Found 56 hits Enz. Inhib. hit(s) with all data for entry = 50036823 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50089825
(1-[4-(3-Chloro-4-methoxy-benzylamino)-6-nitro-phth...)Show SMILES COc1ccc(CNc2nnc(N3CCC(O)CC3)c3ccc(cc23)[N+]([O-])=O)cc1Cl Show InChI InChI=1S/C21H22ClN5O4/c1-31-19-5-2-13(10-18(19)22)12-23-20-17-11-14(27(29)30)3-4-16(17)21(25-24-20)26-8-6-15(28)7-9-26/h2-5,10-11,15,28H,6-9,12H2,1H3,(H,23,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description 50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine platelets |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50089837
(4-(3-Chloro-4-methoxy-benzylamino)-1-thiomorpholin...)Show SMILES COc1ccc(CNc2nnc(N3CCSCC3)c3ccc(cc23)C#N)cc1Cl Show InChI InChI=1S/C21H20ClN5OS/c1-28-19-5-3-15(11-18(19)22)13-24-20-17-10-14(12-23)2-4-16(17)21(26-25-20)27-6-8-29-9-7-27/h2-5,10-11H,6-9,13H2,1H3,(H,24,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.320 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description 50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine platelets |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50089826
(1-[4-(3-Chloro-4-methoxy-benzylamino)-6-cyano-phth...)Show SMILES COc1ccc(CNc2nnc(N3CCC(CC3)C(N)=O)c3ccc(cc23)C#N)cc1Cl Show InChI InChI=1S/C23H23ClN6O2/c1-32-20-5-3-15(11-19(20)24)13-27-22-18-10-14(12-25)2-4-17(18)23(29-28-22)30-8-6-16(7-9-30)21(26)31/h2-5,10-11,16H,6-9,13H2,1H3,(H2,26,31)(H,27,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description 50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine platelets |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50089807
(4-(3-Chloro-4-methoxy-benzylamino)-1-(4-oxo-piperi...)Show SMILES COc1ccc(CNc2nnc(N3CCC(=O)CC3)c3ccc(cc23)C#N)cc1Cl Show InChI InChI=1S/C22H20ClN5O2/c1-30-20-5-3-15(11-19(20)23)13-25-21-18-10-14(12-24)2-4-17(18)22(27-26-21)28-8-6-16(29)7-9-28/h2-5,10-11H,6-9,13H2,1H3,(H,25,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.530 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description 50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine platelets |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50089833
(4-(3-Chloro-4-methoxy-benzylamino)-1-piperidin-1-y...)Show SMILES COc1ccc(CNc2nnc(N3CCCCC3)c3ccc(cc23)C#N)cc1Cl Show InChI InChI=1S/C22H22ClN5O/c1-29-20-8-6-16(12-19(20)23)14-25-21-18-11-15(13-24)5-7-17(18)22(27-26-21)28-9-3-2-4-10-28/h5-8,11-12H,2-4,9-10,14H2,1H3,(H,25,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.550 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description 50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine platelets |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50089814
(4-(3-Chloro-4-methoxy-benzylamino)-1-(4-hydroxy-pi...)Show SMILES COc1ccc(CNc2nnc(N3CCC(O)CC3)c3ccc(cc23)C#N)cc1Cl Show InChI InChI=1S/C22H22ClN5O2/c1-30-20-5-3-15(11-19(20)23)13-25-21-18-10-14(12-24)2-4-17(18)22(27-26-21)28-8-6-16(29)7-9-28/h2-5,10-11,16,29H,6-9,13H2,1H3,(H,25,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.560 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description Inhibition of phosphodiesterase 5 (PDE5) from porcine platelets, range 0.442-0.710 |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50089821
(4-(3-Chloro-4-methoxy-benzylamino)-1-(4-hydroxy-4-...)Show SMILES COc1ccc(CNc2nnc(N3CCC(C)(O)CC3)c3ccc(cc23)C#N)cc1Cl Show InChI InChI=1S/C23H24ClN5O2/c1-23(30)7-9-29(10-8-23)22-17-5-3-15(13-25)11-18(17)21(27-28-22)26-14-16-4-6-20(31-2)19(24)12-16/h3-6,11-12,30H,7-10,14H2,1-2H3,(H,26,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description 50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine platelets |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50089827
(4-(3-Chloro-4-methoxy-benzylamino)-1-[4-(2-hydroxy...)Show SMILES COc1ccc(CNc2nnc(N3CCC(CCO)CC3)c3ccc(cc23)C#N)cc1Cl Show InChI InChI=1S/C24H26ClN5O2/c1-32-22-5-3-18(13-21(22)25)15-27-23-20-12-17(14-26)2-4-19(20)24(29-28-23)30-9-6-16(7-10-30)8-11-31/h2-5,12-13,16,31H,6-11,15H2,1H3,(H,27,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description 50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine platelets |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50369544
(CHEMBL545012)Show SMILES COc1ccc(CNc2nnc(N3CCS(=O)CC3)c3ccc(cc23)C#N)cc1Cl Show InChI InChI=1S/C21H20ClN5O2S/c1-29-19-5-3-15(11-18(19)22)13-24-20-17-10-14(12-23)2-4-16(17)21(26-25-20)27-6-8-30(28)9-7-27/h2-5,10-11H,6-9,13H2,1H3,(H,24,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description 50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine platelets |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50089815
(1-[4-(3-Chloro-4-methoxy-benzylamino)-6-trifluorom...)Show SMILES COc1ccc(CNc2nnc(N3CCC(O)CC3)c3ccc(cc23)C(F)(F)F)cc1Cl Show InChI InChI=1S/C22H22ClF3N4O2/c1-32-19-5-2-13(10-18(19)23)12-27-20-17-11-14(22(24,25)26)3-4-16(17)21(29-28-20)30-8-6-15(31)7-9-30/h2-5,10-11,15,31H,6-9,12H2,1H3,(H,27,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.730 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description 50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine platelets |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50089841
(4-(3-Chloro-4-methoxy-benzylamino)-1-(1,1-dioxo-1l...)Show SMILES COc1ccc(CNc2nnc(N3CCS(=O)(=O)CC3)c3ccc(cc23)C#N)cc1Cl Show InChI InChI=1S/C21H20ClN5O3S/c1-30-19-5-3-15(11-18(19)22)13-24-20-17-10-14(12-23)2-4-16(17)21(26-25-20)27-6-8-31(28,29)9-7-27/h2-5,10-11H,6-9,13H2,1H3,(H,24,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.790 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description 50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine platelets |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50089832
(1-[6,7-Dichloro-4-(3-chloro-4-methoxy-benzylamino)...)Show SMILES COc1ccc(CNc2nnc(N3CCC(O)CC3)c3cc(Cl)c(Cl)cc23)cc1Cl Show InChI InChI=1S/C21H21Cl3N4O2/c1-30-19-3-2-12(8-18(19)24)11-25-20-14-9-16(22)17(23)10-15(14)21(27-26-20)28-6-4-13(29)5-7-28/h2-3,8-10,13,29H,4-7,11H2,1H3,(H,25,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.860 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description 50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine platelets |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50089820
(4-(3-Chloro-4-methoxy-benzylamino)-1-(4-hydroxymet...)Show SMILES COc1ccc(CNc2nnc(N3CCC(CO)CC3)c3ccc(cc23)C#N)cc1Cl Show InChI InChI=1S/C23H24ClN5O2/c1-31-21-5-3-17(11-20(21)24)13-26-22-19-10-16(12-25)2-4-18(19)23(28-27-22)29-8-6-15(14-30)7-9-29/h2-5,10-11,15,30H,6-9,13-14H2,1H3,(H,26,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.930 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description 50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine platelets |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50089830
(4-(3-Chloro-4-methoxy-benzylamino)-1-(4-methyl-pip...)Show SMILES COc1ccc(CNc2nnc(N3CCN(C)CC3)c3ccc(cc23)C#N)cc1Cl Show InChI InChI=1S/C22H23ClN6O/c1-28-7-9-29(10-8-28)22-17-5-3-15(13-24)11-18(17)21(26-27-22)25-14-16-4-6-20(30-2)19(23)12-16/h3-6,11-12H,7-10,14H2,1-2H3,(H,25,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.950 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description 50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine platelets |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50089816
(4-(3-Chloro-4-methoxy-benzylamino)-1-(4-methoxy-pi...)Show SMILES COC1CCN(CC1)c1nnc(NCc2ccc(OC)c(Cl)c2)c2cc(ccc12)C#N Show InChI InChI=1S/C23H24ClN5O2/c1-30-17-7-9-29(10-8-17)23-18-5-3-15(13-25)11-19(18)22(27-28-23)26-14-16-4-6-21(31-2)20(24)12-16/h3-6,11-12,17H,7-10,14H2,1-2H3,(H,26,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description 50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine platelets |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50089838
(4-(3-Chloro-4-methoxy-benzylamino)-1-(3-hydroxy-pi...)Show SMILES COc1ccc(CNc2nnc(N3CCCC(O)C3)c3ccc(cc23)C#N)cc1Cl Show InChI InChI=1S/C22H22ClN5O2/c1-30-20-7-5-15(10-19(20)23)12-25-21-18-9-14(11-24)4-6-17(18)22(27-26-21)28-8-2-3-16(29)13-28/h4-7,9-10,16,29H,2-3,8,12-13H2,1H3,(H,25,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description 50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine platelets |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50089809
(4-(3-Chloro-4-methoxy-benzylamino)-1-piperazin-1-y...)Show SMILES COc1ccc(CNc2nnc(N3CCNCC3)c3ccc(cc23)C#N)cc1Cl Show InChI InChI=1S/C21H21ClN6O/c1-29-19-5-3-15(11-18(19)22)13-25-20-17-10-14(12-23)2-4-16(17)21(27-26-20)28-8-6-24-7-9-28/h2-5,10-11,24H,6-9,13H2,1H3,(H,25,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description 50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine platelets |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50089842
(4-(3-Chloro-4-methoxy-benzylamino)-1-imidazol-1-yl...)Show SMILES COc1ccc(CNc2nnc(-n3ccnc3)c3ccc(cc23)C#N)cc1Cl Show InChI InChI=1S/C20H15ClN6O/c1-28-18-5-3-14(9-17(18)21)11-24-19-16-8-13(10-22)2-4-15(16)20(26-25-19)27-7-6-23-12-27/h2-9,12H,11H2,1H3,(H,24,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description 50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine platelets |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50089818
(4-(3-Chloro-4-methoxy-benzylamino)-1-[4-(2-hydroxy...)Show SMILES COc1ccc(CNc2nnc(N3CCN(CCO)CC3)c3ccc(cc23)C#N)cc1Cl Show InChI InChI=1S/C23H25ClN6O2/c1-32-21-5-3-17(13-20(21)24)15-26-22-19-12-16(14-25)2-4-18(19)23(28-27-22)30-8-6-29(7-9-30)10-11-31/h2-5,12-13,31H,6-11,15H2,1H3,(H,26,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description 50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine platelets |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50089812
(4-(3-Chloro-4-methoxy-benzylamino)-1-(3,6-dihydro-...)Show SMILES COc1ccc(CNc2nnc(N3CCC=CC3)c3ccc(cc23)C#N)cc1Cl |c:15| Show InChI InChI=1S/C22H20ClN5O/c1-29-20-8-6-16(12-19(20)23)14-25-21-18-11-15(13-24)5-7-17(18)22(27-26-21)28-9-3-2-4-10-28/h2-3,5-8,11-12H,4,9-10,14H2,1H3,(H,25,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description 50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine platelets |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50089836
(4-(3-Chloro-4-methoxy-benzylamino)-1-(4-hydroxy-pi...)Show SMILES COc1ccc(CNc2nnc(N3CCC(O)CC3)c3ccc(cc23)C(N)=O)cc1Cl Show InChI InChI=1S/C22H24ClN5O3/c1-31-19-5-2-13(10-18(19)23)12-25-21-17-11-14(20(24)30)3-4-16(17)22(27-26-21)28-8-6-15(29)7-9-28/h2-5,10-11,15,29H,6-9,12H2,1H3,(H2,24,30)(H,25,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description 50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine platelets |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM14390
(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB PubMed
| n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description 50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine platelets |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50089817
(4-(3-Chloro-4-methoxy-benzylamino)-1-(3-hydroxy-pr...)Show InChI InChI=1S/C20H20ClN5O2/c1-28-18-6-4-14(10-17(18)21)12-24-20-16-9-13(11-22)3-5-15(16)19(25-26-20)23-7-2-8-27/h3-6,9-10,27H,2,7-8,12H2,1H3,(H,23,25)(H,24,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description 50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine platelets |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50089823
(4-(3-Chloro-4-methoxy-benzylamino)-1-[(pyridin-2-y...)Show SMILES COc1ccc(CNc2nnc(NCc3ccccn3)c3ccc(cc23)C#N)cc1Cl Show InChI InChI=1S/C23H19ClN6O/c1-31-21-8-6-16(11-20(21)24)13-27-23-19-10-15(12-25)5-7-18(19)22(29-30-23)28-14-17-4-2-3-9-26-17/h2-11H,13-14H2,1H3,(H,27,30)(H,28,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description 50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine platelets |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50066450
(1-Chloro-4-(3-chloro-4-methoxy-benzylamino)-phthal...)Show InChI InChI=1S/C17H12Cl2N4O/c1-24-15-5-3-11(7-14(15)18)9-21-17-13-6-10(8-20)2-4-12(13)16(19)22-23-17/h2-7H,9H2,1H3,(H,21,23) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description 50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine platelets |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50089839
(1-[4-(3-Chloro-4-methoxy-benzylamino)-6-cyano-phth...)Show SMILES COc1ccc(CNc2nnc(N3CCC(CC3)C(O)=O)c3ccc(cc23)C#N)cc1Cl Show InChI InChI=1S/C23H22ClN5O3/c1-32-20-5-3-15(11-19(20)24)13-26-21-18-10-14(12-25)2-4-17(18)22(28-27-21)29-8-6-16(7-9-29)23(30)31/h2-5,10-11,16H,6-9,13H2,1H3,(H,26,27)(H,30,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description 50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine platelets |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50066454
(CHEMBL25616 | Sodium; 1-{4-[(benzo[1,3]dioxol-5-yl...)Show SMILES [O-]C(=O)C1CCN(CC1)c1nc(NCc2ccc3OCOc3c2)c2cc(Cl)ccc2n1 Show InChI InChI=1S/C22H21ClN4O4/c23-15-2-3-17-16(10-15)20(24-11-13-1-4-18-19(9-13)31-12-30-18)26-22(25-17)27-7-5-14(6-8-27)21(28)29/h1-4,9-10,14H,5-8,11-12H2,(H,28,29)(H,24,25,26)/p-1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description 50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine platelets |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50089808
(1-[6-Chloro-4-(3-chloro-4-methoxy-benzylamino)-pht...)Show SMILES COc1ccc(CNc2nnc(N3CCC(O)CC3)c3ccc(Cl)cc23)cc1Cl Show InChI InChI=1S/C21H22Cl2N4O2/c1-29-19-5-2-13(10-18(19)23)12-24-20-17-11-14(22)3-4-16(17)21(26-25-20)27-8-6-15(28)7-9-27/h2-5,10-11,15,28H,6-9,12H2,1H3,(H,24,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description 50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine platelets |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50089834
(4-(3-Chloro-4-methoxy-benzylamino)-1-[(pyridin-4-y...)Show SMILES COc1ccc(CNc2nnc(NCc3ccncc3)c3ccc(cc23)C#N)cc1Cl Show InChI InChI=1S/C23H19ClN6O/c1-31-21-5-3-17(11-20(21)24)14-28-23-19-10-16(12-25)2-4-18(19)22(29-30-23)27-13-15-6-8-26-9-7-15/h2-11H,13-14H2,1H3,(H,27,29)(H,28,30) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 6.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description 50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine platelets |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50089822
(4-(3-Chloro-4-methoxy-benzylamino)-1-[(pyridin-3-y...)Show SMILES COc1ccc(CNc2nnc(NCc3cccnc3)c3ccc(cc23)C#N)cc1Cl Show InChI InChI=1S/C23H19ClN6O/c1-31-21-7-5-16(10-20(21)24)13-27-23-19-9-15(11-25)4-6-18(19)22(29-30-23)28-14-17-3-2-8-26-12-17/h2-10,12H,13-14H2,1H3,(H,27,30)(H,28,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 6.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description 50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine platelets |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50089811
(4-(3-Chloro-4-methoxy-benzylamino)-1-(4-pyridin-2-...)Show SMILES COc1ccc(CNc2nnc(N3CCN(CC3)c3ccccn3)c3ccc(cc23)C#N)cc1Cl Show InChI InChI=1S/C26H24ClN7O/c1-35-23-8-6-19(15-22(23)27)17-30-25-21-14-18(16-28)5-7-20(21)26(32-31-25)34-12-10-33(11-13-34)24-4-2-3-9-29-24/h2-9,14-15H,10-13,17H2,1H3,(H,30,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description 50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine platelets |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50089810
(4-(3-Chloro-4-methoxy-benzylamino)-1-(4-hydroxy-cy...)Show SMILES Cl.COc1ccc(CNc2nnc(N[C@H]3CC[C@H](O)CC3)c3ccc(cc23)C#N)cc1Cl |r,wU:14.12,wD:17.16,(7.9,-2.3,;-1.55,-10.62,;-2.62,-10.02,;-2.63,-8.48,;-1.3,-7.7,;-1.31,-6.16,;-2.65,-5.4,;-2.66,-3.85,;-1.33,-3.08,;-1.33,-1.54,;-2.68,-.77,;-2.68,.77,;-1.33,1.54,;-1.33,3.08,;-2.66,3.85,;-3.99,3.09,;-5.32,3.86,;-5.32,5.4,;-6.39,6.02,;-3.98,6.17,;-2.65,5.39,;,.77,;1.33,1.54,;2.66,.77,;2.66,-.77,;1.33,-1.54,;,-.77,;4,-1.54,;5.06,-2.16,;-3.98,-6.17,;-3.97,-7.71,;-5.03,-8.34,)| Show InChI InChI=1S/C23H24ClN5O2.ClH/c1-31-21-9-3-15(11-20(21)24)13-26-22-19-10-14(12-25)2-8-18(19)23(29-28-22)27-16-4-6-17(30)7-5-16;/h2-3,8-11,16-17,30H,4-7,13H2,1H3,(H,26,28)(H,27,29);1H/t16-,17-; | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description 50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine platelets |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50089819
(CHEMBL544540 | N-{1-[4-(3-Chloro-4-methoxy-benzyla...)Show SMILES COc1ccc(CNc2nnc(N3CCC(CC3)NS(C)(=O)=O)c3ccc(cc23)C#N)cc1Cl Show InChI InChI=1S/C23H25ClN6O3S/c1-33-21-6-4-16(12-20(21)24)14-26-22-19-11-15(13-25)3-5-18(19)23(28-27-22)30-9-7-17(8-10-30)29-34(2,31)32/h3-6,11-12,17,29H,7-10,14H2,1-2H3,(H,26,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description 50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine platelets |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50089840
(4-(3-Chloro-4-methoxy-benzylamino)-1-(4-pyrimidin-...)Show SMILES COc1ccc(CNc2nnc(N3CCN(CC3)c3ncccn3)c3ccc(cc23)C#N)cc1Cl Show InChI InChI=1S/C25H23ClN8O/c1-35-22-6-4-18(14-21(22)26)16-30-23-20-13-17(15-27)3-5-19(20)24(32-31-23)33-9-11-34(12-10-33)25-28-7-2-8-29-25/h2-8,13-14H,9-12,16H2,1H3,(H,30,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description 50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine platelets |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50089829
(1,4-Bis-(3-chloro-4-methoxy-benzylamino)-phthalazi...)Show SMILES COc1ccc(CNc2nnc(NCc3ccc(OC)c(Cl)c3)c3cc(ccc23)C#N)cc1Cl Show InChI InChI=1S/C25H21Cl2N5O2/c1-33-22-7-4-16(10-20(22)26)13-29-24-18-6-3-15(12-28)9-19(18)25(32-31-24)30-14-17-5-8-23(34-2)21(27)11-17/h3-11H,13-14H2,1-2H3,(H,29,31)(H,30,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description 50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine platelets |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM23620
(2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin...)Show SMILES OCCN(CCO)c1nc(N2CCCCC2)c2nc(nc(N3CCCCC3)c2n1)N(CCO)CCO Show InChI InChI=1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank PubMed
| n/a | n/a | 574 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description Inhibition of phosphodiesterase 5 (PDE5) from porcine platelets, range 0.244-1.35 |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50089835
(4-(3-Chloro-4-methoxy-benzylamino)-1-(4-hydroxy-pi...)Show SMILES COc1ccc(CNc2nnc(N3CCC(O)CC3)c3ccc(cc23)C(O)=O)cc1Cl Show InChI InChI=1S/C22H23ClN4O4/c1-31-19-5-2-13(10-18(19)23)12-24-20-17-11-14(22(29)30)3-4-16(17)21(26-25-20)27-8-6-15(28)7-9-27/h2-5,10-11,15,28H,6-9,12H2,1H3,(H,24,25)(H,29,30) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description 50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine platelets |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |
Phosphodiesterase
(Sus scrofa) | BDBM15296
(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)Show InChI InChI=1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16) | PDB
KEGG
UniProtKB/TrEMBL
GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| n/a | n/a | 843 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description Inhibition of phosphodiesterase 3 (PDE3) from porcine platelets, range 0.581-1.23 |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50089814
(4-(3-Chloro-4-methoxy-benzylamino)-1-(4-hydroxy-pi...)Show SMILES COc1ccc(CNc2nnc(N3CCC(O)CC3)c3ccc(cc23)C#N)cc1Cl Show InChI InChI=1S/C22H22ClN5O2/c1-30-20-5-3-15(11-19(20)23)13-25-21-18-10-14(12-24)2-4-17(18)22(27-26-21)28-8-6-16(29)7-9-28/h2-5,10-11,16,29H,6-9,13H2,1H3,(H,25,26) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 984 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description Inhibition of phosphodiesterase 2 (PDE2) from porcine platelets, range 0.841-1.15 |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM14363
(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)Show InChI InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1.11E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description Inhibition of phosphodiesterase 5 (PDE5) from porcine platelets, range 0.733-1.68 |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |
3',5'-cyclic-AMP phosphodiesterase
(Sus scrofa) | BDBM50089814
(4-(3-Chloro-4-methoxy-benzylamino)-1-(4-hydroxy-pi...)Show SMILES COc1ccc(CNc2nnc(N3CCC(O)CC3)c3ccc(cc23)C#N)cc1Cl Show InChI InChI=1S/C22H22ClN5O2/c1-30-20-5-3-15(11-19(20)23)13-25-21-18-10-14(12-24)2-4-17(18)22(27-26-21)28-8-6-16(29)7-9-28/h2-5,10-11,16,29H,6-9,13H2,1H3,(H,25,26) | UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.17E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description Inhibition of phosphodiesterase 4 (PDE4) from porcine liver, range 1.01-1.36 |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM23620
(2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin...)Show SMILES OCCN(CCO)c1nc(N2CCCCC2)c2nc(nc(N3CCCCC3)c2n1)N(CCO)CCO Show InChI InChI=1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MCE PC cid PC sid PDB UniChem
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| n/a | n/a | 3.24E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description Inhibition of phosphodiesterase 2 (PDE2) from porcine platelets, range 2.54-4.14 |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |
3',5'-cyclic-AMP phosphodiesterase
(Sus scrofa) | BDBM14361
((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18) | UniProtKB/TrEMBL
GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
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| n/a | n/a | 3.63E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description Inhibition of phosphodiesterase 4 (PDE4) from porcine liver |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |
3',5'-cyclic-AMP phosphodiesterase
(Sus scrofa) | BDBM23620
(2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin...)Show SMILES OCCN(CCO)c1nc(N2CCCCC2)c2nc(nc(N3CCCCC3)c2n1)N(CCO)CCO Show InChI InChI=1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2 | UniProtKB/TrEMBL
GoogleScholar AffyNet
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CHEMBL DrugBank MCE PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| n/a | n/a | 5.27E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description Inhibition of phosphodiesterase 4 (PDE4) from porcine liver, range 0.058-7.78 |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |
3',5'-cyclic-AMP phosphodiesterase
(Sus scrofa) | BDBM15296
(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)Show InChI InChI=1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16) | UniProtKB/TrEMBL
GoogleScholar AffyNet
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description Inhibition of phosphodiesterase 4 (PDE4) from porcine liver, range 10.4-16.3 |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |
Phosphodiesterase
(Sus scrofa) | BDBM50089814
(4-(3-Chloro-4-methoxy-benzylamino)-1-(4-hydroxy-pi...)Show SMILES COc1ccc(CNc2nnc(N3CCC(O)CC3)c3ccc(cc23)C#N)cc1Cl Show InChI InChI=1S/C22H22ClN5O2/c1-30-20-5-3-15(11-19(20)23)13-25-21-18-10-14(12-24)2-4-17(18)22(27-26-21)28-8-6-16(29)7-9-28/h2-5,10-11,16,29H,6-9,13H2,1H3,(H,25,26) | PDB
KEGG
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.75E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description Inhibition of phosphodiesterase 3 (PDE3) from porcine platelets, range 11.4-26.9 |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |
Phosphodiesterase
(Sus scrofa) | BDBM23620
(2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin...)Show SMILES OCCN(CCO)c1nc(N2CCCCC2)c2nc(nc(N3CCCCC3)c2n1)N(CCO)CCO Show InChI InChI=1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2 | PDB
KEGG
UniProtKB/TrEMBL
GoogleScholar AffyNet
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CHEMBL DrugBank MCE PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| n/a | n/a | 4.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description Inhibition of phosphodiesterase 3 (PDE3) from porcine platelets, range 31.8-60.7 |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50089828
(4-(3-Chloro-4-methoxy-benzylamino)-1-(4-hydroxy-pi...)Show SMILES COc1ccc(CNc2nnc(N3CCC(O)CC3)c3ccc(cc23)C(=O)N(C)C)cc1Cl Show InChI InChI=1S/C24H28ClN5O3/c1-29(2)24(32)16-5-6-18-19(13-16)22(26-14-15-4-7-21(33-3)20(25)12-15)27-28-23(18)30-10-8-17(31)9-11-30/h4-7,12-13,17,31H,8-11,14H2,1-3H3,(H,26,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 5.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description 50% inhibitory concentration against phosphodiesterase 5 (PDE5) from porcine platelets |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM14363
(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)Show InChI InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 9.02E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description Inhibition of phosphodiesterase 2 (PDE2) from porcine platelets, range 68.1-119 |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM14361
((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description Inhibition of phosphodiesterase 2 (PDE2) from porcine platelets |
J Med Chem 43: 2523-9 (2000)
BindingDB Entry DOI: 10.7270/Q2T72J4N |
More data for this Ligand-Target Pair | |