,18,23H,(H,21,22) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50305187
(9-(3-fluorophenyl)-8,12,14,16-tetraazatetracyclo[8...)Show InChI InChI=1S/C19H13FN4/c20-12-5-3-4-11(8-12)17-14-9-21-19-16(14)18(22-10-23-19)13-6-1-2-7-15(13)24-17/h1-10,17,24H,(H,21,22,23) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50305158
(9-ethyl-8,12,14-triazatetracyclo[8.6.1.0^{2,7}.0^{...)Show InChI InChI=1S/C16H15N3/c1-2-13-12-9-18-16-15(12)11(7-8-17-16)10-5-3-4-6-14(10)19-13/h3-9,13,19H,2H2,1H3,(H,17,18) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50305165
(9-[(benzyloxy)methyl]-8,12,14-triazatetracyclo[8.6...)Show InChI InChI=1S/C22H19N3O/c1-2-6-15(7-3-1)13-26-14-20-18-12-24-22-21(18)17(10-11-23-22)16-8-4-5-9-19(16)25-20/h1-12,20,25H,13-14H2,(H,23,24) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50305160
(9-(propan-2-yl)-8,12,14-triazatetracyclo[8.6.1.0^{...)Show InChI InChI=1S/C17H17N3/c1-10(2)16-13-9-19-17-15(13)12(7-8-18-17)11-5-3-4-6-14(11)20-16/h3-10,16,20H,1-2H3,(H,18,19) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50305180
(CHEMBL604246 | N-(4-{8,12,14-triazatetracyclo[8.6....)Show SMILES CS(=O)(=O)Nc1ccc(cc1)C1Nc2ccccc2-c2ccnc3[nH]cc1c23 Show InChI InChI=1S/C21H18N4O2S/c1-28(26,27)25-14-8-6-13(7-9-14)20-17-12-23-21-19(17)16(10-11-22-21)15-4-2-3-5-18(15)24-20/h2-12,20,24-25H,1H3,(H,22,23) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50305161
(9-tert-butyl-8,12,14-triazatetracyclo[8.6.1.0^{2,7...)Show InChI InChI=1S/C18H19N3/c1-18(2,3)16-13-10-20-17-15(13)12(8-9-19-17)11-6-4-5-7-14(11)21-16/h4-10,16,21H,1-3H3,(H,19,20) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50305167
(4-{8,12,14-triazatetracyclo[8.6.1.0^{2,7}.0^{13,17...)Show InChI InChI=1S/C18H19N3O/c22-10-4-3-7-16-14-11-20-18-17(14)13(8-9-19-18)12-5-1-2-6-15(12)21-16/h1-2,5-6,8-9,11,16,21-22H,3-4,7,10H2,(H,19,20) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50305168
(3-{8,12,14-triazatetracyclo[8.6.1.0^{2,7}.0^{13,17...)Show InChI InChI=1S/C17H17N3O/c21-9-3-6-15-13-10-19-17-16(13)12(7-8-18-17)11-4-1-2-5-14(11)20-15/h1-2,4-5,7-8,10,15,20-21H,3,6,9H2,(H,18,19) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50305164
(9-cyclohexyl-8,12,14-triazatetracyclo[8.6.1.0^{2,7...)Show InChI InChI=1S/C20H21N3/c1-2-6-13(7-3-1)19-16-12-22-20-18(16)15(10-11-21-20)14-8-4-5-9-17(14)23-19/h4-5,8-13,19,23H,1-3,6-7H2,(H,21,22) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 2.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50305181
(4-{8,12,14-triazatetracyclo[8.6.1.0^{2,7}.0^{13,17...)Show SMILES OC(=O)c1ccc(cc1)C1Nc2ccccc2-c2ccnc3[nH]cc1c23 Show InChI InChI=1S/C21H15N3O2/c25-21(26)13-7-5-12(6-8-13)19-16-11-23-20-18(16)15(9-10-22-20)14-3-1-2-4-17(14)24-19/h1-11,19,24H,(H,22,23)(H,25,26) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 3.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50305159
(9-(2-methylpropyl)-8,12,14-triazatetracyclo[8.6.1....)Show InChI InChI=1S/C18H19N3/c1-11(2)9-16-14-10-20-18-17(14)13(7-8-19-18)12-5-3-4-6-15(12)21-16/h3-8,10-11,16,21H,9H2,1-2H3,(H,19,20) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 3.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50305197
(10-(4-methoxyphenyl)-9,13,15-triazatetracyclo[9.6....)Show SMILES COc1ccc(cc1)C1NC(=O)c2ccccc2-c2ccnc3[nH]cc1c23 Show InChI InChI=1S/C22H17N3O2/c1-27-14-8-6-13(7-9-14)20-18-12-24-21-19(18)16(10-11-23-21)15-4-2-3-5-17(15)22(26)25-20/h2-12,20H,1H3,(H,23,24)(H,25,26) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 3.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50305186
(9-phenyl-8,12,14,16-tetraazatetracyclo[8.6.1.0^{2,...)Show InChI InChI=1S/C19H14N4/c1-2-6-12(7-3-1)17-14-10-20-19-16(14)18(21-11-22-19)13-8-4-5-9-15(13)23-17/h1-11,17,23H,(H,20,21,22) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 3.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50305182
(CHEMBL592269 | N-methyl-4-{8,12,14-triazatetracycl...)Show SMILES CNC(=O)c1ccc(cc1)C1Nc2ccccc2-c2ccnc3[nH]cc1c23 Show InChI InChI=1S/C22H18N4O/c1-23-22(27)14-8-6-13(7-9-14)20-17-12-25-21-19(17)16(10-11-24-21)15-4-2-3-5-18(15)26-20/h2-12,20,26H,1H3,(H,23,27)(H,24,25) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 4.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50305189
(10,20,22-triazahexacyclo[15.6.1.0^{2,10}.0^{3,8}.0...)Show SMILES O=C1N2C(c3ccccc13)c1c[nH]c3nccc(-c4ccccc24)c13 Show InChI InChI=1S/C21H13N3O/c25-21-15-7-2-1-6-14(15)19-16-11-23-20-18(16)13(9-10-22-20)12-5-3-4-8-17(12)24(19)21/h1-11,19H,(H,22,23) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 4.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50305185
(9-[(benzyloxy)methyl]-8,12,14,16-tetraazatetracycl...)Show InChI InChI=1S/C21H18N4O/c1-2-6-14(7-3-1)11-26-12-18-16-10-22-21-19(16)20(23-13-24-21)15-8-4-5-9-17(15)25-18/h1-10,13,18,25H,11-12H2,(H,22,23,24) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50305191
(4-methylbenzene-1-sulfonic acid; N-{dispiro[adaman...)Show SMILES O=C1N2C(c3ccccc13)c1c[nH]c3ncnc(-c4ccccc24)c13 Show InChI InChI=1S/C20H12N4O/c25-20-12-6-2-1-5-11(12)18-14-9-21-19-16(14)17(22-10-23-19)13-7-3-4-8-15(13)24(18)20/h1-10,18H,(H,21,22,23) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of JAK2 by radiometric assay |
Bioorg Med Chem Lett 20: 153-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.021 BindingDB Entry DOI: 10.7270/Q2PN95RQ |
More data for this Ligand-Target Pair | |